Clinical trials: polymerase chain reaction
Keratoconus
Thyroid Gland Dysfunction and Vitamin D Polymorphism in Keratoconus
This prospective study the thyroid gland dysfunction and vitamin D receptor polymorphism in keratoconus patients
- Trial name
- NCT05073601
- Testing
- ELISA,DNA extraction
- Where
- Egypt
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Autism Spectrum Disorder
The Association Between Herpes Simplex Viruses and Autism
Autism spectrum disorders are pervasive developmental disorders that include autistic disorder, Asperger's disorder, and pervasive developmental disorder-not otherwise specified.They are characterized by stereotypic behaviors…
- Trial name
- NCT03180112
- Testing
- enzyme linked immunosorbent assay and polymerase chain reaction
- Volunteers
- 80 people
- Sponsor
- Assiut University
Colorectal Cancer
Effect of Folate on DNA in Colon Tissue and Blood Samples From Patients at Increased Risk of Developing Colorectal Neoplasia
RATIONALE: Studying samples of blood and tissue from patients at risk of cancer in the laboratory may help doctors learn more about the effect of folate on DNA and identify biomarkers related to cancer.
- Trial name
- NCT00611000
- Testing
- folic acid, DNA methylation analysis, gene expression analysis
- Volunteers
- 20 people
- Sponsor
- Rockefeller University
Leukemia, Lymphoma
Pentostatin, Cyclophosphamide, Rituximab, and Mitoxantrone in Treating Patients With Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Cancer
RATIONALE: Pentostatin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cyclophosphamide and mitoxantrone, work in different ways to stop the growth…
- Trial name
- NCT00546377
- Testing
- filgrastim, pegfilgrastim, rituximab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Leukemia
Nilotinib in Treating Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia
RATIONALE: Nilotinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well nilotinib works in treating patients with newly diagnosed chronic…
- Trial name
- NCT00809211
- Testing
- nilotinib, cytogenetic analysis, mutation analysis
- Where
- 6 sites in United States, Germany and 2 more
- Volunteers
- 40 people
- Sponsor
- Cancer Trials Ireland
Depression, Fatigue
Depression and Interleukin-6 Production in Patients With Ovarian Epithelial Cancer
RATIONALE: Measuring levels of interleukin-6 and depression may help doctors understand the relationship between interleukin-6 and depression. It may also help the study of cancer in the future.
- Conditions
- Depression, Fatigue, Ovarian Cancer, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT00460200
- Testing
- polymorphism analysis, laboratory biomarker analysis, physiologic testing
- Sponsor
- Jonsson Comprehensive Cancer Center
Breast Cancer Female
Letrozole in Post-Menopausal Patients With Operable Hormone-Sensitive Breast Cancer
A short pre-surgical non-therapeutic trial involving postmenopausal women with newly diagnosed eR+, HeR2-negative operable breast cancers.
- Trial name
- NCT03747042
- Testing
- Letrozole
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Texas Southwestern Medical Center
Leukemia
Identifying Risk Factors for Bone Tissue Death in Young Patients With Acute Lymphoblastic Leukemia Treated on Clinical Trial CCG-1882
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to bone tissue death.
- Trial name
- NCT00898469
- Testing
- polymorphism analysis
- Volunteers
- 671 people
- Sponsor
- Children's Oncology Group
HIV Infections, Hepatitis C
Determining Responses to Two Different Vaccines in HIV and HCV Infected Individuals
Infection with either HIV or hepatitis C virus (HCV) affects immune system responses. The purpose of this study is to investigate the immune responses to two different vaccine formulations in HIV-infected, HCV-infected, and…
- Trial name
- NCT00393276
- Testing
- Twinrix, Decavac
- Where
- 12 sites in United States, Puerto Rico
- Volunteers
- 29 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Viral Pulmonary Infections
VIRal Pulmonary Infections in Older AGE
Severe acute respiratory infections (SARIs) represent one of the leading causes of hospitalization and mortality worldwide. These infections are associated with substantial in-hospital mortality and often constitute a turning…
- Trial name
- VIRAGE (NCT07539103)
- Where
- 20 sites in France
- Volunteers
- 5,900 people
- Sponsor
- Gérond'if
Infection Viral, Infection, Hospital
Early Risk Stratification of Patient Hospitalized for SARS-CoV2 Infection: Critical COVID-19 France CCF
The COVID-19 pandemic of SARS CoV2 (Severe Acute Respiratory Syndrome, COVID-19) infection, which is currently evolving in France, raises many questions about the clinical and biological profile of infected hospitalized patients.
