Clinical trials: sponsored by Asan Medical Center
Pancreatic Tumor
Effect of Thrombin-containing Collagen-based Hemostatic Matrix
Under the hypothesis that collagen-based hemostatic agents improve the suppression of leakage of hemostatic pancreatic fluid at the surgical site during surgery, thrombin-containing collagen-based hemostatic agents are applied in…
- Trial name
- TCM (NCT04357483)
- Testing
- flowable thrombin containing collagen hemostat matrix, thrombin coated L-dopa contained collagen patch
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Mild Cognitive Impairment
Home-based Cognitive Monitoring in MCI
This study is an observational study to confirm usefulness of a home-based cognitive monitoring in non-demented patients with high-risk of dementia
- Trial name
- NCT04350801
- Testing
- home-based cognitive monitoring
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Asan Medical Center
Pulmonary Disease, Chronic Obstructive, Microbiota
Analysis of the Microbiome in the Healthy Smokers and COPD Patients
This study is to build a microbiome cohort by collecting sputum and fecal samples every few months for three years from healthy smokers and chronic obstructive pulmonary disease (COPD) patients.
- Trial name
- NCT04336423
- Testing
- Obtain samples from sputum and feces
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Metastatic Colorectal Cancer
Avelumab for MSI-H or POLE Mutated Metastatic Colorectal Cancer
The POLE mutations represent high somatic mutation loads in patients with colorectal cancer, especially in those with MMR proficient or MSS, therefore, tumors harbouring POLE mutations might be susceptible to immune checkpoint…
- Trial name
- NCT03150706
- Testing
- Avelumab
- Where
- South Korea
- Volunteers
- 33 people
- Sponsor
- Asan Medical Center
Liver Transplant; Complications
Von Willebrand Factor and Protein C Ratio in Graft Function After Liver Transplant
In liver cirrhosis (LC),the activity of von Willebrand factor (vWF)-cleaving enzyme ADAMTS13 is reduced in LC patients and consequent progression of liver injury.
- Trial name
- NCT04324255
- Testing
- LT
- Where
- South Korea
- Volunteers
- 1,199 people
- Sponsor
- Asan Medical Center
Prostate Cancer
MR-target Biopsy vs. TRUS-biopsy in Men With Suspicious Prostate Cancer
This paired cohort blinded trial aims to assess the detection rate of clinically significant cancer of MRI-targeted biopsy compared to standard 12-core TRUS biopsy in men referred with clinical suspicion of prostate cancer who…
- Trial name
- NCT04320147
- Testing
- Artemia
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Asan Medical Center
Pancreatic Cancer, Metastatic Pancreatic Cancer
Retrospective Analysis of 2nd-line Nab-Paclitaxel + Gemcitabine After 1st-line FOLFIRINOX in Pancreatic Cancer
In this study, clinical data of patients who received 2nd-line Nab-paclitaxel plus Gemcitabine (nab-P+GEM) after progression on 1st-line FOLFIRINOX will be reviewed retrospectively.
- Trial name
- NCT04133155
- Testing
- nab paclitaxel plus gemcitabine
- Where
- South Korea
- Volunteers
- 103 people
- Sponsor
- Asan Medical Center
Cryptogenic Stroke, High Risk Patent Foramen Ovale
Evaluation of Prevalence and Clinical Impact of Atrial Fibrillation in Elderly Patients With Cryptogenic Stroke and High-Risk Patent Foramen Ovale
The purpose of DEFENSE-ELDERLY is to identify the prevalence of AF and evaluate the clinical impact of AF in elderly ESUS patients and no other known sources of stroke besides a high-risk patent foramen ovale, and compare it with…
- Trial name
- DefenseElderly (NCT04285918)
- Testing
- Percutaneous device closure
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Asan Medical Center
Polyp of Large Intestine
EFficacy of Prophylactic Clip Application in Decrease of Immediate Postpolypectomy Bleeding and Delayed Postpolypectomy Bleeding After Colonoscopic Removal for a Large Pedunculated Polyps
The aim of this study is to evaluate the efficacy of prophylactic clip application after colonoscopic removal for a large pedunculated polyp (> 1cm) in preventing immediate postpolypectomy bleeding (IPPB) and delayed…
- Trial name
- NCT01437631
- Testing
- prophylactic clip application
- Where
- South Korea
- Volunteers
- 137 people
- Sponsor
- Asan Medical Center
Glioma
Radiogenomic and Prognosis Analysis in Glioma
This study aims to evaluate whether MRI can be used to predict genomics and prognosis in glioma. Given the profound prognostic significance of genetic mutations seen in glioma, there have been increasing attempts to correlate…
- Trial name
- NCT04122521
- Testing
- MRI
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Asan Medical Center
Colonic Polyps
Efficacy and Safety of Precut-EMR for Resecting of Colonic Polyp
This study was attempted to determine the efficacy and complication of precut EMR comparing with convetional EMR for resecting of 10 ~ 20 mm colon polyp through prospective, randomized controlled trial.
