Clinical trials: sponsored by Beijing Tiantan Hospital
Amyotrophic Lateral Sclerosis (ALS)
Study on the Safety and Efficacy of RAG-21 in the Treatment of Amyotrophic Lateral Sclerosis Patients With FUS Gene Mutations
Amyotrophic lateral sclerosis (ALS) is a chronic progressive neurodegenerative disease that remains incurable, with limited existing therapies or drugs available. Familial ALS can be caused by mutations in various genes.
- Trial name
- RAG-21-FUS-ALS (NCT07080801)
- Testing
- RAG-21
- Volunteers
- 6 people
- Sponsor
- Beijing Tiantan Hospital
ALS (Amyotrophic Lateral Sclerosis)
Extended Study of RAG-17 in the Treatment of Amyotrophic Lateral Sclerosis Patients With SOD1 Gene Mutation
This study primarily evaluates the safety, tolerability, and efficacy of RAG - 17 in adult ALS patients with SOD1 - mutated genes in the real - world setting.
- Trial name
- NCT07077668
- Testing
- A sterile aqueous solution of RAG - 17 preparation (sodium salt)
- Volunteers
- 10 people
- Sponsor
- Beijing Tiantan Hospital
Anesthesia, Neurosurgery
Study of Post-anesthesia Management in Patients Undergoing Neurosurgery
The postoperative complications of neurosurgery are various and complex, which brings heavy economic and social burden to families.
- Conditions
- Anesthesia, Neurosurgery, Complication
- Trial name
- NCT04362709
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Tiantan Hospital
Pain Management, Spine Surgery
Minimum Effective Dose of Incisional Local Infiltration Betamethasone for the Prevention of Pain After Spinal Surgery
Incisional pain is a common complication after surgery and is an important cause of delayed postoperative recovery, increased length of hospital stay, increased risk of wound infection and respiratory/cardiovascular…
- Trial name
- NCT06785350
- Testing
- 0.012%diprospan+0.5%ropivacaine, 0.009%diprospan+0.5%ropivacaine, 0.006%diprospan+0.5ropivacaine
- Where
- China
- Volunteers
- 535 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Vascular Accident
PROpranolol for Cerebral Hemorrhage-ASsociated pnEumonia (PRO-CHASE)
Stroke-associated pneumonia (SAP) is a grave complication of stroke and one of the most important predictors for patients' poor outcomes.
- Conditions
- Stroke, Vascular Accident, Intracranial Hemorrhages, Intracerebral Hemorrhage
- Trial name
- PRO-CHASE (NCT05419193)
- Testing
- Propranolol Hydrochloride, control group
- Where
- 12 sites in China
- Volunteers
- 168 people
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Hemorrhage, Cerebrovascular Disorders
Remote Ischemic Conditioning for Efficacy in Patients With Aneurysmal Subarachnoid Hemorrhage
Several recent large-scale clinical trials aimed at improving subarachnoid hemorrhage(SAH) outcomes have concluded with negative results, failing to enhance the prognosis for these patients.
- Conditions
- Subarachnoid Hemorrhage, Cerebrovascular Disorders, Brain Diseases, Stroke
- Trial name
- REPAIR (NCT06711302)
- Testing
- Remote Ischemic Conditioning treatment instrument
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Tiantan Hospital
Alzheimers Disease
Deep Cervical Lymphatic Venous Anastomosis in the Treatment of Alzheimer's Disease (CLEAN-AD Registry)
This multicenter, prospective registry is to evaluate the efficacy and safety of deep cervical lymphatic venous anastomosis (DC-LVA) in reduing the clinical dementia rating-sum of boxes (CDR-SB) score of Alzheimer's Disease (AD)…
- Trial name
- NCT07058129
- Testing
- Deep cervical lymphatic venous anastomosis
- Where
- China
- Volunteers
- 814 people
- Sponsor
- Beijing Tiantan Hospital
Glossopharyngeal Neuralgia, Pulsed Radiofrequency
Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet Rich Plasma to Treat Idiopathic Glossopharyngeal Neuralgia (GPN)
To investigate the efficacy and safety of the application of PRF combined PRP to the for the treatment of GPN.
- Conditions
- Glossopharyngeal Neuralgia, Pulsed Radiofrequency, Platelet Rich Plasma
- Trial name
- NCT06931457
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Colchicine for Secondary Prevention After Ischemic Stroke (CHANCE-3 EX)
The role of colchicine in the secondary prevention of ischemic stroke has not been determinded. This multicenter, randomized, double-blind, placebo-controlled, event-driven clinical trial of CHANCE-3 EX was aimed to assess the…
- Trial name
- NCT07035405
- Testing
- Colchicine 0.5 mg
- Volunteers
- 7,500 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Y-6 Sublingual Tablets for Patients With Acute Ischemic Stroke
This study aims to evaluate the efficacy of Y-6 sublingual tablets in improving microcirculation dysfunction and reducing thrombo-inflammation in patients who had AIS caused by LVO and will receive EVT.
