Clinical trials: therapeutic conventional surgery
Circumcision, Male
Comparison of the Shang Ring With Conventional Surgical Methods
This is a randomized control trial of 400 adult male circumcision procedures with a one to one ratio between Shang Ring and the in-country standard surgical technique (forceps guided in Kenya and dorsal slit in Zambia).
- Trial name
- NCT01300910
- Testing
- Shang Ring, Male circumcision
- Where
- 2 sites in Kenya, Zambia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- FHI 360
Transversus Abdominis Plane Block
Adjuvant Dexmedetomidine and Tramadol in Subcostal Transversus Abdominis Plan Block
In this study, dexmedetomidine and tramadol were added as adjuvant to bupivacaine in transversus abdominis plane block (TAP), intraoperative hemodynamics, opioid consumption, muscle relaxant use, postoperative analgesic effects…
- Trial name
- NCT05905757
- Testing
- Dexmedetomidin + bupivacaine, Tramadol + Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Metastatic Mismatch Repair Proficient Colorectal Carcinoma, Refractory Mismatch Repair Proficient Colorectal Carcinoma
CBX-12 for the Treatment of Metastatic Chemotherapy-Refractory Microsatellite Stable Colorectal Cancer
This phase II trial studies how well CBX-12 works in treating patients with microsatellite stable colorectal cancer that has spread to other parts of the body (metastatic) and is no longer responding to chemotherapy treatment…
- Conditions
- Metastatic Mismatch Repair Proficient Colorectal Carcinoma, Refractory Mismatch Repair Proficient Colorectal Carcinoma, Stage IV Colorectal Cancer AJCC v8
- Trial name
- NCT06730100
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- 15 sites in United States
- Volunteers
- 35 people
- Sponsor
- National Cancer Institute (NCI)
Cardiac Surgery
Goal Directed Hemodynamic Management of Acute Heart Failure After Cardiac Surgery in Children
Goal directed therapy (GDT) utilises various monitoring techniques to assess cardiovascular performance and allows for timely interventions based on predetermined algorithms.
- Trial name
- NCT02617602
- Testing
- Goal directed therapy, Control
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Spinal Cord Injuries, Neuromodulation
Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury
It has been demonstrated that the human lumbosacral spinal cord can be neuromodulated with epidural (ESS) and transcutaneous (TSS) spinal cord stimulation to enable recovery of standing and volitional control of the lower limbs…
- Trial name
- NCT06213012
- Testing
- Transcutaneous Spinal cord Stimulation, Epidural Spinal Stimulation (ESS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Methodist Hospital Research Institute
NSCLC (Non-small Cell Lung Cancer)
Oral Paclitaxel Solution With Immunotherapy and Concurrent SBRT as Neoadjuvant Treatment for Older Adults With NSCLC
his multicenter, open-label, single-arm phase I/II trial will evaluate the safety, tolerability, and preliminary efficacy of oral paclitaxel solution combined with an immune checkpoint inhibitor and concurrent stereotactic body…
- Trial name
- NCT07754812
- Testing
- Oral Paclitaxel Solution, PD-1/PD-L1 inhibitor, Stereotactic Body Radiotherapy (SBRT)
- Where
- 5 sites in China
- Volunteers
- 78 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Anal Squamous Cell Carcinoma, HIV Infection
Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection
This phase II trial studies surgery in treating patients with anal canal or perianal cancer that is small and has not spread deeply into the tissues and human immunodeficiency virus (HIV) infection.
- Conditions
- Anal Squamous Cell Carcinoma, HIV Infection, Stage 0 Anal Canal Cancer, Stage I Anal Canal Cancer
- Trial name
- NCT02437851
- Testing
- Therapeutic Conventional Surgery
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- AIDS Malignancy Consortium
Malignant Mesothelioma
Surgery and Photodynamic Therapy in Treating Patients With Malignant Mesothelioma
RATIONALE: Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill cancer cells. Combining photodynamic therapy with surgery may be an effective treatment for malignant mesothelioma.
- Trial name
- NCT00054002
- Testing
- adjuvant therapy, conventional surgery, porfimer sodium
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Roswell Park Cancer Institute
Myocardial Infarction
Intravenous MSC Therapy on Ischemia-Reperfusion Injury in Patients With Myocardial Infarction
The investigators scheduled to assess the value of intravenous injection of WJ-MSC in patients with ST-segment elevation myocardial infarction (STEMI).
- Trial name
- NCT03533153
- Testing
- WJ-MSC cells implantation, CTSTMD PBS without WJ-MSC, Conventional drug therapy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Adult Glioblastoma, Adult Gliosarcoma
Sorafenib Tosylate and Temsirolimus in Treating Patients With Recurrent Glioblastoma
This phase I/II trial studies the side effects and best dose of temsirolimus when given together with sorafenib tosylate and to see how well they work in treating patients with glioblastoma that has come back.
