Clinical trials: sponsored by Asan Medical Center
Advanced Urothelial Carcinoma
Gemcitabine-Carboplatin Versus Gemcitabine-Oxaliplatin in Cisplatin-unfit Urothelial Carcinoma
Cisplatin-based chemotherapy is the standard regimen for advanced urothelial carcinoma. But cisplatin-unfit patients account for up to 30-40% of patients in clinical practice.
- Trial name
- COACH (NCT01487915)
- Testing
- GCb, GemOx
- Where
- 5 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Asan Medical Center
Urothelial Carcinoma
Pemetrexed and Cisplatin in Advanced Urothelial Carcinoma
Pemetrexed has demonstrated a favorable response with minimal toxicity when used as single agent as first-line and second-line treatment for advanced urothelial carcinoma.
- Trial name
- PECULIAR (NCT01490437)
- Testing
- Pemetrexed, Cisplatin, Dexamethasone
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Asan Medical Center
Metastatic Renal Cell Carcinoma
Study of Sunitinib Administered as 4/2 vs. 2/1 Schedule in Advanced Renal Cell Carcinoma (RCC)
This study is to evaluate the efficacy, safety, and feasibility of sunitinib in 4/2 and 2/1 regimen in previously untreated metastatic RCC to select the most promising regimen, which should be used in further studies of this…
- Trial name
- NCT00570882
- Testing
- Sunitinib 2/1, Sunitinib 4/2
- Where
- 3 sites in South Korea
- Volunteers
- 76 people
- Sponsor
- Asan Medical Center
Asthma
Efficacy of Bronchial Thermoplasty in Korean
The investigators will find out if bronchial thermoplasty shows efficacy in reducing acute exacerbation and improving quality of life for uncontrolled asthma in Korea through this research.
- Trial name
- NCT02031263
- Testing
- bronchial thermoplasty system
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Asan Medical Center
Graft vs Host Disease, Bronchiolitis Obliterans
Efficacy Study of Azithromycin-based Therapy for Bronchiolitis Obliterans
[Study Objectives] To evaluate the efficacy of azithromycin, N-acetylcystein, and inhaled corticosteroid combination therapy in patients with bronchiolitis obliterans as a complication of allogeneic hematopoietic cell…
- Trial name
- NCT01327625
- Testing
- azithromycin + N-acetylcystein + inhaled corticosteroid
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Asan Medical Center
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pharmacogenomics Validation for Imatinib in Chronic Myeloid Leukemia
This is a multicenter, retrospective, observational study to validate a pharmacogenetics model for imatinib metabolism and resistance in patients with chronic myeloid leukemia among patients in different independent cohort.
- Trial name
- VATIC (NCT01437202)
- Where
- 3 sites in Canada, South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Hepatocellular Carcinoma
Efficacy of Radiation Therapy and Transarterial Chemoembolization (TACE) to Treat Hepatocellular Carcinoma (HCC)
In this study, the investigators are to prospectively evaluate patient's survival, tumor response, and safety of RT followed by TACE in Child A patients with unilobar portal vein invasion.
- Trial name
- RTANDTACE (NCT01432314)
- Testing
- Radiation therapy, Transarterial chemoembolization
- Sponsor
- Asan Medical Center
Healthy
Phase 1 Study of Daewon-ES(B) & Megace in Healthy Male Volunteers Under Fasting and Fed Condition
The purpose of this study is to evaluate pharmacokinetics of Daewon DW-ES(B) 625mg/5ml and Megace 800mg/20ml in healthy male volunteers under fasting and fed condition.
- Trial name
- NCT01456624
- Testing
- Megace, DW-ES(B)
- Where
- South Korea
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Overactive Bladder
Observational Study to Estimate the Dry Mouth in OAB Patients With Solifenacin
A prospective, multicenter, observation study to estimate the dry mouth in OAB patients with solifenacin
- Trial name
- OAB (NCT01437670)
- Testing
- solifenacin 5mg, 10mg
- Where
- South Korea
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Pancreatic Masses
Optimal Number of To-and-fro Motion in EUS-guided Fine Needle Aspiration for Pancreatic Masses
EUS-FNA is the standard of care for diagnosing pancreatic masses. According to the operator's preference, EUS-FNA with suction or without suction technique has been used.
- Trial name
- NCT01576497
- Testing
- EUS-FNA, EUS-FNA with suction, EUS-FNA without suction
- Where
- South Korea
- Volunteers
- 193 people
- Sponsor
- Asan Medical Center
Hypertension, Cardiovascular Risk Factors
Rosuvastatin Effect on Serial Echocardiographic Measurement of Coronary Flow Velocity Reserve
In ASCOT study, lipid lowering with a statin provided additional beneficial effects in hypertensive patients with average levels of serum total cholesterol.
- Trial name
- RESERVE (NCT01490398)
- Testing
- Rosuvastatin
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Asan Medical Center
Invasive Fungal Infection
Voriconazole Trough Plasma Levels : Genetic Polymorphism, Efficacy, Safety in Patients With Hematologic Malignancy
Multiple factors are associated with a large variability in voriconazole exposure following standard dose administration, such as non-linear saturable pharmacokinetics, drug-drug interactions, liver disease, patient age, and…
- Trial name
- NCT01148160
- Testing
- voriconazole
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Asan Medical Center
Colorectal Neoplasms
Oral Iohexol for Fecal/Fluid Tagging for CT Colonography: A Study to Improve Image Quality by Preventing Colonic Bubbles
To determine whether colonic bubbles associated with CT colonography performed with iohexol for fecal/fluid tagging could be reduced by adding simethicone to the standard cathartic preparation.
- Trial name
- NCT01790139
- Testing
- Oral simethicone
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Asan Medical Center
Healthy
Clinical Trial to Characterize Pharmacokinetic-pharmacodynamic (PKPD) of Prasugrel 10 mg or 30 mg in Healthy Volunteers
An open label, parallel study to characterize the pharmacokinetics and pharmacodynamics of Prasugrel 30 mg or 60 mg in healthy male adult subjects
- Trial name
- PRAS-AM (NCT02075268)
- Testing
- prasugrel
- Where
- South Korea
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
HEPATITIS
TO Compare the Triple Drug Therapy and Dual Therapy .
Study to Compare the Safety and Efficacy of Tacrolimus and Steroids in Combination With Mycophenolate Mofetil or Without Mycophenolate Mofetil in Liver Transplantation with Hepatitis B Virus(HBsAg) Positive
- Trial name
- OPTIMUS-A (NCT02075242)
- Testing
- Mycophenolate Mofetil, Tacrolimus
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Asan Medical Center
Healthy
PKPD Study of Ticagrelor and Prasugrel in Healthy Korean Males
This study is to characterize the pharmacokinetic and pharmacodynamics of ticagrelor and prasugrel in healthy Korean male subjects. The study is open label, one sequence, crossover design.
- Trial name
- NCT01876797
- Testing
- ticagrelor/prasugrel
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Stomach Cancer
Trial of Adjuvant Chemotherapy for Gastric Cancer
This is a phase III randomized study designed to evaluate the efficacy of mitomycin, doxifluridine, and cisplatin compared to mitomycin and doxifluridine.
- Trial name
- NCT00296335
- Testing
- Mitomycin, doxifluridine and cisplatin, Mitomycin and doxifluridine
- Where
- South Korea
- Volunteers
- 855 people
- Sponsor
- Asan Medical Center
Validation of In-vitro Turbidometric Platelet Aggregation Assay
Study for Validation of In-vitro Turbidometric Platelet Aggregation Assay Using Human Blood in Healthy Volunteers
This study is designed for validation of in-vitro platelet aggregation assay using human blood in healthy volunteers. 32ml blood, 2ml for complete blood count test and 30ml for platelet aggregation assay, was collected from ten…
- Trial name
- NCT02071628
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Gastric Cancer
Capecitabine Versus S-1 in Elderly Advanced Gastric Cancer (AGC): Randomized Trial
A significant proportion of advanced gastric cancer (AGC) occurs in individuals 65 years of age and older. In addition, patient delay in seeking care for symptoms results in diagnosis at a more advanced stage than that seen in…
- Trial name
- NCT00278863
- Testing
- S-1, Capecitabine
- Where
- 9 sites in South Korea
- Volunteers
- 96 people
- Sponsor
- Asan Medical Center
Vertebral Osteomyelitis
Characterization and Differential Diagnosis of Vertebral Osteomyelitis
Vertebral osteomyelitis is a uncommon disease that can lead to neurologic deficits if not diagnosed in time. The etiologies of vertebral osteomyelitis include pyogenic bacteria, M. tuberculosis, Brucella species, and fungus.
- Trial name
- NCT01125839
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center