Clinical trials: medical devices, open to volunteers
Pain, Procedural Pain
E-MOHS Trial of TENS and Vibration During Local Anesthesia
The E-MOHS Trial is a randomized controlled trial evaluating whether active vibration plus transcutaneous electrical nerve stimulation reduces pain during local anesthetic infiltration in adults undergoing Mohs micrographic…
- Conditions
- Pain, Procedural Pain, Local Anesthesia, Mohs Surgery
- Trial name
- E-MOHS (NCT07852455)
- Testing
- Active Vibration:TENS
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Minnesota
Tricuspid Regurgitation (TR)
A Post-Market Assessment of the Safety and Performance of the TriClip™ System
The objective of the TREAT TR study is to confirm the safety and performance of the TriClip System for tricuspid TEER in a contemporary, real-world setting, using the commercially available device in accordance with its approved…
- Trial name
- TREAT TR (NCT07586995)
- Testing
- Tricuspid Transcatheter Edge-to-Edge Repair (TEER)
- Where
- 9 sites in United States, Germany and 2 more
- Volunteers
- 1,000 people
- Sponsor
- Abbott Medical Devices
Glaucoma
Comparative Study of the Tomey FT-1000, and Goldmann Applanation Tonometer (GAT)
This study is intended to evaluate the agreement between Intraocular pressure(IOP) measurements obtained with the FT-1000 non-contact tonometer and a GAT to confirm the feasibility of the measurement procedures.
- Trial name
- NCT07804277
- Testing
- Non Contact Tonometer and Applanation Tonometer
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tomey Corporation
Bladder Carcinoma, Breast Carcinoma
The Vanguard Study: Testing a New Way to Screen for Cancer
The Vanguard Study is a feasibility study to explore several aspects of evaluating multi-cancer detection (MCD) tests in a future definitive randomized controlled trial.
- Conditions
- Bladder Carcinoma, Breast Carcinoma, Colorectal Carcinoma, Esophageal Carcinoma
- Trial name
- NCT06995898
- Testing
- Biospecimen Collection, Device Usage, Electronic Health Record Review
- Where
- 45 sites in United States
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Stroke
Using Omnidirectional Virtual Reality and Treadmill Training for Chronic Stroke
The primary objective of this pilot randomized controlled trial (RCT) is to test the feasibility (consent rate, retention rate, participant burden, adherence, technical issues, safety) and usability (system usability scale, SUS)…
- Trial name
- PROVE (NCT06495450)
- Testing
- Omnidirectional Virtual Reality and Treadmill Training, Traditional Exercise
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Nova Scotia Health Authority
Maxillary Transverse Deficiency
Three-Dimensional Facial Soft Tissue Changes and Clinical Perception Following MARPE
This prospective, controlled observational study aims to evaluate three-dimensional (3D) facial soft tissue changes following miniscrew-assisted rapid palatal expansion (MARPE) and determine whether these changes are clinically…
- Trial name
- NCT07858370
- Testing
- Miniscrew-Assisted Rapid Palatal Expansion (MARPE)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Adiyaman University
Healthy, Olfaction
Olfactory Transcranial Focused Ultrasound
This study investigates the causal effects of low-intensity transcranial focused ultrasound (tFUS) on odor valence perception and odor-elicited avoidance behaviors in healthy adults.
- Trial name
- O-tFUS (NCT07658365)
- Testing
- transcranial focused ultrasound (tFUS)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
High-risk PCI
SAVE-PCI Ⅱ: NyokAssist™ Small-Bore VAD vs. ECMO in Elective High-Risk PCI
SAVE-PCI Ⅱ is a prospective, multi-center, randomized controlled trial evaluating the safety and efficacy of NyokAssist™, a small-bore percutaneous ventricular assist device (pVAD), in comparison with ECMO in patients undergoing…
- Trial name
- NCT07860671
- Testing
- NyokAssist, ECMO
- Where
- 14 sites in China
- Volunteers
- 204 people
- Sponsor
- magAssist, Inc.
Polycystic Ovarian Syndrome (PCOS)
Continuous Glucose Monitoring in Polycystic Ovarian Syndrome
The purpose of this study is to learn more about blood sugar control in polycystic ovarian syndrome. The patient will be asked to wear a continuous glucose monitor (CGM) device that is applied to the arm with a sensor or filament…
- Trial name
- NCT07392476
- Testing
- Stelo glucose biosensor by Dexcom
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Cleveland Clinic
Bipolar Depression, Bipolar Disorder
Theta-Burst Stimulation for Bipolar Depression
The purpose of this trial is to determine if intermittent theta-burst stimulation (iTBS) can reduce the symptoms of depression in treatment-resistant bipolar disorder.
