Clinical trials: sponsored by Beijing Anzhen Hospital
Obstructive Sleep Apnea of Adult, Acute Coronary Syndrome
OSA-ACS Project: Association of OSA and CPAP Therapy With Outcomes in ACS Patients
Obstructive sleep apnea (OSA) is an increasingly common chronic disorder in adults that has been strongly associated with various forms of cardiovascular disease.
- Trial name
- NCT03362385
- Testing
- Patients with OSA based on sleep study, Patients without OSA based on sleep study
- Where
- China
- Volunteers
- 2,160 people
- Sponsor
- Beijing Anzhen Hospital
Acute Respiratory Distress Syndrome, Inflammation
The Mechanism of lncRNA NEAT1 in Alleviating Acute Respiratory Distress Syndrome Through miR-27b Regulated Nrf2 Pathway
The acute respiratory distress syndrome, formerly known as the acute lung injury (ARDS/ALI), is a critical illness with high mortality due to the lack of effective treatment.
- Trial name
- NCT04937855
- Testing
- no intervention
- Where
- China
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Randomized Controlled Trials
Impact of PCSK9 Inhibitors on Coronary Plaque Composition and Vulnerability Assessed by Optical Coherence Tomography
The study is a prospective, open-label, randomized, single-center study involving patients with intermediate coronary lesions (50%-70% diameter stenosis) and who have elevated LDL-C values (LDL-C≥100 mg/dL) despite stable statin…
- Trial name
- NCT04851769
- Testing
- PCSK9 inhibitor plus statin, standard statin therapy, Coronary imaging follow-up
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Disease
Randomized Comparison of Distal Radial Versus Conventional Radial Access for Coronary Angiography and Intervention
Distal radial access (dTRA) represents a novel site for radial artery access in interventional cardiology, there is little data compare dTRA with conventional radial access (cTRA) in a randomized manner.
- Trial name
- NCT04784078
- Testing
- Coronary Angiography and Intervention
- Volunteers
- 938 people
- Sponsor
- Beijing Anzhen Hospital
Acute Kidney Injury, Hypoxia-Ischemia, Brain
Tissue Oxygenation During Treatment of Infant Congenital Heart Defects
Background: Acute kidney injury (AKI) is a common and serious postoperative complication in children with congenital heart disease.
- Conditions
- Acute Kidney Injury, Hypoxia-Ischemia, Brain, Mesenteric Ischemia
- Trial name
- NCT03941015
- Where
- China
- Volunteers
- 245 people
- Sponsor
- Beijing Anzhen Hospital
Outcomes of Mitral Valve Surgery in Patients Affected by Rheumatic Heart Disease
Outcomes of Mitral Valve Surgery in Patients Affected by Rheumatic Heart Disease
rheumatic heart disease remains the majority valvular disease in low and middle income countries, which mostly affected mitral valve, surgical treatment is the most effective strategy to improve the outcomes of middle or…
- Trial name
- NCT04780607
- Testing
- mitral valve repair
- Where
- China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease, Coronary Occlusion
Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Total Occlusions
The purpose of this study is to investigate the safety and efficacy of drug-coated balloon angioplasty for the treatment of chronic total occlusions patients with chronic total occlusion (CTO) lesion.
- Conditions
- Coronary Artery Disease, Coronary Occlusion, Percutaneous Coronary Intervention, Chronic Total Occlusion of Coronary Artery
- Trial name
- NCT04744571
- Testing
- aspirin, betaloc, atorvastatin, rosuvastatin, clopidogrel, ticagrelor, coronary wires. or coronary balloons, drug-coated balloon
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Respiratory Distress Syndrome, Adult, Thoracic Surgery
Risk Factors and Prediction Score of ARDS After Cardiac Surgery
Acute respiratory distress syndrome following cardiac surgery severely affects the prognosis of patients; the mortality is up to 40%.
- Conditions
- Respiratory Distress Syndrome, Adult, Thoracic Surgery, Risk Factors
- Trial name
- NCT02759770
- Testing
- no intervention
- Where
- China
- Volunteers
- 1,333 people
- Sponsor
- Beijing Anzhen Hospital
Antiplatelet Therapy, CYP2C19 Polymorphism
The Influence of Gene Polymorphism on Clinical Outcomes in Patients Undergoing PCI
Dual antiplatelet therapy with aspirin and thienopyridines is an essential treatment in patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- NCT03758248
- Testing
- CYP2C19
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- Beijing Anzhen Hospital
Dyslipidemia, High Risk Coronary Artery Disease
Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With High Risk Coronary Artery Disease (FORWARD)
The primary objective was to evaluate the effect of treatment with evolocumab on the risk for cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization, whichever…
- Trial name
- FORWARD (NCT04087915)
- Testing
- Evolocumab
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
Chronic Total Occlusion of Coronary Artery, Percutaneous Coronary Intervention
The Success of Opening Concurrent CTO leSion to Improve Cardiac Function Trial in Patients With Multi-vessel Disease
The purpose of this study is to investigate the effect of percutaneous coronary intervention (PCI) on cardiac function in multi-vessel disease patients with concurrent chronic total occlusion (CTO) lesion.
