Clinical trials: sponsored by Beijing Anzhen Hospital
Hypertension (HTN), Sleep Apnea Syndrome, Obstructive
A Cohort Study on Increasing Blood Pressure Benefits in Sleep Apnea Patients After CPAP Treatment
Research Title "Quadruple-Blind Randomized Controlled Trial of the Effect of CPAP on Blood Pressure in Patients with Sleep Apnea" Why are we conducting this study? Sleep apnea (OSA) is very common, affecting approximately one in…
- Trial name
- NCT07357272
- Testing
- continuous positive airway pressure
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Sleep Disordered Breathing (SDB)
Comprehensive Care of Sleep Disordered Breathing
The Comprehensive Care of Sleep Disordered Breathing study (Care-SDB) is a prospective, multi-center, registry-based cohort study designed to investigate the integrated management of sleep-disordered breathing (SDB).
- Trial name
- Care-SDB (NCT07339371)
- Testing
- Clinical Management for SDB
- Where
- China
- Volunteers
- 11,100 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
Coronary Imaging and Metabolic Indicators-Based Risk Prediction Model for Coronary Artery Disease(CMI-RiskCAD)
The primary design of this study is an ambispective cohort study. We plan to integrate coronary imaging features (including parameters derived from Coronary Computed Tomography Angiography(CCTA) and coronary angiography(CAG))…
- Trial name
- CMI-RiskCAD (NCT07353762)
- Where
- China
- Volunteers
- 10,960 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation (AF), Atrial Flutter
Intracardiac Echocardiography-Guided Cavotricuspid Isthmus Ablation With a Circular-Shaped Pulsed Field Ablation Catheter
This observational study aims to evaluate the effectiveness and safety of a circular-shaped pulsed field ablation (PFA) catheter for CTI ablation under the guidance of intracardiac echocardiography (ICE).
- Trial name
- NCT07353775
- Testing
- ICE-guided CTI ablation with PFA
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Heart Disease, Percutaneous Coronary Intervention
Digital Remote Management for Care and Continuous Optimization Versus Usual Care in Patients With Coronary Heart Disease (DigiCare-CHD)
The DigiCare-CHD study is an investigator-initiated, multicenter, open-label, parallel-group randomized controlled trial. It aims to evaluated the efficacy of a smartphone-based digital remote management platform compared to…
- Trial name
- DigiCare-CHD (NCT07332494)
- Testing
- Digital Remote Management Group
- Where
- 4 sites in China
- Volunteers
- 792 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation (AF)
Effectiveness of Artificial IntelliGence-Driven Single-LEad Long-TerM Electrocardiograms MonItoring in Detecting New-Diagnosed Atrial FIbrillation
Abstract Purpose: Atrial fibrillation (AF) is a leading cause of stroke and heart failure, yet detection remains suboptimal in rural settings due to limited resources.
- Trial name
- GEMINI (NCT06842147)
- Testing
- 7-day single-lead long-term ECG monitoring device., Standard Screening Group
- Where
- China
- Volunteers
- 15,360 people
- Sponsor
- Beijing Anzhen Hospital
Cardiac Surgery Intensive Care Treatment, Hemodynamics
Correlation Between Postoperative Blood Pressure Variability, Perfusion Index and Perioperative Adverse Events in Cardiac Surgery
In patients after cardiac surgery, disturbances in macrocirculatory fluctuations and tissue perfusion commonly coexist. The stress state induced by factors such as surgical manipulation, cardiopulmonary bypass, anesthetic agents…
- Trial name
- NCT07316634
- Testing
- Blood Pressure Variability and Perfusion Index
- Volunteers
- 1,200 people
- Sponsor
- Beijing Anzhen Hospital
OSA - Obstructive Sleep Apnea, Coronary Microvascular Dysfunction (CMD)
The Correlation Between Obstructive Sleep Apnea-Related Nocturnal Hypoxemia Parameters and Coronary Microvascular Dysfunction: A Prospective Cohort Study (SLEEP-CMD)
In a cohort of patients with suspected myocardial ischemia undergoing sleep studies, the objectives of this study were: 1. To determine the association between various obstructive sleep apnea (OSA)-related nocturnal hypoxemia…
- Conditions
- OSA - Obstructive Sleep Apnea, Coronary Microvascular Dysfunction (CMD), Coronary Artery Disease (CAD)
- Trial name
- SLEEP-CMD (NCT07315399)
- Testing
- Polysomnography
- Where
- China
- Volunteers
- 560 people
- Sponsor
- Beijing Anzhen Hospital
Angina, Stable, Acute Coronary Syndrome
Genotyping GUided Antiplatelet theRapy in pAtieNts Treated With Drug Eluting stEnts (GUARANTEE)
The aim of this study is to assess the efficacy and safety of the CYP2C19 genotype guided antiplatelet treatment strategy, using clopidogrel in non-carriers of a CYP2C19*2 or *3 allele and ticagrelor in carriers of a CYP2C19*2 or…
- Conditions
- Angina, Stable, Acute Coronary Syndrome, Drug-Eluting Stents, Genotype
- Trial name
- NCT03783351
- Testing
- CYP2C19 genotype testing
- Where
- 9 sites in China
- Volunteers
- 4,009 people
- Sponsor
- Beijing Anzhen Hospital
Acute Ischemic Stroke
Intravenous Thrombolysis Combined With Tirofiban in Acute Ischemic Stroke
This multicenter, prospective, double-blind, placebo-controlled, randomized trial (ANGEL-DRUG2) aims to evaluate the efficacy and safety of intravenous tirofiban following intravenous thrombolysis in patients with acute ischemic…
- Trial name
- NCT07290751
- Testing
- Tirofiban
- Where
- China
- Volunteers
- 976 people
- Sponsor
- Beijing Anzhen Hospital
CABG, Aortic Dissection
CLEAR Trial: CA330 Cytokine Adsorption Column for Anticoagulant/Antiplatelet Patients in Non-Elective CPB Surgery.
