Clinical trials: sponsored by Anhui Provincial Hospital
Refractory Thrombocytopenia
A Clinical Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of MegaLT Injection for Treating Refractory Thrombocytopenia Following Radiotherapy, Chemotherapy, or Transplantation.
A study to evaluate the safety, efficacy, and pharmacokinetics of MegaLT in treating refractory thrombocytopenia following radiotherapy, chemotherapy, or transplantation.
- Trial name
- NCT06534255
- Testing
- MegaLT injection
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Anhui Provincial Hospital
Pneumocystis Jirovecii Pneumonia, Kidney Transplantation
Low- vs Standard-Dose TMP-SMX for Prevention of Pneumocystis Pneumonia After Kidney Transplantation
This study is a prospective randomized controlled trial designed to evaluate the efficacy and safety of low-dose versus standard-dose trimethoprim-sulfamethoxazole (TMP-SMX) for the prevention of Pneumocystis jirovecii pneumonia…
- Trial name
- TMP-SMX PJP (NCT07619027)
- Testing
- Trimethoprim-Sulfamethoxazole (TMP-SMX)
- Volunteers
- 1,084 people
- Sponsor
- Anhui Provincial Hospital
Liver Metastases, Metastases to Liver
China Metastatic Liver Cancer Clinical Registry Cohort Database
This study is led by the Department of Hepatobiliary Surgery of the First Affiliated Hospital of the University of Science and Technology of China (USTC), in close collaboration with multiple participating centers nationwide.
- Conditions
- Liver Metastases, Metastases to Liver, Liver Cancer, Neoplasms
- Trial name
- NCT07602504
- Testing
- Standard of Care for Metastatic Liver Cancer
- Where
- 3 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Anhui Provincial Hospital
Hepatocellular Carcinoma (HCC), Liver Diseases
The Treatment of Liver Injury After Liver Resection With Polyene Phosphatidylcholine
A multicenter, open-label, randomized, controlled study. It is proposed to evaluate the treatment plan of receiving 930mg polyene phosphatidylcholine injection one day before the operation, twice a day, and 930mg polyene…
- Trial name
- NCT07150624
- Testing
- Experimental Group, control group
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Anhui Provincial Hospital
Locally-Advanced Non-Small Cell Lung Cancer, Radiotherapy
Centrally Confined 8Gy/1f to Tumor Core Followed by Concurrent Chemoradiotherapy for Unresectable Stage III NSCLC
This is a single-center, prospective, open-label, single-arm phase I exploratory study designed to evaluate the safety and feasibility of a novel central immune-priming radiotherapy strategy in patients with unresectable stage…
- Trial name
- NCT07523464
- Testing
- Centrally Confined 8 Gy/1 Fraction Immune-Priming Radiotherapy to the Tumor Core Followed by Definitive Concurrent Chemoradiotherapy
- Volunteers
- 24 people
- Sponsor
- Anhui Provincial Hospital
Steroid-refractory Acute Graft-versus-host Disease(SR-aGVHD)
A Trial to Evaluate the Safety and Preliminary Efficacy of iMesenchymal Stromal Cells(iMSC) in Subjects With SR-aGVHD
A study to evaluate the safety and preliminary efficacy of iMSC in subjects with SR-aGVHD
- Trial name
- NCT06321198
- Testing
- iMSC
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Anhui Provincial Hospital
Acute Brain Injuries, Moderate to Severe Traumatic Brain Injury
Effects of Recombinant Human Growth Hormone in Elderly Patients With Moderate to Severe Acute Brain Injury (GH-ABI-RCT)
This study is a multicenter, randomized controlled trial aimed at evaluating the effectiveness and safety of recombinant human growth hormone (rhGH) in elderly patients who have suffered moderate to severe acute brain injuries…
- Trial name
- GH-ABI-RCT (NCT07481656)
- Testing
- Recombinant Human Growth Hormone (rhGH) Injection, Standard Care (Treatment as Usual)
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Anhui Provincial Hospital
Ventriculoperitoneal Shunt (VPS), Cranioplasty
Simultaneous Vs Staged VPS and CP :A Multi-cnter RCT.
The purpose of this prospective, multi-center randomized controlled trail is to compare the safety and efficacy of sequential surgery or staged surgery in patients with skull defect and hydrocephalus.
- Trial name
- NCT07462676
- Testing
- Time of choosing VPS and VP
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Anhui Provincial Hospital
B-cell Lymphoma
Anti CD19 Gene Therapy for B-cell Lymphoma
This is an open label, single-site, dose-escalation study in up to 18 participants with treatment of relapsed/refractory B-cell lymphoma.
