Clinical trials: polymerase chain reaction
Diarrhea
Epidemiology of Diarrheal Diseases in Pediatric Oncology Patients
Diarrhea is a common problem in the pediatric population. Children with cancer are especially at increased risk for gastrointestinal infection-related morbidity and mortality due to their ongoing immunosuppression.
- Trial name
- NCT02464098
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- St. Jude Children's Research Hospital
Breast Cancer
Biomarkers in Tissue Samples From Patients With Breast Cancer Treated With Bevacizumab
RATIONALE: DNA analysis of tumor tissue may help doctors predict how well patients will respond to treatment. PURPOSE: This research study is studying biomarkers in tissue samples from patients with breast cancer treated with…
- Trial name
- NCT01156168
- Testing
- DNA analysis, gene expression analysis, polymorphism analysis
- Volunteers
- 363 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
COVID-19
Study on the Safety and Efficacy of Meplazumab for Injection Patients COVID-19
This is a multicenter, randomized, double-blind, placebo-controlled, add-on Phase III clinical study. Based on the "Diagnosis and Treatment Protocol for COVID-19 Pneumonia (Trial 10th edition)" and according to the results of…
- Trial name
- NCT05679492
- Testing
- Meplazumab foe injection, Normal saline
- Where
- China
- Sponsor
- Jiangsu Pacific Meinuoke Bio Pharmaceutical Co Ltd
B-cell Childhood Acute Lymphoblastic Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia
Studying Genes in Samples From Younger Patients With Relapsed Acute Lymphoblastic Leukemia
This laboratory study is looking into genes in samples from younger patients with relapsed acute lymphoblastic leukemia. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about…
- Conditions
- B-cell Childhood Acute Lymphoblastic Leukemia, Recurrent Childhood Acute Lymphoblastic Leukemia, Untreated Childhood Acute Lymphoblastic Leukemia
- Trial name
- NCT01625143
- Testing
- laboratory biomarker analysis
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Oncology Group
Beta-Thalassemia
Detection Of β-thalassemia Carriers In Assiut
Thalassemia is different in kids with microcytic hypochromic anemia than general population because there is a confusion between symptoms of thalassemia and iron deficiency anemia in kids and both of them differ in management and…
- Trial name
- NCT03822585
- Testing
- CBC, Iron Study, Serum Ferrittin, HPLC,Genitic Study
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Breast Cancer
SWOG 8897-A DNA Analysis in Predicting Treatment Outcome in Women With Breast Cancer in SWOG 8897
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00896623
- Testing
- mutation analysis, polymorphism analysis, surface-enhanced laser desorption/ionization-time of flight mass spectrometry
- Volunteers
- 1,577 people
- Sponsor
- SWOG Cancer Research Network
Contraception
Acceptability of Depo-subQ in Uniject
This is an observational study to assess the experience of current depot medroxyprogesterone acetate (DMPA) intramuscular (IM) clients and providers when they try Depo-subQ in Uniject and offer recommendations for the…
- Trial name
- NCT01667276
- Where
- 2 sites in Senegal, Uganda
- Volunteers
- 476 people, healthy volunteers welcome
- Sponsor
- FHI 360
Stroke, Acute, Stroke, Ischemic
Circulating Non-coding RNA in Acute Ischemic Stroke With Endovascular Treatment (EVTRNA)
EVTRNA is to analyze the differentiated expression pattern of circular RNA (circRNA), long non-coding RNA (lncRNA) and micro-RNA (miRNA) by next-generation sequencing in acute ischemic stroke patients before and/or after…
- Conditions
- Stroke, Acute, Stroke, Ischemic, Endovascular Treatment
- Trial name
- EVTRNA (NCT04230785)
- Testing
- Sequencing of circRNA/lncRNA/miRNA
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Cutaneous Leishmaniases, Treatment Adherence
Study of Cases of Cutaneous Leishmaniasis Treated With Miltefosine in French Guiana, Retrospective Study
Miltefosine is the only oral treatment currently available for Cutaneous Leishmaniasis. Despite several reports of good efficiency in other countries of South America, miltefosine remains limited to a compassionate use in France.
- Conditions
- Cutaneous Leishmaniases, Treatment Adherence, Primary Health Care, Drug Evaluation
- Trial name
- MILT2022 (NCT05493059)
- Testing
- Data collection, Questionnaires
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier de Cayenne
Liver Cancer
Biomarkers in Stored Tumor Samples From Younger Patients With Liver Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00899002
- Testing
- comparative genomic hybridization, molecular genetic technique, mutation analysis
- Sponsor
- Vanderbilt-Ingram Cancer Center
Disseminated Neuroblastoma, Localized Resectable Neuroblastoma
Study of DNA in Blood Samples From Patients With Neuroblastoma
This research trial studies is deoxyribonucleic acid (DNA) in blood samples from patients with neuroblastoma. Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that…
- Conditions
- Disseminated Neuroblastoma, Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma, Recurrent Neuroblastoma
- Trial name
- NCT00898391
- Testing
- laboratory biomarker analysis, polymerase chain reaction, polyacrylamide gel electrophoresis
- Where
- United States
- Volunteers
- 329 people
- Sponsor
- Children's Oncology Group
Prostate Cancer
Study of Genes and the Environment in Patients With Prostate Cancer Residing in the East Anglia, Trent, or West Midlands Regions of the United Kingdom
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00758173
- Testing
- polymorphism analysis, laboratory biomarker analysis, questionnaire administration
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Cancer Research UK
Caries,Dental, Dental Caries
The Impact of Sage Extract on GTS B and D Gene Expression in S. Mutans
Glucosyltransferases (Gtfs) play a crucial role in the pathogenesis of dental caries caused by Streptococcus mutans. Gtfs is recognized as an attractive target for effective therapeutic interventions aimed at inhibiting…
- Conditions
- Caries,Dental, Dental Caries, Dental Diseases
- Trial name
- NCT06703554
- Testing
- Sage Oil Mouthwash, Chlorohexidine Mouthwash
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Central Nervous System Infection
Lymphocytic Herpesviruses and Cerebrospinal Fluid Polymerase Chain Reaction (PCR)
Enterovirus and herpes simplex viruses 1 and 2 are the main causative agents of central nervous system infections. Instead, the role of lymphocytic herpesviruses in the etiology of central nervous system (CNS) infections is not…
- Trial name
- NCT01438879
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- PaijatHame Central Hospital
Influenza, Acute Respiratory Distress Syndrome
The Role of Cxcr4Hi neutrOPhils in InflueNza
Influenza is still responsible for more than 650,000 deaths per year worldwide and no major improvements in patients' care has been made despite 50 years of research.
- Trial name
- CHOPIN (NCT06254313)
- Testing
- Additional tubes and LBA
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Bordeaux