Clinical trials: sponsored by ANRS, Emerging Infectious Diseases
HIV Infections
ANRS 12392 Sanu Gundo
Sanu Gundo ANRS 12392 is a non-randomized and non-comparative intervention trial in Mali. The main objective of the project is to study the feasibility of the community-based HIV care in the context of the artisanal gold mining…
- Trial name
- SANU GUNDO (NCT04482010)
- Testing
- Local community-based HIV care
- Where
- 4 sites in Mali
- Volunteers
- 265 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV-2 Infection
Cohorte Nationale VIH-2
The HIV2 study is an open cohort of prospective, multicentric, national observation. The main objective is to study HIV-2 infection in adult patients followed in France.
- Trial name
- ANRS CO VIH2 (NCT04658329)
- Testing
- Antiretroviral
- Where
- 29 sites in France
- Volunteers
- 1,185 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infections
A Chronological Study of the Formation of HIV Cellular Reservoirs Through the Expression of Surface Markers on CD4 + T Lymphocytes, Including CD32a
To analyze the HIV viral sequences present in the CD32 + CD4a + T lymphocytes of the patients who have participated in the ANRS 139 TRIO trial, always followed and in virological success, and carrying multi-resistant viruses…
- Trial name
- ANRS EP63 (NCT03298360)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 11 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV-1 Infection
Systematic Empirical vs. Test-guided Anti-TB Treatment Impact in Severely Immunosuppressed HIV-infected Adults Initiating ART With CD4 Cell Counts <100/mm3
In countries with a high tuberculosis (TB) prevalence, TB and invasive bacterial infections are leading causes of early death in patients who initiate antiretroviral therapy (ART) with advanced immunodeficiency.
- Trial name
- STATIS (NCT02057796)
- Testing
- Xpert MTB/RIF®, Determine TB LAM, Chest X-ray, ART (Atripla, Truvada, Efavirenz, Combivir), Rifampin, isoniazid, pyrazinamide, ethambutol
- Where
- 4 sites in Cambodia, Côte d’Ivoire and 2 more
- Volunteers
- 1,050 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Tuberculosis
Lowering InterLeukin-1 Receptor Antagonist Concentrations After TB Treatment Onset
Despite marked improvements in the diagnosis of tuberculosis there are difficulties in diagnosing and monitoring treatment outcome among TB patients.
- Trial name
- LILAC-TB (NCT04015713)
- Where
- 2 sites in Cambodia, Côte d’Ivoire
- Volunteers
- 100 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infection, Tuberculosis Infection
Micro RNA as Prediction and/or Prognostic Markers of IRIS in TB-HIV Co-infected Patients
The role of miRNAs in HIV disease is yet to be completely defined. Host miRNAs target certain HIV genes, thus can affect HIV replication and participate in viral control.
- Trial name
- miRNA (NCT03941210)
- Testing
- Detection of molecular Biomarkers
- Where
- Cambodia
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Seropositivity, HCV Infection
HIV and HCV Infections in 2 Communes From the Battambang Province, Cambodia: Prevalence Rates, Viral Strains, and Unsafe Injection Practices (12352 ANRS ROK INVEST)
This cross-sectional survey will be conducted prospectively in 2 communes in the Battambang Province, Roka and Prey Khpos commune.
- Trial name
- NCT04044586
- Where
- Cambodia
- Volunteers
- 1,098 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Mother to Child HIV Transmission
HIV Diagnosis and Treatment at Birth for Newborn With High Risk HIV Exposure
Principal objective Assess the operational efficacy of a strategy combining early diagnosis and preventive antiretroviral treatment systematically reinforced from the birth* among infants at high risk of infection with HIV** .
- Trial name
- DIAVINA (NCT03642704)
- Testing
- Reinforced preventive ARV therapy
- Where
- Guinea
- Volunteers
- 56 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Hepatitis B Chronic Infection, Pregnancy
Tenofovir As Prevention Of Hepatitis b Mother-to-child Transmission
The World Health Organization recommends that all high endemic countries for HBV infection based their mother to child transmission prevention strategies on vaccination of all children and administration of immunoglobulins (HBIG)…
- Trial name
- TA-PROHM (NCT02937779)
- Testing
- Tenofovir disoproxil fumarate, Rapid tests HBe Ag
- Where
- 3 sites in Cambodia
- Volunteers
- 933 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Chronic Hepatitis b
Cross Sectional Survey on the Burden and Impacts of Chronic Hepatitis B in the Rural Area of Niakhar, Senegal
This study aims at estimating the prevalence of chronic hepatitis B virus (HBV) infection in rural Senegal (area of Niakhar) and at evaluating the associated burden in terms of both health-related and socio-economic consequences.
