Clinical trials: polymerase chain reaction
Brain and Central Nervous System Tumors, Thrombocytopenia
Pharmacokinetics in Patients With Newly Diagnosed High-Grade Glioma Receiving Temozolomide and Radiation Therapy
RATIONALE: Studying samples of blood in the laboratory from patients receiving temozolomide may help doctors learn how temozolomide works in the body.
- Trial name
- NCT00471653
- Testing
- temozolomide, comparative genomic hybridization, polymorphism analysis
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Metastatic Cancer, Prostate Cancer
Biomarkers of Response to Taxotere in HRPC. ICORG 08-08, V2
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01160705
- Testing
- docetaxel, RNA analysis, reverse transcriptase-polymerase chain reaction
- Where
- 5 sites in Ireland
- Volunteers
- 73 people
- Sponsor
- Cancer Trials Ireland
Wound Surgical, Wound Heal
Early Healing of Oral Soft Tissues: a Clinical and Biomolecular Analysis. Part I
The purpose of the present study is to observe and compare -through a biomolecular analysis- the differences in the gene expression and cellular behavior in the early wound healing process -24 hours after injury- between the…
- Conditions
- Wound Surgical, Wound Heal, Oral Soft Tissue Conditions
- Trial name
- NCT04202822
- Testing
- Oral soft tissues biopsies
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Roma La Sapienza
Pneumonia
A Polymerase Chain Reaction (PCR) - Based Method to Improve Antibiotic Prescribing for Pneumonia
Pneumonia, or lung infection, is usually treated with antibiotics targeted against the organisms that the physician guesses are causing the problem. The determination of the exact cause of a patient's pneumonia is difficult.
- Trial name
- NCT00867841
- Testing
- nasopharyngeal swab
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Lymphoma, Small Intestine Cancer
Alemtuzumab and Combination Chemotherapy in Treating Patients With Stage I, Stage II, Stage III, or Stage IV Peripheral T-Cell Lymphoma
RATIONALE: Monoclonal antibodies, such as alemtuzumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread.
- Trial name
- NCT00562068
- Testing
- alemtuzumab, cyclophosphamide, doxorubicin hydrochloride
- Where
- 5 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cancer Research UK
Colorectal Cancer
Cetuximab and Capecitabine in Treating Patients With Metastatic Colorectal Cancer That Failed Irinotecan Treatment
RATIONALE: Monoclonal antibodies such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00538291
- Testing
- cetuximab, capecitabine, gene expression analysis
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- City of Hope Medical Center
Ovarian Cancer
Studying DNA in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial Cancer
RATIONALE: Studying tissue and blood samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00900289
- Testing
- DNA methylation analysis, microarray analysis, polymerase chain reaction
- Where
- 26 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Liz-Anne Lewsley
HIV Infections
A Study of Chlorhexidine in the Prevention of HIV-1 Transmission From Mothers to Their Babies
The purpose of this study is to find the best strength of chlorhexidine (a solution that kills germs), for washing the mother's vagina during labor and the newborn baby, that may reduce the chance of HIV being passed from an…
- Trial name
- NCT00006075
- Testing
- Chlorhexidine gluconate
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Preeclampsia
Vascular Endothelial Factor Gene Polymorphism in Preeclampsia
In this study, the investigators assessed one of the released protein factors during the pathophysiology of preeclampsia. They evaluated vascular endothelial growth factor gene mutation which affects the angiogenesis in case of…
- Trial name
- NCT03500588
- Testing
- PCR, Doppler ultrasound
- Where
- Egypt
- Volunteers
- 290 people
- Sponsor
- Beni-Suef University
SARS-CoV Infection
COVID-19 Contact Study by Antigen Detection Test
Stopping the SARS-CoV2 spread is essential to control the pandemic cause by this virus. A great effort is being made to carry out surveillance, case detection and contact control protocols in order to detect and isolate those…
- Trial name
- DETAC (NCT04745533)
- Testing
- Antigen detection test
- Sponsor
- Juan Fernando Masa Jiménez
Breast Cancer
Doxorubicin Hydrochloride Liposome in Treating Women With Ductal Carcinoma in Situ Undergoing Surgery
RATIONALE: Drugs used in chemotherapy, such as doxorubicin hydrochloride liposome, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00671476
- Testing
- pegylated liposomal doxorubicin hydrochloride, DNA methylation analysis, TdT-mediated dUTP nick end labeling assay
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Dr. Susan Love Research Foundation
Blood Stream Infection, Blood Stream Infections
Evaluation of Diagnostic Accuracy and Clinical Performance of the UllCORE Bloodstream Infection (BSI) Test
This study is designed to evaluate the clinical performance of the UllCORE Bloodstream Infection (BSI) Test, an investigational molecular diagnostic test intended to detect microorganisms and selected antimicrobial resistance…
- Conditions
- Blood Stream Infection, Blood Stream Infections, Sepsis, Fungemia
- Trial name
- B-RAPID (NCT07859852)
- Testing
- UllCORE BSI Test
- Where
- 20 sites in United States, France and 3 more
- Volunteers
- 1,500 people
- Sponsor
- Deepull Diagnostics S.L.
