Clinical trials: sponsored by Beijing Tiantan Hospital
Acute Ischemic Stroke
The Androtriol Injection for the Treatment of Acute Ischemic Stroke
This is a prospective, multicenter, randomized, double-blind, placebo-controlled, phase IIb clinical trial of Androtriol injection for the treatment of acute ischemic stroke.
- Trial name
- NCT06679322
- Testing
- Androtriol Injection (High-dose group), Androtriol Injection (Low-dose group), Hydroxypropyl-β-cyclodextrin injection
- Volunteers
- 300 people
- Sponsor
- Beijing Tiantan Hospital
Extubation Success, Craniofacial Pain Syndrome
The Predictive Value of Peak Cough Flow for Endotracheal Extubation of Patients After Craniotomy
In severe cases after craniotomy, tracheal intubation is often required, and the removal of tracheal intubation presents certain risks and challenges.
- Conditions
- Extubation Success, Craniofacial Pain Syndrome, Cough Peak Flow, Endotracheal Tube
- Trial name
- PCFET (NCT04000997)
- Where
- China
- Volunteers
- 785 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Acute
Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-D )
To compare the prognosis of patients with hyperacute ischemic stroke (arriving at the emergency department between 4.5-6 hours of symptom onset) managed in a standard stroke unit adherent to guidelines versus managed in Emergency…
- Trial name
- NCT06522282
- Testing
- Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Mild
ProUrokinase for Mild Ischemic Cerebrovascular Events (PUMICE)
The purpose of this study is to investigate the safety and efficacy of rhPro-UK (35mg) versus standard medical treatment in acute mild ischemic stroke within 4.5 hours of symptom onset.
- Conditions
- Ischemic Stroke, Mild, Thrombosis
- Trial name
- PUMICE (NCT05507645)
- Testing
- Recombinant Human Prourokinase for Injection (rhPro-UK), standard medical treatment
- Where
- 89 sites in China
- Volunteers
- 1,446 people
- Sponsor
- Beijing Tiantan Hospital
Traumatic Brain Injury
Comparative Effectiveness of Intervention in Multi-level Hospitals for Acute Traumatic Brain Injury(Metric-TBI)
A prospective, multicenter, observational cohort study is designed to compare the effectiveness of intervention in multi-grade hospitals for acute traumatic brain injury and to optimize clinical outcomes.
- Trial name
- NCT06429774
- Testing
- Neurological function, Mental State, cognitive function, and life quality assessment, Peripheral blood test
- Where
- 64 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Communicating Hydrocephalus, Cerebral Intraventricular Hemorrhage
The Safety and Efficacy of Rapamycin on Communicating Hydrocephalus Secondary to Intraventricular Hemorrhage
This prospective, multicenter, open-label clinical trial is designed to evaluate the safety and efficacy of rapamycin in the treatment of communicating hydrocephalus secondary to intraventricular hemorrhage.
- Conditions
- Communicating Hydrocephalus, Cerebral Intraventricular Hemorrhage, Secondary Normal Pressure Hydrocephalus, Post Hemorrhagic Hydrocephalus
- Trial name
- Saturn (NCT06563817)
- Testing
- Rapamycin
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Pain
Electroencephalographic Characteristics of Chronic Pain in Patients With Spinal Cord Injury
The diagnosis of chronic pain currently lacks objective and quantifiable biomarkers. This study aims to observe the EEG characteristics of patients with chronic pain following spinal cord injury and subsequently administer…
- Trial name
- NCT06531837
- Testing
- Esketamine(Continuous infusion), Remifentanil (Target-Controlled Infusion), Flurbiprofen (Single intravenous injection)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Anesthesia, Covert Stroke
A Prospective Cohort Study of Perioperative Covert Stroke and Postoperative Cognitive Dysfunction
With the development of population aging, the incidence of covert stroke gradually increased. Currently, there is still lack of prospective cohort study with large sample size on the relationship between perioperative covert…
- Trial name
- PRECISION (NCT03081429)
- Where
- 2 sites in China
- Volunteers
- 934 people
- Sponsor
- Beijing Tiantan Hospital
PD - Parkinson's Disease, Deep Brain Stimulation
Esketamine in Microelectrode Recording-guided Subthalamic Deep-Brain Stimulation for Parkinson's Disease
Under regional anesthesia, subthalamic nucleus deep brain stimulation (STN-DBS) has proven to be an effective therapeutic approach for improving motor symptoms in Parkinson's disease.
