Clinical trials: rTMS
Healthy, Chronic Pain
H-coil TMS to Reduce Pain: A Pilot Study Evaluating Relative Efficacy of the H1 vs H7 Coil
Chronic pain is a serious public health problem with estimates as high as nearly half of the adult population experiencing some form of pain that lasts for more than 6 months.
- Conditions
- Healthy, Chronic Pain, Opioid Use, Pain, Chronic
- Trial name
- NCT04203199
- Testing
- Real rTMS to the mPFC using H7 Coil, Real rTMS to the dlPFC using H1 Coil
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Stroke, Aphasia, Non-fluent
rTMS and Multi-Modality Aphasia Therapy for Post-Stroke Aphasia
Many stroke survivors experience aphasia, a loss or impairment of language affecting the production or understanding of speech. One common type of aphasia is known as non-fluent aphasia.
- Trial name
- TMAT (NCT04901156)
- Testing
- 1Hz inhibitory rTMS, Multi-Modality Aphasia Therapy (M-MAT)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Obsessive-Compulsive Disorder
iTBS-DCS in Obsessive Compulsive Disorder
Obsessive Compulsive Disorder (OCD)is a common and debilitating illness. For an unacceptable proportion of patients, depressive symptoms remain impairing despite multiple treatments.
- Trial name
- NCT05177601
- Testing
- iTBS repetitive Transcranial Magnetic Stimulation (rTMS), D-cycloserine
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- University of Calgary
Mild Cognitive Impairment
Plasticity Using Stimulation and Habit: A Pilot Open-label rTMS Study for MCI
The goal of this pilot study is to determine whether a high-dose form of non-invasive brain stimulation is a promising and safe treatment for Mild Cognitive Impairment (MCI).
- Trial name
- PUSH-Pilot (NCT04503096)
- Testing
- High-dose accelerated rTMS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Medical University of South Carolina
Tobacco Use Disorder, Schizophrenia
Combining rTMS With Varenicline to Prevent Smoking Lapse in Schizophrenia
Tobacco smokers with schizophrenia are known to be resistant smokers, with high rates of smoking and inability to quit in the long-term, often related to smoking relapse.
- Conditions
- Tobacco Use Disorder, Schizophrenia, Cognitive Functioning, Craving
- Trial name
- NCT03497299
- Testing
- Active rTMS (20Hz)
- Sponsor
- Centre for Addiction and Mental Health
Repetitive Transcranial Magnetic Stimulation (rTMS), Schizophrenia
Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Cannabis Use and Cognitive Outcomes in Schizophrenia
The high prevalence of cannabis and other substance use disorders are a major barrier to recovery in people with schizophrenia. Moreover, schizophrenia patients have significant deficits in cognitive function, which may be…
- Conditions
- Repetitive Transcranial Magnetic Stimulation (rTMS), Schizophrenia, Cannabis Use Disorder, Cognition
- Trial name
- rTMSCANSZ (NCT03189810)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Weekly Counselling Session
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Centre for Addiction and Mental Health
Stroke
Customized Cortical Stimulation Therapy in the Rehabilitation of Stroke Patients
The purpose of this study is to identify and establish how the area of the brain that controls motor function (motor cortex) of the non-affected hemisphere after stroke might serve as a new target for therapeutic interventions to…
- Trial name
- NCT02544503
- Testing
- Single-pulse Transcranial Magnetic Stimulation (TMS), Paired-pulse Transcranial Magnetic Stimulation (ppTMS), Low-frequency Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Emory University
Complex Regional Pain Syndrome Type I
rTMS and Rehabilitation for Individuals With CRPS Type 1
Subjects with complex regional pain syndrome (CRPS) Type 1 will be randomized to receive repeated transcranial magnetic stimulation (rTMS) followed by rehabilitation or sham rTMS followed by rehabilitation.
- Trial name
- NCT05745025
- Testing
- Repeated Transcranial Magnetic Stimulation, Rehabilitation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- State University of New York - Upstate Medical University
Healthy
Metaplasticity Experimental Design and Comparison of Motor Outcome Measure Sensitivity to Change
The overall objective is to validate the methodology of a metaplasticity experimental design by assessing change in motor excitability after administration of priming transcranial direct current stimulation (tDCS) followed by…
- Trial name
- NCT03304262
- Testing
- rTMS
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Parkinson's Disease
A Multicenter Clinical Study of rTMS for Parkinson's Disease
Through rTMS, motor dysfunction and non-motor dysfunction of PD patients can be improved, working and living ability and quality of life of patients can be improved, and social burden and family burden can be reduced.
