Clinical trials: therapeutic conventional surgery
Quality of Life, Congenital Heart Disease
Exercise Training in Children With Corrective Cardiac Surgeries
To determine the effects of preoperative exercise therapy on postoperative cardiopulmonary outcomes and quality of life in children with corrective cardiac surgeries.Within literature there is limited evidence on preoperative…
- Conditions
- Quality of Life, Congenital Heart Disease, Heart; Surgery, Heart, Functional Disturbance as Result
- Trial name
- NCT05763238
- Testing
- INTERVENTION GROUP, CONTROL GROUP
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Riphah International University
Peripheral Nerve Injuries
Evaluating the Safety and Efficacy of Polyethylene Glycol (PEG) Mediated Fusion (PEG Fusion)
The overall objective of this study is to determine the safety of PEG fusion when used with primary repair or reconstruction in patients with an acute upper extremity peripheral nerve injury.
- Trial name
- NCT04789044
- Testing
- NTX-001
- Where
- 7 sites in United States
- Volunteers
- 40 people
- Sponsor
- Major Extremity Trauma Research Consortium
Carpal Tunnel
Platelet Rich Plasma Injection Versus Surgical and Medical Treatment of Mild-moderate Carpel Tunnel Syndrome.
to evaluate the therapeutic efficacy of single ultrasound guided Platelet Rich Plasma injection of the carpal tunnel Vs. surgical procedures and medical treatment and hand support in patients with mild-moderate carpal tunnel…
- Trial name
- NCT04235426
- Testing
- 30 patients received conventional medical treatment (NSAIDs, diclofenac 150 mg/day for 2 weeks and 1500 g vitamin B 12 per day for 6 weeks) and hand support., 30 patients went to surgical procedure, Injection
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Dalia Salah Saif
Periodontitis
Impact of C-reactive Protein on Non Surgical Periodontal Treatment
In light of the controversy that are already approved but that however still exists regarding the efficacy and influence the management of Periodontitis, the aim of this study was to evaluates, at 12-months follow-up, the…
- Trial name
- NCT05836298
- Testing
- Non-surgical periodontal treatment
- Where
- Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Catania
Protein-Energy Malnutrition
Reducing In-Hospital and 60-Day Mortality in ICU Patients After Surgery With Strict Nutritional Supplementation
Malnutrition in critically ill patients is a global concern due to its association with increased infectious complications, prolonged hospital stays, and higher morbidity rates.
- Trial name
- NCT06058247
- Testing
- Active nutritional supplementation, Conventional nutritional supplementation
- Where
- South Korea
- Volunteers
- 368 people
- Sponsor
- Seoul St. Mary's Hospital
Digestive System Surgical Procedure, Pancreaticoduodenectomy
Impact of the Absence of Nasogastric Decompression After Pancreaticoduodenectomy
The use of nasogastric (NG) decompression after pancreaticoduodenectomy (PD) is a current practice. NG tube is associated with a high rate of morbidity including pulmonary morbidity, delayed gastric emptying and finally an…
- Trial name
- IPOD (NCT02594956)
- Testing
- no nasogastric tube, nasogastric tube
- Where
- France
- Volunteers
- 125 people
- Sponsor
- Rennes University Hospital
Recurrent B Acute Lymphoblastic Leukemia, Recurrent B-Cell Non-Hodgkin Lymphoma
Interferon-Beta-1a (FP-1201) to Prevent Toxicities After CD19-Directed CAR T-Cell Therapy
This phase I/II trial tests the safety and how well intravenous interferon-beta-1a (FP-1201) works in preventing toxicities after CD19-directed chimeric antigen receptor (CAR) T-cell therapy in patients with B-cell cancers that…
- Conditions
- Recurrent B Acute Lymphoblastic Leukemia, Recurrent B-Cell Non-Hodgkin Lymphoma, Refractory B Acute Lymphoblastic Leukemia, Refractory B-Cell Non-Hodgkin Lymphoma
- Trial name
- NCT05936229
- Testing
- Interferon Beta-1A, X-Ray Imaging, Echocardiography
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Atrial Fibrillation Recurrent
Pulsed Field Ablation Versus Conventional Radiofrequency Catheter Ablation for Repeat PVI in Patients With Paroxysmal AF
Various methods exist for performing pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF), including thermal ablation and pulse-field ablation (PFA).
- Trial name
- REPEAT-AF (NCT06199180)
- Testing
- pulmonary vein isolation with RFA, pulmonary vein isolation with PFA
- Where
- Netherlands
- Volunteers
- 154 people
- Sponsor
- University Medical Center Groningen
Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
Combination Chemotherapy in Treating Children With Newly Diagnosed Malignant Germ Cell Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00066482
- Testing
- bleomycin sulfate, filgrastim, cisplatin
- Where
- 98 sites in United States, Australia and 2 more
- Volunteers
- 19 people
- Sponsor
- Children's Oncology Group
Early-stage Breast Cancer, Hormone Receptor Positive Breast Carcinoma
Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer
This phase II trial investigates how well trastuzumab deruxtecan works alone or in combination with anastrozole in treating patients with HER2 low, hormone receptor positive breast cancer.
