Clinical trials: sponsored by Alexandria University
Periodontal Diseases
Locally Delivered Melatonin Gel in Management of Stage II Grade B Periodontitis
Background: Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth-supporting tissues, driven by an imbalance between bacterial pathogens and the host immune response.
- Trial name
- NCT07813936
- Testing
- 2% Melatonin gel
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Alexandria University
Gingival Hyperpigmentation
Licorice Extract Gel Versus Diode Laser for Physiologic Gingival Pigmentation
This randomized controlled clinical trial aims to compare the effectiveness of topical licorice extract gel and diode laser (445 nm) in the treatment of physiologic gingival pigmentation.
- Trial name
- NCT07325825
- Testing
- Diode Laser 445 nm, Licorice Extract Gel
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Alexandria University
Orbital Floor Reconstruction, PEEK IMPLANTS
Patient-specific PEEK Implants for Post-maxillectomy Orbital Floor Reconstruction
The study aims to evaluate the utilization of Patient-specific PEEK implantsd in reconstruction of orbital floor after maxilla ablation surgery
- Conditions
- Orbital Floor Reconstruction, PEEK IMPLANTS, MAXILLECTOMY
- Trial name
- NCT07789392
- Testing
- Patient-specific PEEK implants
- Where
- Egypt
- Volunteers
- 6 people
- Sponsor
- Alexandria University
Rectal Cancer Patients, Anastomotic Leakage
CRP/CT-Guided Selective Ileostomy After LAR
This single-center, parallel-group randomized controlled trial compared routine diverting loop ileostomy with a postoperative CRP/CT-guided selective ileostomy strategy in adults undergoing laparoscopic low anterior resection for…
- Conditions
- Rectal Cancer Patients, Anastomotic Leakage, Low Anterior Resection
- Trial name
- less stoma (NCT07722533)
- Testing
- Serial C-reactive protein-guided computed tomography surveillance and selective omission of defunctioning ileostomy, routine follow up
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Alexandria University
Delirium in Intensive Care Unit, Acute Heart Failure (AHF)
Intravenous Infusion of Low Dose Ketamine Versus Dexmedetomedine for Delirium Treatment in Acute Heart Failure
Delirium is an acute, fluctuating disturbance in attention and cognition that commonly complicates the course of critically ill patients, particularly those admitted with acute heart failure (AHF).
- Trial name
- NCT07781462
- Testing
- Low dose ketamine infusion, Dexmedetomidine infusion
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Alexandria University
Dental Implants
Laser Modification of Dental Implant Abutment Surfaces
Introduction: Tight soft tissue integration to the dental implants is essential to achieve a successful outcome of dental implants.
- Trial name
- NCT07780227
- Testing
- ND: YAG laser, Machined abutment
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Alexandria University
Dental Plaque, Gingival Diseases
Effectiveness of Dental Health Education Methods on Oral Hygiene, Oral Health Care Self-Efficacy and Self-Esteem of Young Orphans
Background: Orphan children are at higher risk of developing oral diseases, compared to non-orphans. They also face various emotional, social, and psychological distresses which affect their general as well as oral health.
- Conditions
- Dental Plaque, Gingival Diseases, Oral Health, Self Efficacy
- Trial name
- NCT07771634
- Testing
- Conventional dental health education, Game based dental health education, Peer-group based dental health education
- Where
- Egypt
- Volunteers
- 264 people
- Sponsor
- Alexandria University
Mandibular Angle Fracture
Evaluation of Patient-specific Surgical Stents and Plates for Guided Reduction And Fixation of Mandibular Angle Fractures
This study will evaluate the patient specific surgical stent and plate for guided reduction and fixation of mandibular angle fractures.
- Trial name
- NCT07375030
- Testing
- Patient specific surgical stents and plates for guided reduction and fixation of mandibular angle fixation, fracture reduction performed using conventional intraoperative manual techniques without a reduction guide.
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Alexandria University
Medical Misinformation, Medication Adherence
Impact of Online Medical Misinformation
A cross-sectional analytical study was conducted among adult patients diagnosed with chronic diseases to assess the impact of online medical misinformation on medication adherence, treatment decision-making, and health…
- Conditions
- Medical Misinformation, Medication Adherence, Health-Seeking Behavior, Chronic Diseases
- Trial name
- NCT07601308
- Testing
- None (observational)
- Where
- Egypt
- Volunteers
- 402 people
- Sponsor
- Alexandria University
Orbital Fractures
Clinical Outcomes of Transconjunctival Vs Transcutaneous Approaches in Orbital Fracture Repair
Open reduction and internal fixation of zygomaticomaxillary complex (ZMC) fractures has a challenging impact on the selection of the suitable surgical approach to the orbital and zygomatic skeleton.