- Trial name
- NCT06009471
- Testing
- Routine treatment in Neurology, Routine treatment in Neurology and rTMS
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Affiliated Hospital of Nantong University
Dystonia, Tremor
Repetitive Transcranial Magnetic Stimulation (rTMS) for Dystonia and Tremor
The study will include subjects diagnosed with Dystonic Tremor (DT), Essential Tremor (ET), and healthy controls in the age range of 21-80 years. Electroencephalography (EEG) will be used as the primary outcome measure.
- Trial name
- NCT04299087
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS), Control group
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Florida
Stroke
Stroke Therapy With Brain Oscillation Synchronized Stimulation
This randomized, controlled, double-blind clinical pilot trial investigates the therapeutic potential of a novel personalized therapeutic brain-stimulation protocol in chronic stroke patients with spasticity.
- Trial name
- STROKEBOSS (NCT05005780)
- Testing
- Negative peak triggered 100 Hz triplet burst TMS, 1 Hz rTMS
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Tuebingen
Cannabis Use Disorder
A Preliminary Investigation of Pre-Frontal Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder
This investigation will preliminarily determine if a course of high-frequency rTMS applied to the left dorsolateral prefrontal cortex, will reduce behavioral craving, and fMRI cue-reactivity in treatment-seeking cannabis use…
- Trial name
- NCT03144232
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Stanford University
Schizophrenia
Interactions of Fronto-Parietal High Frequency rTMS on Anterior Cingulate Cortex Activation in Schizophrenia
This will be a single site pilot study. 20 subjects with EPP (Early Phase Psychosis), defined as medical record documentation of the onset of clinically significant psychotic symptoms within the past 10 years, will be enrolled.
- Trial name
- rTMS-FPCC (NCT04309370)
- Testing
- 20 Hz rTMS
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Indiana University
Schizophrenia
rTMS as a Probe of Episodic Memory Neurocircuitry in Schizophrenia
This will be a single site pilot study. 30 subjects with Early Phase Psychosis (EPP), defined as medical record documentation of the onset of clinically significant psychotic symptoms within the past ten years, will be enrolled.
- Trial name
- rTMS-EM (NCT04182113)
- Testing
- 1 Hz rTMS Stimulation
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Indiana University
Obsessive-Compulsive Disorder, OCD
pBFS Guided rTMS Therapy for Treatment-resistant Obsessive-Compulsive Disorder
The investigators aim to evaluate the safety and efficacy of pBFS-guided rTMS therapy targeting DLPFC for patients with treatment-resistant Obsessive-Compulsive Disorder.
- Trial name
- NCT05964049
- Testing
- active rTMS treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Changping Laboratory
Obsessive-Compulsive Disorder, OCD
pBFS Guided High-dose rTMS Therapy for Treatment-Resistant Obsessive-Compulsive Disorder
The research aims to evaluate the safety and efficacy of pBFS-guided High-dose rTMS therapy targeting preSMA for patients with treatment-resistant Obsessive-Compulsive Disorder.
- Trial name
- NCT05964062
- Testing
- active rTMS treatment
- Volunteers
- 30 people
- Sponsor
- Changping Laboratory
Moderate Depression, Major Depressive Disorder
pBFS Guided 20min Inter-session Interval rTMS Treatment for MDD
The investigators aim to explore the efficacy and safety of rTMS therapies with different intervals between sessions for treating patients with moderate to severe depression.
- Conditions
- Moderate Depression, Major Depressive Disorder, Severe Depression
- Trial name
- NCT05957341
- Testing
- active rTMS: 20min inter-session interval, active rTMS: 50min inter-session interval
- Volunteers
- 50 people
- Sponsor
- Changping Laboratory
Moderate Depression, Major Depressive Disorder
The Dosage Effect of pBFS Guided rTMS Treatment for MDD
The investigators aim to find the optimal dosage of the pBFS-guided rTMS treatment for patients with moderate to severe depression.
- Conditions
- Moderate Depression, Major Depressive Disorder, Severe Depression
- Trial name
- NCT05842278
- Testing
- 4 session rTMS, 6 session rTMS, 8 session rTMS
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changping Laboratory
Dyslexia, Specific Learning Disability
Efficacy of rTMS as an Adjunct to AI Enabled Remedial Intervention in Children With Dyslexia
Dyslexia is the most common neurobehavioral disorder affecting children, with prevalence rates ranging from 17.5% to 21%. Studies have shown incomplete response to remediation and behavioural therapies in children with dyslexia.
- Conditions
- Dyslexia, Specific Learning Disability, Transcranial Magnetic Stimulation
- Trial name
- NCT05923645
- Testing
- Transcranial magnetic stimulation (Hf rTMS)
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences