Clinical trials: polymerase chain reaction
SARS-CoV2 Infection
COVID-19 Antigen Rapid Test Kit
The SG Diagnostics COVID-19 Antigen Rapid Test Kit (Colloidal Gold-Based) is a single-use test kit intended to detect the novel coronavirus SARS-CoV-2 that causes COVID-19.
- Trial name
- SETCOV (NCT04889365)
- Testing
- SG Diagnostics COVID-19 Antigen Rapid Test Kit, Polymerase chain reaction (PCR) test
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Polish Society of Disaster Medicine
Recurrent Melanoma, Stage III Melanoma
Therapeutic Autologous Lymphocytes, Aldesleukin, and Denileukin Diftitox in Treating Patients With Stage III-IV Melanoma
RATIONALE: White blood cells that have been treated in a laboratory may be able to kill tumor cells in patients with melanoma. Aldesleukin and denileukin diftitox may stimulate the white blood cells to kill melanoma cells.
- Conditions
- Recurrent Melanoma, Stage III Melanoma, Stage IV Melanoma
- Trial name
- NCT00945269
- Testing
- therapeutic autologous lymphocytes, aldesleukin, denileukin diftitox
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Fred Hutchinson Cancer Center
Lung Cancer
Study of Tissue Samples From Patients With Stage I Non-Small Cell Lung Cancer Enrolled on Research Study CALGB-140202
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.
- Trial name
- NCT00990873
- Testing
- gene expression analysis, microarray analysis, reverse transcriptase-polymerase chain reaction
- Volunteers
- 100 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Sarcoma
Studying Tumor Tissue Samples From Patients With Soft Tissue Sarcoma
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00900341
- Testing
- DNA analysis, gene expression analysis, protein expression analysis
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Arizona
Vitamin D Deficiency, Primary Open- Angle Glaucoma
Associations of Vitamin D Deficiency and Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma
This study investigated whether vitamin D receptor gene polymorphism is altered in primary open-angle glaucoma subjects carrying the risk allele and vitamin D deficiency is an important factor in the development of glaucoma.
- Trial name
- NCT02539745
- Testing
- Vitamin D receptor polymorphic analysis, Serum levels of 1a, 25-Dihydroxyvitamin D3
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Lv Yingjuan
Prostate Cancer
Study of a Polymorphism in Patients With Prostate Cancer
RATIONALE: Studying samples of blood from patients with cancer and from healthy participants in the laboratory may help doctors learn more about changes that may occur in DNA.
- Trial name
- NCT00900185
- Testing
- mutation analysis, polymerase chain reaction, polymorphism analysis
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Observational
Adenovirus Infection in Children With Autoimmune Hepatitis
Adenoviruses have been linked to severe hepatitis in children. They are non-enveloped, icosahedral viruses of medium size (90-100 nm) (5).
- Trial name
- NCT05693714
- Testing
- Pcr
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Assiut University
Influenza
The Effect of Oseltamivir Treatment on the Yield of Polymerase Chain Reaction Test for Confirmed Influenza Infection
The purpose of this study is to determine the duration of viral shedding in hospitalized patients with influenza virus, treated with oseltamivir.
- Trial name
- NCT02334514
- Where
- Israel
- Volunteers
- 215 people
- Sponsor
- Rambam Health Care Campus
Breast Cancer, Chronic Myeloproliferative Disorders
Collecting and Storing Tissue and DNA Samples From Patients Undergoing a Donor Stem Cell Transplant
RATIONALE: Collecting and storing samples of blood, urine, and tissue from patients undergoing a donor stem cell transplant to test in the laboratory may help the study of graft-versus-host disease in the future.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Graft Versus Host Disease
- Trial name
- NCT00900406
- Testing
- gene expression analysis, microarray analysis, polymorphism analysis
- Where
- 3 sites in United States
- Volunteers
- 190 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Leukemia
Biomarkers in Samples From Young Patients With Acute Myeloid Leukemia
RATIONALE: Studying bone marrow samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01247584
- Testing
- DNA analysis, mutation analysis, polymerase chain reaction
- Volunteers
- 234 people
- Sponsor
- Children's Oncology Group
Cancer
Genetic Susceptibility and Risk of Second Cancers in Patients Who Have Undergone Stem Cell Transplant for Cancer
RATIONALE: Identifying genes that increase a person's susceptibility to second cancers may help the study of cancer treatment. PURPOSE: This study is looking at genetic susceptibility and risk of second cancers in patients who…
- Trial name
- NCT00949052
- Testing
- DNA analysis, polymorphism analysis, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Urethritis, Cervicitis
Rapid Diagnostic Assay for Gonorrhea and Chlamydia
This study is a pilot randomized controlled trial evaluating the use of either a) rapid 30-minute desktop assay or b) point-of-care gram stain (current standard of care) to guide the clinical management of patients with…
- Conditions
- Urethritis, Cervicitis, Sexually Transmitted Infections
- Trial name
- NCT05564299
- Testing
- Rapid 30-minute Desktop Assay
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Massachusetts General Hospital
Knee Prosthesis
In Vivo Kinematics Comparison of Stryker or Zimmer Total Knee Arthroplasty
This study will compare the kinematics data collected from patients with implants created by different manufacturers to see which of these implants provides a more normal-like kinematic pattern compared to the normal knee.
