Clinical trials: sponsored by Beijing Anzhen Hospital
Left Ventricular Remodeling, Plasma Multi-Omics
Prediction of LVAR and MACE in STEMI Though Plasma Multiomics Analysis
To identify plasma multi-omics biomarkers that predict left ventricular adverse remodeling (LVAR) and major adverse cardiovascular events (MACE) in patients with acute ST-segment elevation myocardial infarction, and to…
- Conditions
- Left Ventricular Remodeling, Plasma Multi-Omics, Acute ST-segment Elevation Myocardial Infarction, Immunomics
- Trial name
- NCT06885619
- Testing
- Diagnostic Test: echocardiography and blood collection
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
CAD - Coronary Artery Disease, CABG
Low-dose Colchicine for CABG Graft Failure Prevention
This study aims to evaluate whether daily low-dose colchicine (0.5 mg), administered in addition to the standard secondary prevention regimen recommended in clinical guidelines after coronary artery bypass grafting (CABG), can…
- Conditions
- CAD - Coronary Artery Disease, CABG, Colchicine
- Trial name
- NCT07569328
- Testing
- Colchicine Pill
- Where
- China
- Volunteers
- 622 people
- Sponsor
- Beijing Anzhen Hospital
Heart Failure With Reduced Ejection Fraction
Digital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF)
DigiCare-HFrEF is an investigator-initiated, multicentre, randomised, open-label, endpoint-blinded, superiority trial designed to evaluate whether a structured digital remote-management platform can optimise guideline-directed…
- Trial name
- DigiCare-HFrEF (NCT07352891)
- Testing
- Digital Remote Management
- Where
- 6 sites in China
- Volunteers
- 252 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Bypass Grafting, Heart Valve Disease
LLM-Based Intelligent Health Management Assistant in Life-Cycle Health Management of Cardiac Surgery Patients
This is a single-center, prospective, randomized, open-label, parallel-controlled clinical study to evaluate the effectiveness of a large language model (LLM)-based intelligent health management assistant in the life-cycle health…
- Conditions
- Coronary Artery Bypass Grafting, Heart Valve Disease, Aortic Aneurysm, Aortic Dissection
- Trial name
- cFT-LLM (NCT07521488)
- Testing
- LLM-Based Intelligent Health Management Assistant
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Anzhen Hospital
Acute Type A Aortic Dissection, Hypothermia
Arch-Clamping Technique Under Mild Hypothermia in Treating With Acute Type A Aortic Dissection
The study is a multicenter, three-arm, open-label, randomized, parallel-controlled trial, which plans to enroll 306 participants diagnosed with acute type A aortic dissection (ATAAD) from 7 hospitals in China.
- Conditions
- Acute Type A Aortic Dissection, Hypothermia, Total Aortic Arch Replacement, Frozen Elephant Trunk
- Trial name
- AHEAD (NCT07150559)
- Testing
- Arch-Clamping Technique under Mild Hypothermia, Arch-Clamping Technique under Moderate Hypothermia, Total Arch Replacement combined Frozen Elephant Trunk Implantation using Bilateral Antegrade Cerebral Perfusion under Moderate Hypothermic Circulatory Arrest
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
Angiography-Derived Physiological Indices for Outcome Prediction in Patients Undergoing OCT-Guided PCI
The primary design of this study is an ambispective observational cohort study. In patients undergoing successful optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) with post-procedural…
- Trial name
- ADOPT-PCI (NCT07511231)
- Testing
- OCT-guided PCI
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Beijing Anzhen Hospital
Stable Coronary Artery Disease CAD
Helium-free Magnetocardiography Guided Therapy for Stable Coronary Artery Disease - A Randomized Controlled Trial
This rigorously designed randomized controlled trial aims to investigate whether Magnetocardiography (MCG) can optimize the clinical pathway, improve quality of life, and reduce healthcare costs in patients with stable coronary…
- Trial name
- NCT07341932
- Testing
- MCG Group, Conventional Management Group
- Where
- 5 sites in China
- Volunteers
- 1,312 people
- Sponsor
- Beijing Anzhen Hospital
Acute Non-variceal Upper Gastrointestinal Hemorrhage, Coronary Heart Disease
Timing of Endoscopy in Coronary Heart Disease Patients Taking Antiplatelet Drugs With Acute Non-variceal Upper Gastrointestinal Bleeding
This is a prospective randomized controlled trial (RCT) evaluating the optimal timing of endoscopy in patients with coronary heart disease who are taking antiplatelet drugs and present with acute non-variceal upper…
- Trial name
- PACT-UGIB (NCT07507162)
- Testing
- Urgent Endoscopy (Within 12 Hours of Admission), Early Endoscopy (12-24 Hours After Admission)
- Volunteers
- 212 people
- Sponsor
- Beijing Anzhen Hospital
Aortic Stenosis, Calcific
PCSK9 Inhibitors in the Treatment of Calcific Aortic Stenosis
Calcific aortic stenosis (CAS) can cause severe adverse cardiac events, but there are currently no effective drugs that can prevent or delay the progression of the disease.
- Trial name
- PICASO (NCT07256197)
- Testing
- Treatment with PCSK9 inhibitors, Treatment without PCSK9 inhibitors
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Beijing Anzhen Hospital
Acute Myocardial Infarction (AMI)
Construction and Analysis of a Risk Prediction Model for Acute Myocardial Infarction Based on Spatiotemporal Heterogeneous Data
Acute myocardial infarction (AMI), as the leading cause of death among cardiovascular diseases, has its diagnosis and treatment efficiency directly affecting survival.
- Trial name
- NCT07496931
- Testing
- Acute Myocardial Infarction Risk Prediction Model
- Volunteers
- 3,000 people
- Sponsor
- Beijing Anzhen Hospital
ECMO
Early Intra-aortic Balloon Pump Use After Venoarterial Extracorporeal Membrane Oxygenation
The goal of this multicenter, randomized trial is to compare early early left ventricular unloading by Intra-aortic Balloon Pump (IABP) versus conventional approach in patients with cardiogenic shock (CS) undergoing venoarterial…
- Trial name
- EASE-ECMO (NCT06872021)
- Testing
- Early IABP use, Conventional approach
- Where
- China
- Volunteers
- 358 people
- Sponsor
- Beijing Anzhen Hospital
Glycemic Management During CPB in Elderly Diabetic Cardiac Surgery
Glycemic Targets During CPB in Elderly Diabetes
The goal of this clinical trial is to compare the effects of tight versus liberal glycemic management strategies on patient outcomes during cardiopulmonary bypass in elderly diabetic patients undergoing cardiac surgery.
- Trial name
- NCT07485101
- Testing
- Tight Glycemic Management Protocol, Liberal Glycemic Management Protocol, Short-acting Insulin
- Volunteers
- 3,000 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation (AF), Catheter Ablation
Efficacy and Safety of Catheter abLation in patiEnts With seVere mitrAl regurgiTation and pErsistent Atrial Fibrillation: a Randomized Controlled Trial
Atrial fibrillation (AF) leads to atrial functional mitral regurgitation (MR) through mechanisms including mitral annular dilatation, systolic leaflet motion distance alteration, and contractility decrease.
- Conditions
- Atrial Fibrillation (AF), Catheter Ablation, Atrial Functional Mitral Regurgitation
- Trial name
- ELEVATE-AF (NCT06883864)
- Testing
- Catheter ablation plus medication, Medication, (ELEVATE-AF X) experimental group
- Where
- 17 sites in China
- Volunteers
- 146 people
- Sponsor
- Beijing Anzhen Hospital
Symptomatic Bradycardia, Autonomic Nervous System Diseases
Basic and Clinical Study of Cardiac Ganglion Catheter Ablation for the Treatment of Significant Bradycardia
This study adopts a strategy combining basic research with clinical investigation to systematically explore the therapeutic value of cardioneuroablation in the treatment of vagally-mediated bradycardia.
- Trial name
- NCT07468383
- Testing
- Cardioneuroablation
- Where
- China
- Volunteers
- 188 people
- Sponsor
- Beijing Anzhen Hospital
Acute Myocardial Infarction Complicated With Cardiogenic Shock
Multidisciplinary Collaborative Care System for Acute Myocardial Infarction Complicated With Cardiogenic Shock
Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) represents the most life-threatening subtype of acute cardiovascular diseases.
- Trial name
- AMICS-Reg (NCT07470814)
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
Cardiovascular Disease
Application of Non-inductive Intelligent Physical Sign Monitoring Equipment Based on Flexible Electronic Devices in the Diagnosis and Treatment of Cardiovascular Diseases
This project is a single-center clinical evaluation study designed to validate a non-invasive mattress-based smart monitoring system.
- Trial name
- NCT07466056
- Testing
- Non-invasive Smart Mattress Monitoring System
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation (AF)
Discontinuation of Anticoagulation With Intensive Rhythm Monitoring in Post-ablation Patients With Atrial Fibrillation
DIAMOND-AF is a multicenter, randomized, open-label trial evaluating whether discontinuing oral anticoagulation after successful atrial fibrillation ablation can reduce bleeding risk without increasing death or thromboembolism…
- Trial name
- DIAMOND-AF (NCT06871228)
- Testing
- NOAC discontinuation, NOAC continuation, Smartwatch single-lead ECG monitoring
- Where
- 22 sites in China
- Volunteers
- 4,100 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation (AF), PFA
Electrophysiologist-led Deep Sedation Protocols for Pulsed Field Ablation for Atrial Fibrillation Using a Bipolar Tip-Catheter: The DEEP-PFA Randomized Controlled Trial
The DEEP-PFA trial is an investigator-initiated, prospective, single-center, three-arm (1: 1: 1), randomized controlled study comparing three anesthesia regimens-midazolam + fentanyl (DS1), flurbiprofen + midazolam + fentanyl…
- Conditions
- Atrial Fibrillation (AF), PFA, Deep Sedation
- Trial name
- NCT07149545
- Testing
- Arm A (Fentanyl + Midazolam), Arm B (Flurbiprofen axetil + Fentanyl + Midazolam), Arm C (Fentanyl + Dexmedetomidine)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing Anzhen Hospital
Acute Kidney Injury, Nitrous Oxide
Perioperative Nitric Oxide Prevents Acute Kidney Injury in Acute Type A Aortic Dissection Patients
The goal of this clinical trial is to determine the effectiveness of exogenous nitric oxide therapy in reducing the occurrence of acute kidney injury in patients with acute type A aortic dissection.
- Conditions
- Acute Kidney Injury, Nitrous Oxide, Acute Type A Aortic Dissection
- Trial name
- NCT06622291
- Testing
- Nitric Oxide
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Beijing Anzhen Hospital
Acute Myocardial Infarction, Large Language Models
Acute Myocardial Infarction Clinical Intelligent Decision Support System
Acute Myocardial Infarction (AMI) remains the leading cause of cardiovascular mortality globally. In China, while the incidence of AMI is escalating at an annual rate of 5.2%, significant clinical challenges persist: diagnostic…
- Conditions
- Acute Myocardial Infarction, Large Language Models, Clinical Decision Support System
- Trial name
- AMI-CIDSS (NCT07367399)
- Where
- China
- Volunteers
- 15,000 people
- Sponsor
- Beijing Anzhen Hospital