- Conditions
- Infection Viral, Infection, Hospital, COVID
- Trial name
- CCF (NCT04344327)
- Where
- 23 sites in France
- Volunteers
- 2,878 people
- Sponsor
- French Cardiology Society
Ischemic Cardiomyopathy
Genetics of Ischemic Cardiomyopathy
Background:Ischemic heart disease is one of the heaviest health-related burdens worldwide.We aimed to identify the common hub mRNA and pathways that are involved in pathological progression of ischemic cardiomyopathy.
- Trial name
- NCT05508269
- Testing
- quantitative polymerase chain reaction(QPCR) for four genes, Cardiac biopsy, blood sampling
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Breast Cancer, Chronic Myeloproliferative Disorders
Collecting and Storing Tissue and DNA Samples From Patients Undergoing a Donor Stem Cell Transplant
RATIONALE: Collecting and storing samples of blood, urine, and tissue from patients undergoing a donor stem cell transplant to test in the laboratory may help the study of graft-versus-host disease in the future.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Graft Versus Host Disease
- Trial name
- NCT00900406
- Testing
- gene expression analysis, microarray analysis, polymorphism analysis
- Where
- 3 sites in United States
- Volunteers
- 190 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Endometrial Carcinoma Cellular Diagnosis
Expression Analysis of the COPB 2 and Bcl-2 in Early Stages of Endometrial Carcinoma
COPB2 is a subunit of the intracellular transport system between cell organelles that participates in the regulation of cell division and differentiation.
- Trial name
- NCT05951426
- Testing
- 1.hysterectomy with bilateral oophorectomy and pelvic lymphonodectomy. 2 explorative curettage
- Volunteers
- 60 people
- Sponsor
- Clinical Center Kragujevac
Chronic Myeloid Leukemia
A Study of Full Treatment-free Remission in Patients With Chronic Myeloid Leukemia
This study is constituted of two stage: Treatment-Free Remission 1 (TFR1) stage and Treatment-Free Remission 2 (TFR2) stage. The purpose of the TFR1 stage is to assess the effect of nilotinib reduced to half the standard dose for…
- Trial name
- DANTE (NCT03874858)
- Testing
- Nilotinib, Asciminib
- Where
- 26 sites in Italy
- Volunteers
- 135 people
- Sponsor
- Novartis Pharmaceuticals
Pneumonia, Pneumococcal, Pneumonia Childhood
Paediatric Pneumococcal Pneumonia in Malaysia Prior to and During Pneumococcal Conjugate Vaccine (PCV) Implementation
The purpose of this research is to provide baseline surveillance of pneumonia in young children in Malaysia before and during the implementation of the pneumococcal conjugate vaccine (PCV).
- Trial name
- MSIP PCV (NCT04923035)
- Where
- 3 sites in Malaysia
- Volunteers
- 1,010 people, healthy volunteers welcome
- Sponsor
- IMU University, Malaysia
Coronavirus Disease 2019 (COVID-19) Pneumonia
Saliva PCR in Pregnant Women with COVID-19
Abstract: Objectives We aim to study the relative viral load using saliva polymerase chain reaction among pregnant women treated with Paxlovid.
- Trial name
- NCT06735300
- Testing
- Nirmatrelvir/Ritonavir (Paxlovid)
- Where
- Taiwan
- Volunteers
- 37 people
- Sponsor
- National Cheng-Kung University Hospital
Metastatic Invasive Lobular Carcinoma (mILC)
Longitudinal Tumor Burden Quantification Using Circulating Tumor DNA in Metastatic Lobular Breast Cancer
The goal of this study is to characterize early dynamic changes in ctDNA, which can aid in tailoring early therapy in patients with metastatic Invasive lobular carcinoma (ILC).
- Trial name
- LBC-Monitor (NCT06666439)
- Testing
- circulating tumor DNA (ctDNA)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Julia Foldi
Lymphoma
Biomarkers in Samples From Patients With Follicular Lymphoma Treated With Rituximab
RATIONALE: Studying the effects of rituximab in blood and tumor tissue samples from patients with cancer in the laboratory may help doctors learn more about the effects of rituximab on cancer cells.
- Trial name
- NCT01150643
- Testing
- gene expression analysis, microarray analysis, polymerase chain reaction
- Volunteers
- 559 people
- Sponsor
- Eastern Cooperative Oncology Group
Lung Cancer
Sorafenib and Erlotinib in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer That Has Not Responded to Chemotherapy
RATIONALE: Sorafenib and erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Sorafenib may also stop the growth of non-small cell lung cancer by blocking blood flow to the tumor.
- Trial name
- NCT00801385
- Testing
- erlotinib hydrochloride, sorafenib tosylate, DNA analysis
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Yonsei University