- Trial name
- Vs: versus (NCT07759440)
- Testing
- orbital fracture reduction and fixation
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Colonic Surgery
Perioperative Zinc Supplementation and Pediatric Colonic Surgical Recovery
The goal of this randomized controlled clinical trial is to evaluate the role of perioperative zinc supplementation on postoperative outcomes (specifically gastrointestinal mucosal integrity and inflammation) in children aged 1…
- Trial name
- NCT07760493
- Testing
- Perioperative Zinc Supplementation
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Alexandria University
Abdominal Surgery, Postoperative Recovery
Effect of AI-Personalized Virtual Reality on Postoperative Recovery After Major Abdominal Surgery
Major abdominal surgery is frequently associated with postoperative pain, anxiety, delayed recovery, and prolonged hospitalization.
- Conditions
- Abdominal Surgery, Postoperative Recovery, Postoperative Pain, Length of Hospital Stay
- Trial name
- VR-RECOVER (NCT07493499)
- Testing
- Immersive Virtual Reality (VR), Standard Perioperative Care and Enhanced Recovery Protocol
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Alexandria University
Artificial Intelligence (AI), Perioperative Nursing
Artificial Intelligence in Perioperative Nursing
This mixed-methods study aims to assess current perspectives, attitudes, and preparedness of perioperative nurses regarding the integration of artificial intelligence (AI) in clinical practice.
- Conditions
- Artificial Intelligence (AI), Perioperative Nursing, Surgical Care, Nursing Informatics
- Trial name
- NCT07601373
- Testing
- No interventions (observational study)
- Where
- 2 sites in Egypt
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Infected Extraction Sockets
Photoactivated Disinfection Versus Laser Disinfection of Infected Sockets on the Success of Immediate Implant Placement
Background: Dental implantology offers reliable tooth replacement options, but infections in extraction sockets can compromise osseointegration.
- Trial name
- NCT07753044
- Testing
- Photoactivated disinfection, Er,Cr:YSGG laser disinfection, Chlorohexidine disinfection
- Where
- Egypt
- Volunteers
- 9 people
- Sponsor
- Alexandria University
Molar Incisor Hypomineralization
Aesthetic Masking and Resin Infiltration Time in MIH-affected Incisors
Background: Resin infiltration often shows unpredictable outcomes in teeth affected by molar incisor hypomineralisation (MIH) due to variable enamel porosities, hypermineralised surface layers, and elevated protein content.
- Trial name
- NCT07753070
- Testing
- macroabrasion followed by oxidative pretreatment, macroabrasion alone
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Sinus Lifting
Graftless Lateral Sinus Lifting Using Peizo Electric Device in Patients With Atrophic Maxilla
Background: Dental implant therapy in the posterior maxilla may be difficult owing to limited bone height after dental extraction with sinus pneumatization.
- Trial name
- NCT07753057
- Testing
- lateral sinus lifting with guide, conventional lateral sinus lifting
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Olanzapine, Breast Cancer
Olanzapine Based Dexamethasone-sparing Regimen for Breast Cancer Patients With Metabolic-risk Factors
The aim of THE STUDY to determine whether an olanzapine-based dexamethasone-sparing antiemetic regimen is non-inferior to the standard dexamethasone-containing regimen in preventing delayed-phase Chemotherapy-induced nausea and…
- Conditions
- Olanzapine, Breast Cancer, Dexamethasone
- Trial name
- NCT07743827
- Testing
- Pantoprazole, olanzapine, Dexamethasone
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Alexandria University
Fiberoptic Bronchoscopy (FOB), Lung Cancer (Diagnosis)
Nebulized Lidocaine And Ketamine Before Fiberoptic Bronchoscopy
The current study is looked for the comparison between nebulized lidocaine and ketamine, nebulized lidocaine, and usual lidocaine spray in the oral and nasal cavities before flexible bronchoscopy.
- Conditions
- Fiberoptic Bronchoscopy (FOB), Lung Cancer (Diagnosis), Premedication
- Trial name
- NCT07743333
- Testing
- Nebulized lidocaine and ketamine, Nebulized Lidocaine, Lidocaine spray (2%)
- Where
- Egypt
- Volunteers
- 134 people
- Sponsor
- Alexandria University
Weaning Mechanical Ventilation, Pediatric Cardiac Surgery
Weaning From Mechanical Ventilation After Pediatric Cardiac Surgery
Weaning from mechanical ventilation post congenital cardiac surgery is often challenging. It is well known that not all patients can be early extubated, although most are suitable for early postoperative weaning and extubating…
- Trial name
- NCT07066748
- Testing
- group P:pressure support ventilation mode, group A:automatic tube compensation (ATC).
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Alexandria University
Anastomotic Leak, Colorectal Cancer
Predictors of Rescue Surgery, Mortality, and Permanent Stoma After Anastomotic Leak Following Colorectal Cancer Resection
Anastomotic leakage is a serious complication following colorectal cancer resection and may result in emergency reoperation, severe sepsis, death, loss of the colorectal anastomosis, and formation of a long-term or permanent…
- Conditions
- Anastomotic Leak, Colorectal Cancer, Colon Cancer, Postoperative Complication
- Trial name
- leak predictor (NCT07725692)
- Where
- Egypt
- Volunteers
- 3,200 people
- Sponsor
- Alexandria University