- Trial name
- NCT04253990
- Testing
- Precut EMR, Conventional MER
- Where
- South Korea
- Sponsor
- Asan Medical Center
Advanced Gastric Cancer
Capecitabine and Cisplatin (XP)+Sorafenib in Advanced Gastric Cancer (AGC): Sorafenib+XP
There is strong scientific rationale for exploring the role of sorafenib with capecitabine and cisplatin (XP) in AGC. XP is a new standard of care in AGC and sorafenib is a novel signal transduction inhibitor that prevents tumor…
- Trial name
- NCT00565370
- Testing
- Capecitabine, Cisplatin, Sorafenib
- Where
- South Korea
- Volunteers
- 22 people
- Sponsor
- Asan Medical Center
Gastrointestinal Stromal Tumors
Dovitinib for Imatinib/Sumitinib-failed Gastrointestinal Stromal Tumors (GIST): TKI258
With discovery of KIT mutations and the advent of KIT tyrosine kinase inhibitor imatinib (GlivecTM, Novartis), there has been substantial improvement in overall survival in patients with advanced and/or metastatic…
- Trial name
- NCT01440959
- Testing
- dovitinib
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Asan Medical Center
Abdominal Neoplasm, Thoracic Neoplasm
Ultrasound-assisted Thoracic Epidural Catheter Insertion
The aim of the present study is to access the success rate of ultrasound-guided thoracic epidural catheter insertion, using fluoroscopy.
- Trial name
- NCT03890640
- Testing
- Ultrasound-guided TECI
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Asan Medical Center
Ulcerative Colitis, Cytomegalovirus Infections
Assessment of CMV-specific ELISPOT Assay for Predicting CMV Colitis in Patient With Ulcerative Colitis
Consequences of latent cytomegalovirus (CMV) infection reactivation on ulcerative colitis flare, as a flare-worsening factor or simple bystander, are debated.
- Conditions
- Ulcerative Colitis, Cytomegalovirus Infections, Disease Exacerbation
- Trial name
- ACE-UC (NCT02439372)
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Asan Medical Center
Stomach Cancer
Study of Docetaxel, Capecitabine and Oxaliplatin in Advanced Stomach Cancer
Considering synergism between docetaxel (D), capecitabine (X), and oxaliplatin (O) and favourable toxicity profile of oxaliplatin over cisplatin, it is to be expected that combination of docetaxel, capecitabine, and oxaliplatin…
- Trial name
- NCT00446290
- Testing
- Docetaxel, Capecitabine and Oxaliplatin
- Where
- South Korea
- Volunteers
- 22 people
- Sponsor
- Asan Medical Center
Stomach Cancer
Trial of Adjuvant Chemotherapy for Gastric Cancer
This study is designed to evaluate the efficacy of the intraperitoneal chemotherapy with early mitomycin administration and adding cisplatin to prolonged treatment with doxifluridine compared to mitomycin plus doxifluridine in…
- Trial name
- NCT00296322
- Testing
- cisplatin, mitomycin-C, doxifluridine
- Where
- South Korea
- Volunteers
- 528 people
- Sponsor
- Asan Medical Center
Hypertension
Amlodipine Versus Valsartan for Improvement of Diastolic Dysfunction Associated With Hypertension
Hypertensive patients are at increased risk of developing LV hypertrophy and myocardial fibrosis, which cause diastolic dysfunction.
- Trial name
- NCT02973035
- Testing
- Amlodipine, Valsartan
- Where
- 4 sites in South Korea
- Volunteers
- 104 people
- Sponsor
- Asan Medical Center
Gastrointestinal Stromal Tumors
Rechallenge of Imatinib in GIST Having no Effective Treatment: RIGHT
The objective of this study is to compare the clinical outcomes following resumption of dosing (re-challenge) with Imatinib plus best supportive care versus placebo plus best supportive care in patients with advanced/incurable…
- Trial name
- NCT01151852
- Testing
- Imatinib
- Where
- South Korea
- Volunteers
- 81 people
- Sponsor
- Asan Medical Center
Diarrhea, Anorexia
Plasma Citrulline: A Marker for Monitoring & Quantifying Radiation-Induced Small Bowel Toxicity
Small bowel irradiation results in epithelial cell loss and consequently impairs function and metabolism. A metabolic end product of small bowel enterocytes is plasma citrulline.
- Conditions
- Diarrhea, Anorexia, Dyspepsia
- Trial name
- NCT01849107
- Testing
- Plasma citrulline
- Where
- South Korea
- Volunteers
- 49 people
- Sponsor
- Asan Medical Center