Clinical trials: sponsored by Asan Medical Center
Pulmonary Disease, Chronic Obstructive, Emphysema or COPD
The Microbiome of Sputum, Urine and Feces in Healthy Persons and Chronic Obstructive Pulmonary Disease (COPD) Patients
Extensive studies suggest composition of microbiome of respiratory samples or lung tissues in COPD patients is different from the composition of healthy smokers.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Emphysema or COPD, Microbiota
- Trial name
- COPD (NCT03755505)
- Testing
- obtain samples from sputum, feces and urine
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Cancer, Lung Cancer Metastatic
Capmatinib in Patients With Non-small Cell Lung Cancer Harboring cMET exon14 Skipping Mutation
This study is a phase II, single-arm, open label study under an umbrella trial for NSCLC. This clinical study is targeted for the patients who harbor exon 14 skipping mutation of MET and all patients will be treated with…
- Conditions
- Cancer, Lung Cancer Metastatic, MET Gene Mutation
- Trial name
- NCT03693339
- Testing
- Capmatinib
- Where
- South Korea
- Volunteers
- 27 people
- Sponsor
- Asan Medical Center
Cancer, Lung Cancer Metastatic
PDR001 in Patients With Non-small Cell Lung Cancer Harboring KRAS/NRAS Mutation or no Actionable Genetic Abnormalities
This study is a phase II, single-arm, open label study. All participating patients must sign on the written informed consent form, and a separate form of consent will be used for the use of tissue for the biomarker research.
- Conditions
- Cancer, Lung Cancer Metastatic, Immunotherapy
- Trial name
- NCT03693326
- Testing
- PDR001
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Asan Medical Center
Prostate Cancer
Effect of Anesthetic Method on Optic Nerve Sheath Diameter in Patients Undergoing RALP
The purpose of this study was to evaluate the effect of anesthetic method on the optic nerve sheath diameter in patients undergoing robot-assisted laparoscopic prostatectomy.
- Trial name
- NCT03529643
- Testing
- Dexmedetomidine, Without dexmedetomidine
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Asan Medical Center
Pancreatic Neoplasms
Evaluation of Killing Activity of Expanded Natural Killer Cells From Blood in Patients With Pancreatic Cancer
Pancreatic cancer, one of the deadliest epithelial malignancies, has a 5-year survival rate of only about 8%. The mortality rate has decreased slightly, but the incidence rate has been steadily increasing, and it is predicted to…
- Trial name
- NCT03665571
- Testing
- Receptor specific activation method
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Carcinoma, Hepatocellular
Needle Guiding Robot for Radiofrequency Ablation: Safety and Efficacy Study on Hepatocellular Carcinoma Patients
The needle guiding robot helps targeting of radiofrequency ablation needles by matching computed tomography images and patients' bodies. Actual insertion of needles will be performed by doctors.
- Trial name
- NGR (NCT03005756)
- Testing
- Needle guiding robot
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Non-HIV Patients With Pneumocystis Jiroveci Pneumonia
Assessment of CMV-specific ELISPOT Assay for Predicting CMV Co-infection in Patients With Pneumocystitis Pneumonia (ACE-PCP)
PCP (Pneumocystis jiroveci pneumonia) is one of the important opportunistic infections in immunocompromised patients including HIV-infected patients, transplant recipients, and immunosuppressant users.
- Trial name
- NCT02109887
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Asan Medical Center
Suspected Tuberculous Peritonitis
IFN-gamma-releasing Assay Based Approach in Patients With Suspected Tuberculous Peritonitis
The diagnosis of tuberculous peritonitis (TBP) is still challenging, and largely dependent on invasive procedures such as laparoscopy.
- Trial name
- NCT02175134
- Testing
- Blood and Ascites ELISPOT
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Asan Medical Center
Kidney Transplantation
Assessment of VZV-specific ELISPOT Assay for Predicting VZV Infection in Kidney Transplant Recipients (AVE-KT)
VZV is one of the important opportunistic infection in transplant recipients.Until now, there is no laboratory method to stratify the risk of VZV reactivation after solid organ transplantation.
- Trial name
- NCT02081729
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Asan Medical Center
Reversible Cerebral Vasoconstriction Syndrome, Varicella-zoster Virus Infection
Reversible Cerebral Vasoconstriction Syndrome and Varicella Zoster Virus
Among patients with thunderclap headache who were admitted to the four participating hospitals, who has diffuse segmental vasoconstriction on CT angiography or MR angiography will be eligible for the study.
