Clinical trials: sponsored by Beijing Tiantan Hospital
Aneurysmal Subarachnoid Hemorrhage
The Optimal Dose of Mannitol for Intraoperative Brain Relaxation During the Operation of Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) tended to lead to a sudden increase in intracerebral pressure (ICP), which can cause decreased cerebral perfusion and transient global cerebral ischemia.
- Trial name
- ODAS (NCT04135456)
- Testing
- Mannitol
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Beijing Tiantan Hospital
Pain, Postoperative
Scalp Infiltration With Dexamethasone Plus Ropivacaine for Post-craniotomy Pain
According to recent studies, patients following craniotomy suffer more than minimal pain; two-thirds of patients experienced moderate to severe pain. Postoperative pain most often occurs within 48 hours after surgery.
- Trial name
- NCT04488315
- Testing
- Dexamethasone lipid microsphere plus ropivacaine, Ropivacaine alone
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke, Large Vessel Occlusion
EFfects of Y-6 SUblingual Tablets foR PaTients With AcUte Ischemic StRokE (FUTURE)
This study aims to evaluate the efficacy of Y-6 sublingual tablets in improving microcirculation dysfunction and reducing thrombo-inflammation in patients who had AIS caused by LVO and received reperfusion therapy.
- Conditions
- Acute Ischemic Stroke, Large Vessel Occlusion, Reperfusion
- Trial name
- NCT06138834
- Testing
- Low-dose Y-6 sublingual tablets, High-dose Y-6 sublingual tablets, Low-dose Cilostazol
- Volunteers
- 300 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
Guided Antiplatelet Therapy in Interventional Treatment of Intracranial Aneurysms
The use of intracranial stents expands the possibilities for endovascular treatment of intracranial aneurysms and improves the success rate. However, it also increases the risk of ischemic complications in patients.
- Trial name
- GATITIA (NCT05825391)
- Testing
- Adjustment of Antiplatelet Drugs
- Where
- 2 sites in China
- Volunteers
- 590 people
- Sponsor
- Beijing Tiantan Hospital
Esketamine, Pregabaline
Esketamine Combined With Pregabalin on CPSP in Spinal Patients.
Chronic postsurgical pain has become one of the most common complications of surgery. The quality of life will be impacted once the postsurgical patients are combined with persistent pain.
- Conditions
- Esketamine, Pregabaline, Chronic Post Operative Pain
- Trial name
- NCT06117917
- Testing
- S-ketamine and pregabalin
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Propofol, Glioma
Effects of Propofol on Auditory Event-related Potentials and Brain Functional Connectivity in Patients With Supratentorial Glioma
The growth of gliomas often infiltrates important brain tissues and impairs subcortical fiber transmission, resulting in changes in global brain network connectivity.
- Conditions
- Propofol, Glioma, Auditory Event-related Potential (AERP), Electroencephalogram (EEG)
- Trial name
- NCT05352685
- Testing
- Propofol Injection
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Cerebral Small Vessel Diseases, Ischemic Stroke
A Registry Study of Microcirculation Disorder After Cerebral Small Vessel Disease and Ischemic Stroke
This study aims to construct a registry platform for microcirculatory disorders in a large sample of Chinese patients with cerebral small vessel disease and ischemic stroke; To explore the role of microcirculatory disorders in…
- Trial name
- MODEST (NCT06077305)
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Study of Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients With a Large Infarct Core
Endovascular therapy (EVT) was recommended as the primary treatment for patients with acute large vascular occlusion (LVO) in anterior circulation.
- Trial name
- ANGEL-ASPECT (NCT04551664)
- Testing
- Best medical management, Endovascular therapy
- Where
- China
- Volunteers
- 456 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke, Reperfusion
Cilostazol Dexborneol Versus Placebo for Microcirculation Dysfunction After Reperfusion Therapy in Patients With Acute Ischemic Stroke With Large Vessel Occlusion
This study aims to evaluate the efficacy of Y-6 sublingual tablets in improving microcirculation dysfunction and reducing thrombo-inflammation in patients who had AIS caused by LVO and received reperfusion therapy.
- Conditions
- Acute Ischemic Stroke, Reperfusion, Large Vessel Occlusion
- Trial name
- CRYSTAL (NCT05836766)
- Testing
- Y-6 sublingual tablets
- Where
- 3 sites in China
- Volunteers
- 120 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease
Prognostic Prediction Model in Patients With Moyamoya Disease Undergoing Revascularization Surgery
Moyamoya Disease (MMD) is a rare chronic cerebrovascular disease characterized by progressive occlusion of the internal carotid artery or its major branches, with blood flow compensated by the formation of an abnormal vascular…
- Trial name
- NCT06051552
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Heart Disease, Cardiac Arrest
Registry of Multicenter Brain-Heart Comorbidity in China
This study is a multi-center, prospective, registry study. This research was supported by the National Key Research and Development Program.