- Conditions
- Early-stage Breast Cancer, Hormone Receptor Positive Breast Carcinoma, Invasive Breast Cancer, Stage II Breast Cancer
- Trial name
- NCT04553770
- Testing
- Anastrozole, Therapeutic Conventional Surgery, Trastuzumab Deruxtecan
- Where
- 9 sites in United States
- Volunteers
- 88 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Skin Transplantation, Skin Grafting
Lower Extremity Graft Study (LEGS): A Multicentre Randomised Controlled Trial of Negative Pressure Wound Therapy Versus Conventional Dressings for Split-thickness Skin Grafts After Lower Leg Skin Tumour Excision
The goal of this clinical trial is to compare the effect of negative pressure wound therapy (NPWT) versus traditional dressings on the incidence of transplant infection in adult patients undergoing split-thickness skin grafting…
- Conditions
- Skin Transplantation, Skin Grafting, Split Thickness Skin Graft, Negative-Pressure Wound Therapy
- Trial name
- LEGS (NCT07040683)
- Testing
- Negative Pressure Wound Therapy (NPWT), Traditional Dressing
- Where
- Sweden
- Volunteers
- 232 people
- Sponsor
- Region Skane
ExtraCorporeal Membrane Oxygenation (ECMO), Wound Complications
Closed Incision NPWT to Prevent Wound Complications Post-ECMO
Patients undergoing extracorporeal membrane oxygenation (ECMO) are at increased risk of wound complications at the vascular access site after decannulation. These complications may delay recovery and increase healthcare burden.
- Conditions
- ExtraCorporeal Membrane Oxygenation (ECMO), Wound Complications, Surgical Site Infection (SSI)
- Trial name
- PREVENT-ECMO (NCT07709546)
- Testing
- Prophylactic Closed-Incision Negative Pressure Wound Therapy, Standard Wound Dressing
- Volunteers
- 144 people
- Sponsor
- St. Antonius Hospital
Skeletal Class III Malocclusion
Evaluation of Treatment Outcomes With Palatal Plate Versus Conventional Tooth Borne Anchorage in Class III Patients
evaluation of treatment outcomes with palatal plate versus conventional tooth borne anchorage in class III patients
- Trial name
- NCT07360509
- Testing
- treatment of skeletal class III by maxillary advancement using transpalatal arch and face mask, treatment of skeletal class III by maxillary advancement using palatal plate and face mask
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Critical Illness, Hyperglycemia
Tight Glycemic Control in Critical Care Patients
The purpose of this study is to evaluate the impact of tight control of serum glucose levels with an intensive insulin treatment in patients hospitalized in an intensive care unit with medical and surgical patients.
- Conditions
- Critical Illness, Hyperglycemia, Insulin Resistance
- Trial name
- NCT00096421
- Testing
- Tight control of blood glucose levels, Conventional control of glucose levels
- Where
- Colombia
- Volunteers
- 504 people
- Sponsor
- Hospital Pablo Tobón Uribe
Renal Transplantation
Systematic Transplantectomy Versus Conventional Care After Kidney Graft Failure
Our hypothesis is early and systematic transplantectomy under a well-conducted immunosuppression is associated with a decreased risk of anti-HLA immunization against a conservative attitude including a gradual reduction of…
- Trial name
- DESYRE (NCT01817504)
- Testing
- Systematic transplantectomy, Progressive reduction of immunosuppression
- Where
- 9 sites in France
- Volunteers
- 56 people
- Sponsor
- Hospices Civils de Lyon
Bladder Cancer
Celecoxib and Rosiglitazone in Treating Patients Who Are Undergoing Cystoscopic Surveillance for Early-Stage Noninvasive Carcinoma of the Bladder or Radical Cystectomy for Muscle-Invasive Carcinoma of the Bladder
RATIONALE: Celecoxib may stop the growth of tumor cells by blocking the enzymes necessary for their growth and by stopping blood flow to the tumor. Rosiglitazone may help tumor cells develop into normal bladder cells.
- Trial name
- NCT00084578
- Testing
- celecoxib, rosiglitazone maleate, conventional surgery
- Sponsor
- Fox Chase Cancer Center
Partially Edentulous Mandible
Artificial Intelligence Assisted Workflow Versus Conventional Workflow in Guided Implant Placement
The AI assisted CAD/CAM workflow will be adopted for the treatment planning and guide design generation with the aim of comparing precision of implant placement with conventional digital workflow.
- Trial name
- Implant (NCT07523815)
- Testing
- AI assisted implant placement, Conventional computer guided implant placement
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sandra Moussa Botros El Tarzi
Soft Tissue Sarcoma
Exercise and Soft Tissue Sarcoma
The purpose of this study is to evaluate the effect of a neoadjuvant (i.e. pre-treatment) exercise regimen on extremity function and postoperative wound healing.
- Trial name
- NCT04921917
- Testing
- neoadjuvant exercise therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
General Anesthesia, Laryngeal Mask Airways
Insertion of Laryngeal Mask Airways and Postoperative Sore Throat
When the instruction guidelines of classical laryngeal mask airways (cLMAs) were examined, it was seen that they should be stored between 10 °C and 25 °C.
- Conditions
- General Anesthesia, Laryngeal Mask Airways, Postoperative Sore Throat, Insertion of LMA
- Trial name
- NCT06713343
- Testing
- Laryngeal Mask Airways
- Where
- Turkey (Türkiye)
- Volunteers
- 172 people
- Sponsor
- Ankara City Hospital Bilkent
Breast Cancer
Radiofrequency Ablation in Treating Patients With Early Invasive Breast Cancer or Ductal Carcinoma in Situ
RATIONALE: Radiofrequency ablation uses a high-frequency, electric current to kill tumor cells. Giving radiofrequency ablation before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be…
- Trial name
- NCT00388115
- Testing
- conventional surgery, neoadjuvant therapy, radiofrequency ablation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Davis
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