- Trial name
- NCT07211048
- Testing
- Anti-CD19 gene injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Anhui Provincial Hospital
Primary Liver Cancer
Precision Dietary Intervention Improves Postoperative Energy Intake, Nutritional Status, and Recovery in Patients Undergoing Hepatectomy for Liver Cancer: A Randomized Controlled Trial
Objective:To explore the application effect of postoperative refined early dietary plan in the enhanced recovery of patients undergoing hepatectomy for primary liver cancer, and to provide scientific evidence for optimizing…
- Trial name
- NCT07349576
- Testing
- Special diet plan and whole protein preparation NUTRICIA for 5 days after liver resection for liver cancer, Conventional dietary intervention
- Where
- China
- Volunteers
- 139 people
- Sponsor
- Anhui Provincial Hospital
Acute Graft-versus-host Disease
Effect of Stem Cell Infusion Time on aGVHD in Patients With Hematological Malignancies
To observe the effect of stem cell infusion on the development of acute graft-versus-host disease (aGVHD) in patients with malignant hematologic diseases after allogeneic peripheral blood hematopoietic stem cell transplantation…
- Trial name
- NCT06294678
- Testing
- Time of stem cell infusion
- Where
- 6 sites in China
- Volunteers
- 198 people
- Sponsor
- Anhui Provincial Hospital
Acute Graft Versus Host Disease
Effect of Stem Cell Infusion Time on aGVHD in Patients With Hematological Malignancies Post UCBT
To observe the effect of stem cell infusion on the development of acute graft- versus-host disease (aGVHD) in patients with malignant hematologic diseases after single-unit unrelated cord blood transplantation (sUCBT).
- Trial name
- NCT07047456
- Testing
- Time of umbilical cord blood infusion
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Anhui Provincial Hospital
Fever, Chest Tightness
Sulfamethoxazole Prophylaxis Duration After Renal Transplantation
Renal transplantation is the most ideal and effective treatment for end-stage renal disease. Pneumocystis jirovecii pneumonia (PJP) is one of the most common pulmonary infections after renal transplantation, with high morbidity…
- Trial name
- SPDART (NCT07231770)
- Testing
- Time-driven dosing
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Anhui Provincial Hospital
Parkinson's Disease
An Open-label, Observational, Long-term Follow-up Study Evaluating the Safety and Efficacy of RGL-193 Putamen Injection in Patients With Primary Parkinson's Disease
To evaluate the long-term safety of RGL-193 capsid injection in patients with primary Parkinson's disease over 5 years
- Trial name
- NCT07279844
- Testing
- Observational
- Volunteers
- 6 people
- Sponsor
- Anhui Provincial Hospital
Alzheimer Disease (AD)
Intravenous Infusion of Umbilical Cord Blood as an Adjunctive Treatment for Alzheimer's Disease
This study is a single-center, prospective, double-blind, randomized controlled clinical trial (RCT). Employing a parallel-group design, the trial plans to enroll 30 clinically diagnosed AD patients, who will be randomly assigned…
- Trial name
- NCT07208344
- Testing
- Intravenous infusion of mononuclear cells from umbilical cord blood, Conventional medical treatment：donepezil, rivastigmine or galantamine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Anhui Provincial Hospital
Esophageal Squamous Cell Carcinoma
Ivonescimab Plus Short-Course Hypofractionated Radiotherapy as Second-Line Therapy for Esophageal Squamous Cell Carcinoma
In the era of immunotherapy, the standard second-line treatment regimen for locally advanced/metastatic esophageal squamous cell carcinoma (ESCC) remains controversial.
- Trial name
- NCT07188103
- Testing
- Ivonescimab+Radiotherapy
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Anhui Provincial Hospital
Advanced Solid Tumors
Safety and Efficacy of Metabolically Armed Tumor-lnfiltrating Lymphocytes (Meta10-TIL) for the Treatment of Advanced Solid Tumors
A Study of Metabolically Armed Tumor-Infiltrating Lymphocytes (Meta10-TIL) Therapy for Patients With Advanced Solid Tumors
- Trial name
- NCT07106814
- Testing
- Metabolically Armed TIL cells
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Anhui Provincial Hospital
MDS, AML
QH101 Cell Therapy Relapsed/Refractory(R/R) Acute Myeloid Leukemia(AML) and Myelodysplastic Syndromes(MDS)
QH101 is an allogeneic TCR-enhanced Vδ2 T cell therapy product engineered to express BTN protein-specific binding elements on the cell surface.
- Trial name
- NCT07131085
- Testing
- Allogeneic TCR-enhanced γδ T cell(QH101), Fludarabine (FLU), Cyclophosphamide (CTX)
- Volunteers
- 9 people
- Sponsor
- Anhui Provincial Hospital
Liver Cancer
China Liver Cancer Clinical Registry Cohort Database (HEAL)
This study was led by the Department of Hepatobiliary Surgery of the First Affiliated Hospital of the University of Science and Technology of China (USTC), in close cooperation with many participating units across the country, to…
- Trial name
- NCT06777485
- Testing
- Procedure/Surgery treatment, Anti-Tumor Drugs
- Where
- 38 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Anhui Provincial Hospital
Hepatocellular Carcinoma (HCC), Immunotherapy
A Single-Arm, Multicenter, Exploratory Clinical Study of Transarterial Chemoembolization (TACE) Combined With Iparomlimab and Tuvonralimab Injection and Bevacizumab Injection for the Treatment of Unresectable, Non-Metastatic Hepatocellular Carcinoma (HCC)
This is a single-arm, multicenter, exploratory clinical study designed to evaluate the efficacy and safety of TACE combined with Iparomlimab and Tuvonralimab Injection and Bevacizumab Injection in patients with unresectable…
- Conditions
- Hepatocellular Carcinoma (HCC), Immunotherapy, PD-1, CTLA-4
- Trial name
- NCT07128251
- Testing
- TACE treatment, Iparomlimab and Tuvonralimab Injection (QL1706), Bevacizumab
- Volunteers
- 47 people
- Sponsor
- Anhui Provincial Hospital