Clinical trials: sponsored by ANRS, Emerging Infectious Diseases
HIV Infections
Prevention of HIV in "Île-de-France"
Interventional HIV prevention strategy based on pre-exposure prophylaxis (PrEP) with Truvada® for people in the Île-de-France area (or Paris region) who don't have HIV but who are at high risk of becoming infected with HIV (men…
- Trial name
- ANRS-PREVENIR (NCT03113123)
- Testing
- PrEP with Truvada®
- Where
- 22 sites in France
- Volunteers
- 3,257 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections
Frailty in People Living With HIV Aged 70 Years or More
The ANRS EP66 SEPTAVIH Study aims to screen feasibility of evaluating frailty in people living with HIV aged 70 or older, to estimate its prevalence, to analyse associated risk factors and to evaluate the impact of frailty on…
- Trial name
- NCT03958786
- Testing
- Simplified Geriatric Evaluation, Sampling
- Where
- France
- Volunteers
- 512 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Healthy Participant
Transmission of Covid-19 During Clubbing Events in Closed Places
The ITOC study is a cluster randomised, controlled, multicentre trial in Paris region, France. The intervention is an 8-hour indoor clubbing event with no mask wearing, no social distancing, at maximum room capacity.
- Trial name
- ITOC (NCT05311865)
- Testing
- Club event
- Where
- France
- Volunteers
- 1,216 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV-1
Preventing Childhood HIV: Rescue Intervention. ANRS 12388 PREVENIR-PEV
The second visit of the Expanded Programme of Immunization when the child is 2 months old (EPI-2) represents a unique opportunity to link the EPI and PMTCT programmes and to introduce preventive and therapeutic rescue…
- Trial name
- PREVENIR-PEV (NCT03869944)
- Testing
- Lamivudine Oral Solution
- Where
- Burkina Faso
- Volunteers
- 97 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Hepatitis B, Chronic
ANRS HB07 IP-Cure-B Proof of Concept (PoC) Clinical Trial. Educating the Liver Immune Environment Through TLR8 Stimulation Followed by NUC Discontinuation
The ANRS HB07 IP-cure-B study is a proof of concept Phase II clinical trial in HBeAg negative virally suppressed non-cirrhotic CHB patients.
- Trial name
- IP-CURE-B (NCT05045261)
- Testing
- administration of SLGN in arm C, Discontinuation of NUC treatment in arms B and C
- Where
- 8 sites in France, Germany and 2 more
- Volunteers
- 100 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Papillomavirus Infections, HIV Infections
Prevalence and Longitudinal Follow-up of Anal Lesions, HPV Infection and Associated Sexually Transmitted Infections Among Men Who Have Sex With Men in Togo.
The DepIST-H study, funded by the French AIDS and Hepatitis Research Agency (ANRS), is to estimate prevalence (the number of cases over a given period of time) and incidence (the number of new cases over a given period of time)…
- Trial name
- DepIST-H (NCT04910438)
- Testing
- STIs screening and care
- Where
- Togo
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections, HPV - Anogenital Human Papilloma Virus Infection
Evaluation of Triage Options After HPV Testing for Cervical Cancer Screening Among HIV-infected Women
Cervical cancer is the most common cause of cancer and a leading cause of death among HIV-infected women living in resource-limited settings.
- Trial name
- AIMA-CC (NCT03789513)
- Testing
- HPV test with partial genotyping and VIA triage
- Where
- 3 sites in Burkina Faso, Cambodia and 1 more
- Volunteers
- 3,000 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Corona Virus Infection
Protective Measures Against SARS-CoV-2 Contamination of Young Healthy Volunteers During a Concert of Actual Music
The aim of this study is to assess whether the protective measures can limit the contaminations by SARS-CoV-2 during the participation in a concert at a non-inferior level to a non-concert / current life situation.
- Trial name
- CONCERTSAFE (NCT04868942)
- Testing
- Assisting to the event
- Volunteers
- healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections
HUSH Restriction in HIV Infected Patients
HIV eradication faces a major obstacle that is viral persistence in latent reservoir cells despite antiretroviral therapy. Epigenetic repression plays a central role in viral transgene latency and several epigenetic regulators…
- Trial name
- NCT04172480
- Testing
- Blood sampling
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections
Dual Therapy in HIV Patients in 4 Days a Week Versus 7 Days a Week
The trial is an open-label, multicenter, prospective, randomized trial in 2 parallel groups, evaluating at W48 the non inferiority of antiretroviral dual therapy taken 4 consecutive days per week versus antiretroviral dual…
- Trial name
- NCT04867083
- Testing
- ARV bitherapie
- Where
- 38 sites in France, Martinique
- Volunteers
- 440 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Ebola Virus Disease
Prophylaxis Vaccine Antibodies Ebola
Three measures are currently being implemented to control Ebola outbreaks: Monitoring of contacts Isolation and treatment of sick people Vaccination of the population in high-risk areas.