- Trial name
- AMBASS (NCT03215732)
- Testing
- HBV testing with dried blood spots (DBS) technique
- Where
- Senegal
- Volunteers
- 3,119 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV-1-infection
An HIV Vaccine Trial in Individuals Who Started ART During Primary or Chronic Infection
EVHA T01 is an international, phase I/II, multicentre, multi-stage, double-blind study that will evaluate at least three experimental arms compared to placebo control in HIV-1 infected participants to see if one or more has a…
- Trial name
- EHVAT01 (NCT02972450)
- Testing
- GTU-MultiHIV B-clade vaccine + MVA HIV-B HIV vaccine, GTU-MultiHIV B-clade vaccine + MVA HIV-B HIV vaccine+ Vedolizumab, Vedolizumab 300 MG [Entyvio]
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 1 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Growth and Development
Infant Peri-Exposure Prophylaxis to Prevent HIV-1 Transmission by Breastfeeding: Mechanisms & Safety
General objective To assess the long-term safety and efficacy of one-year infant prophylaxis using lamivudine (3TC) or lopinavir/ritonavir (LPV/r) to prevent post-natal transmission through breastfeeding.
- Trial name
- NCT03519503
- Where
- 4 sites in Burkina Faso, South Africa and 2 more
- Volunteers
- 562 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Chronic Hepatitis C
"Real Life" Evaluation of Efficacy and Safety of Direct Antiviral Agents (DAAs) for the Treatment of Hepatitis C Virus in Egypt
The primary purpose of the ANRS 12332 HepNile study cohort is to assess in "Real-Life" condition the efficacy and the safety profile of new Direct Acting Antivirals (DAAs) introduced in the Egyptian National Treatment Programme…
- Trial name
- HepNile (NCT03510637)
- Where
- 3 sites in Egypt
- Volunteers
- 7,500 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV-2 Infection
First-Line Treatment for HIV-2
FIT-2 is a multi-country, phase IIb, randomized, non-comparative study, carried out in West Africa (Côte d'Ivoire, Burkina Faso, Senegal, Togo).
- Trial name
- FIT-2 (NCT02150993)
- Testing
- Tenofovir + Emtricitabine or Lamivudine + Zidovudine, Tenofovir + Emtricitabine or Lamivudine + Lopinavir/ritonavir, Tenofovir + Emtricitabine or Lamivudine + Raltegravir
- Where
- 9 sites in Burkina Faso, Côte d’Ivoire and 2 more
- Volunteers
- 210 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Seropositivity, Disclosure
ANRS12373 GUNDO SO - Evaluation of an Empowerment Program for WLHIV in Mali
The objective of this research is to measure the short- and mid-term effects of an empowerment program focused on serostatus disclosure management for women living with HIV (WLHIV) in Mali on the "burden of secrecy".
- Conditions
- HIV Seropositivity, Disclosure, Empowerment, HIV/AIDS
- Trial name
- NCT03795415
- Testing
- Gundo So
- Where
- 6 sites in Mali
- Volunteers
- 224 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV-1 Infection
Lipopeptide Immunisation With GTU-multiHIV Trial
The combination of GTU-MultiHIV B DNA and LIPO-5 vaccines in a prime-boost strategy is expected to induce strong and diverse HIV-specific immune responses in HIV-infected patients.
- Trial name
- NCT01492985
- Testing
- GTU-multHIV B vaccine and LIPO-5 vaccine
- Where
- France
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Reservoirs
IL-23/IL-12 Imbalance and T Lymphocyte Polarization in HIV Infection
Progressive HIV or HIV infection seems to be related to a preferential loss of CD4+ T lymphocytes, especially Th17+, within the mucosal intestinal lymphoid tissue, and with intestinal mucosal damage and bacterial product…
- Trial name
- INTESTIPAX (NCT01942655)
- Testing
- Blood sample and recto-colic biopsies
- Where
- France
- Volunteers
- 26 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infection
CLEAC (Comparison of Late Versus Early Antiretroviral Therapy in HIV-infected Children)
The study aims to define and compare the immunological characteristics (lymphocyte subpopulations, specific immunity against HIV, lymphocyte activation, inflammatory parameters) and the virological characteristics (study of viral…
- Trial name
- CLEAC (NCT02674867)
- Testing
- Blood draw
- Where
- 11 sites in France
- Volunteers
- 80 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV-1 Infection, Tuberculosis
Raltegravir Versus Efavirenz in Naive HIV-1-infected Patients Receiving Rifampin for Active Tuberculosis
Phase III trial evaluating raltegravir as an alternative to efavirenz for antiretroviral treatment of HIV-infected patients with tuberculosis.
- Trial name
- REFLATE TB2 (NCT02273765)
- Testing
- Tenofovir + lamivudine + raltegravir, Tenofovir + lamivudine + efavirenz
- Where
- 5 sites in Brazil, Côte d’Ivoire and 3 more
- Volunteers
- 460 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infection
Co-adaptation Between Human Immunodeficiency Virus (HIV) and Cluster of Differentiation 8 (CD8) Cellular Immunity
The objective is to characterize the viral evolution and viral factors determining HIV virulence, the evolution of the HIV reservoir in PBMC and the co-evolution of anti-HIV CD8 T cell repertoires.
- Trial name
- "ImmunoCo27" (NCT02886416)
- Testing
- Non interventional study
- Volunteers
- 22 people
- Sponsor
- ANRS, Emerging Infectious Diseases