Clinical trials: polymerase chain reaction
Gastric Atrophy, Gastric Cancer
Epidemiology of Helicobacter Pylori Infection in Moscow
H. pylori is transmitted from individual to individual and causes chronic active gastritis in all infected people. H. pylori infection can result in gastroduodenal ulcers, atrophic gastritis (AG), gastric carcinoma, and gastric…
- Conditions
- Gastric Atrophy, Gastric Cancer, Helicobacter Pylori Infection
- Trial name
- NCT05775120
- Testing
- OLGA and H.pylori culture
- Where
- Russia
- Volunteers
- 5,121 people, healthy volunteers welcome
- Sponsor
- Moscow Clinical Scientific Center
Patient With Influenza Like Illness
Effect of Influenza Vaccination of Healthcare Workers (HCW) on the Risk of Influenza in Patients Hospitalized in Short Stays Units
Hospital acquired influenza is associated with significant morbidity and mortality in hospitalized patients notably elderly patients. Vaccination of HCW is recommended to prevent influenza transmission in healthcare setting.
- Trial name
- NCT02198638
- Testing
- A nasal swab
- Where
- 2 sites in France
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Bloodstream Infections
Clinical Impact of Rapid Identification of Positive Blood Cultures vs. Internal Laboratory Standard
In this before-after study, different new methods for bacterial species identification from positive blood cultures will be compared towards historic controls.
- Trial name
- NCT04156633
- Testing
- conventional identification method: biochemical profiling or MALDI-TOF MS, new identification method: Biofire FilmArray© BCID panel, new identification method: metagenomic WGS
- Where
- Switzerland
- Volunteers
- 800 people
- Sponsor
- University Hospital, Basel, Switzerland
The Study Goal is to Assess the Introduction of Sustainable Family Planning/Reproductive Health Information and Services Through, Land O' Lakes-supported Dairy Cooperatives
Family Planning Through Dairy Cooperatives
This observational study will assess a model for providing family planning through quarterly events organized by dairy cooperatives supported by Land O'Lakes in Kenya.
- Trial name
- NCT01226433
- Where
- Kenya
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- FHI 360
Beta Thalassemia Major
Effect of Spirulina on Liver Fibrosis by Transient Elastography in Beta Thalassemic Children With Hepatitis C
Thalassemics can develop liver fibrosis because of iron overload and hepatitis C infection. The latter is the main risk factor for liver fibrosis in transfusion dependent thalassemics.
- Trial name
- NCT02744105
- Testing
- Spirulina
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Colorectal Cancer
Irinotecan in Treating Patients With Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of irinotecan in treating patients who have colorectal…
- Trial name
- NCT00003843
- Testing
- irinotecan hydrochloride, mutation analysis, polymorphism analysis
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- California Cancer Consortium
Leukemia
Obatoclax Mesylate in Samples From Young Patients With Acute Myeloid Leukemia
RATIONALE: Studying the effects of obatoclax mesylate in cell samples from patients with cancer in the laboratory may help doctors learn more about the effects of obatoclax mesylate on cancer cells.
- Trial name
- NCT01150656
- Testing
- gene expression analysis, microarray analysis, protein expression analysis
- Volunteers
- 50 people
- Sponsor
- Children's Oncology Group
Leukemia
Dasatinib and Vorinostat in Treating Patients With Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia or Acute Lymphoblastic Leukemia
RATIONALE: Dasatinib and vorinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving dasatinib together with vorinostat may kill more cancer cells.
- Trial name
- NCT00816283
- Testing
- dasatinib, vorinostat, cytogenetic analysis
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- City of Hope Medical Center
Leukemia
Biomarker Changes in Samples From Young Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of blood or tumor tissue from patients with cancer in the laboratory may help doctors learn about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01139931
- Testing
- DNA methylation analysis, gene expression analysis, microarray analysis
- Volunteers
- 15 people
- Sponsor
- Children's Oncology Group
Prostate Cancer
Study of Genes and the Environment in Patients With Prostate Cancer Residing in the East Anglia, Trent, or West Midlands Regions of the United Kingdom
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00758173
- Testing
- polymorphism analysis, laboratory biomarker analysis, questionnaire administration
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Cancer Research UK
COVID-19, Pain, Chronic
Pain-related Long Covid in Covid-19 Survivors
The exploratory project aims to investigate the presence of pain as a long Covid-19 symptom in previously hospitalised patients and in non-hospitalised persons previously tested positive in a PCR test.