- Conditions
- Ischemic Heart Disease, Cardiac Arrest, Atrial Fibrillation, Heart Failure
- Trial name
- BHC-C (NCT05961748)
- Testing
- Multi-disciplinary assessment
- Where
- 14 sites in China
- Volunteers
- 100,000 people
- Sponsor
- Beijing Tiantan Hospital
Visual Evoked Potentials
Cyclopol on Electrophysiological Monitoring During Spine Surgery: a Randomized Controlled, Noninferiority Study
Postoperative visual function injury occurs after spinal cord, neurosurgery, ophthalmology and other operations, which directly affects the postoperative quality of life of patients.
- Trial name
- NCT05617690
- Testing
- Cyclopol, Propofol
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Beijing Tiantan Hospital
Brain Arteriovenous Malformations
Evaluation of Clinical Outcomes of Unruptured bAVMs Treated With Medical Management Alone Based on Multimodal CT
The purpose of this study is to investigate the role of multimodal CT in evaluating and predicting different clinical outcomes in patients with unruptured brain arteriovenous malformations with medical management alone.
- Trial name
- NCT05449106
- Where
- 4 sites in China
- Volunteers
- 200 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Endarterectomy
Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (MRI Part)
This study was a single-center, exploratory, randomized controlled trial. First, the effects of ephedrine, phenylephrine, or norepinephrine on cerebral blood flow hemodynamics in CEA patients were evaluated using DSC-MRI to…
- Trial name
- NCT05414877
- Testing
- Ephedrine, Phenylephrine, Norepinephrine
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke, Mechanical Thrombectomy
Treatment of Acute Ischemic STroke With Edaravone Dexborneol II (TASTE-2)
This study is a multicentre, randomized, double-blind, placebo parallel controlled, investigator-sponsored study that aims to investigate the efficacy and safety of Edaravone Dexborneol treatment in patients with acute ischemic…
- Conditions
- Acute Ischemic Stroke, Mechanical Thrombectomy, Edaravone Dexborneol, Phase III
- Trial name
- NCT05249920
- Testing
- Edaravone Dexborneol Concentrated Solution for injection
- Where
- China
- Volunteers
- 1,362 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Randomized Study of Bailout Intracranial Angioplasty Following Thrombectomy for Acute Large Vessel Occlusion
Unfavorable outcomes were associated with failed thrombectomy of acute large vessel occlusions (LVO). The failed thrombectomy rate was 12-41% reported in multiple randomized controlled trials (RCT).
- Trial name
- ANGEL-REBOOT (NCT05122286)
- Testing
- Bailout angioplasty, Standard therapy
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Beijing Tiantan Hospital
Cognitive Impairment
China Alzheimer's and Neurodegenerative Disorder Research
This is a multi-center study that has three cohorts: 1) cognitive normal cohort (CN), 2) Alzheimer's disease cohort (AD) and 3) vascular cognitive impairment cohort (VCI).
- Trial name
- CANDOR (NCT04320368)
- Where
- China
- Volunteers
- 3,100 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Small Vessel Diseases, Postmenopausal Symptoms
Effect of Menopause Hormone Therapy In Postmenopausal Women With CSVD And MCI
The objective of this clinical trial is to explore the efficacy of menopausal hormone therapy in early menopausal women with CSVD and MCI.
- Conditions
- Cerebral Small Vessel Diseases, Postmenopausal Symptoms, Mild Cognitive Impairment, White Matter Hyperintensity
- Trial name
- MIRACLE (NCT05982470)
- Testing
- Estradiol Gel, Progesterone Soft Capsule
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Beijing Tiantan Hospital
Multiple Sclerosis, NMO Spectrum Disorder
China National Registry of Neuro-Inflammatory Diseases
Central nervous system (CNS) idiopathic inflammatory demyelinating diseases (IDD) are mainly diseases caused by autoimmune factors that result in CNS demyelination damage and loss.
- Conditions
- Multiple Sclerosis, NMO Spectrum Disorder, Clinically Isolated Syndrome, CNS Demyelinating Autoimmune Diseases
- Trial name
- CNRID (NCT05154370)
- Testing
- Intravenous steroid
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Acute
Efficacy and Safety of Sarecycline in Patients With Acute Ischemic Stroke After Reperfusion Therapy
The aim of this study was to evaluate the efficacy and safety of Sarecycline versus placebo in the treatment of microcirculation dysfunction after reperfusion therapy in patients with large vessel occlusion stroke.
- Trial name
- ESPRIT (NCT05836753)
- Testing
- Sarecycline Tablet
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Tiantan Hospital