Clinical trials: sponsored by Beijing Friendship Hospital
Carbapenem Resistant Bacterial Infection, Hemophagocytic Lymphohistiocytoses
Efficacy and Safety of Carrimycin Tablets in HLH Patients With Carbapenem-resistant Infections
This study aimed to investigate the efficacy and safety of Carrimycin tablets in hemophagocytic lymphohistiocytosis patients with Carbapenem-resistant infections.
- Trial name
- NCT05988177
- Testing
- Carrimycin tablets
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Friendship Hospital
Maintenance Hemodialysis
Changes of Cognitive Function and Brain Magnetic Resonance in Maintenance Hemodialysis Patients With Diabetes Mellitus
In recent years, due to the frequent occurrence of kidney disease and diabetes, the number of patients entering maintenance hemodialysis is increasing.
- Trial name
- NCT05953818
- Testing
- Chinese version of the Montreal Cognitive Assessment Scale (MoCA) and brain magnetic resonance high resolution structural imaging
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Beijing Friendship Hospital
Chronic Active Epstein-Barr Virus Infection, Virus-Associated Hemophagocytic Syndrome
Clinical Study of Donor EBV-CTL Infusion in Patients With CAEBV and EBV-HLH After Allo-HSCT
To evaluate the efficacy and safety of donor EBV-specific T lymphocytes (EBV-CTL) infusion in patients with chronic active Epstein-Barr virus infection (CAEBV) and EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH) after…
- Trial name
- NCT05532826
- Testing
- donor EBV-specific T lymphocytes
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Beijing Friendship Hospital
Primary Sclerosing Cholangitis
PSC Clinical Epidemiology in China
Primary sclerosing cholangitis (PSC) is a rare disease but is increasingly reported in China (mainly in the Chinese language). However, most of the PSC literatures reported from China are case reports, small case series, and…
- Trial name
- NCT04981756
- Testing
- observation
- Where
- 3 sites in China
- Volunteers
- 800 people
- Sponsor
- Beijing Friendship Hospital
Obesity
Efficacy and Safety of the Gastric Bypass Stent System on Body Weight and Metabolic Parameters in Obese Patients
In this study, the investigators use a novel endoscopic duodenal-jejunal bypass liner-the Gastric Bypass Stent System (Hangzhou Tangji Medical Technology Co., Ltd., China) for the treatment of obesity.
- Trial name
- NCT05864911
- Testing
- the Gastric Bypass Stent System
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Beijing Friendship Hospital
Pulsatile Tinnitus
The Recurrence Mechanism of Venous Tinnitus After Boney Wall Reconstruction Based on Multimodal Imaging and Multiphysics Coupling
Venous tinnitus (VT) is seriously affecting the quality of life of five million patients in China. Bony wall reconstruction is the main treatment method, but the postoperative recurrence rate exceeds 30%, and the specific…
- Trial name
- NCT05856175
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
HLH
Thiotepa Incorporating TBI/Cy Conditioning Regimen for EBV-HLH With Central Nervous System Involvement
EBV-HLH is the most common in virus-associated hemophagocytic syndrome (VAHS). There are no uniform clinical criteria for the diagnosis of CNS-HLH.
- Trial name
- NCT05854225
- Testing
- Thiotepa
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Friendship Hospital
Locally Advanced Rectal Cancer
Total Neoadjuvant Therapy Combined With Tislelizumab for Local Advanced of Middle and Low Rectal Cancer
This study is a prospective, randomized, open, controlled, multi-center phase II clinical trial, which included patients with locally advanced low rectal cancer as the research object, and evaluated the application of long-term…
- Trial name
- NCT05845268
- Testing
- Long-course chemoradiation, with Tislelizumab (PD-1 inhibitor), Long-course chemoradiation, without Tislelizumab (PD-1 inhibitor)
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Beijing Friendship Hospital
Secondary Hemophagocytic Lymphohistiocytosis, Chronic Active Epstein-Barr Virus Infection
Prospective Study of Immune Function and PD-1 Antibody Therapy Efficacy Predictors on CAEBV and EBV-HLH Patients
This prospective case-control study aims to evaluate the immune function and find PD-1 antibody efficacy predictors on Chronic Active Epstein-Barr Virus Infection and Epstein-Barr virus-associated hemophagocytic…
- Trial name
- NCT05841342
- Testing
- No intervention
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Stage II Breast Cancer, Stage I Breast Cancer
Comparison Between Prepectoral and Subpectoral Breast Reconstruction
There are controversies about breast implant-based reconstruction techniques. Our center pioneered single-port insufflation endoscopic nipple-sparing mastectomy (SIE-NSM) combined with stage I prosthesis reconstruction.
- Trial name
- RESPECT (NCT05833659)
- Testing
- The breast reconstruction method after single-port insufflation endoscopic nipple-sparing mastectomy
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Beijing Friendship Hospital
Advanced Solid Tumor
Gut Microbial Metabolites Inosine Combined With PD-1/PD-L1 Inhibitor for Patients With Malignant Advanced Solid Tumors
We conducted a single-center, prospective randomized ,Parallel controls, open labels Clinical Studies,The study is about Gut Microbial Metabolites Inosine Combined With PD-1/PD-L1 Inhibitor for Patients with malignant Advanced…
- Trial name
- NCT05809336
- Testing
- Inosine 0.2g orally 3 times/day, PD-1/PD-L1 inhibitor ,chemotherapy/targeting
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Beijing Friendship Hospital
Chronic Hepatitis b, Non-Alcoholic Fatty Liver Disease
Comparison of Hepatus and FibroScan for Evaluation of Fibrosis and Steatosis
Totals of 400 chronic hepatitis B or non-alcoholic fatty liver disease (NAFLD) patients with or without cirrhosis will be enrolled.
- Trial name
- NCT05786963
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Friendship Hospital
Idiopathic Membranous Nephropathy
Efficacy of Rituximab Combined With Cyclosporine in the Treatment of Idiopathic Membranous Nephropathy
Idiopathic membranous nephropathy (IMN) is one of the common types of primary glomerular diseases and the most common cause of nephrotic syndrome in adults.
- Trial name
- NCT05782933
- Testing
- Rituximab, Modified Ponticelli regimen
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Beijing Friendship Hospital
Esophageal Carcinoma, Neoadjuvant Immunotherapy
Neoadjuvant Therapy of PD-1 Blockade Combined With Chemotherapy for Esophageal Carcinoma
This prospective study aims to clarify the clinical efficacy and survival prognosis of neoadjuvant immune checkpoint inhibitor (ICI) combined with chemotherapy for esophageal cancer.
- Trial name
- NCT05777707
- Testing
- PD-1 blockade, Albumin paclitaxel, Carboplatin/Nedaplatin
- Where
- China
- Volunteers
- 89 people
- Sponsor
- Beijing Friendship Hospital
Parkinson Disease, Parkinsonian Disorders
Role and Mechanism of Probiotics in Improving Motor Symptoms in Mild to Moderate Parkinson's Disease
This study is a multicenter randomized double-blind placebo-controlled study. The research content is 1. The improvement effect of Bifidobacterium triple viable capsules（BIFICO） on motor symptoms and constipation and sleep in…
- Conditions
- Parkinson Disease, Parkinsonian Disorders, Basal Ganglia Diseases, Brain Diseases
- Trial name
- NCT04871464
- Testing
- Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules
- Where
- 10 sites in China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
IgG4 Related Disease
Study to Evaluate the Efficacy and Safety of CM310 in Subjects With IgG4-related Disease
This study is a single-arm study initiated to evaluate the efficacy and safety of CM310 in subjects with recurrent IgG4-related disease.
- Trial name
- NCT05728684
- Testing
- CM310
- Volunteers
- 20 people
- Sponsor
- Beijing Friendship Hospital
Idiopathic Membranous Nephropathy
COVID-19 Infection and Idiopathic Membranous Nephropathy
Infection is one of common risk factors for relapsing of idiopathic membranous nephropathy (IMN). However, it is still unclear wheather COVID-19 infection can induce the relapsing of IMN.
- Trial name
- NCT05691179
- Where
- 3 sites in China
- Volunteers
- 130 people
- Sponsor
- Beijing Friendship Hospital
Maintenance Hemodialysis, Older Patient
A New Risk Score for Predicting 1-year Mortality in Older r Maintenance Hemodialysis Patients.
The goal of this retrospective observational cohort study is to analysis the 1-year mortality in older patients undergoing maintenance hemodialysis.
- Trial name
- NCT05699447
- Volunteers
- 1,500 people
- Sponsor
- Beijing Friendship Hospital
Hemophagocytic Lymphohistiocytoses, EBV
Response Prediction in EBV-HLH Using Metabonomics Analysis
Hemophagocytic lymphohistiocytosis (HLH) is a rare, poorly recognized and underdiagnosed syndrome of excessive immune activation, which is rapidly fatal.
- Conditions
- Hemophagocytic Lymphohistiocytoses, EBV, Metabonomics
- Trial name
- NCT05677178
- Testing
- observational
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Friendship Hospital
Cirrhosis, Liver, Portal Hypertension
Carvedilol for Prevention of Esophageal Varices Progression
Carvedilol has been shown to be more potent in decreasing portal hypertension to propranolol. But the efficacy of carvedilol to delay the growth of esophageal varices in chronic hepatitis B patients was unclear.
- Trial name
- Carvedilol (NCT03736265)
- Testing
- Carvedilol
- Where
- 6 sites in China
- Volunteers
- 240 people
- Sponsor
- Beijing Friendship Hospital