Clinical trials: sponsored by Anhui Provincial Hospital
Prostate Cancer
Conducting Active Surveillance Without Prostate Biopsy for Patients With Low-risk Suspected Prostate Cancer
The goal of this observational study is to evaluate the role of the USTC diagnostic model in risk-adaptive strategies for biopsy decision-making in patients with low-risk suspected prostate cancer in order to reduce unnecessary…
- Trial name
- ASWBP (NCT05940415)
- Testing
- active surveillance
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Anhui Provincial Hospital
Esophageal Squamous Cell Carcinoma, Chemoradiotherapy
Oral Microbiome is Associated With the Response to Chemoradiotherapy in Initial Inoperable Patients With Esophageal Squamous Cell Cancer
Esophageal cancer accounts for more than half of the world, seriously affecting people's health in China. 95% patients are squamous cell carcinoma.
- Conditions
- Esophageal Squamous Cell Carcinoma, Chemoradiotherapy, Initial Inoperable
- Trial name
- NCT06190847
- Testing
- regular chemoradiotherapy
- Where
- China
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Hospital
Esophageal Squamous Cell Carcinoma, Chemoradiotherapy
Whole-course Immunonutrition Combined With Chemoradiotherapy±ICIs for Local Advanced Patients With Inoperable Esophageal Squamous Cell Carcinoma
Chemoradiotherapy has been a standard modality for inoperable locally advance esophageal carcinoma. The goal of this randomized control study is to compare the feasibility, and survival benefits of whole-course immunonutrition…
- Conditions
- Esophageal Squamous Cell Carcinoma, Chemoradiotherapy, Immunonutrition, Inoperable
- Trial name
- NCT05833594
- Testing
- Whole-course Immunonutrition Combined With Chemoradiotherapy±ICIs
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Anhui Provincial Hospital
B-cell Acute Lymphoblastic Leukemia
Safety and Efficacy of Metabolically Armed CD19 CAR-T Cells (Meta10- 19) in the Treatment of r/r B-ALL Clinical Research
A Study of Metabolically Armed CD19 CAR-T Cells Therapy for Patients With Relapsed and/or Refractory B-cell Acute Lymphoblastic Leukemia
- Trial name
- NCT05747157
- Testing
- Metabolically Armed CD19 CAR-T cells
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Anhui Provincial Hospital
Myelodysplastic Syndromes
Safety and Efficacy of Unrelated Umbilical Cord Blood Microtransplantation in Patients With Higher-risk MDS
This study aimed to evaluate the safety and efficacy of unrelated umbilical cord blood microtransplantation in the treatment of above-mentioned MDS patients by observing the factors related to the efficacy and adverse reactions.
- Trial name
- NCT06109064
- Testing
- Unrelated Umbilical Cord Blood, Venetoclax, Decetabine
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Anhui Provincial Hospital
Acute Myelocytic Leukemia
Safety and Efficacy of Unrelated Umbilical Cord Blood Microtransplantation in Patients With AML
This study aimed to evaluate the safety and efficacy of unrelated umbilical cord blood microtransplantation in the treatment of AML patients by observing the factors related to the efficacy and adverse reactions.
- Trial name
- NCT06105658
- Testing
- Unrelated umbilical cord blood, Venetoclax, Decetabine
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Anhui Provincial Hospital
B-cell Acute Lymphoblastic Leukemia
QH103 Cell Injection for the Treatment of Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia
This is a single-arm, single-center, interventional, dose-escalation clinical study designed to evaluate the safety and tolerability of QH103 Cell Injection in the treatment of patients with relapsed/refractory B-cell acute…
- Trial name
- NCT06056752
- Testing
- QH103 Cell Injection, Fludarabine, Cyclophosphamide
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Anhui Provincial Hospital
Severe Aplastic Anemia
Conditioning Regimen Containing Low Dose ATG for The Treatment of Acquired SAA Receiving sUCBT
To evaluate the safety and efficacy of Single Umbilical Cord blood transplantation (sUCBT) containing low dose ATG based conditioning regimen in the treatment of acquired Severe Aplastic Anemia (SAA).
- Trial name
- NCT06039436
- Testing
- Anti-Thymocyte Globulin (Rabbit)
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Anhui Provincial Hospital
Hematologic Diseases
Allogeneic γ9δ2 T Cells Treatment of Recurrent Hematologic Tumors
This is an open single-arm clinical study aimed at evaluating the safety and tolerance of allogeneic γ9δ2 T cell injection in the treatment of patients with recurrent hematologic tumors after allogeneic hematopoietic stem cell…
- Trial name
- NCT05755854
- Testing
- allogeneic γ9δ2 T Cells, Fludarabine, Cyclophosphamide
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Anhui Provincial Hospital
Parkinson Disease
The Novel 18F-labeled MAO-B PET Tracer Study in Parkinsonism Patients
This study mainly aims to prospectively evaluate the changes of reactive astrogliosis in Parkinsonism patients of Chinese population by the novel 18F-labeled MAO-B PET tracer.