- Conditions
- Adult Glioblastoma, Adult Gliosarcoma, Recurrent Adult Brain Neoplasm
- Trial name
- NCT00329719
- Testing
- Conventional Surgery, Laboratory Biomarker Analysis, Sorafenib Tosylate
- Where
- 190 sites in United States
- Volunteers
- 115 people
- Sponsor
- National Cancer Institute (NCI)
Electroacupuncture, Lung Injury, Ventilator Induced
Protective Effect of Electroacupuncture on Lung in Patients Undergoing General Anesthesia
Objective to investigate the protective effect of preoperative electroacupuncture on lung function in patients with mechanical ventilation for more than 2 hours under general anesthesia
- Trial name
- NCT05019079
- Testing
- electroacupuncture
- Volunteers
- 72 people
- Sponsor
- Lingling Ding
Gastrointestinal Dysfunction
Clinical Study on the Treatment of Gastrointestinal Dysfunction After Knee Joint Surgery Under General Anesthesia With Floating Needle
A randomized controlled trial was conducted to compare the clinical efficacy of Fu's subcutaneous acupuncture and western medication in the treatment of gastrointestinal dysfunction after knee surgery under general anesthesia.
- Trial name
- NCT07607249
- Testing
- Fu's Acupuncture group, Mosapride
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Zhenyu Zhang
Lymphoma
Surgery Alone or With CYC VBL and PRED or CVP Alone in Stage IA or IIA Nodular Lymphocyte-Predominant Hodgkin Lymphoma
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, vinblastine, and prednisolone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- EuroNetLP1 (NCT01088750)
- Testing
- cyclophosphamide, prednisolone, vinblastine sulfate
- Where
- Germany
- Volunteers
- 225 people
- Sponsor
- Christine Mauz-Körholz
Cystocele
RUG-WEAVING PLICATION IN CYSTOCELE TREATMENT
In this study was to compare the 2-year results of the Rug Wave plication technique, which it present as a natural tissue repair technique in cystocele, with the conventional technique in terms of both recurrence and patient…
- Trial name
- NCT07336108
- Testing
- rug weaving-like plication technique, group 2:conventional technique cystocele treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara City Hospital Bilkent
Dizziness
Vestibular Evaluation After Vestibular Schwannoma Treatment
Vestibular schwannoma is a benign tumor located on the vestibular nerve. Patient could present dizziness symptoms cause to the tumor, and at least after the treatment by gamaknife radiosurgery or microsurgery resection.
- Trial name
- EVTSVCGEC (NCT03670589)
- Testing
- Radiosurgery gammaknife, Microsurgery resection
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Grenoble
Carcinoma of the Appendix, Primary Peritoneal Cavity Cancer
Surgery and Oxaliplatin or Mitomycin C in Treating Patients With Tumors of the Appendix
This randomized phase II trial is studying the side effects and how well giving oxaliplatin or mitomycin C directly into the abdomen after surgery works in treating patients with tumors of the appendix.
- Trial name
- NCT01580410
- Testing
- mitomycin C, oxaliplatin, therapeutic conventional surgery
- Where
- 3 sites in United States
- Volunteers
- 136 people
- Sponsor
- Wake Forest University Health Sciences
Idiopathic Osteoarthritis
Moxibustion for Knee Osteoarthritis
This study aims to assess the feasibility, effectiveness and safety of moxibustion for symptom management and function improvement in patients with knee osteoarthritis, compared to usual care group.
- Trial name
- NCT01354860
- Testing
- Moxibustion treatment plus usual care, Usual care alone group
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Korea Institute of Oriental Medicine
Colorectal Cancer, Metastatic Cancer
Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00899210
- Testing
- laboratory biomarker analysis, cryosurgery, radiofrequency ablation
- Volunteers
- 75 people
- Sponsor
- University Hospital, Grenoble
Ductal Breast Carcinoma in Situ, Estrogen Receptor-negative Breast Cancer
Breast-Conserving Surgery Followed by Radiation Therapy With MRI-Detected Stage I or Stage II Breast Cancer
RATIONALE: Breast-conserving surgery is a less invasive type of surgery for breast cancer and may have fewer side effects and improve recovery. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Conditions
- Ductal Breast Carcinoma in Situ, Estrogen Receptor-negative Breast Cancer, Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Cancer
- Trial name
- NCT01100489
- Testing
- external beam radiation therapy, questionnaire administration, therapeutic conventional surgery
- Where
- 3 sites in United States
- Sponsor
- Case Comprehensive Cancer Center
Estrogen Receptor-negative Breast Cancer, HER2-negative Breast Cancer
Pegylated Liposomal Doxorubicin Hydrochloride and Carboplatin Followed by Surgery and Paclitaxel in Treating Patients With Triple Negative Stage II-III Breast Cancer
This phase II trial studies how well pegylated liposomal doxorubicin hydrochloride and carboplatin followed by surgery and paclitaxel work in treating patients with stage II-III breast cancer that does not have estrogen…
- Conditions
- Estrogen Receptor-negative Breast Cancer, HER2-negative Breast Cancer, Progesterone Receptor-negative Breast Cancer, Stage IIA Breast Cancer
- Trial name
- NCT02315196
- Testing
- pegylated liposomal doxorubicin hydrochloride, epirubicin hydrochloride, carboplatin
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Rutgers, The State University of New Jersey
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.