Clinical trials: therapeutic conventional surgery
Esophageal Adenocarcinoma, Gastric Adenocarcinoma
Genetic Analysis-Guided Irinotecan Hydrochloride Dosing of mFOLFIRINOX in Treating Patients With Locally Advanced Gastroesophageal or Stomach Cancer
This pilot clinical trial studies genetic analysis-guided irontecan hydrochloride dosing of modified fluorouracil, irinotecan hydrochloride, leucovorin calcium, oxaliplatin (mFOLFIRINOX) in treating patients with gastroesophageal…
- Conditions
- Esophageal Adenocarcinoma, Gastric Adenocarcinoma, Stage IIB Gastric Cancer, Stage IIIA Esophageal Adenocarcinoma
- Trial name
- NCT02366819
- Testing
- Oxaliplatin, Leucovorin Calcium, Irinotecan Hydrochloride
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Chicago
Breast Carcinoma, Anatomic Stage IV Breast Cancer AJCC v8
Primary Breast Oligoprogressive Sites Treated With Radiotherapy to Obviate the Need to Change Systemic Therapy
This study assesses if metastasis-directed radiation therapy (Stereotactic body radiation therapy - SBRT) can delay a change in systemic therapy, and if circulating tumor cells in the bloodstream can help guide treatment options…
- Conditions
- Breast Carcinoma, Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Cancer
- Trial name
- BOSS (NCT06055881)
- Testing
- Biospecimen Collection, Surveys, Stereotactic Body Radiation Therapy (SBRT)
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic
Periampullary Cancer, Postoperative Pancreatic Fistula
Pancreatic Head Resection or Total Pancreatectomy With Islet Autotransplantation in Patients With Periampullary Cancer and High Risk Profile for the Development of Postoperative Pancreatic Fistula
The primary objective of this clinical trial is to evaluate whether primary total pancreatectomy with simultaneous islet autotransplantation compared with pancreatic head resection (alone) can reduce perioperative morbidity and…
- Trial name
- XandTX (NCT05843877)
- Testing
- Intraportal transplantation of isolated autologous pancreatic islets after total pancreatectomy, Pancreaticoduodenectomy (classic Whipple or pylorus-preserving)
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Technische Universität Dresden
Breast Cancer
Vaccine Therapy in Treating Patients Who Are Undergoing Surgery for Ductal Carcinoma In Situ of the Breast
RATIONALE: Vaccines made from peptides and a person's white blood cells may help the body build an effective immune response to kill tumor cells.
- Trial name
- NCT00107211
- Testing
- therapeutic autologous dendritic cells, conventional surgery, neoadjuvant therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Candida Sepsis, Candidiasis, Invasive
Early Identification of Candida in Intra-abdominal Candidiasis
Intra-abdominal candidiasis remains the first origin of invasive candidiasis in critically ill patients with a mortality up to 60%. This high mortality is partly related to delay of anti-fungal treatment administration.
- Conditions
- Candida Sepsis, Candidiasis, Invasive, Peritonitis Infectious, Critically Ill
- Trial name
- ICCA (NCT05264571)
- Testing
- calscreener, Metabolic profile, optical microscopy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France
Recurrent Adult Tethered Cord Syndrome
A Randomized Controlled Trial for Surgical Treatment of Recurrent Adult Tethered Cord Syndrome
This trial compares detethering surgery and spinal column shortening surgery, two treatments for adults with recurrent tethered cord syndrome (TCS), a neurological disorder where the spinal cord becomes abnormally attached to…
- Trial name
- NCT06197399
- Testing
- Detethering Surgery, Spinal Column Shortening Surgery
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Xuanwu Hospital, Beijing
Sarcoma
Combination Chemotherapy in Treating Patients Undergoing Surgery for Newly Diagnosed High-Grade Osteosarcoma
RATIONALE: Drugs used in chemotherapy, such as ifosfamide, methotrexate, cisplatin, and doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00645632
- Testing
- cisplatin, doxorubicin hydrochloride, ifosfamide
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Peripheral Nerve Injuries
Evaluating the Safety and Efficacy of Polyethylene Glycol (PEG) Mediated Fusion (PEG Fusion)
The overall objective of this study is to determine the safety of PEG fusion when used with primary repair or reconstruction in patients with an acute upper extremity peripheral nerve injury.
- Trial name
- NCT04789044
- Testing
- NTX-001
- Where
- 7 sites in United States
- Volunteers
- 40 people
- Sponsor
- Major Extremity Trauma Research Consortium
Estrogen Receptor-positive Breast Cancer, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast
Neo-adjuvant Therapy With Anastrozole Plus Pazopanib in Stage II and III ER+ Breast Cancer
This phase II trial studies how well giving pazopanib hydrochloride and anastrozole before surgery works in treating patients with stage II-III estrogen receptor-positive breast cancer.
- Conditions
- Estrogen Receptor-positive Breast Cancer, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast, Male Breast Cancer, Recurrent Breast Cancer
- Trial name
- NCT01394211
- Testing
- anastrozole, pazopanib hydrochloride, therapeutic conventional surgery
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Arizona
Head and Neck Cancers
Biomedical Innovation for Facial Bone Reconstruction in Oncology: BIOFACE PASS a Medico-economic Study Describing the Standard Pathway of Patients Treated by Free Bone Flap
The purpose of this study is to describe the standard of care pathway of patients treated by free bone flap for facial mandibullar or maxillar reconstruction after surgery for head and neck cancers.
