Clinical trials: sponsored by Asan Medical Center
Hepatocellular Carcinoma, Liver Cancer
Immunogenomic Dynamics and Biomarkers in Patients With Hepatocellular Carcinoma Receiving Immunotherapy
1. Research purpose To perform genomic and immune profiling analysis on blood and tissue samples obtained from blood sampling and tumor biopsy in patients with advanced hepatocellular carcinoma with immuno-oncology treatment. 2.
- Trial name
- NCT07186010
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Asan Medical Center
Mitral Stenosis
Prospective Multicenter Registry of Patients With Mitral Stenosis Undergoing Percutaneous Mitral Balloon Commissurotomy
The goal of this observational study is to learn about the clinical outcomes after percutaneous mitral balloon commissurotomy (PMBC) for patients with mitral stenosis (MS) using nation-wide multicenter prospective registry…
- Trial name
- NCT07175532
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Asan Medical Center
Hepatocellular Carcinoma
ThinkRadial: A Prospective Study of Transradial deTACE in HCC Patients
This study is a prospective, observational clinical trial designed to evaluate the feasibility, safety, and effectiveness of performing transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) using a transradial…
- Trial name
- ThinkRADIAL (NCT07160374)
- Testing
- Transradial drug-eluting beadsTransarterial Chemoembolization (DEB-TACE)
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Asan Medical Center
Acute Myeloid Leukemia (AML)
Allogeneic HCT Using Conditioning Regimen of BuFluATG for AML CR1
1. Study Objectives To evaluate the effect of various clinical variables including HLA-disparity and NK cell-related variables, upon outcomes of allogeneic hematopoietic cell transplantation (HCT) using uniform conditioning…
- Trial name
- NCT07155382
- Where
- South Korea
- Volunteers
- 98 people
- Sponsor
- Asan Medical Center
Acute Leukemia, Myelodysplastic Syndrome, Myeloproliferative Neoplasms, Lymphoma, Multiple Myeloma
Establishment of a Strategy for Preventing Graft-versus-host Disease After Allogeneic Hematopoietic Cell Transplantation by Exploring Immune Mechanisms of Regulatory and Effector T Cells
The purpose of this study was to explore the regulatory and effector T cell-related immune mechanisms associated with the development of graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT)…
- Trial name
- NCT07150468
- Testing
- sampling blood
- Where
- South Korea
- Volunteers
- 146 people
- Sponsor
- Asan Medical Center
Gastrointestinal Stromal Tumors
5 Years of Adjuvant Imatinib in Patients With Gastrointestinal Stromal Tumor With a High Risk
In this study, the investigators aim to investigate the efficacy and safety of 5 years of adjuvant imatinib treatment in patients with tumor rupture defined by Nishida classification or those with a tumor size 10cm or larger and…
- Trial name
- NCT05385549
- Testing
- Imatinib Mesylate
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Asan Medical Center
Primary Prevention, Vascular Calcification
GUIDE-CAC: Statin-Ezetimibe Without Aspirin vs. Statin Monotherapy With Aspirin in High Coronary Calcification
A Multicenter, randomized trial comparing the efficacy and safety of intensive lipid-lowering therapy using a statin-ezetimibe combination without aspirin versus statin monotherapy with aspirin in asymptomatic patients with…
- Trial name
- NCT06722521
- Testing
- Pitavastatin 4mg and ezetimibe 10mg, taken once daily, Pitavastatin 2 mg with aspirin 100 mg, taken once daily.
- Where
- South Korea
- Volunteers
- 7,435 people
- Sponsor
- Asan Medical Center
Stomach Neoplasm, Gastric (Stomach) Cancer
A Phase Ib/II Trial of Neoadjuvant Zolbetuximab Plus Docetaxel, Oxaliplatin and S-1 Chemotherapy in Patients With Locally Advanced Gastric Cancer
Claudin 18.2 is a promising therapeutic target overexpressed on the surface of gastric cancer cells. The addition of zolbetuximab, the monoclonal antibody targeting Claudin 18.2 to chemotherapy in two recent Phase 3 studies…
- Trial name
- NEO-CLAUD (NCT06732856)
- Testing
- zolbetuximab, Oxaliplatin, Docetaxel
- Where
- 2 sites in South Korea
- Volunteers
- 57 people
- Sponsor
- Asan Medical Center
Hepatocellular Carcinoma, Esophageal Varix
Prophylactic Endoscopic Variceal Ligation in Patients With High-risk Esophageal Varices Receiving Atezo/Bev for HCC
The goal of this study is to evaluate whether prophylactic endoscopic variceal ligation (EVL) can prevent esophageal variceal bleeding in patients with hepatocellular carcinoma (HCC) receiving atezolizumab and bevacizumab…
- Conditions
- Hepatocellular Carcinoma, Esophageal Varix, Bleeding Esophageal Varices
- Trial name
- ESCOAT (NCT06819566)
- Testing
- Endoscopic variceal ligation (EVL)
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Asan Medical Center
Advanced Heart Failure, Left Ventricular Assist Devices
Trial of Low-intensity Anticoagulation to Reduce GI or Other Bleeding Complications With Equivalent Therapeutic Efficacy in HeartMate 3 LVAD Patients
The TARGET trial is a prospective, single-center, randomized, open-label, active-controlled inequality clinical trial designed to evaluate the safety and efficacy of low-intensity anticoagulation therapy (target INR 1.5-2.0)…
- Conditions
- Advanced Heart Failure, Left Ventricular Assist Devices, Anticoagulation Treatment, Bleeding Complications
- Trial name
- TARGET (NCT07081035)
- Testing
- Warfarin (low-intensity anticoagulation), Warfarin (standard anticoagulation)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Asan Medical Center
HEART RATE
Intraoperative Heart Rate Thresholds and Postoperative Mortality
This retrospective observational study investigates the association between intraoperative heart rate and 30-day postoperative mortality among patients undergoing non-cardiac surgery.
