Clinical trials: sponsored by Ain Shams University
Pain, Postoperative, Root Resorption
Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue Repair
Management of non-vital primary molars is challenging due to the natural anatomy of primary teeth, patients' young age, and their behavior toward dental treatment.
- Conditions
- Pain, Postoperative, Root Resorption, Persistent Infection, Necrotic Pulp
- Trial name
- NCT06926322
- Testing
- Conventional double antibiotic paste of Metronidazole 500 mg plus Ciprofloxacin 500 mg mixed with propylene glycol, Double antibiotic paste of Metronidazole and Ciprofloxacin loaded chitosan-coated silver nanoparticles, chitosan-coated silver nanoparticles
- Where
- Egypt
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Tetanus, Manifest
Tetanus Severity Score for Prediction of Mortality in Manifest Tetanus
Three scoring systems will be applied to patients suffering from manifest tetanus and will be related to mortality.
- Trial name
- NCT07512167
- Testing
- Tetanus Severity Score (TSS), Philips Score, Dakar Score
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Ain Shams University
Oral Lichen Planus
Low Level Laser Therapy With Injectable Platelet Rich Fibrin in Management of Oral Lichen Planus
The Injectable PRF (i-PRF) is a variant of PRF, which is a liquid blood derivative rich in leukocytes and acts as a growth factor release, with its potential anti-inflammatory role, it may alleviate the symptoms of OLP.
- Trial name
- NCT07846891
- Testing
- Injectable Platelet Rich Fibrin, Low Level Laser Therapy, Triamcinolone acetonide (injection)
- Where
- 2 sites in Egypt
- Volunteers
- 39 people
- Sponsor
- Ain Shams University
Semaglutide-Induced Gastric Motility, Anesthesia
Effect of Itopride on Semaglutide Gastroparesis
Semaglutide delays gastric emptying and increases the risk of aspiration with anesthesia; So, the addition of prokinetics as Itopride, could enhance gastric emptying and hasten surgery.
- Trial name
- NCT07254715
- Testing
- Itopride HCI 50 mg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Left Ventricular Function, Cardiac Surgery
Artificial Intelligence Versus Anesthesiologist Visual Assessment of Ejection Fraction by Transesophageal Echocardiography During Cardiac Surgery
This prospective observational study evaluated the reliability of a general-purpose artificial intelligence application in estimating left ventricular ejection fraction from intraoperative transesophageal echocardiography images…
- Trial name
- NCT07841327
- Testing
- Artificial Intelligence Assessment of TEE Images
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Ain Shams University
Paediatric, Flexible Ureteroscopy
The Efficacy and Safety of Adjunctive Alpha-blocker Therapy Before Flexible Ureteroscopy in the Management of Upper Ureteric Stones in Pediatrics Group
A unique aspect of pediatric URS is the smaller ureteral diameter, which often results in failure to access the ureter during an initial URS attempt.
- Trial name
- NCT07841340
- Testing
- Tamsulosin
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery
PCO₂ Gap and Lactate as Predictors of POCD After Cardiac Surgery
This prospective observational study aims to evaluate whether intraoperative venous-to-arterial carbon dioxide partial pressure difference (PCO₂ gap) and arterial lactate levels can serve as early predictors of postoperative…
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT07843186
- Volunteers
- 185 people
- Sponsor
- Ain Shams University
Length of Hospital Stay
Preoperative Coadministration of Low-concentration Carbohydrate and Nitrates Loading vs Low- Concentration Carbohydrate Loading Alone in Patients Undergoing Open Gynecological Surgeries
Surgery is known to be associated with stress response affecting in a negative way the clinical outcome and patient experience. The stress response includes both sympathetic nervous system activation and systemic inflammatory…
- Trial name
- NCT04962776
- Testing
- Low-concentration carbohydrate and nitrates, Low-concentration carbohydrate
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Obstructive Sleep Apnea
Automated vs Manual Polysomnography Scoring in Adults With Obstructive Sleep Apnea
This prospective study aims to compare automated polysomnographic scoring with manual scoring in adult patients with Obstructive Sleep Apnea (OSA).
- Trial name
- NCT07826143
- Testing
- Polysomnographic Scoring (Automated vs. Manual)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Acute Decompensated Heart Failure (ADHF), Cardiorenal Syndrome (CRS)
Clinical Outcomes of Levosimendan Versus Dobutamine Versus Milrinone in Cases With Acute Decompensated Heart Failure With Impaired Renal Function
This study aimed to assess and compare the cardiac, renal, and clinical efficacy of Levosimendan (LEV), Dobutamine (DOB), and milrinone (MIL) in cases with acute decompensated heart failure (ADHF) complicated by renal impairment…
- Trial name
- NCT07186062
- Testing
- Levosimendan, Dobutamine, Milrinone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Dental Crowding, Malocclusion
Clear Aligners With Two Different Change Schedules vs Traditional Braces for People With Crowded Lower Front Teeth
The goal of this clinical trial was to compare two clear aligner treatment plans with traditional braces for treating crowded lower front teeth in adults. Clear aligners were removable plastic trays.
