Clinical trials: sponsored by Beijing Tiantan Hospital
Cerebrovascular Disease
Application of QDSA Platform in Cerebrovascular Diseases
Cerebrovascular diseases pose a major global public health challenge, characterized by exceptionally high mortality and disability rates, with their pathogenesis closely linked to hemodynamic abnormalities.
- Trial name
- RADAR (NCT06902415)
- Testing
- QDSA (Quantitative Digital Subtraction Angiography)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Tiantan Hospital
Asymptomatic Carotid Artery Stenosis
Efficacy and Safety Study of Endovascular Treatment of Asymptomatic Carotid Artery Stenosis
This study is a multicenter, prospective, open-label, endpoint-blinded, randomized controlled trial designed to evaluate the safety and efficacy of endovascular stenting combined with optimal medical therapy versus optimal…
- Trial name
- NCT06899399
- Testing
- Endovascular treatment, Best medical treatment
- Where
- China
- Volunteers
- 982 people
- Sponsor
- Beijing Tiantan Hospital
Cluster Headache, Pain Management
Pulsed Radiofrequency Combined With Platelet-Rich Plasma Applied to the Sphenopalatine Ganglion in Treating Episodic Cluster Headache
Cluster headache (CH) is one of the most severe pain accompanied by ipsilateral autonomic symptoms such as lacrimation and conjunctival injection.
- Conditions
- Cluster Headache, Pain Management, Episodic Cluster Headache
- Trial name
- NCT06882278
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Beijing Tiantan Hospital
Supratentorial Tumors
Opioid-free Anesthesia Protocol for Neurosurgical Supratentorial Tumor Resection
Opioids have many side effects, such as constipation, urinary retention, itchy skin, respiratory depression, and postoperative nausea and vomiting.
- Trial name
- NCT06607029
- Testing
- the opioid-based control group, the opioid-free anesthesia group
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Beijing Tiantan Hospital
Pain, Postoperative Children
Pre-emptive Infiltration of the Scalp with Diprospan Plus Ropivacaine for Pain After Craniotomy in Children
At present, pediatric postoperative analgesia has not been fully understood and controlled, particularly craniotomy surgery. On the one hand, professional evaluation of postoperative pain for young children is difficult; on the…
- Trial name
- NCT06321354
- Testing
- The diprospan plus ropivacaine group, The ropivacaine group
- Where
- 2 sites in China
- Volunteers
- 108 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Hemorrhages, Cerebrovascular Disorders
Minimally Invasive Surgery and rhTNK-tPA for Intracerebral Hemorrhage Evacuation
The purpose of this trial is to determine the safety of using a combination of robot-assisted stereotactic puncture and clot lysis with rhTNK-tPA to remove intracerebral hemorrhage (ICH) and to provide dose evidence for a phase…
- Conditions
- Intracranial Hemorrhages, Cerebrovascular Disorders, Cerebral Hemorrhage, Hemorrhage
- Trial name
- NCT06668441
- Testing
- Minimally invasive surgery plus low-dose rhTNK-tPA group, Minimally invasive surgery plus medium dose rhTNK-tPA group, Minimally invasive surgery plus high dose rhTNK-tPA group
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Beijing Tiantan Hospital
Seizures, Meningioma
The Safety of Intravenous Tranexamic Acid in Patients Undergoing Supratentorial Meningiomas Resection
Growing evidence of Tranexamic Acid (TXA) being used to reduce blood loss and blood transfusions in various guidelines. However, the adverse effects of TXA especially seizure has always been a problem of concern, especially in…
- Trial name
- STAMP (NCT04595786)
- Testing
- Tranexamic acid, 0.9% saline
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Acute
Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-A )
To compare the door-to-needle time of patients with hyperacute ischemic stroke (within 4.5 hours after the onset of symptoms) managed in a standard stroke unit adherent to guidelines versus managed in Emergency Stroke Unit (a new…
- Trial name
- NCT06492239
- Testing
- Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit adherent to guidelines
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Endarterectomy
Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (TCD Part)
This study was a single-center, exploratory, randomized controlled trial. First, the effects of ephedrine, phenylephrine, or norepinephrine on cerebral blood flow hemodynamics in patients undergoing carotid endarterectomy were…
- Trial name
- NCT05665881
- Testing
- Ephedrine, Phenylephrine, Norepinephrine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Beijing Tiantan Hospital
Intraventricular Hemorrhage
rhTNK-tPA Thrombolytic Removal of Intraventricular Hemorrhage
The purpose of this pilot study is to determine the safety and optimal dose of clot lysis with rhTNK-tPA for intraventricular hemorrhage, using stereotactic guidance for extraventricular drain placement.