- Trial name
- NCT01864434
- Testing
- Stryker posterior cruciat retaining (PCR) total knee arthroplasty (TKA), Zimmer PCR TKA
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- The University of Tennessee, Knoxville
Head and Neck Cancer
Pathological Validation of Functional Imaging in Head and Neck Squamous Cell Carcinoma
Chemo-radiotherapy (CRT) is currently the cornerstone in the management of locoregional advanced head and neck cancer (HNC). Optimization of the quality of RT is therefore an important issue, if the investigators want to improve…
- Trial name
- NCT01827709
- Testing
- A polymerase chain reaction -based hypoxia classifier, Functional imaging before treatment., Immunohistochemical staining
- Where
- Belgium
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Autism Spectrum Disorder
The Association Between Herpes Simplex Viruses and Autism
Autism spectrum disorders are pervasive developmental disorders that include autistic disorder, Asperger's disorder, and pervasive developmental disorder-not otherwise specified.They are characterized by stereotypic behaviors…
- Trial name
- NCT03180112
- Testing
- enzyme linked immunosorbent assay and polymerase chain reaction
- Volunteers
- 80 people
- Sponsor
- Assiut University
Lymphoma
Lenalidomide, Rituximab, and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Diffuse Large Cell or Follicular B-Cell Lymphoma
RATIONALE: Lenalidomide may stimulate the immune system in different ways and stop cancer cells from growing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways.
- Trial name
- NCT00670358
- Testing
- pegfilgrastim, rituximab, cyclophosphamide
- Where
- 3 sites in United States
- Volunteers
- 138 people
- Sponsor
- Mayo Clinic
Moyamoya Disease, Moyamoya
Imaging in Moyamoya Disease - Study to Investigate Different Imaging Technologies for a Better Understanding of Various Imaging Techniques to Evaluate Cerebral Hemodynamics, Disease-activity and Possibly the Etiology in Moyamoya Patients
Aim of this study is to improve patient care in Moyamoya Patients by improving Imaging technologies and aiming to identify factors involved in disease progression.
- Trial name
- IMAGINE (NCT06330818)
- Testing
- MRI, H2 15O PET/CT, Biosampling
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Lupus Erythematosus, Systemic, Adverse Effects
Exploration of Genotype Based Personalized Prescription of Cyclophosphamide in Systemic Lupus Erythematosus Treatment
The purpose of this study is to investigate the relationship between the side effects of cyclophosphamide in the treatment of systemic lupus erythematosus (SLE) in Han Chinese and the genetic polymorphisms of drug metabolizing…
- Trial name
- NCT01060410
- Testing
- Polymorphism Analysis, Cyclophosphamide, Pharmacokinetic analysis
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Sun Yat-sen University
Leukemia, Myelodysplastic Syndromes
Detection of Residual Disease in Children Receiving Therapy for Acute Myeloid Leukemia or Myelodysplastic Syndrome
RATIONALE: Diagnostic procedures may improve the ability to detect residual disease. PURPOSE: Clinical trial to detect the presence of residual disease in children who are receiving therapy for acute myeloid leukemia or…
- Trial name
- NCT00003790
- Testing
- polymerase chain reaction, flow cytometry
- Where
- 43 sites in United States, Australia and 1 more
- Volunteers
- 496 people
- Sponsor
- Children's Oncology Group
HIV Infections
A Study of Patients Who Recently Have Been Infected With HIV
The purpose of this study is to find out if anti-HIV drugs, taken by patients who are newly infected with HIV, can make the level of HIV in the body too low to detect.
- Trial name
- NCT00006415
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)