Clinical trials: sponsored by Beijing Tiantan Hospital
Recurrent High Grade Glioma
PTCs-based Precision Treatment Strategy on Recurrent High-grade Gliomas
This trial is an open-label, single-arm, phase 0/1 study of high-grade glioma that aims to evaluate the feasibility, preliminary efficacy and safety of the precision treatment strategy.
- Trial name
- NCT05473923
- Testing
- Receiving chemotherapeutic or targeted drugs recommended by molecular tumor board.
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Epidemiology, Acute Kidney Injury
Acute Kidney Injury After Craniotomy
The aim of this study was to investigate the incidence, risk factors and prognosis of acute kidney injury (AKI) in critically ill patients after craniotomy.
- Conditions
- Epidemiology, Acute Kidney Injury, Risk Factor
- Trial name
- NCT03789747
- Testing
- As a observational study, there is no intervention.
- Where
- China
- Volunteers
- 143 people
- Sponsor
- Beijing Tiantan Hospital
Post-craniotomy, Critical Illness
Scores in Critically Ill Patients After Craniotomy
This study planned to review patients admitted to three ICU wards at Beijing Tiantan Hospital between 2017 and 2020. It focused on adult patients who had undergone craniotomy and stayed in the ICU for more than 24 hours.
- Conditions
- Post-craniotomy, Critical Illness, Mortality, Severity of Illness Scores
- Trial name
- SCORES (NCT06762184)
- Where
- Chile
- Volunteers
- 1,600 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease
Study on Evaluating the Effectiveness of Statins in the Treatment of Moyamoya Disease
The purpose of this study is to investigate the effectiveness of statins in the treatment of moyamoya disease based on multimodal magnetic resonance imaging.
- Trial name
- SEST-MOYA (NCT06817434)
- Testing
- Revascularization/Conservative management
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Beijing Tiantan Hospital
Headache, Cluster
SPG Pulsed Radiofrequency for Chronic Cluster Headache
Cluster headache (CH) is a devastating disorder characterized by ipsilateral headache and associated trigeminal autonomic symptoms, with a yearly prevalence of 0.1%.
- Trial name
- NCT06787677
- Testing
- PRF, NB
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Beijing Tiantan Hospital
Esketamine, Sleep Disturbance
Esketamine on Postoperative Sleep Disturbance of Patients Undergoing Spinal Surgery
The goal of this clinical trial is to learn about the effect of intraoperative esketamine infusion on postoperative sleep disturbance(PSD) of patients undergoing spinal surgery.
- Conditions
- Esketamine, Sleep Disturbance, Spinal Surgery
- Trial name
- NCT06451627
- Testing
- Esketamine, saline
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Artery Stenosis, Glioma
Detection of Microplastics and Nanoplastics in Neurosurgery Patients (DT-MiNi)
Plastic particles are a ubiquitous pollutant in the living environment and food chain, so far, plenty of studies have reported the internal exposure of microplastics and nanoplastics in human tissues and enclosed body fluids.
- Conditions
- Carotid Artery Stenosis, Glioma, Intracranial Aneurysm, Intracranial Hemorrhages
- Trial name
- DT-MiNi (NCT05968053)
- Testing
- biological samples analysis
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Migraine
Ultrasound-guided Stellate Ganglion Block for Treatment of Chronic Migraine in Adult
To assess the 6-months effects and safety of stellate ganglion block(SGB) for Chronic Migraine (CM) patients who failure to undergo preventive therapy and are seeking a more suitable non-pharmacological therapy.
- Trial name
- NCT06322407
- Testing
- Stellate Ganglion Block (SGB), standardized drug treatment
- Where
- China
- Volunteers
- 206 people
- Sponsor
- Beijing Tiantan Hospital
Pain, Postoperative Children
Pre-emptive Scalp Infiltration with Triamcinolone Acetonide Plus Ropivacaine for Post-Craniotomy Pain in Children
At present, pediatric postoperative analgesia has not been fully understood and controlled, particularly craniotomy surgery. On the one hand, professional evaluation of postoperative pain for young children is difficult; on the…
- Trial name
- NCT06779396
- Testing
- The triamcinolone acetonide plus ropivacaine group, The ropivacaine group
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Beijing Tiantan Hospital
Pituitary Adenoma, Pituitary Neuroendocrine Tumor
Hydrocortisone in Hormone Replacement Therapy for Large Pituitary Neuroendocrine Tumors
The goal of this clinical trial is to assess the need for hydrocortisone replacement therapy during the perioperative period for large pituitary neuroendocrine tumors.