- Trial name
- NCT07821723
- Testing
- Clear aligner, 0.25 mm per step, Clear aligner, 0.35 mm per step, Conventional fixed orthodontic appliance
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Ain Shams University
Necrotic Teeth With Apical Periodontitis
Evaluation of the Aloe Vera Anti-inflammatory Effect on Apical Periodontitis.
The goal of this clinical trial is to evaluation aloe vera as intracanal medication anti-inflammatory also inter-appointment pain incidence compared with calcium hydroxide.
- Trial name
- NCT07826091
- Testing
- Aloe vera gel, Calcium Hydroxide (Ca(OH)2) Intracanal Medication
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Ain Shams University
Molar-Incisor Hypomineralization (MIH)
Nano Silver Fluoride and Photobiomodulation Therapy for Hypersensitivity and Pain in MIH-Affected Molars
Molar-incisor hypomineralization (MIH) is a developmental condition affecting primarily the first permanent molars and may be associated with post-eruptive enamel breakdown, hypersensitivity, and difficulties in achieving…
- Trial name
- NCT07826130
- Testing
- Nano Silver Fluoride, Photobiomodulation Therapy, Pre-appointment analgesics
- Volunteers
- 45 people
- Sponsor
- Ain Shams University
Renal Stones, Flexible Ureteroscopy
Criteria for DJ Stent Omission Following Retrograde Intrarenal Surgery Using Flexible and Navigable Suction Sheath: A Prospective Cohort Study
Retrograde intrarenal surgery is widely used for the treatment of upper urinary tract stones. Traditionally, ureteral stents are placed postoperatively to prevent complications such as pain and stone obstruction.
- Trial name
- NCT07826169
- Testing
- flexible ureteroscopy using flexible and navigable suction sheath
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Ain Shams University
Polycystic Ovary Syndrome, Infertility, Female
Effect of ALA Combined With Letrozole on Polycystic Ovary Syndrome Clinical Outcome in Infertile Females
This research study aims to investigate the effect of adding Alpha lipoic acid (ALA) supplement to letrozole treatment in infertile women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT06418347
- Testing
- Alpha lipoic acid, Letrozole
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Ain Shams University
Anesthesia
Effect of Total Intravenous Anesthesia vs Inhalational Anesthesia on the Level of Inflammatory Markers
This study aims to compare the effects of total intravenous anesthesia (TIVA) vs inhalational anesthesia on postoperative levels of inflammatory markers, length of hospital stay, and the incidence of postoperative nausea and…
- Trial name
- NCT07271459
- Testing
- Venous blood sampling preoperatively, Venous blood sampling at 6 hours postoperative, Venous blood sampling at 24 hours postoperative
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Rheumatoid Arthritis (RA)
The Effect of Nicorandil on Rheumatoid Arthritis Patients
The aim of this clinical trial is to determine whether nicorandil works in minimizing disease severity in patients with rheumatoid arthritis. The study will also assess the safety and tolerability of nicorandil.
- Trial name
- NCT07730723
- Testing
- Nicorandil Oral Tablet, conventional synthetic antirheumatic drugs (cDMARDs)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Lupus Nephritis (LN)
The Role of Transforming Growth Factor- Beta (TGF- β) Expression in Renal Biopsy of Lupus Nephritis Patients
To investigate the possible role of TGF-β expression in renal biopsy and it's relation with fibrosis, activity and chronicity indices
- Trial name
- NCT07823556
- Testing
- renal biopsy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Ulcerative Colitis (UC)
Palmitoylethanolamide in Ulcerative Colitis
Evaluate the effects of PEA supplementation on disease activity, health-related quality of life (HRQoL) and inflammatory biomarkers in patients with active mild-to-moderate UC.
- Trial name
- NCT07609810
- Testing
- Palmitoylethanolamide (PEA)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Helicobacter Pylori Infection
Efficacy and Safety of Black Seed Oil With Vonoprazan Based Triple Therapy in Treatment of Helicobacter Pylori
The aim of this study is to: Evaluation of efficacy and safety of adding black seed oil with vonoprazan triple therapy ( vonoprazan ,clarithromycin and amoxicillin ) in eradication of Helicobacter pylori infection and this will…
- Trial name
- NCT05957432
- Testing
- Black Seed Oil Cap/Tab, Vonoprazan, Amoxicillin and Clarithromycin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University