- Trial name
- NCT06814964
- Testing
- Low dose group, Medium dose group, High dose group
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Beijing Tiantan Hospital
Infraorbital Neuralgia, Platelet-rich Plasma
The Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet-rich Plasma for Infraorbital Neuralgia
This is a multicenter, prospective, observational, propensity score matching, cohort, and assessor-blinded study designed to compare the effectiveness and safety of PRP injections combined with PRF treatment with PRF alone in…
- Trial name
- NCT06492213
- Testing
- No interventions
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease
Study on the Mechanism of Cognitive Impairment in Patients with Moyamoya Disease
The purpose of this study is to comprehensively evaluate the risk factors for cognitive decline in patients with moyamoya disease, identify imaging target areas associated with cognitive damage in the brain, and explore the…
- Trial name
- NCT06832839
- Testing
- Revascularization
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Postoperative Delirium
Perioperative Dexmedetomidine on Postoperative Delirium in Patients With Brain Tumors
Neurosurgery is a risk factor for delirium. Dexmedetomidine might reduce delirium by reducing neuroinflammation, improving postoperative analgesia and sleep quality.
- Trial name
- NCT06164314
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Beijing Tiantan Hospital
Brain Network Connectivity, Postoperative Delirium
The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma
Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor.
- Conditions
- Brain Network Connectivity, Postoperative Delirium, Dexmedetomidine, Propofol
- Trial name
- NCT06138340
- Testing
- Dexmedetomidine, Propofol, Remimazolam Injection
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Tiantan Hospital
Skull Base Tumor, Postoperative Complications
Postoperative Complications Following Skull Base Tumor Resection
The skull base tumor is located in the deep intracranial layer and is closely related to the brain stem and intracranial nerves. The incidence of postoperative complications after skull base tumor resection is high.
- Trial name
- NCT06587906
- Testing
- Pulmonary ultrasound examination
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Beijing Tiantan Hospital
Myocardial Injury, Trigeminal Cardiac Reflex
Trigeminal Nerve Cardiac Reflex During Resection of Cerebellopontine Angle Tumors and Postoperative Myocardial Injury
Myocardial injury after noncardiac surgery is significantly related to postoperative 30-day mortality. Trigeminal cardiac reflex is one of the main causes of perioperative cardiac emergency.
- Trial name
- NCT05198648
- Testing
- Trigeminal cardiac reflex, Non-trigeminal cardiac reflex
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Oxygen Saturation, Postoperative Delirium
Association Between Local Cerebral Oxygenation Monitoring and Postoperative Delirium in Carotid Endarterectomy
Postoperative delirium (POD) is a common perioperative complication, which can lead to adverse outcomes. Patients undergoing carotid endarterectomy (CEA) were elderly, complicated with vascular risk factors, cognitive…
- Conditions
- Cerebral Oxygen Saturation, Postoperative Delirium, Carotid Endarterectomy
- Trial name
- NCT05198635
- Testing
- local cerebral oxygen saturation
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease
Functional Magnetic Resonance-Based Observations of Brain Networks in Moyamoya Disease Patients Under Anesthesia
Moyamoya disease is characterized by progressive stenosis of the genesis of the distal internal carotid arteries bilaterally and progressive generation of compensatory pathological vascular networks at the basis cranii, and these…
- Trial name
- NCT06041659
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Beijing Tiantan Hospital
Dexmedetomidine, Delirium
Effect of Dexmedetomidine on Postoperative Delirium After Awake Craniotomies
Postoperative delirium (POD) is a common complication, and the incidence of POD ranges from 10% to 60%. Previous studies suggested that frontal approach and tumor located at the temporal lobe were independent risk factors for POD…
- Conditions
- Dexmedetomidine, Delirium, Awake Craniotomy
- Trial name
- NCT05195034
- Testing
- Dexmedetomidine, 0.9% saline
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Beijing Tiantan Hospital
Plexus Block;Analgesia;Neurosurgery
Superficial Cervical Plexus Block for Postoperative Analgesia
The incidence of postoperative pain after craniotomy is high. Severe postoperative pain can lead to a series of complications that are detrimental to the recovery of craniotomy patients.
- Trial name
- NCT04036812
- Testing
- Superficial cervical plexus block, Control group
- Where
- 2 sites in China
- Volunteers
- 106 people
- Sponsor
- Beijing Tiantan Hospital