Clinical trials: sponsored by Asan Medical Center
Acute Myeloid Leukemia
A Prospective Randomized Comparison of HDAC Vs AD in the Induction Chemothrapy for AML.
This trial is a single-center, non-blind, two-arm randomized prospective controlled trial to compare the effectiveness of two induction chemotherapy regimens (high-dose cytarabine plus daunorubicin [HDAC] vs.
- Trial name
- NCT03507842
- Testing
- High dose Cytarabine, Cytarabine, Hign dose Daunorubicin
- Where
- South Korea
- Volunteers
- 380 people
- Sponsor
- Asan Medical Center
Leukemia, Myeloid
Autologous Hematopoietic Cell Transplantation for Core-binding Factor Acute Myeloid Leukemia
Primary study objective is the evaluation of efficacy of autologous hematopoietic cell transplantation (HCT) with core-binding factor (CBF) positive acute myeloid leukemia (AML) in the first CR (CR1) in terms of relapse incidence…
- Trial name
- NCT01050036
- Testing
- autologous hematopoietic cell transplantation
- Where
- 11 sites in South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Colon Cancer, Lymph Node Dissection
A Comparative Study of Tumor Specific Mesocolic Excision and Complete Mesocolic Excision for Right Sided Colon Cancer : Asian Multicenter Retrospective Study
The goal of this observational study is to determine the optimal surgical strategy based on oncologic outcomes in patients with stage I-III right-sided colon cancer who underwent curative right hemicolectomy.
- Conditions
- Colon Cancer, Lymph Node Dissection, Laparoscopic Colon Surgery, Robotic Surgical Procedure
- Trial name
- NCT06865586
- Where
- South Korea
- Volunteers
- 3,326 people
- Sponsor
- Asan Medical Center
Pancreatic Pseudocyst
Efficacy and Safety of HANAROSTEN® HOT Plumber™ With Z-EUSIT™ for Pancreatic Pseudocyst Drainage
The goal of this prospective, single-center observational study is to evaluate the safety and effectiveness of the HANAROSTEN® HOT Plumber™ with Z-EUSIT™ for draining pancreatic pseudocysts.
- Trial name
- ZEUS (NCT06855485)
- Testing
- HANAROSTEN® HOT Plumber™ with Z-EUSIT™
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Hemodynamic Instability
Effect of Remimazolam and Propofol on Hemodynamic Stability in Prone Position
Most of the major spinal surgeries are performed in the supine position, which causes a decrease in stroke volume and cardiac index, which leads to the occurrence of hypotension during surgery.
- Trial name
- NCT05644483
- Testing
- Remimazolam, Propofol
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Asan Medical Center
Remimazolam, Propofol
Comparison in Frequency of Hypotension Between Remimazolam and Propofol in Hip Surgery
The purpose of this study is to compare the incidence of hypotension between remimazolam and propofol for intraoperative sedation in patients undergoing hip surgery with spinal anesthesia.
- Conditions
- Remimazolam, Propofol, Orthopedic Procedures, Sedatives
- Trial name
- NCT05651399
- Testing
- Remimazolam, Propofol
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Asan Medical Center
Transfusions
Transfusion Prediction in Major Abdominal Surgery
The transfusion nomogram, integrating preoperative variables, may effectively predict intraoperative transfusion in major abdominal surgery.
- Trial name
- NCT06847490
- Testing
- No intervention (observational study)
- Where
- South Korea
- Volunteers
- 128,749 people
- Sponsor
- Asan Medical Center
Rectal Cancer, Liver Metastases
Preoperative CRT With or Without Induction Chemotherapy for Rectal Cancer With Liver Metastases
To investigate the feasibility of preoperative chemoradiation with oxaliplatin plus capecitabine, with or without prior induction chemotherapy in patients with locally advanced or marginally resectable rectal cancer with…
- Trial name
- NCT01643070
- Testing
- Capecitabine, Oxaliplatin, Radiotherapy
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Asan Medical Center
Hepatocellular Carcinoma, Hepatocellular Cancer
Atezolizumab Plus Bevacizumab Alone or Combined with External Beam Radiotherapy for HCC with Macrovascular Invasion
The recent global IMbrave150 study evaluated the combination of atezolizumab and bevacizumab versus sorafenib in 501 patients with advanced or metastatic Hepatocellular Carcinoma (HCC).
- Conditions
- Hepatocellular Carcinoma, Hepatocellular Cancer, Hepatocellular Carcinoma Non-resectable, Hepatocellular Carcinoma Stage IV
- Trial name
- ALERT-HCC (NCT05992220)
- Testing
- Atezolizumab plus bevacizumab, combined EBRT to vascular invasion, Atezolizumab plus bevacizumab
- Where
- South Korea
- Volunteers
- 138 people
- Sponsor
- Asan Medical Center
Uric Acid
Uric Acid and Surgical Prognosis
Preoperative serum uric acid significantly impacted mortality and morbidity in non-cardiac surgery.