- Conditions
- PD - Parkinson's Disease, Deep Brain Stimulation, Esketamine
- Trial name
- ASPIRE (NCT06543563)
- Testing
- esketamine, normal Saline
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Beijing Tiantan Hospital
Pregnancy-associated or Puerperium-associated Acute Stroke
Clinical Characteristics and Prognosis of Acute Stroke in Pregnancy and Puerperium
The objectives of this study are: (1) to describe the detailed clinical characteristics and prognosis of ASPP patients in order to explore the risk factors of ASPP, and to compare the short-term and long-term functional recovery…
- Trial name
- ASPP (NCT06527807)
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Beijing Tiantan Hospital
Trigeminal Neuralgia
The Efficacy and Safety of Pulsed Radiofrequency Combined With Continuous Radiofrequency for the Trigeminal Neuralgia
Trigeminal neuralgia is a very painful condition, and radiofrequency therapy is reserved for patients who are resistant or intolerant to pharmacological therapy.
- Trial name
- PRFCRF (NCT04174443)
- Testing
- High-voltage pulsed radiofrequency, Low-temperature continuous radiofrequency
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Beijing Tiantan Hospital
Post-anesthesia Recovery
Effects of Esketamine on Recovery of Consciousness After Propofol Anesthesia
Esketamine is an antagonist of N-methyl-d-aspartate (NMDA) receptor different from other gamma-aminobutyric acid (GABA) receptor agonists.
- Trial name
- NCT06430645
- Testing
- Esketamine, Saline
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Post Operative Pain, Oxycodone
Effects of Oxycodone Combined With Pregabalin on Chronic Postsurgical Pain in Spinal Surgery
Chronic postoperative pain is one of the common perioperative complications, which seriously affects the prognosis of patients. Currently, no specific perioperative pain management strategy has been found to be effective in…
- Conditions
- Chronic Post Operative Pain, Oxycodone, Pregabalin, Postoperative Complications
- Trial name
- NCT05795478
- Testing
- Oxycodone and Pregabalin, Pregabalin and NS
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Prognostic Prediction Model of Patients With AcUte Stroke undeRgoing EndOvascular TheRApy (AURORA)
Stroke is the leading cause of disability-adjusted life years (DALYs) in China, imposing a heavy burden on society and families.
- Trial name
- AURORA (NCT06009315)
- Where
- China
- Volunteers
- 949 people
- Sponsor
- Beijing Tiantan Hospital
Disorders of Consciousness
Brain Network Analysis of Anesthesia Characteristics in Patients With pDoC Based on PSG
The goal of this prospective, exploratory and observational study is to learn about in healthy volunteers and patients with prolonged disorders of consciousness(pDoC). The main questions it aims to answer are: 1.
- Trial name
- NCT06157008
- Testing
- General Anesthetics
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Consciousness Disorder
Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness
Consciousness-specific Brain Network Connection of Propofol Sedation and Prolonged Disorders of Consciousness based on Electroencephalography and Auditory Event-related Potentials
- Trial name
- NCT05823454
- Testing
- Different drug dosage
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Sedation
The Effects of Different Anesthetics on Functional Connectivity
This research is a prospective cohort study. The aim of the study is to determine different levels of sedative mechanism and the effect on brain functional connectivity of midazolam, dexmedetomidine and propofol.
- Trial name
- ACTION (NCT03343873)
- Testing
- Midazolam, Propofol, Dexmedetomidine
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Chronic Postsurgical Pain
The Effect of Esketamine Combined With Pregabalin on Chronic Postsurgical Pain in Patients After Craniotomy.
Chronic postsurgical pain (CPSP), which is one of the most common and serious long term complication of surgery，occurs in approximately 10% of patients after a surgical procedure.
- Trial name
- NCT05160493
- Testing
- S-ketamine and pregabalin
- Where
- China
- Volunteers
- 246 people
- Sponsor
- Beijing Tiantan Hospital
PD - Parkinson's Disease, Dexmedetomidine
Choice of Anesthesia in Microelectrode Recording Guided Deep Brain Stimulation for Parkinson's Disease
Subthalamic nucleus (STN)-deep brain stimulation (DBS) under general anesthesia has been applied to PD patients who cannot tolerate awake surgery, but general anesthesia will affect the electrical signal in microelectrode…
- Conditions
- PD - Parkinson's Disease, Dexmedetomidine, Desflurane, Deep Brain Stimulation
- Trial name
- CHAMPION (NCT05550714)
- Testing
- general anesthesia, Conscious sedation
- Where
- China
- Volunteers
- 188 people
- Sponsor
- Beijing Tiantan Hospital
Esketamine, Consciousness Disorders
Effect of Esketamine on Conscious State in Patients With pDoC
The goal of this clinical trial is to learn about the effect of intraoperative infusion of subanesthetic dose of esketamine on conscious status in patients with prolonged disorders of consciousness under sevoflurane anesthesia.
- Trial name
- NCT06389344
- Testing
- Esketamine, normal saline
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Beijing Tiantan Hospital