- Trial name
- BIOFACE PASS (NCT06771336)
- Testing
- Questionnaires
- Where
- 9 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Toulouse
Adverse Anesthesia Outcome
Liberal Versus Goal-directed Intraoperative Fluid Therapy in Pediatric Patients
The objectives of this study are 1) to investigate the influence of different fluid regimen (Liberal regimen versus Goal directed therapy regimen) on postoperative outcome such as weight gain, delayed gut function recovery…
- Trial name
- GDT (NCT01350076)
- Testing
- conventional liberal fluid regimen, restricted fluid regimen
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
To Compare the Efficacy and Safety of Hybrid ESD and ESD in the Treatment of Colorectal LST
Endoscopic Therapy for Laterally Spreading Tumors (LSTs)
This study will retrospectively include LST patients who were admitted to 6 medical centers (The Second Affiliated Hospital, College of Medicine, Zhejiang University; The Affiliated Jinhua Hospital, Zhejiang University School of…
- Trial name
- LST (NCT06464874)
- Testing
- Conventional ESD, Hybrid ESD
- Where
- China
- Volunteers
- 890 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Parkinson Disease, Oral Infection
Oral Therapeutic Education in Stimulated Parkinsonian Patients
The effect of periodontal disease on the general condition of patients remains today underestimated in Parkinson's disease. The BUCCO-PARK project aims to carry out an exploratory study of oral therapeutic education on the…
- Trial name
- BUCCO-PARK (NCT03965390)
- Testing
- Oral education
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Rennes University Hospital
Tumors Metastatic to Brain
Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study
This Phase I/II trial studies the ability to stop brain metastases from coming back after treatment with radiosurgery followed by surgical resection.
- Trial name
- NCT01891318
- Testing
- radiosurgery, therapeutic conventional surgery, quality-of-life assessment
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Case Comprehensive Cancer Center
Polycythemia Vera (PV)
A Study to Evaluate P1101 in Japanese PV Patients
This is a Phase 3 single arm study to investigate efficacy and safety of P1101's rapid titration for adult Japanese patients with PV.
- Trial name
- NCT06002490
- Testing
- P1101, Low-dose aspirin, Phlebotomy
- Where
- 6 sites in Japan
- Volunteers
- 21 people
- Sponsor
- PharmaEssentia Japan K.K.
Periodontitis
Minimally Invasive Non- Surgical Periodontal Therapy of Intrabony Defects: Healing Patterns and Smoking Impact
This study is consisted of two arms. At first, a randomized controlled clinical trial will be conducted. Eighty systematically healthy, non-smoker patients with Periodontitis stage III or IV, grades B to C will be included.
- Trial name
- NCT07117097
- Testing
- Minimally Invasive Non- Surgical Periodontal Therapy (MINST), conventional Non-Surgical Periodontal Treatment (cNSPT)
- Volunteers
- 120 people
- Sponsor
- University of Turku
Diabetic Foot Ulcer
Dermagraft(R) for the Treatment of Patients With Diabetic Foot Ulcers
This study randomly assigns patients with plantar diabetic foot ulcers to receive conventional therapy (debridement, infection control, saline-moistened gauze dressings, and standardized off-weighting) alone or conventional…
- Trial name
- NCT01181440
- Testing
- Dermagraft(R), Conventional care
- Where
- United States
- Volunteers
- 281 people
- Sponsor
- Organogenesis
Pelvic Organ Prolapse
Performance of Tension Free Vaginal Mesh (Prolift) Versus Conventional Vaginal Prolapse Surgery in Recurrent Prolapse.
Pelvic organ prolapse is a common problem. A lot of women have surgery for prolapse. The recurrence rate op pelvic organ prolapse after surgical treatment is high.
- Trial name
- NCT00372190
- Testing
- Tensionfree vaginal mesh kit (Prolift), classic vaginal prolapse surgery (fascia plication)
- Where
- 13 sites in Netherlands
- Volunteers
- 194 people
- Sponsor
- Radboud University Medical Center
Intertrochanteric Fractures, Intertrochanteric Fractures of the Hip
Robot-Assisted Closed Reduction and Internal Fixation for Intertrochanteric Femoral Fractures
The goal of this clinical trial is to compare the clinical effectiveness and safety of robot-assisted autonomous closed reduction versus traditional manual closed reduction in adult patients aged 18 to 80 years with acute, closed…
- Conditions
- Intertrochanteric Fractures, Intertrochanteric Fractures of the Hip, Intertrochanteric Fractures of the Femur
- Trial name
- NCT07738458
- Testing
- Robot-assisted closed reduction and internal fixation, Conventional manual closed reduction and internal fixation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Jishuitan Hospital
Rectal Cancer Patients
Rectal Cancer CTC Trial
This prospective, multi-centre, randomised clinical trial aims to compare the effect of neoadjuvant chemoradiotherapy versus primary surgery on circulating tumor cells (CTCs) in patients with stage II-III rectal cancer without…
- Trial name
- NCT07194616
- Testing
- Primary Surgery, Neoadjuvant radiochemotherapy and surgery
- Where
- 4 sites in Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
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