- Trial name
- RCVS&VZV (NCT03509701)
- Testing
- VZV-specific antibody response from blood
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Asan Medical Center
End Stage Liver Disease, Acute Kidney Injury
Effect of Preoperative Beta Blocker Use Postoperative Renal Function in the Patients Undergoing Liver Transplantation
This is prospective cohort study of patients classified by the premedication history of beta-blocker. The investigators aim to evaluate the hemodynamic effect of beta blocker through Swan-Ganz catheter monitoring and arterial…
- Trial name
- NCT03633812
- Testing
- Observational study, Beta blocker medication history
- Where
- 2 sites in South Korea
- Volunteers
- 477 people
- Sponsor
- Asan Medical Center
Indirect Calorimetry
Using Indirect Calorimetry for Liver Transplants Patients
Although predicted REE calculated using the Penn state 1988 method agreed (ICC 0.61, p=0.00014) with the measured REE, all three predictive equations had a fixed bias and appeared to be inaccurate for predicting REE for liver…
- Trial name
- NCT03622268
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Asan Medical Center
Alzheimer's Disease
Optimal Dose Escalation Strategy to Successful Achievement of High Dose Donepezil 23mg
This study evaluates the side effects of dose escalation in the treatment of donepezil 23mg for patients with Alzheimer's disease.
- Trial name
- ODESA (NCT02550665)
- Testing
- donepezil
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Asan Medical Center
Memory Loss
Efficacy of Cognitive Training in Subjective Memory Impairment
This study evaluates the efficacy of cognitive training in subjects with subjective memory impairment. The first group will receive cognitive training and lifestyle modification in combination, the second group will receive only…
- Trial name
- NCT02555774
- Testing
- cognitive training, lifestyle modification
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Asan Medical Center
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Rituximab+mVPDL for CD20(+) Adult Acute Lymphoblastic Leukemia
The investigators would like to propose a phase-2 prospective multicenter trial evaluating the efficacy of rituximab combination with our current chemotherapy strategy for adult Acute Lymphoblastic Leukemia (ALL), in order to…
- Trial name
- RADICAL (NCT01429610)
- Testing
- Rituximab+mVPDL
- Where
- 19 sites in South Korea
- Volunteers
- 78 people
- Sponsor
- Asan Medical Center
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Allogeneic Hematopoietic Cell Transplantation for Adult Acute Lymphoblastic Leukemia (2015)
This study is a prospective multicenter observational study to evaluate the feasibility and the efficacy of the conditioning regimens which are modified by the donor differences and the age of recipients among patients who will…
- Trial name
- ATLAS2015 (NCT02428517)
- Testing
- AlloHCT for Young/MSD, AlloHCT for Young/MUD&FMD, AlloHCT for Old/MSD
- Where
- 4 sites in South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Acute Lymphoid Leukemia
Donor-specific Allogeneic Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia (ALL)
[Study Objectives] To evaluate the efficacy of allogeneic hematopoietic cell transplantation (HCT) in patients with acute lymphoblastic leukemia (ALL) in the first or second complete remission (CR).
- Trial name
- AHCTALL (NCT01037764)
- Testing
- alloHCT
- Where
- 2 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Hemophagocytic Lymphohistiocytosis
Pilot Study of Etoposide-based Therapy and Hematopoietic Cell Transplantation for Hemophagocytic Lymphohistiocytosis
The investigators would like to propose a pilot study evaluating the efficacy of etoposide combined with immunosuppressive agents for adult secondary hemophagocytic lymphohistiocytosis (HLH), in order to prove out whether the…
- Trial name
- HELA2012 (NCT01547143)
- Testing
- IST and/or alloHCT
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Asan Medical Center
Leukemia, Chronic Myeloid, Myeloid Leukemia, Chronic, Accelerated Phase
Chronic Myelod Leukemia Registry at Asan Medical Center
The investigators would like to propose a prospective longitudinal observational cohort study for patients who will be diagnosed and/or treated for chronic myeloid leukemia at Asan Medical Center, Seoul, Korea, to use the…
- Conditions
- Leukemia, Chronic Myeloid, Myeloid Leukemia, Chronic, Accelerated Phase, Myeloid Leukemia, Chronic, Chronic Phase
- Trial name
- NCT01761695
- Testing
- Diagnosed as CML
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Leukemia, Acute Lymphoblastic, Precursor B-Cell Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia Registry at Asan Medical Center
The investigators would like to propose a prospective longitudinal observational cohort study for patients who will be diagnosed and/or treated for acute lymphoblastic leukemia at Asan Medical Center, Seoul, Korea, to use the…
- Conditions
- Leukemia, Acute Lymphoblastic, Precursor B-Cell Lymphoblastic Leukemia, Leukemia, Biphenotypic, Acute, Leukemia, Lymphoblastic, Acute, Philadelphia-Positive
- Trial name
- NCT01761682
- Testing
- Diagnosed as ALL
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Asan Medical Center