Clinical trials: polymerase chain reaction
Colonoscopy, Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis)
Tissue Cytomegalovirus Viral Load and Associated Factors in Pediatric Patients Undergoing Colonoscopy
Introduction and Objectives Patients diagnosed with Inflammatory Bowel Disease (IBD) carry a significantly elevated risk for opportunistic infections and the reactivation of latent pathogens, most notably Cytomegalovirus (CMV).
- Conditions
- Colonoscopy, Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), CMV
- Trial name
- NCT07419204
- Testing
- Colonoscopy after bowel cleansing
- Where
- Turkey (Türkiye)
- Volunteers
- 139 people
- Sponsor
- Gazi University
MicroRNA Expression Profile in Human Vitreous
MicroRNA Expression in Human Blood Serum and Vitreous Body
MicroRNAs are important regulators of many cellular functions but their expression profile in human vitreous is still unclear. Aim of this study is to investigate microRNA expression profile by PCR in human vitreous of macula…
- Trial name
- NCT01462734
- Testing
- human vitreous and blood serum sampling, PCR
- Where
- Japan
- Volunteers
- 8 people
- Sponsor
- Kyorin University
Glioma
Biomarker-based Algorithm for Diagnosis of Glioma
ATRX (X-linked mental retardation and alpha-thalassaemia syndrome protein) loss and pTERT (Telomerase reverse transcriptase) mutation are diagnostic markers of gliomas.
- Trial name
- TELOGNOSTIC (NCT04194593)
- Testing
- PCR (Polymerase Chain Reaction)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Leukemia
Imatinib Mesylate With or Without Hydroxychloroquine in Treating Patients With Chronic Myeloid Leukemia
RATIONALE: Imatinib mesylate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Biological therapies, such as hydroxychloroquine, may stimulate the immune system in different ways and stop…
- Trial name
- NCT01227135
- Testing
- hydroxychloroquine, imatinib mesylate, cytogenetic analysis
- Where
- 3 sites in United Kingdom
- Volunteers
- 66 people
- Sponsor
- Lynn McMahon
RSV Infection
Impact of the Covid-19 on Respiratory Syncytial Virus (RSV) Epidemic
The magnitude of seasonal Respiratory Syncytial Virus (RSV) epidemics brings each year new logistical challenges for the hospitalization of young infants with bronchiolitis that overwhelm hospital capacities and lead to specific…
- Trial name
- IPCoVRS (NCT04944160)
- Testing
- Medical records analysis, Comparison of cohorts
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Hospices Civils de Lyon
Infection Viral
Nosocomial Influenza Surveillance of 2022 - 2027 Seasonal Period
Hospital-Acquired Influenza (HAI) is closely linked to the intensity of influenza in the community. HAI is associated with significant morbidity, mortality and extra costs due to prolonged hospital stay.
- Trial name
- NOSOGRIPPE (NCT05712759)
- Testing
- Influenza-like illness group
- Sponsor
- Hospices Civils de Lyon
Hepatitis B, Chronic
Prospective Exploratory Study to Evaluate the Safety and Efficacy of Telbivudine in the Fifth Year of Treatment in Chinese Patients With Compensated Chronic Hepatitis B
This study will explore efficacy and safety of Telbivudine in the fifth year of treatment.
- Trial name
- NCT00646503
- Testing
- Telbivudine
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Novartis
Cytomegalovirus Infections, HIV Infections
Preventing Cytomegalovirus (CMV) Organ Damage With Valganciclovir in People With HIV
Cytomegalovirus (CMV) infection is a common opportunistic infection (OI) in HIV patients. The purpose of this study is to find out whether valganciclovir, an antiviral approved by the FDA for the treatment of CMV in the eye, is…
- Trial name
- NCT00006145
- Testing
- Valganciclovir
- Where
- 57 sites in United States, Puerto Rico
- Volunteers
- 350 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cholangiocarcinoma, Cholangiocarcinoma, Intrahepatic
Detecting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma (LyMIC)
Lymph node metastasis (LNM) is a major prognostic factor in intrahepatic cholangiocarcinoma (ICC), and accurate preoperative prediction of the presence or absence of LNM has significant clinical implications in determining…
- Conditions
- Cholangiocarcinoma, Cholangiocarcinoma, Intrahepatic, Cholangiocarcinoma Resectable, Cholangiocarcinoma; Liver
- Trial name
- LyMIC (NCT06381648)
- Testing
- LyMIC (Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma)
- Where
- 4 sites in United States, Japan
- Volunteers
- 230 people
- Sponsor
- City of Hope Medical Center
Primary Apical Periodontitis, Root Canal Infection
Bacterial Profiles in Primary Apical Periodontitis Using 16S rRNA PCR
This pilot randomized clinical study aims to compare bacterial profiles in symptomatic and asymptomatic primary apical periodontitis using 16S rRNA polymerase chain reaction sequencing.
- Conditions
- Primary Apical Periodontitis, Root Canal Infection, Endodontic Infection
- Trial name
- NCT07637305
- Testing
- 3% Sodium Hypochlorite Irrigation with Ultrasonic Activation, 5.25% Sodium Hypochlorite Irrigation with Ultrasonic Activation
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- Hasanuddin University
Colorectal Cancer
Studying Biomarkers in Tumor Tissue and Blood Samples From Patients Undergoing Chemotherapy and Radiation Therapy for Stage II or Stage III Rectal Cancer That Can Be Removed By Surgery
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00960427
- Testing
- systemic chemotherapy, RNA analysis, gene expression analysis
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Leukemia
Laboratory Study of Lymphoblasts in Young Patients With High-Risk Acute Lymphoblastic Leukemia
RATIONALE: Collecting and storing samples of bone marrow and blood from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00896766
- Testing
- loss of heterozygosity analysis, microarray analysis, polymorphism analysis
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Children's Oncology Group
SARS-CoV Infection, Polymerase Chain Reaction
Self-Collected Saliva Samples Without Viral Transport Media for COVID-19 Testing Via RT-PCR
This is a study that will attempt to validate the process for detecting SARS-CoV-2 (COVID19) on a non-FDA-approved technology using self-collected saliva as the specimen.
- Conditions
- SARS-CoV Infection, Polymerase Chain Reaction, Laboratory Testing
- Trial name
- NCT04604145
- Testing
- SARS-CoV-2 testing on the Eppendorf Thermal Cycler PCR system using self-collected saliva as the specimen
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
Possible Fungal Infection
Immediate vs. Deferred Empirical Antifungal Treatment With Voriconazole In Neutropenic Patients
A well-known side-effect of cytostatics (drugs against malignancies) is a decrease in the number of white blood cells, especially of the so-called neutrophil granulocytes, which are very important for the defense against…
- Trial name
- IDEA (NCT00150345)
- Testing
- voriconazole (Vfend)
- Where
- 28 sites in Germany
- Volunteers
- 147 people
- Sponsor
- Pfizer
Covid19, Obstetric Complication
COVID-19 Infection and Fetal-neonatal Outcomes
COVID-19, the coronavirus responsible for the pandemic that began at the end of 2019 in China, spreads through respiratory droplets and direct contact.
- Conditions
- Covid19, Obstetric Complication, SARS-CoV Infection, Preterm Birth
- Trial name
- NCT04699578
- Testing
- Covid-19 positive
- Where
- Italy
- Volunteers
- 230 people
- Sponsor
- University of Campania Luigi Vanvitelli
Colorectal Cancer
Signaling Pathways Targeting Colorectal Cancer in Egypt
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related death worldwide. In Egypt, CRC constitutes 4.2% of all cancers with median age is 50 years old.
- Trial name
- NCT03467308
- Testing
- Markers in tissue samples: (TIGAR , TRIM59, P53, AKT, GSH)
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Assiut University
Leukemia
Studying Genes in Samples From Younger Patients With Acute Lymphoblastic Leukemia
RATIONALE: Studying samples of blood and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01653613
- Testing
- DNA analysis, fluorescence in situ hybridization, gene expression analysis
- Volunteers
- 400 people
- Sponsor
- Eastern Cooperative Oncology Group
Acute Stroke, Ischemic Stroke
Circulating Non-coding RNA in Acute Ischemic Stroke (AISRNA)
AISRNA is to analyze the expression pattern of circular RNA (circRNA), micro-RNA (miRNA) and long non-coding RNA (lncRNA) by next-generation sequencing in patients with acute ischemic stroke and healthy control.
- Trial name
- AISRNA (NCT04175691)
- Testing
- Sequencing of circRNA/miRNA/lncRNA
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Encephalitis, Meningitis
Optimal Encephalitis/Meningitis Roadmap Via Precise Diagnosis and Treatment
Encephalitis and meningitis are serious central nervous system diseases. There is currently a lack of comprehensive and accurate diagnosis and treatment pathways.
- Conditions
- Encephalitis, Meningitis, Meningoencephalitis, Next-Generation Sequencing
- Trial name
- NCT04946682
- Testing
- Types of etiological diagnostic methods
- Where
- 7 sites in China
- Volunteers
- 484 people
- Sponsor
- Wen-hong Zhang
Leber Hereditary Optic Neuropathy
Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year
The goal of this clinical trial is to assess the efficacy and safety of GS010 gene therapy - (lenadogene nolparvovec) in subjects with LHON due to the G11778A ND4 mitochondrial mutation with a vision loss up to one year.
- Trial name
- REFLECT (NCT03293524)
- Testing
- GS010
- Where
- 13 sites in United States, Belgium and 5 more
- Volunteers
- 98 people
- Sponsor
- GenSight Biologics