- Conditions
- Bipolar Depression, Bipolar Disorder, Treatment- Resistant Bipolar Disorder, Type 2 Bipolar Disorder
- Trial name
- TRIBE (NCT06370988)
- Testing
- iTBS Stimulation
- Where
- 2 sites in Canada
- Volunteers
- 124 people
- Sponsor
- Centre for Addiction and Mental Health
Aortic Aneurysm, Abdominal, Juxtarenal Aortic Aneurysm
Zenith® Fenestrated+ Clinical Study
The Zenith® Fenestrated+ Endovascular Graft Clinical Study will assess the safety and effectiveness of the Zenith® Fenestrated+ Endovascular Graft (ZFEN+) in combination with the BeGraft Balloon-Expandable FEVAR Bridging Stent…
- Conditions
- Aortic Aneurysm, Abdominal, Juxtarenal Aortic Aneurysm, Extent IV Thoracoabdominal, Pararenal Aneurysm
- Trial name
- NCT04875429
- Testing
- Zenith Fenestrated+ Endovascular Graft in combination with the BeGraft Balloon-Expandable FEVAR Bridging Stent Graft System and Unibody2
- Where
- 33 sites in United States, United Kingdom
- Volunteers
- 105 people
- Sponsor
- Cook Research Incorporated
Nasal Surgery, Hemostasis
Efficacy and Safety of NasoAid® After Nasal Surgery
The goal of this clinical trial is to evaluate the effectiveness and safety of collagen-based absorbable nasal packing (NasoAid®) after nasal surgery.
- Conditions
- Nasal Surgery, Hemostasis, Nasal Packing
- Trial name
- NCT07861061
- Testing
- NasoAid® Intranasal Splint, "Stryker" NasoPore Nasal Dressing
- Where
- 3 sites in Taiwan
- Volunteers
- 154 people
- Sponsor
- Maxigen Biotech Inc.
Neonate, Sepsis
Point of Care - Sepsis Study
This pilot study will evaluate whether a rapid point-of-care blood test can help identify early signs of infection and sepsis in preterm infants.
- Conditions
- Neonate, Sepsis, IL6, PCT
- Trial name
- POCT Sepsis (NCT07774013)
- Testing
- Point-of-Care Measurement of Inflammatory Biomarkers
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Graz
Healthy Young Adults, Accommodation Disorder
Study in Young Adults to Understand How Glasses With a Small Reading Addition Affect Focusing and Eye Coordination During Vision Tasks
This clinical study aims to understand how glasses with a small reading addition affect the way the eyes focus and work together in young adults with normal near vision.
- Trial name
- BIPBIP (NCT07859917)
- Testing
- Eye exam, Questionnaires, Washout lenses
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Essilor International
Presbyopia Correction, Presbyopia
Clinical Evaluation of Visual Performance, Spectacle Independence, and Patient Satisfaction With TECNIS PureSee Mini-Monovision and TECNIS PureSee-TECNIS Odyssey Mix-Match
The purpose of the study is to evaluate the binocular clinical endpoints of distance, intermediate, and near vision and patient reported outcomes utilizing mini-monovision versus mix-match approaches for the correction of…
- Conditions
- Presbyopia Correction, Presbyopia, Dysphotopsia, Visual Acuity
- Trial name
- NCT07860567
- Testing
- TECNIS PureSee IOL (Model DEN00V/DET150), TECNIS Odyssey IOL (Model DRN00V/DRT150)
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Dr. Daniel H. Chang, MD
Ischemic Stroke
Transcranial Focused Ultrasound Neuromodulation for Post-Stroke Motor Dysfunction
This study aims to evaluate how transcranial focused ultrasound (tFUS) technology can promote neural network remodeling and functional recovery after stroke.
- Trial name
- NCT07637825
- Testing
- Transcranial Focused Ultrasound Neuromodulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jiangsu Taizhou People's Hospital
Metastatic Non-small Cell Lung Cancer
LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC
This study, known as LUNAR-2, aims to investigate the effectiveness and safety of using TTFields, delivered by the NovoTTF-200T device, concomitantly administered with pembrolizumab and platinum-based chemotherapy for patients…
- Trial name
- LUNAR-2 (NCT06216301)
- Testing
- NovoTTF-200T, Pembrolizumab, Platinum based chemotherapy
- Where
- 104 sites in United States, Austria and 15 more
- Volunteers
- 734 people
- Sponsor
- NovoCure GmbH
Heart Failure
Alleviant ALLAY-HFrEF Study
Prospective, multicenter, randomized, sham-controlled, double blind (patient and observer), study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using the Alleviant ALV1 System in…
- Trial name
- NCT06812533
- Testing
- Alleviant ALV1 System
- Where
- 70 sites in United States, Australia and 9 more
- Volunteers
- 350 people
- Sponsor
- Alleviant Medical, Inc.
Rhematoid Arthritis, Osteo Arthritis of the Knee
Persona SoluTion PPS Femur PMCF
The goal of this study is to generate clinical evidence and evaluate the safety and performance of the Persona® SoluTion® PPS Femurs in the US market, with data supporting global regulatory submissions, including CE marking under…
- Conditions
- Rhematoid Arthritis, Osteo Arthritis of the Knee, Traumatic Arthritis of Knee (Diagnosis), Polyarthritis
- Trial name
- NCT07286513
- Testing
- Total knee arthroplasty
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Transforaminal Lumbar Interbody Fusion Surgery
The Objective of the Protocol is to Generate Real World Evidence (RWE) Supporting the Safety, Performance, and Health Economics of Using the Regulatory Approved and Commercially Available EARP Interbody System Used During Lumbar Interbody Fusion (LIF) Procedures With the EARP Nerve Cuff Electrode
The goal of the trial is to generate data to support the safety, performance, and cost effectiveness of using the EARP devices during Lumbar Interbody Fusion (LIF) procedures.
- Trial name
- EARP-2 (NCT07020000)
- Testing
- Device: Nerve Cuff and Retractor System
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- Retropsoas Technologies, LLC