Clinical trials: polymerase chain reaction
Graft Versus Host Disease, Infection
Early Diagnosis of Aspergillosis in Patients at High Risk of Fungal Infection Caused by Treatment for Hematologic Cancer or Other Disease
RATIONALE: Studying ways to diagnose fungal infections early may help doctors plan the best treatment. PURPOSE: This clinical trial is studying laboratory tests to see how well they find aspergillosis early in patients at high…
- Conditions
- Graft Versus Host Disease, Infection, Leukemia, Myelodysplastic Syndromes
- Trial name
- NCT00462657
- Testing
- polymerase chain reaction, bronchoalveolar lavage, immunoenzyme technique
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- St. Bartholomew's Hospital
Sexually Transmitted Diseases
Utility and Acceptability of a Molecular Test in the Management of Sexually Transmitted Diseases in Uganda
The goal of this clinical trial is to assess utility and acceptability of a molecular test in comparison with clinical syndromic approach in the management of sexually transmitted diseases (STD) at STD clinic of Mulago National…
- Trial name
- ASTRHA (NCT05994495)
- Testing
- nuclear acid amplification tests, Clinical Syndromic Approach
- Where
- Uganda
- Volunteers
- 220 people
- Sponsor
- Riccardo Serraino
Maternal and Child Health
Evaluation of the Effectiveness of a Quality Improvement Intervention
This rigorous evaluation demonstrated that implementation of a time-limited quality improvement strategy effectively improved coverage of some components of an integrated maternal and child health service in a complex health…
- Trial name
- NCT04278612
- Testing
- Quality improvement intervention to strengthen health service provision
- Volunteers
- 1,438 people
- Sponsor
- University of KwaZulu
Systemic Lupus Erythematosus (SLE)
LUMIER² Study : LUpus Molecular Immunomonitoring to Evaluate the Risk of Relapse
We aim to determine the accuracy or blood transcriptomic signatures to predict the occurrence of flares in patients with SLE that are clinically quiescent at inclusion Systemic Lupus Erythematosus (SLE) is a chronic auto-immune…
- Trial name
- LUMIER² (NCT02811094)
- Testing
- polymerase chain reaction (PCR) technique of blood transcriptome analysis
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Graft Versus Host Disease, Nonneoplastic Condition
T-Lymphocyte Infusion or Standard Therapy in Treating Patients at Risk of Cytomegalovirus Infection After a Donor Stem Cell Transplant
RATIONALE: An infusion of cytomegalovirus-specific T lymphocytes may prevent or reduce cytomegalovirus infection during the first year after a donor stem cell transplant.
- Trial name
- NCT00986557
- Testing
- adoptive immunotherapy, alemtuzumab, in vitro-treated peripheral blood lymphocyte therapy
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- University Hospital Birmingham
Asthma, COVID-19
Relationship Between Bronchial Asthma and COVID-19 Infection in Adults: Clinical and Laboratory Assessment
Background: Asthma is still considered a major chronic respiratory disease that affects a large number in the world. The association between COVID-19 infection and asthma was studied in different ways focusing on hospital…
- Trial name
- NCT05165953
- Testing
- no intervention
- Where
- Saudi Arabia
- Volunteers
- 1,309 people
- Sponsor
- Benha University
Oral Premalignant Lesions
The Senstivity and Specificity of Using Salivary miRNAs in Detection of Malignant Transformation of Oral Lesions.
Due to cancer is a leading cause of death world wide , we will coduct the study to evaluate the diagnostic accuracy of using salivary miRNAs (412,512) from the salivary extracellular vesicles (index test) in detection of the…
- Trial name
- NCT04913545
- Testing
- using salivary miRNA (412,512)
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cairo University
Colorectal Cancer, Diarrhea
Genetic Trial to Study Diarrhea in Patients With Stage III Colon Cancer Who Are Receiving Chemotherapy
RATIONALE: Genetic testing may help predict how patients will respond to chemotherapy drugs and may help doctors plan more effective treatment with fewer side effects.
- Conditions
- Colorectal Cancer, Diarrhea, Neutropenia
- Trial name
- NCT00048971
- Testing
- mutation analysis, polymorphic microsatellite marker analysis
- Where
- 84 sites in United States, Canada and 1 more
- Volunteers
- 308 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Kidney Cancer
Studying Genes Using Cord Blood and Placenta Samples From Relatively Healthy Newborns and Samples From Younger Patients With Wilms Tumor
RATIONALE: Studying samples of blood and tissue from newborns and from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01576211
- Testing
- DNA methylation analysis, RNA analysis, allele-specific oligonucleotide real-time quantitative polymerase chain reaction
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's Oncology Group
Dental Pulp Necroses
Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals
The purpose of this study is to understand the effect that 3 different types of root canal procedures have on bacteria.