Kidney Cancer
Studying Biomarkers in Samples From Younger Patients With Wilms Tumor
RATIONALE: Studying samples of tissue and urine from patients with cancer in the laboratory may help doctor learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01542333
- Testing
- gene expression analysis, proteomic profiling, reverse transcriptase-polymerase chain reaction
- Volunteers
- 20 people
- Sponsor
- Children's Oncology Group
Single-Gene Disease
Analysis of Human Genomic DNA in Embryo's Culture Media
try to find genomic DNA in culture medium after the embryos develop on Day 3 and Day 5 also in single step culture media. using direct PCR Polymerase Chain Reaction and also WGA Whole Genome Amplification before PCR and…
- Trial name
- NCT02359747
- Testing
- Polymerase Chain Reaction and Whole Genome Amplification
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Cervesi Hospital, Cattolica, Italy
Uterine Cervical Neoplasms, Uterine Cervical Dysplasia
Self-sampling and Human Papillomavirus (HPV)-Testing for Unscreened Women in Cervical Cancer Prevention
Scientific Context High-risk types of human papillomavirus (HPV) are the causative agents for cervical cancer. Cervical cancer screening strategies rely on periodic Papanicolaou (Pap) testing.
- Trial name
- APACHE-1 (NCT01014026)
- Testing
- Screening test
- Where
- 5 sites in France
- Volunteers
- 734 people
- Sponsor
- University Hospital, Tours
Burns, Wounds
A New Method for Detection of Bacteria in the Bloodstream
The primary aim is to determine if this new technique will detect and identify bacteria in the blood sooner than standard blood cultures or identify patients who may be septic without growing bacteria in their cultures.
- Trial name
- NCT02323165
- Testing
- Molecular Detection of Bacteria in the Bloodstream
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Florida
Gastroenteritis
Gastroenteritis in Pediatric Population of Qatar
Comparison of clinical and laboratory diagnosis for cause of Gastroenteritis(GE) depending on the clinical manifestation.Identifying the sources of viral, bacterial and parasitic GE in Pediatric population of Qatar
- Trial name
- GE (NCT03046342)
- Testing
- Molecular method (PCR)
- Where
- Qatar
- Volunteers
- 3,000 people
- Sponsor
- Hamad Medical Corporation
Pharyngitis, Infective
SPOTFIRE Sore Throat (ST) Study
The purpose of this study is to evaluate where urgent care (UC) clinicians see the most benefit for a novel, point of care pharyngitis test, SPOTFIRE ST, and describe its performance, potential clinical utility, and satisfaction…
- Trial name
- NCT06713642
- Testing
- SPOTFIRE ST System
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Wisconsin, Madison
Chronic Hepatitis c
Changes in Liver Fibrosis, Lipid Profile and Insulin Resistance in HCV Patients Who Received Antiviral Therapy
Hepatitis C virus (HCV) is one of the major globally cause of death and morbidity.Chronic hepatitis C is the leading cause of end-stage liver disease, hepatocellular carcinoma and liver-related death in Egypt.It could be…
- Trial name
- NCT03612973
- Testing
- lipid profile, fasting insulin, fibro scan
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Syphilis
Modernizing Perinatal Syphilis Testing
The purpose of this study is to determine the testing performance of real-time quantitative polymerase chain reaction and transcription mediated amplification by comparing test performance of these novel molecular tests to…
- Trial name
- NCT06082453
- Testing
- Quantitative polymerase chain reaction (qPCR) assay for detection of Treponema pallidum, Aptima Treponema pallidum transcription-mediated amplification (TMA) assay for detection of Treponema pallidum, Center for Disease Control (CDC) Sexually Transmitted Infections (STI) 2021 Treatment Guidelines for diagnosis of syphilis
- Where
- 9 sites in United States
- Volunteers
- 924 people
- Sponsor
- The University of Texas Health Science Center, Houston