- Trial name
- NCT07040085
- Testing
- Y-6
- Volunteers
- 892 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Arteriosclerosis, Stroke (CVA) or TIA
Evaluating the Safety and Efficacy of the Maurora® DES in ICAS
The purpose of the RCT trial is to evaluate whether implantation of drug-eluting stent (DES) is more efficacious than bare metal stent (BMS) in prevention of in-stent restenosis (ISR) and improvement of outcomes for symptomatic…
- Trial name
- Maurora ICAS (NCT05719883)
- Testing
- Maurora® Sirolimus Eluting Stent System, APOLLO™ Intracranial Stent System
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Beijing Tiantan Hospital
Cavernous Malformation, Cerebral
Daratumumab for Familial Cerebral Cavernous Malformations: A Single-Arm Safety and Efficacy Study
Cerebral cavernous malformation (CCM) is a common vascular abnormality of the brain, affecting 0.1%-0.5% of people. It often causes recurrent brain hemorrhages, epilepsy, and neurological impairments, with surgery being the main…
- Trial name
- CCM-DS01 (NCT07026604)
- Testing
- Daratumumab
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing Tiantan Hospital
Parkinson Disease, Deep Brain Stimulation
Impact of Frequency-specific Subthalamic Nucleus Subregion Stimulation on Inhibitory Control in Parkinson's Disease
The core symptoms of Parkinson's disease (PD) include both motor and non-motor symptoms. Cognitive impairment is one of the most common non-motor symptoms in PD patients, with approximately 30% of patients exhibiting cognitive…
- Trial name
- NCT07022522
- Testing
- 5Hz stimulation on the STN motor subregion, 5Hz stimulation on the STN associative subregion, 130Hz stimulation on the STN motor subregion
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Tiantan Hospital
Healthy Male and Female Subjects
To Evaluate the Effect of Food on the Pharmacokinetics of Y-4 Tablets in Healthy Subjects
Y-4 is a new fixed-dose combination drug product containing two active ingredients of pregabalin and riluzole. The objective is to assess the effect of food on the pharmacokinetics (PK) of pregabalin and riluzole in healthy adult…
- Trial name
- Y-4-LC-03 (NCT07013773)
- Testing
- Y-4 tablet
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Brain Glioma, Midazolam
The Effects of Mild Sedation on Motor Function Networks in Patients With Brian Gliomas
It has been shown through functional MRI (Magnetic Resonance Imaging) that patients with gliomas in eloquent areas have compensated neurological function by virtue of brain post-injury reorganization.
- Conditions
- Brain Glioma, Midazolam, Dexmedetomidine
- Trial name
- NCT03984240
- Testing
- Midazolam, Dexmedetomidine
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Parkinson's Disease and Parkinsonism
Mechanism and Application of DBS in the Treatment of PD
Project name: The mechanism and application of deep brain stimulation in the treatment of Parkinson's disease Objective: To test the hypothesis that electrical stimulation of substantia nigra regulates cognitive dysfunction in…
- Trial name
- NCT06400017
- Testing
- microelectrode stimulation of DBS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Acute Hemorrhagic Stroke
AI-Driven Early Warning System for Perioperative Risks in Acute Hemorrhagic Stroke
Acute hemorrhagic cerebrovascular disease is a life-threatening condition characterized by sudden onset, rapid progression, multiple complications, poor prognosis, and high mortality.
- Trial name
- NCT06998082
- Where
- China
- Volunteers
- 1,533 people
- Sponsor
- Beijing Tiantan Hospital
Tourette Syndrome, Deep Brain Stimulation
Multitarget Stereotactic Electrophysiological Recording and Stimulation for Tourette Syndrome
The goal of this clinical trial is to investigate the neural mechanisms underlying Tourette syndrome (TS) and see if personalized deep brain stimulation (DBS) can help reduce tics in TS patients and improve related issues like…
- Trial name
- MASTERS-TS (NCT06889480)
- Testing
- New Target DBS, CM-DBS
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
Population-based Investigation of Aneurysm Incidence
Most intracranial aneurysms are found accidentally in neurovascular imaging. And these inspection methods are limited by the problems of instrument fixation, radiation, time-consuming, contrast agent toxicity and so on.
- Trial name
- NCT06412783
- Testing
- blood test
- Where
- China
- Volunteers
- 4,711 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Acute
Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke
The aim of this study was to evaluate the efficacy and safety of Minocycline versus placebo in the treatment of patients with moderate to severe acute ischemic stroke.
- Trial name
- EMPHASIS (NCT05836740)
- Testing
- Minocycline hydrochloride capsule
- Where
- 58 sites in China
- Volunteers
- 1,724 people
- Sponsor
- Beijing Tiantan Hospital