- Trial name
- NCT06569329
- Testing
- GentleWave System Root Canal Therapy, EdgePro Laser Root Canal Therapy, The ProUltra Piezo Ultrasonic with EndoUltra Tips Root Canal Therapy
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Abhishek Parolia
Leukemia
DNA Analysis of Tumor Tissue From Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897936
- Testing
- DNA methylation analysis, comparative genomic hybridization, fluorescence in situ hybridization
- Volunteers
- 418 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Coronavirus Disease (COVID-19)
Feasibility of Rapid COVID-19 Testing in Disadvantaged Populations
The purpose of this study is to assess the feasibility of establishing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing at a federally-qualified health center (FQHC) during a global health crisis to mitigate…
- Trial name
- NCT04558307
- Testing
- Pilot a rapid SARS-CoV-2 testing strategy, Community-driven messages to promote COVID-19 testing
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Colorectal Cancer
Effect of Folate on DNA in Colon Tissue and Blood Samples From Patients at Increased Risk of Developing Colorectal Neoplasia
RATIONALE: Studying samples of blood and tissue from patients at risk of cancer in the laboratory may help doctors learn more about the effect of folate on DNA and identify biomarkers related to cancer.
- Trial name
- NCT00611000
- Testing
- folic acid, DNA methylation analysis, gene expression analysis
- Volunteers
- 20 people
- Sponsor
- Rockefeller University
Leukemia
S9031-S9126-S9333-S9500-B Biomarker Expression in Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01059734
- Testing
- DNA analysis, RNA analysis, mutation analysis
- Volunteers
- 357 people
- Sponsor
- SWOG Cancer Research Network
Periodontal Therapy, miRNA-223
The Effects of Smoking on miRNA-223 Before-After Non-Surgical Periodontal Therapy
Periodontal diseases are one of the most common inflammatory diseases. Periodontal disease results from a complex interplay between the subgingival biofilm and the host immune-inflammatory events that develop in the gingival and…
- Conditions
- Periodontal Therapy, miRNA-223, Periodontitis, Biomarker
- Trial name
- NCT05372965
- Testing
- experimental-periodontitis-mirna-223-gingival tissue-saliva samples, control-clinical healthy mirna-223-gingival tissue-saliva samples
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Biruni University
Malaria (Uncomplicated)
Efficacy of Artemether-Lumefantrine in the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Children Under 12 Years at Four Sentinel Sites in Mozambique
This is a classical in vivo clinical trial, following World Health organization's recommendations, ran as a multisite study within Mozambique trying to assess the efficacy and safety in four sites of artemether-lumefantrine (AL)…
- Trial name
- NCT06970600
- Testing
- Artemether-lumefantrine (Coartem)
- Where
- 4 sites in Mozambique
- Volunteers
- 352 people
- Sponsor
- Centro de Investigacao em Saude de Manhica
Sepsis, Bacteremia
Evaluation in the Treatment of Nosocomial Sepsis Comparing Polymerase Chain Reaction With Conventional Blood Culture.
The objective of this study is to evaluate the consumption of antimicrobial therapy in patients comparing a rapid molecular test (PCR in Real-Time Multiplex) with blood cultures to identify the etiological agents of sepsis.
- Conditions
- Sepsis, Bacteremia, Fungemia
- Trial name
- NCT01450358
- Testing
- Antibiotic regimen
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Instituto do Coracao
Malaria
Markers of T Cell Suppression: Antimalarial Treatment and Vaccine Responses in Healthy Malian Adults
Background: People with malaria often show altered immune responses to many illnesses and vaccines. This means that the malaria might cause immune suppression. It is not clear how or which vaccines are impacted by malaria.
- Trial name
- NCT02544048
- Where
- Mali
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Cancer
Development of a Model to Predict Progression-Free Survival After Erlotinib in Patients With Non-Small Cell Lung Cancer
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897533
- Testing
- gene mapping, polymorphism analysis, diagnostic laboratory biomarker analysis
- Volunteers
- 137 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
COVID-19, Coronavirus Infections
Butterfly - Clinical Performance Study
This prospective clinical performance study is a non-interventional, multi-center study to evaluate the assay performance of the COVID-19 test using upper respiratory specimens.
- Trial name
- NCT05800158
- Testing
- Applied Biosystems™ TaqPath™ COVID-19 Diagnostic PCR Kit
- Where
- 11 sites in United States
- Volunteers
- 1,076 people
- Sponsor
- Thermo Fisher Scientific, Inc