The goal of this clinical trial is to evaluate whether the CA330 cytokine adsorption column can reduce perioperative severe bleeding adverse events in patients receiving anticoagulant and/or antiplatelet therapy who undergo…
- Conditions
- CABG, Aortic Dissection, Valvular Heart Diseases
- Trial name
- CLEAR (NCT07284199)
- Testing
- CA330 Cytokine Adsorption Column
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Anzhen Hospital
Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease
For Patients With Myocardial Infarction and Multiple Vessel: Testing if Ultrasound (UFR) Can Guide All Needed Treatment in One Procedure, Avoiding a Return Hospital Visit for a Second Operation.
Brief Summary The Purpose of the Study : The purpose of this study is to find a safe and reliable "one-stop" solution for treating heart attack patients who have multiple blocked arteries.
- Conditions
- Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease, ACS (Acute Coronary Syndrome), ST Elevation Myocardial Infarction (STEMI)
- Trial name
- ACT-EVOLVE (NCT07264881)
- Testing
- IVUS-based Fractional Flow Reserve (UFR), Invasive Coronary Physiology Measurement (FFR/RFR/IMR), Cardiac Magnetic Resonance (CMR)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Acute Ischemic Stroke
Endovascular Therapy Combined With Tirofiban for Intracranial Atherosclerotic Acute Ischemic Stroke
This randomized controlled trial aims to evaluate whether adjunctive tirofiban therapy combined with endovascular treatment (EVT) improves neurological outcomes in patients with acute large vessel occlusion due to large-artery…
- Trial name
- ANGEL-DRUG (NCT07026318)
- Testing
- Tirofiban
- Where
- China
- Volunteers
- 716 people
- Sponsor
- Beijing Anzhen Hospital
Acute Myocardial Infarction Complicated With Cardiogenic Shock, Mild Therapeutic Hypothermia
Evaluation of MTH in PCI Under VA-ECMO for AMICS
This study is a randomized controlled trial conducted at Beijing Anzhen Hospital, Capital Medical University. The primary objective is to assess the efficacy of mild therapeutic hypothermia in reducing infarct size and improving…
- Conditions
- Acute Myocardial Infarction Complicated With Cardiogenic Shock, Mild Therapeutic Hypothermia, Venous-arterial Extracorporeal Membrane Oxygenation
- Trial name
- HOPE-CS (NCT07186972)
- Testing
- Mild therapeutic hypothermia
- Volunteers
- 44 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation (AF), Hypertension
Village-Based Management of Chronic Cardiovascular Disease in Qu Jiang Elderly Population Registry: The BOUQUET Cohort Study
This is a prospective observational cohort study conducted in Qujiang District, Zhejiang Province, China, aiming to evaluate the effectiveness of a comprehensive management program for elderly patients with chronic cardiovascular…
- Conditions
- Atrial Fibrillation (AF), Hypertension, Coronary Heart Disease (CHD), Heart Failure
- Trial name
- NCT07149688
- Testing
- Comprehensive management program (pharmacologic treatment, lifestyle modification, health education, structured follow-up)
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Sudden Death, Cardiac, Myocardial Scarring
Cardiac Magnetic Resonance - PROgnostic HEart Scar for Sudden Cardiac Death Prediction StudY
The purpose of this observational study is to investigate whether myocardial scar characteristics assessed by cardiac magnetic resonance (CMR) can predict the risk of out-of-hospital sudden cardiac death (SCD) after myocardial…
- Conditions
- Sudden Death, Cardiac, Myocardial Scarring, Myocardial Infarction (MI)
- Trial name
- NCT07137936
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
Arrhythmia
Arrhythmia Cohort Study
The goal of this prospective, observational registry study is to evaluate the long-term effectiveness, safety, and impact of different kinds of treatment on the quality of life across diverse arrhythmia subtypes and patient…
- Trial name
- NCT07123896
- Testing
- Normal treatment with catheter ablation or medicine, Drug Treatment
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Acute Ischemic Stroke
Efficacy of Rescue Stenting/Angioplasty After Failed Thrombectomy for Acute Large Intracranial Vascular Occlusion
The primary objective of this study is to evaluate whether rescue stenting therapy can improve neurological functional outcomes after failed endovascular treatment for acute ischemic stroke caused by large vessel occlusion.
- Trial name
- ANGEL-RESCUE (NCT07026344)
- Testing
- Stent placement, Continued Thrombectomy, balloon angioplasty
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation (AF)
Marshall Vein Ethanol Infusion in Addition to Pulsed Electric Field Ablation Versus Pulsed Electric Field Ablation Alone for Paroxysmal Atrial Fibrillation
The Marvel-PAF trial is an investigator initiated, multi-center, open-label, randomized trial, which aims to compare the effectiveness of vein of Marshall in addition to pulmonary vein isolation using pulsed field ablation in the…
- Trial name
- MARVEL-PAF (NCT07095959)
- Testing
- vein of Marshall ethanol infusion, PVI using pulsed field ablation
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation
Efficacy of Dapagliflozin on Recurrence After Catheter Ablation for Atrial Fibrillation
This is a single-center, parallel-group, randomized, open-label trial evaluating the effect of 3-month treatment with dapagliflozin 10mg once daily on the recurrence of atrial fibrillation after catheter ablation for atrial…
- Trial name
- DARE-AF (NCT06433479)
- Testing
- Dapagliflozin 10 mg per day for 3 months after initial catheter ablation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital