Clinical trials: sponsored by Beijing Friendship Hospital
Drug-induced Liver Injury, Autoimmune Hepatitis
Discrimination of DILI and AIH by Artificial Intelligence
A retrospective, multi-center, non-interventional cohort study has been going to explore whether artificial intelligence can discriminate Drug-induced liver injury and Autoimmune hepatitis.
- Trial name
- NCT05532345
- Where
- China
- Volunteers
- 2,583 people
- Sponsor
- Beijing Friendship Hospital
Colorectal Neoplasms
Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and Thymalfasin for Locally Advanced Mid-low Rectal Cancer
It is a single-center, retrospective, controlled study to investigate the efficacy and safety of neoadjuvant chemoradiotherapy combined with PD-1 inhibitor and thymalfasin for locally advanced mid-low rectal cancer.
- Trial name
- NCT06024356
- Testing
- Thymalfasin
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Beijing Friendship Hospital
Locally Advanced Rectal Adenocarcinoma, Neoadjuvant Chemoradiation
Yang et al. Anti-PD-1/CTLA-4 Dual Immunotherapy for LARC
This is a prospective, multicenter, randomized controlled trial aimed at comparing different radiotherapy fractionation regimens combined with sequential dual immunotherapy versus traditional chemoradiotherapy in neoadjuvant…
- Conditions
- Locally Advanced Rectal Adenocarcinoma, Neoadjuvant Chemoradiation, Neoadjuvant Immunotherapy
- Trial name
- RADICAL (NCT07596290)
- Testing
- Short-course radiotherapy, Long-course radiotherapy, Immunotherapy
- Volunteers
- 342 people
- Sponsor
- Beijing Friendship Hospital
Chronic Diseases, Sub-optimal Health
Real-World Data Linkage Research Platform
This study aims to address the lack of intelligent governance tools in clinical data management to promote efficient governance and secure sharing of real-world health data.
- Trial name
- NCT07635355
- Testing
- This is an observational study. No intervention will be applied.
- Where
- China
- Volunteers
- 300,000 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Osteoporotic Vertebral Compression Fractures, Vertebroplasty
Standardized Study Protocol of Percutaneous Vertebroplasty Based on Pedicle Nine-Grid Zoning Method
The goal of this clinical trial is to verify the safety and efficacy of the pedicle "Nine-grid Zoning Method" in assisting percutaneous vertebroplasty (PVP) for the treatment of lumbar osteoporotic vertebral compression fractures…
- Trial name
- NCT07616583
- Testing
- Nine-grid Area Division Method Assisted PVP, Traditional Standard Percutaneous Vertebroplasty (PVP)
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Beijing Friendship Hospital
Colorectal Cancer Control and Prevention
Prediction Model of Colorectal Adenoma Recurrence-Carcinogenesis Risk With TCM-WM Multimodal Feature Fusion
This project focuses on developing a risk prediction model for the recurrence and malignant transformation of colorectal adenomas by integrating multimodal features from both Traditional Chinese Medicine (TCM) and Western…
- Trial name
- NCT07611266
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Friendship Hospital
Rectal Cancer
Rectal Cancer Neoadjuvant Therapy-Real World Study
This study aims to utilise a real-world data platform to integrate multi-omics data-including radiomics, gut microbiota, pathological quality control and liquid biopsy-to construct a multidimensional predictive model for the…
- Trial name
- RC-NAT-RWS (NCT07566559)
- Testing
- This study is a multicenter, real-world, non-interventional study.
- Where
- China
- Volunteers
- 869 people
- Sponsor
- Beijing Friendship Hospital
Adebrelimab, Adenocarcinoma of GE Junction
Adebrelimab Plus Apatinib Combined With SOX Regimen as Conversion Therapy for Gastric Cancer
This is a prospective, single-center, single-arm, open phase II clinical study. Forty-nine participants with pathologically or cytologically confirmed gastric cancer or gastroesophageal junction cancer are scheduled to be…
- Conditions
- Adebrelimab, Adenocarcinoma of GE Junction, Adenocarcinoma of Stomach
- Trial name
- NCT07353684
- Testing
- Adebrelimab, Apatinib, SOX Chemotherapy
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Beijing Friendship Hospital
Locally Advanced Rectal Cancer (LARC)
Application and Exploration of Personalized ctDNA-MRD Detection Technology in Predicting the Efficacy of Neoadjuvant Therapy for Rectal Cancer
This study is a single-center, prospective, observational clinical trial enrolling patients with locally advanced rectal cancer (cT3-4aN0M0 and cT1-4aN1-2M0).
- Trial name
- ctDNA-MRD-RC (NCT07393048)
- Testing
- Personalized ctDNA-MRD Detection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Friendship Hospital
Liver Failure, Small-for-Size Syndrome
Safety and Tolerability Study of a Novel Bioartificial Liver in Liver Failure and Small-for-Size Syndrome
The goal of this clinical trial is to evaluate the safety and tolerability of a novel bioartificial liver (CiPS-BAL) in patients with liver failure or small-for-size syndrome.
- Trial name
- NCT07312864
- Testing
- Chemically induced pluripotent stem cells biological Artificial Liver
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Beijing Friendship Hospital
Restless Leg Syndrome (RLS), Variant Restless Legs Syndrome
Novel Calcium Channel Modulators in RLS and Variants: Efficacy & Safety
The goal of this [study type: clinical trial] is to [primary purpose: evaluate the efficacy and safety of a novel calcium channel modulator in treating Restless Legs Syndrome (RLS) and its variant subtypes] in [describe…
- Trial name
- NCT07453862
- Testing
- Crisugabalin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Friendship Hospital
Hepatitis B Virus Related Cirrhosis, Portal Hypertension Related to Cirrhosis
Hepatic and Splenic Microcirculatory Perfusion for Ruling Out High-Risk Varices in Patients With Hepatitis B-Related Cirrhosis
Background: Chronic hepatitis B (CHB)-related cirrhosis is a common cause of portal hypertension, which leads to the development of gastroesophageal varices (EGVs).
- Conditions
- Hepatitis B Virus Related Cirrhosis, Portal Hypertension Related to Cirrhosis, Esophagogastric Varices
- Trial name
- NCT07450651
- Volunteers
- 150 people
- Sponsor
- Beijing Friendship Hospital
Anesthesia
Adverse Cardiovascular Events During Painless Gastroscopy Diagnosis and Treatment in Elderly Frail Patients
This study aims to compare the effects of conscious sedation and intravenous general anesthesia on cardiovascular events in frail patients undergoing digestive endoscopy diagnosis and treatment.
- Trial name
- frail (NCT06192082)
- Testing
- The conscious sedation group, Intravenous general anesthesia group
- Where
- China
- Volunteers
- 226 people
- Sponsor
- Beijing Friendship Hospital
Rectal Cancer, Adenocarcinoma, Rectal Cancer Stage II
Short-Course Radiotherapy Combined With Chemotherapy and Immunotherapy in Mid-Low Locally Advanced Rectal Cancer
The goal of this clinical trial is to test a new combination treatment for locally advanced rectal cancer (cancer in the lower or middle part of the rectum that has not spread to distant organs).
- Conditions
- Rectal Cancer, Adenocarcinoma, Rectal Cancer Stage II, Rectal Cancer Stage III
- Trial name
- NCT07397442
- Testing
- Short-Course Radiotherapy Combined with Chemotherapy and Immunotherapy
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Beijing Friendship Hospital
Idiopathic Membranous Nephropathy
Rivaroxaban in Idiopathic Membranous Nephropathy
Through a prospective, single-center, randomized controlled trial, we aim to determine the thromboprophylactic efficacy of rivaroxaban in patients with idiopathic membranous nephropathy (IMN).
- Trial name
- NCT07404436
- Testing
- Rivaroxaban 10 MG, Warfarin Sodium
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Beijing Friendship Hospital
Sub-healthy
Data Mining of Population Health-sub-health-disease Based on Dynamic System Theory
This study aims to explore the dynamic evolution patterns of population health, sub-health, and disease states through dynamic system theory and big data mining methods, providing scientific evidence for personalized prevention…
- Trial name
- NCT07375303
- Testing
- No intervention will be applied.
- Where
- China
- Volunteers
- 380,000 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Chronic Kidney Diseases
Eye-Brain-Kidney in CKD
The goal of this observational study is to learn about the interaction between the eyes, brain, and kidneys in adult patients with Chronic Kidney Disease (CKD).
- Trial name
- NCT07358572
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Friendship Hospital
Lymphohistiocytosis, EBV
Golidocitinib Combined With Selinexor for CAEBVD
This study is a multicenter, prospective, single-arm clinical investigation, with patients with CAEBVD as the main research subjects, to evaluate the effectiveness of the combined treatment regimen of golidocitinib and selinexor.
- Conditions
- Lymphohistiocytosis, EBV, CAEBV
- Trial name
- NCT07369739
- Testing
- golidocitinib, Selinexor (combination therapy)
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Beijing Friendship Hospital
Lymphohistiocytosis, Hemophagocytic
Prospective Single-Arm Clinical Trial of GO Regimen for HLH.
This study aims to investigate the efficacy and safety of Golidocitinib(GO) monotherapy in the treatment of hemophagocytic lymphohistiocytosis.
- Trial name
- NCT07339345
- Testing
- Golidocitinib
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Beijing Friendship Hospital
Locally Advanced Rectal Carcinoma
A Series of Neoadjuvant Chemoradiotherapy Combined With Immunotherapy for Locally Advanced Rectal Cancer
The goal of this clinical trial is to compare the efficacy and safety of neoadjuvant chemoradiotherapy combined with tirelizumab compared with neoadjuvant chemoradiotherapy alone for neoadjuvant therapy in patients with locally…
- Trial name
- NCT06312982
- Testing
- Tislelizumab
- Where
- 2 sites in China
- Volunteers
- 375 people
- Sponsor
- Beijing Friendship Hospital