- Trial name
- NCT06837545
- Testing
- No Intervention (Observational Study)
- Where
- South Korea
- Volunteers
- 309,353 people
- Sponsor
- Asan Medical Center
Atrial Septal Defect, Successful Device Closure
Efficacy of Three Dimensional Transesophageal Echocardiography for Percutaneous Device Closure in Atrial Septal Defect
Background: Three-dimensional echocardiographic image for atrial septal defect (ASD) is useful for evaluation of defect size and shape.
- Trial name
- ASD (NCT02097758)
- Testing
- Transcatheter device closure
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Mitral Regurgitation
Early Surgery Versus Conventional Treatment for Asymptomatic Severe Mitral Regurgitation
The timing of surgical intervention in asymptomatic patients with severe degenerative mitral regurgitation (MR) remains controversial.
- Trial name
- NCT01703806
- Testing
- Early Surgery, Watchful Observation
- Where
- 2 sites in South Korea
- Volunteers
- 1,063 people
- Sponsor
- Asan Medical Center
Pancreatic Adenocarcinoma, Pancreatic Cancer Non-resectable
mFOLFIRINOX With or Without Stereotactic Body Radiotherapy in Locally Advanced Pancreatic Adenocarcinoma
Modified FOLFIRINOX (mFOLFIRINOX) is the standard of care for patients with locally advanced pancreatic adenocarcinoma. While radiotherapy has been investigated for the management of resectable or locally advanced pancreatic…
- Trial name
- SABER (NCT04986930)
- Testing
- SBRT+mFOLFIRINOX, mFOLFIRINOX
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Asan Medical Center
Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma
Liposomal Irinotecan, S-1, and Oxaliplatin in Advanced Pancreatic Adenocarcinoma
In present study, the investigators evaluate the safety and efficacy of OIS-derived NASOX regimen (nal-IRI, S-1, oxaliplatin) in advanced pancreatic cancer.
- Trial name
- NASOX (NCT04662112)
- Testing
- NASOX
- Where
- 2 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Asan Medical Center
Hepatocellular Carcinoma, Biliary Tract Cancer
A Prospective Cohort Study of Patients with Hepatobiliary Cancer Treated with Immune Checkpoint Inhibitors
Although immune checkpoint inhibitors including nivolumab and pembrolizumab are now available for the management of hepatobiliary cancers in Korea, there is a lack of data for the efficacy and safety of these agents in the…
- Trial name
- NCT03695952
- Testing
- Nivolumab or pembrolizumab
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Biliary Tract Neoplasms, Gallbladder Cancer
Neoadjuvant Gemcitabine Plus Cisplatin With or Without Durvalumab in Resectable Biliary Tract Cancer
Considering that the poor prognosis of resected biliary tract cancer and negative impact on the survival outcomes of R1/R2 resection, neoadjuvant chemotherapy may improve R0 resection rates and the survival outcomes of patients…
- Conditions
- Biliary Tract Neoplasms, Gallbladder Cancer, Cholangiocarcinoma
- Trial name
- DEBATE (NCT04308174)
- Testing
- Durvalumab + Gem/Cis, Gem/Cis
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Asan Medical Center
Neuroendocrine Tumors
Asian Investigation of Lanreotide Autogel® in the Management of GEP-NETs
Lanreotide Autogel® has been established as a standard of care for patients with locally advanced or metastatic GEP-NETs based on the success of CLARINET trial.
- Trial name
- AIM-NETs (NCT04696042)
- Testing
- Lanreotide autogel
- Where
- South Korea
- Volunteers
- 71 people
- Sponsor
- Asan Medical Center
Biliary Tract Cancer, DNA Damage Repair Deficiency
Olaparib With or Without Durvalumab for DDR Gene Mutated Biliary Tract Cancer Following Platinum-based Chemotherapy
First-line gemcitabine plus cisplatin chemotherapy is the standard first-line treatment for unresectable or metastatic advanced biliary tract cancer and the optimal duration of the treatment is not mentioned in current clinical…
- Trial name
- OPTIMUM (NCT05222971)
- Testing
- Durvalumab, Olaparib
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Asan Medical Center
Surgery, Non Cardiac Surgery
Surgical Start Time and Prognosis
Surgical start times significantly impacted mortality, morbidity, and resource utilization, particularly in high-risk patients.
- Trial name
- NCT06792578
- Testing
- Surgical Start Time
- Where
- South Korea
- Volunteers
- 291,051 people
- Sponsor
- Asan Medical Center
Mitral Valve Insufficiency, Left Ventricular Systolic Dysfunction
Ertugliflozin for Functional Mitral Regurgitation
In patients with heart failure (HF) and left ventricular (LV) dilation, adverse LV remodeling causes tethering of mitral valve (MV) preventing sufficient coaptation of normal leaflets and resulting in functional MR.
- Trial name
- EFFORT (NCT04231331)
- Testing
- Ertugliflozin
- Where
- 3 sites in South Korea
- Volunteers
- 128 people
- Sponsor
- Asan Medical Center