- Trial name
- PROVAE (NCT04822376)
- Testing
- ansuvimab, Ervebo
- Where
- Guinea
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV-1 Infection
Efficacy and Safety of a Dolutegravir-based Regimen for the Initial Management of HIV Infected Adults in Resource-limited Settings
Several reports indicate that treatment failure due to HIV resistance or to adverse event-related discontinuation could compromise the effectiveness of scaling-up antiretroviral treatment (ART), especially when lack of access to…
- Trial name
- NAMSAL (NCT02777229)
- Testing
- Dolutegravir 50 mg, Tenofovir disoproxil fumarate 300 mg / lamivudine 300 mg, Efavirenz 400 mg
- Where
- 3 sites in Cameroon
- Volunteers
- 616 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV/AIDS
Evaluation of Third-line cART Regimen in Cambodia (3DICAM)
The study aims to evaluate the virological effectiveness of a third-line regimen combining dolutegravir (DTG), ritonavir-boosted darunavir (DRV/r) and optimized NRTI in Cambodian HIV-infected adults, who failed a protease…
- Trial name
- NCT03602690
- Testing
- Dolutegravir + Darunavir/ritonavir + optimized NRTI
- Where
- Cambodia
- Volunteers
- 54 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Influenza -Like Illness, Covid19
Epidemiological Investigation of COVID-19 in Laos Using a One-Health Approach in Human and Animals
The Respiratory infection COVID-19, due to a new coronavirus, SARS-CoV2, appeared in December 2019 in several people who attended the wildlife market in Wuhan, Hubei Province, China.
- Trial name
- LACOVISS (NCT04716543)
- Testing
- ILI and COVID-19 detection
- Volunteers
- 5,400 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infection
Early Identification and Treatment of Early HIV Infection in Côte d'Ivoire
Set-up of a biobank for patients with an estimated date of infection seroconverters: store plasma and cells samples at initial contact and during follow-up for future analysis and analysis in international collaborative cohort…
- Trial name
- PRECO-CI (NCT01917175)
- Where
- 2 sites in Côte d’Ivoire
- Volunteers
- 511 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV-1-infection
ANRS 12406 EvvA Study
ANRS 12406 EvvA is an observational, longitudinal and monocentric study evaluating the virological success rate in HIV-infected adolescents on antiretroviral therapy in Cameroon.
- Trial name
- EvvA (NCT04593979)
- Where
- Cameroon
- Volunteers
- 289 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Mother to Child Transmission of HIV
National Cohort of Children Born to HIV-positive Mothers
The purpose of this study is to provide a surveillance system to monitor changes in the rate of mother to child HIV transmission and preventive practices in France and especially to identify the occurrence of toxicity in children…
- Trial name
- EPF (NCT03306251)
- Where
- 52 sites in France, French Guiana and 2 more
- Volunteers
- 5,200 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Severity of the New UK SARS-Cov2 Variant in COVID-19 Infection
The COVID-19 epidemic has now raged for more than a year with more than 100 million identified cases and nearly 2.5 million deaths worldwide.
- Trial name
- SEVASAR (NCT04863547)
- Testing
- Data collection
- Where
- 53 sites in France, Martinique
- Volunteers
- 2,200 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Hepatitis C Virus Infection, Past or Present, Chronic Hepatitis c
Cross Sectional Survey on the Burden, Impacts and Causes of Hepatitis C Virus (HCV) Outbreak in South West Region in Burkina Faso
This study investigates hepatitis C virus (HCV) outbreak in South West general population in Burkina Faso with three specific objectives: estimate HCV prevalence in South West Region general population in 2019; identify factors…
- Trial name
- REVERSO (NCT04136405)
- Where
- Burkina Faso
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Children Infected by HIV
Cohort of HIV-infected Children
The purpose of this study is to describe the conditions of access to early treatment of children infected with HIV, their management on the long-term, and impact on growth, clinical and immunovirological prognosis, adherence to…
- Trial name
- EPF (NCT03235258)
- Where
- 23 sites in France
- Volunteers
- 812 people
- Sponsor
- ANRS, Emerging Infectious Diseases