- Conditions
- Chronic Total Occlusion of Coronary Artery, Percutaneous Coronary Intervention, Coronary Artery Disease, Viable Myocardium
- Trial name
- SOS-moral (NCT03372785)
- Testing
- aspirin, betaloc, atorvastatin, rosuvastatin, clopidogrel, ticagrelor, coronary wires. stents or coronary balloons
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease, Graft Failure
Clinical Effect of No-touch Harvesting Technique in OPCABG
This study aims to investigate the clinical effect of the new saphenous vein harvesting technique "No-touch" in off-pump coronary artery bypass grafting(OPCABG), comparing to the conventional technique.
- Trial name
- NCT03729531
- Testing
- Conventional vein harvesting technique, no-touch vein harvesting technique
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease
OCT- Versus Angiography-guided Paclitaxel Drug-Coated Balloon Angioplasty in De Novo Coronary Artery
OCT allows precise evaluation of intimal injury after lesion preparation and may improve the acute results and long-term outcomes after paclitaxel drug-coated balloon angioplasty.
- Trial name
- NCT04276389
- Testing
- OCT-guided paclitaxel drug-coated balloon angioplasty, Angiography-guided paclitaxel drug-coated balloon angioplasty
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Heart Disease
The Study of Active Transfer of Plaque Technique for Non-Left Main Coronary Bifurcation Lesions
A Prospective Multi-center Randomized Trial Assessing the Efficacy and Safety of Active Transfer of Plaque vs. Provisional T Stenting for the Treatment of Non-Left-Main Coronary Bifurcation Lesions.
- Trial name
- NCT02768116
- Testing
- Sirolimus Drug-eluting Stent via Active Transfer of Plaque, Sirolimus Drug-eluting Stent implantation via Provisional T Stenting
- Volunteers
- 316 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Heart Disease
The Study of Active Transfer of Plaque Technique for Unprotected Distal Left Main Bifurcation Lesions
A Prospective Multi-center Randomized Trial Assessing the Efficacy and Safety of Active Transfer of Plaque vs. Provisional T Stenting for the Treatment of Unprotected Distal Left Main Bifurcation Lesions
- Trial name
- NCT02127138
- Testing
- Sirolimus eluting Drug stent
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Beijing Anzhen Hospital
Drug Therapy, Acute Coronary Syndrome
Registry Study on Drug Therapy and Clinical Outcomes in Patients With Acute Coronary Syndrome
Registry Study on Drug Therapy and Clinical Outcomes in Patients With Acute Coronary Syndrome
- Trial name
- NCT04184583
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease, Gastroesophageal Reflux Disease
GaStroEsophageal effeCt of indobUfen Versus aspiRin in Patients Undergoing Dual antiplatElet Therapy
The dual antiplatelet therapy based on aspirin plays an important role in the treatment of patients with coronary heart disease.
- Trial name
- SECURE (NCT04129008)
- Testing
- Indobufen and aspirin mimetic, Aspirin and indobufen mimetic
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Bypass Grafting, Myocardial Infarction
ARomatherapy for Cognitive Trajectory in Chinese After Coronary Artery Bypass Grafting
The ARCTIC-CABG (Aromatherapy for Cognitive Trajectory in Chinese after Coronary Artery Bypass Grafting) trial is a randomized, double-blind, 2-arm, parallel group, placebo-controlled study to evaluated the effects of…
- Trial name
- ARCTIC-CABG (NCT04102696)
- Testing
- Aromatherapy
- Volunteers
- 460 people
- Sponsor
- Beijing Anzhen Hospital
Percutaneous Coronary Intervention
ARomatherapy for Cognitive Trajectory in Chinese After Percutaneous Coronary Intervention (ARCTIC-PCI)
The ARCTIC-PCI (Aromatherapy for Cognitive Trajectory in Chinese after Percutaneous Coronary Intervention) trial is a randomized, double-blind, 2-arm, parallel group, placebo-controlled study to evaluated the effects of…
- Trial name
- NCT04103086
- Testing
- Aromatherapy
- Volunteers
- 660 people
- Sponsor
- Beijing Anzhen Hospital
Antiplatelet Therapy, Coronary Artery Disease
LOwer Maintenance Dose TICagrelor in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention
The hypothesis in this study was that ticagrelor switched to 60 mg after 1 month of standard dose, with antiplatelet activity that is not inferior to the standard dose and better than 75 mg clopidogrel for patients with ACS after…
- Conditions
- Antiplatelet Therapy, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- LOTIC (NCT04060914)
- Testing
- Ticagrelor 90mg, Ticagrelor 90mg/60mg, Clopidogrel 75mg
- Where
- China
- Volunteers
- 225 people
- Sponsor
- Beijing Anzhen Hospital