- Trial name
- NCT07075744
- Testing
- Intraoperative Heart Rate Monitoring
- Where
- South Korea
- Volunteers
- 139,149 people
- Sponsor
- Asan Medical Center
Acute Ischemic Stroke, Atrial Fibrillation
Adding Antiplatelet During Edoxaban Treatment in Stroke Patients With Non-valvular Atrial Fibrillation (ADD-ON)
This study aims to compare the effectiveness and safety regarding treatment with standard anticoagulant only or adding antiplatelet to anticoagulant in patients with non-valvular atrial fibrillation and significant…
- Conditions
- Acute Ischemic Stroke, Atrial Fibrillation, Extracranial Atherosclerosis, Intracranial Atherosclerosis
- Trial name
- (ADD-ON) (NCT04010955)
- Testing
- Edoxaban Monotherapy
- Where
- South Korea
- Volunteers
- 1,200 people
- Sponsor
- Asan Medical Center
Uric Acid
Uric Acid and Menopausal Age in Acute Kidney Injury
Preoperative serum uric acid significantly impacted acute kidney injury in female patients undergoing non-cardiac surgery, with differential effects observed before and after menopause.
- Trial name
- NCT07044934
- Testing
- No Intervention: Observational Cohort
- Where
- South Korea
- Volunteers
- 127,052 people
- Sponsor
- Asan Medical Center
Breast Neoplasms
Effect of Preoperative Exercise on the Prevention of Secondary Lymphedema in Breast Cancer Patients
Research purpose: Lymphedema is a very common complication in breast cancer patients. However, since there is currently no curable treatment, it is important to prevent and reduce the severity of lymphedema.
- Trial name
- NCT06421285
- Testing
- Aerobic exercise, Strength training, Flexibility exercise
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Asan Medical Center
Aortic Stenosis
Early Surgery Versus Conventional Treatment in Very Severe Aortic Stenosis
The optimal timing of surgical intervention remains controversial in asymptomatic patients with very severe aortic stenosis. The investigators therefore try to compare long-term clinical outcomes of early surgery with those of…
- Trial name
- RECOVERY (NCT01161732)
- Testing
- Early surgery
- Where
- 4 sites in South Korea
- Volunteers
- 145 people
- Sponsor
- Asan Medical Center
Atrial Fibrillation, Persistent
Comparison Between Extended Cryoablation, Standard Cryoablation, and Radiofrequency Ablation
The objective of this study is to test the efficacy hypothesis that extended cryoballoon ablation is superior to either standard cryoballoon ablation or radiofrequency ablation
- Trial name
- EXCAPE-AF (NCT07034378)
- Testing
- Radiofrequency ablation, Extended cryoballoon ablation, Standard cryoballoon ablation
- Where
- 3 sites in South Korea
- Volunteers
- 288 people
- Sponsor
- Asan Medical Center
Out-Of-Hospital Cardiac Arrest, Postcardiac Arrest Syndrome
Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors
The mortality and neurological outcomes among out-of-hospital cardiac arrest survivors have not improved despite the medical advances. The whole body ischemia/reperfusion injuries after cardiac arrest mainly damaged the brain.
- Trial name
- NCT04921189
- Testing
- The combined supplement of Ascorbic acid, Thiamine, and Cortisol
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Asan Medical Center
Liver Cirrhosis, Hepatocellular Carcinoma
Abbreviated MRI Using Gadoxetic Acid Versus Ultrasonography for Surveillance of Early-stage HCC in Patients at High Risk
Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related deaths worldwide. The incidence of HCC has been rapidly rising worldwide over the last two decades.
- Trial name
- NCT06312826
- Testing
- Abdominal US, AMRI
- Where
- South Korea
- Volunteers
- 806 people
- Sponsor
- Asan Medical Center
Coronary Artery Disease
Intravascular Ultrasound Prediction of Myocardial Size and Coronary Computed Tomography-Derived Ischemic Burden for Coronary Lesion
The aims of this study are 1) to identify IVUS determinants of the CAMS-derived myocardial territories subtended to the diseased vessels, 2) to find IVUS determinant for the extent of CAMS-derived myocardial size, and 3) to…
- Trial name
- IVUS-CAMS (NCT02845505)
- Testing
- Intravascular Ultrasound, coronary computed tomography angiography
- Where
- 12 sites in South Korea
- Volunteers
- 500 people
- Sponsor
- Asan Medical Center
Tricuspid Regurgitation, Right Ventricular Dilatation
Pharmacological Reduction of Right Ventricular Enlargement
Functional tricuspid regurgitation (TR) has been regarded as a secondary phenomenon of heart failure (HF), mitral valve (MV) disease or atrial fibrillation.
- Trial name
- PROVE (NCT04345796)
- Testing
- Carvedilol+Empagliflozin, Carvedilol, Empagliflozin
- Where
- 3 sites in South Korea
- Volunteers
- 56 people
- Sponsor
- Asan Medical Center