- Trial name
- NCT06010290
- Testing
- 18F-SMBT-1
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Hospital
Prostate Cancer, PET/CT
Head-to-head Comparison of [68Ga]Ga-PSMA-D5 With [68Ga]Ga-PSMA-11 PET/CT in PCa Diagnosis, Recurrence, and Metastasis
To prospectively evaluate the radiodrug biodistribution of a novel PET imaging agent [68Ga]Ga-PSMA-D5 in different organs of prostate cancer patients and its diagnostic efficacy in the diagnosis, recurrence and metastasis of…
- Trial name
- NCT05955677
- Testing
- [68Ga]Ga-PSMA-D5, [68Ga]Ga-PSMA-11
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Hospital
Prostatic Neoplasms, Frailty
The Effect of Frailty on Blood Biology Indicators, Quality of Life and Survival of Patients With Radical Prostatectomy
The goal of this observational study is to evaluate the effect of frailty on blood biology indicators, quality of life and survival of patients with radical prostatectomy. The main questions it aims to answer are: 1.
- Conditions
- Prostatic Neoplasms, Frailty, Blood Biological Indicators, Quality of Life
- Trial name
- NCT05941104
- Testing
- frailty
- Volunteers
- 100 people
- Sponsor
- Anhui Provincial Hospital
Diffuse Large B-cell Lymphoma
Safety and Efficacy of Metabolically Armed CD19 CAR-T Cells (Meta10-19) in the Treatment of r/r DLBCL Clinical Research
A Study of Metabolically Armed CD19 CAR-T Cells Therapy for Patients With Relapsed and/or Refractory Diffuse Large B-Cell Lymphoma
- Trial name
- NCT05715606
- Testing
- Metabolically Armed CD19 CAR-T cells
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Anhui Provincial Hospital
Hepatocellular Carcinoma
A Study to Evaluate Tislelizumab Combined With Sitravatinib as Adjuvant Therapy in Participants With HCC at High Risk of Recurrence After Curative Resection
This is an open label, multi-center, single arm study to evaluate the efficacy and safety of tislelizumab combined with sitravatinib as adjuvant therapy in hepatocellular carcinoma (HCC) patients who are at high risk of…
- Trial name
- NCT05407519
- Testing
- Tislelizumab + Sitravatinib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Anhui Provincial Hospital
Liver Venous Deprivation
A Clinical Study of Portal Vein Embolization and Liver Venous Deprivation
The main obstacle to achieving R0 resection in future liver remnant（FLR） deficient liver cancer is the inability to retain sufficient FLR to avoid postoperative liver failure.
- Trial name
- NCT05457374
- Testing
- PVE, LVD
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Anhui Provincial Hospital
HCC
Clinical Study of MRD Recurrence Monitoring After Surgical Resection of Hepatocellular Carcinoma
ctDNA-based liquid biopsy can better detect the presence of MRD before imaging and serological markers, and is suitable for postoperative MRD and recurrence monitoring, which has been clinically validated in several cancer types…
- Trial name
- NCT05458115
- Testing
- Liver resection
- Volunteers
- 200 people
- Sponsor
- Anhui Provincial Hospital
Pregnant Women
Using Teach Back to Improve Postpartum Maternal-infant Health Among Women With Limited Maternal Health Literacy
This is a randomized controlled trial study with two arms teach-back group vs. controlled group. We decided the assignment of the women to each group by tossing a coin (heads for the teach-back group and tails for the control…
- Trial name
- TB (NCT04858945)
- Testing
- Teach-back method
- Where
- China
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Hospital
HCC, Chemotherapy Effect
Clinical Study of Radiotherapy Combined With Donafenib for Neoadjuvant Treatment of Patients With HCC With Portal Vein Carcinoma Thrombosis
For HCC patients with combined PVTT, systemic therapy can be used as a basic approach throughout the treatment and in combination with hepatectomy, TACE, HAIC, radiotherapy, etc.
- Trial name
- NCT05022628
- Testing
- Donafenib
- Volunteers
- 30 people
- Sponsor
- Anhui Provincial Hospital
Preterm Infants
LISA vs INSURE in the Treatment of Respiratory Distress Syndrome in Preterm Infants
To evaluate the efficacy of less invasive surfactant administration（LISA ）technique in the treatment of neonatal respiratory distress syndrome（NRDS） by comparing with the traditional Intubate-Surfactant-Extubate（INSURE） technique.
- Trial name
- NCT04126382
- Testing
- Intubate-Surfactant-Extubate(INSURE), less invasive surfactant administration(LISA)
- Volunteers
- 200 people
- Sponsor
- Anhui Provincial Hospital
HER2 Positive Breast Carcinoma
A Real-world Clinical Study of Pyrotinib Maleate Tablets in the Treatment of Breast Cancer Patients With Positive Her-2
To evaluate the efficacy and safety of Pyrotinib Maleate Tablets in the treatment of advanced breast cancer patients with positive her-2.
- Trial name
- NCT03908749
- Volunteers
- 300 people
- Sponsor
- Anhui Provincial Hospital