- Trial name
- NCT05520931
- Testing
- Questionnaire and register-based data assessment
- Where
- Denmark
- Volunteers
- 600,000 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Lymphoma
GM-CSF and Rituximab in Treating Patients With Previously Untreated Follicular Non-Hodgkin Lymphoma
RATIONALE: Biological therapies, such as GM-CSF, may stimulate the immune system in different ways and stop cancer cells from growing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways.
- Trial name
- NCT00893477
- Testing
- rituximab, sargramostim, gene expression analysis
- Volunteers
- 60 people
- Sponsor
- French Innovative Leukemia Organisation
Influenza
A Human Influenza Transmission Study Using Naturally Infected Community Donors
The purpose of this study is to determine whether influenza A or B can be transmitted from adults with naturally acquired community influenza infection to healthy adult recipients under controlled inpatient exposure conditions…
- Trial name
- FLU-TIDE (NCT07814495)
- Testing
- Influenza Donor Visit, Influenza Recipient Inpatient Exposures Sessions
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Emory University
Human Papillomavirus DNA Tests, Cervical Cancer
IT-system Development for Reaching Cervix Cancer Screening Non-attenders
The main purpose is to develop and test an IT-infrastructure to provide more individualized ways of inviting and reaching women who have not participated, despite having been invited with annual reminders, in cervix cancer…
- Trial name
- NCT02750124
- Testing
- Cobas PCR Female swab sample Packet, Routine practice
- Volunteers
- 8,000 people
- Sponsor
- Karolinska Institutet
Brain and Central Nervous System Tumors
Study of Tissue and Blood Samples From Patients With Low-Grade Glioma
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01004523
- Testing
- fluorescence in situ hybridization, loss of heterozygosity analysis, polymerase chain reaction
- Where
- 38 sites in United States
- Volunteers
- 135 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Intraocular Melanoma
Bone Marrow and Blood Samples From Patients With Metastatic Choroid Melanoma
RATIONALE: Studying samples of bone marrow and blood from patients with cancer may help doctors find out the extent of disease. PURPOSE: This research study is collecting bone marrow and blood samples from patients with…
- Trial name
- NCT00897624
- Testing
- gene expression analysis, reverse transcriptase-polymerase chain reaction, laboratory biomarker analysis
- Volunteers
- 15 people
- Sponsor
- Institut Curie
Gastric Cancer, Colo-rectal Cancer
Association Between ABO Polymorphism and Gastric/Colorectal Cancers
To assess ABO gene polymorphism (rs8176746) in the patients histopathologically confirmed gastric and/or colorectal cancers relative to healthy controls by real time PCR.
- Trial name
- NCT06149923
- Testing
- quantitative Real-time PCR
- Volunteers
- 184 people
- Sponsor
- Assiut University
Leukemia
Biomarkers in Bone Marrow Samples From Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01251159
- Testing
- mutation analysis, polymerase chain reaction, immunologic technique
- Volunteers
- 30 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Oral Cancer, Oral Lichen Planus
Diagnostic Accuracy of Salivary DNA Integrity Index in Oral Malignant and Premalignant Lesions
This study aims to identify the accuracy of DNA integrity index in differentiating between oral premalignant lesions and oral cancer.
- Conditions
- Oral Cancer, Oral Lichen Planus, Oral Leukoplakia
- Trial name
- NCT03682562
- Testing
- DNA Integrity Index
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Cairo University
Head and Neck Cancer
Biomarkers of Response in Blood and Tumor Tissue Samples From Patients With Unresectable Stage IV Squamous Cell Cancer of the Head and Neck Previously Treated With Cetuximab, Cisplatin, and Radiation Therapy
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01194635
- Testing
- fluorescence in situ hybridization, gene expression analysis, polymerase chain reaction
- Volunteers
- 69 people
- Sponsor
- ECOG-ACRIN Cancer Research Group