- Trial name
- NCT06679816
- Testing
- Hormone replacement therapy
- Where
- China
- Volunteers
- 882 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Microvascular Dysfunction, Cerebral Small Vessel Diseases
PRospective Observation on CErebral microvaScular Structure and Function
This is a population-based prospective cohort study, aiming to assess the prevalence, distributional characteristics, and dynamic change of cerebral small vessel dysfunction in a Chinese community population using advanced…
- Conditions
- Cerebral Microvascular Dysfunction, Cerebral Small Vessel Diseases, Cognitive Dysfunction, Cerebrovascular Disorders
- Trial name
- PROCESS (NCT06579677)
- Testing
- Without any intervention
- Where
- 2 sites in China
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Chronic Subdural Hematoma
Efficacy and Safety of Chinese Herbal HuoXue LiShui Formula for Chronic Subdural Hematoma
A prospective, randomised, double-blind, placebo-controlled, multicentre trial was designed to compare the the incidence of hematoma progression requiring operation or hematoma recurrence requiring re-operation and improves…
- Trial name
- CHARM (NCT06427980)
- Testing
- Chinese Herbal formula HuoXue LiShui
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Beijing Tiantan Hospital
Hematoma, Subdural, Chronic
Exhaustive Drainage Versus Fixed-time Drainage for Chronic Subdural Hematoma After One-burr Hole Craniostomy
A prospective, multicenter, randomized controlled trial is designed to compare the recurrence rates and clinical outcomes in patients with chronic subdural hematoma using exhaustive drainage or fixed-time drainage after one-burr…
- Trial name
- ECHO (NCT04573387)
- Testing
- Operation, Fixed-time drainage, Exhaustive drainage
- Where
- 17 sites in China
- Volunteers
- 309 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease
Long-term Outcomes of Conservative Management in Patients with Moyamoya Disease and Their First-degree Relatives (LAMORA)
The purpose of this study is to investigate the long-term outcomes of conservative management in patients with moyamoya disease and their first-degree relatives, and provide potential pathogenesis of moyamoya disease.
- Trial name
- NCT05332756
- Testing
- Conservative management
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Tiantan Hospital
Liposome Bupivacaine
Liposomal Bupivacaine for Postoperative Pain After Craniotomy
Acute postoperative pain is a common postoperative adverse reaction. It refers to acute pain that occurs immediately after surgery and usually lasts no longer than 3-7.
- Trial name
- NCT06701539
- Testing
- Liposome bupivacaine group, Ropivacaine group
- Volunteers
- 106 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
Nomogram for Predicting In-stent Stenosis After Pipeline Embolization Device Treatment in Patients With Intracranial Aneurysm
Intracranial aneurysms (IAs) are the primary cause of non-traumatic subarachnoid hemorrhage with high morbidity and mortality. Flow diverters, such as pipeline embolization devices (PEDs), are among the most effective methods for…
- Trial name
- PED-ISS (NCT06715930)
- Testing
- Interventional treatment
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke
Oxygen Concentration Target in Stroke Endovascular Treatment
The goal of this clinical trial is to compare the effects of different concentrations of normobaric oxygen on early neurological improvement in acute ischemic stroke (AIS) patients receiving endovascular therapy (EVT).
- Trial name
- Oxy-TARGET (NCT06224426)
- Testing
- Normobaric high-concentration oxygen, Normobaric low-concentration oxygen
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Tiantan Hospital
Recurrent High Grade Glioma
Recurrent High Grade Glioma Treated by LITT
This clinical trial aims to investigate the efficiency and safety of laser interstitial thermal therapy (LITT) in recurrent high-grade glioma (rHGG) patients.
- Trial name
- REGALITT (NCT06161610)
- Testing
- LITT, Control
- Where
- 9 sites in China
- Volunteers
- 135 people
- Sponsor
- Beijing Tiantan Hospital
Amyotrophic Lateral Sclerosis
Tofacitinib in Patients With Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, of which motor-neuron's degeneration may be associated with neuroinflammation.
- Trial name
- TALENT (NCT06689982)
- Testing
- Tofacitinib tablets
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Beijing Tiantan Hospital
Vertebral Artery Stenosis
Drug Eluting Stenting and Short Dual Antiplatelet Therapy for Preventing Recurrent Stroke in Vertebral Stenosis Registry Study
This is a prospective, multi-center, registry study exploring the duration of dual antiplatelet therapy (DAPT) after drug-eluting stent(DES) treatment of symptomatic vertebral artery atherosclerotic stenosis.
- Trial name
- M Short DAPT (NCT06683300)
- Testing
- DAPT for 3 months after vertebral artery stenting
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Beijing Tiantan Hospital