Clinical trials: polymerase chain reaction
COVID-19, Immunity
Study on Immune Status of Patients With COVID-19
This study is a prospective cohort study aimed to clarify the continuous immune state changes of patients with COVID-19. Investigators include the patients admitted to the hospital within one week after the onset of COVID-19.
- Conditions
- COVID-19, Immunity, Life Quality
- Trial name
- NCT05682573
- Testing
- hospitalized patient
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Qilu Hospital of Shandong University
COVID19
Study on the Use of Sarilumab in Patients With COVID-19 Infection
Sarilumab is an anti-interleukin-6 human monoclonal antibody, such as tocilizumab, which is administered subcutaneously every two weeks for the treatment of moderate to severe active rheumatoid arthritis in adult patients.
- Trial name
- NCT04386239
- Testing
- Sarilumab Prefilled Syringe
- Where
- Italy
- Sponsor
- ASST Fatebenefratelli Sacco
Infertility, HIV Infections
HIV-discordant Couple Intrauterine Insemination
The investigators propose to treat couples who wish to have a child in which the man is HIV-positive and the woman is HIV-negative. The investigators call these couples HIV-discordant.
- Trial name
- NCT00975546
- Testing
- Sperm washing and testing for HIV contamination, Intrauterine Insemination
- Where
- United States
- Sponsor
- University of Missouri-Columbia
Glaucoma
The Changes Within the Cells of the Drainage System of the Eye in Patients With Glaucoma
The purpose of this study is to try to identify the cause of damage to the drainage system of the eye (the trabecular meshwork).
- Trial name
- NCT02524431
- Testing
- Collection of trabecular meshwork tissue during surgery
- Where
- United States
- Sponsor
- Wills Eye
Colorectal Cancer
DNA Changes That Affect Vitamin D Metabolism in Patients With Colorectal Cancer Receiving Vitamin D Supplements
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00550563
- Testing
- cholecalciferol, polymerase chain reaction, polymorphism analysis
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Roswell Park Cancer Institute
Placenta Previa
ADAMTS,Proteoglycan and Oxidant / Antioxidant Enzyme Levels of Placenta Previa Totalis (Accreta, Increta, Percreta).
Placenta previa totalis (accreta, increta, percreta); ADAMTS and proteoglycans and the oxidant / antioxidant enzyme levels.
- Trial name
- NCT02270593
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
COVID-19
COVID-19 - Cytokine Storm
This is a multi-center study comparing clinical outcomes in patients with COVID-19 in subjects hospitalized at Hadassah and other hospitals for PCR or serology confirmed COVID-19 and compare the outcomes to the presence of…
- Trial name
- NCT04474067
- Testing
- No intervention
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Lung Cancer
Laboratory Study Using Samples From Patients With Non-Small Cell Lung Cancer Treated on Clinical Trial CASE-2507
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and RNA and identify biomarkers related to cancer.
- Trial name
- NCT00907699
- Testing
- DNA analysis, RNA analysis, fluorescence in situ hybridization
- Sponsor
- Case Comprehensive Cancer Center
Advanced NSCLC, Circulating Tumor Cells
Clinical Sensitivity Verification Study of Circulating Tumor Cells Gene Mutation Detection From Advanced NSCLC Patients
Verify the Coincidence rate between Circulating tumor cells (CTCs) and tumor tissue or Circulating tumor DNA (ctDNA) of advanced NSCLC patients with Driver gene mutation
- Conditions
- Advanced NSCLC, Circulating Tumor Cells, Circulating Tumor DNA
- Trial name
- NCT04229121
- Testing
- nonintervention
- Volunteers
- 100 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Sarcoma
DNA Tests in Detecting Disseminated Disease in Tumor, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma
RATIONALE: DNA analysis of tumor, blood, and bone marrow may help doctors predict if the disease has been disseminated. PURPOSE: This research trial studies DNA tests in detecting disseminated disease in tumor, blood, and bone…
- Trial name
- NCT01419509
- Testing
- DNA methylation analysis, microarray analysis, polymerase chain reaction
- Volunteers
- 170 people
- Sponsor
- Children's Oncology Group
Bladder Cancer, Brain and Central Nervous System Tumors
Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Conditions
- Bladder Cancer, Brain and Central Nervous System Tumors, Esophageal Cancer, Intraocular Melanoma
- Trial name
- NCT00757614
- Testing
- DNA analysis, polymorphism analysis, laboratory biomarker analysis
- Where
- United Kingdom
- Volunteers
- 14,000 people
- Sponsor
- Cancer Research UK
Men Who Have Sex With Men
Bacterial Sexually Transmitted Infections (STIs) Viability by Polymerase Chain Reaction (PCR)
It is a cross-sectional, without risk or constraint, monocentric study on the viability of the main bacterial sexually transmitted infections (STIs) in men who have sex with men (MSM).
- Trial name
- VISTH (NCT05959408)
- Testing
- Collection of throat swab, Collection of anal swab, Collection of first void urine
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Bordeaux
COVID-19 Pandemic
Seasonal Factors and COVID 19
Corona Virus - 19 Disease (COVID-19), caused by Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2), first appeared in Wuhan city of Hubei province of China and spread rapidly, causing a pandemic.
- Trial name
- COVID-19 (NCT05264948)
- Testing
- Polymerase chain reaction
- Where
- Turkey (Türkiye)
- Volunteers
- 24,225 people
- Sponsor
- Izmir Katip Celebi University
Pneumonia, Methicillin-Resistant Staphylococcus Aureus
Trial of MRSA Polymerase Chain Reaction for Pneumonia
The purpose of this study is to conduct a randomized clinical trial to compare an antibiotic strategy based on a novel diagnostic test, polymerase chain reaction (PCR) to usual care, in critically ill adults with pneumonia…
- Trial name
- NCT02660554
- Testing
- Polymerase Chain Reaction (PCR)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Northwestern University
Vitamin D Deficiency, Primary Open-angle Glaucoma
Comparison of Vitamin D Status and Vitamin D Receptor Polymorphisms in Patients With High Myopia and Primary Open-angle Glaucoma
Vitamin D deficiency is known to be significantly associated with high myopia. This study investigated the vitamin D status in patients with high myopia and primary open-angle glaucoma, in order to understand the relationship…
- Conditions
- Vitamin D Deficiency, Primary Open-angle Glaucoma, High Myopia, Vitamin D Receptor Polymorphisms
- Trial name
- NCT03021629
- Testing
- Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by an enzyme-linked immuno-absorbent assay
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Lv Yingjuan
Pancreatic Ductal Adenocarcinoma (PDAC)
Microbiota and Metabolites Alterations in Pancreatic Head and Body/Tail Cancer Patients
Pancreatic ductal adenocarcinoma (PDAC) can be divided into pancreatic head cancer (PHC) and pancreatic body/tail cancer (PBTC) according to the anatomical position of tumors.
- Trial name
- NCT06147154
- Testing
- 16S rRNA amplicon sequencing and untargeted metabolomics
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Qilu Hospital of Shandong University
EKLF Mutations in Beta Thalassemia Patients
Detection of Krupple Like Factor -1(KLF1/ EKLF) DNA Mutations in Beta Thalassemia Patients
Detection of KLF1 gene mutations in patients with beta thalassemia considering the alpha and beta molecular status of these patients.
- Trial name
- NCT06433570
- Testing
- multiplex PCR
- Volunteers
- 100 people
- Sponsor
- Assiut University
Pre-Eclampsia
co Ihibtory Receptor in Preeclampsia
Preeclampsia is a form of hypertensive pregnancy disorder with multiorgan involvement. It is characterized by new-onset hypertension and proteinuria after 20 weeks' gestation in a woman whose blood pressure was normal before…
- Trial name
- asd (NCT05294952)
- Testing
- real time PCR
- Volunteers
- 82 people
- Sponsor
- Assiut University
Viral Diseases
Identification of Viruses Associated With Diseases of Unknown Cause
This study will try to identify new or known viruses responsible for diseases or conditions of unknown cause. Viruses are an important cause of illness.
- Trial name
- NCT00359268
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Covid19, Vaccination Reaction
Kidney Histopathology After COVID-19 and SARS-CoV-2 Vaccination
The study aims to summarize kidney histopathological findings in patients with coronavirus disease 2019 (COVID-19) and post-severe acute respiratory syndrome-coronavirus-type 2 (SARS-CoV-2) vaccination.
- Trial name
- NCT05043168
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- University of Giessen