Clinical trials: sponsored by Beijing Tiantan Hospital
Intracerebral Hemorrhage
Clinical Diagnosis and Treatment of Intracerebral Hemorrhage Based on Artificial Intelligence
The purpose of this study is to test the reliability and validity of an artificial intelligence system and a related 5-score scale to predict hematoma expansion, and conduct a study cohort of intracerebral hemorrhage to screen…
- Trial name
- CATCH-AI (NCT04951570)
- Where
- China
- Volunteers
- 1,374 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-Ⅲ）
The trial is prospective, randomized, open-label, blinded endpoint (PROBE) design. Patients with acute ischemic stroke, who are eligible for standard intravenous thrombolysis within 4.5 hours of stroke onset will be randomized…
- Trial name
- NCT05745259
- Testing
- Alteplase, Tenecteplase
- Where
- 63 sites in China
- Volunteers
- 1,630 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Ischemic
Tenecteplase REperfusion in Acute Ischemic sTroke Registry（TREAT）
The aim of the study was to establish tenecteplase thrombolysis database and to investigate the effectiveness and safety of rhTNK-tPA in acute ischemic stroke patients.
- Trial name
- NCT05724342
- Testing
- rhTNK-tPA Thrombolysis
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Beijing Tiantan Hospital
Anesthesia, Postoperative Delirium
Postoperative Delirium and Its Biomarkers in Elderly Patients Undergoing Non-cardiac and Non-neurosurgery.
Postoperative delirium (POD) is a common complication in elderly patients and is associated with negative clinical outcomes, such as prolonged hospitalizations, cognitive impairment, and higher mortality rate.
- Trial name
- NCT05177159
- Testing
- The regional cerebral oxygen saturation (rSO2), The glial fibrillary acidic protein (GFAP), The brain-derived-neurotrophic factor (BDNF)
- Where
- China
- Volunteers
- 417 people
- Sponsor
- Beijing Tiantan Hospital
Medulloblastoma, Childhood
Establishment and Clinical Application of Risk Classification Model Based on Molecular Typing of Medulloblastoma in Children
The purpose of this study:(1) Development of a new risk classification model for childhood medulloblastoma. (2) Evaluation and improvement of existing individualized treatment protocols.
- Trial name
- NCT05406947
- Testing
- Prospective observational study, no intervention
- Volunteers
- 350 people
- Sponsor
- Beijing Tiantan Hospital
Electroencephalography
EEG Characteristics of Different Sedation Depths in Neurosurgery Patients
Gliomas are the most common primary intracranial malignancy, and behavioral experiments in patients with supratentorial gliomas under sedation have shown potential neurological abnormalities; however, these behavioral experiments…
- Trial name
- NCT04365777
- Testing
- OAA/S=5, OAA/S=3, OAA/S=1
- Where
- 2 sites in China
- Volunteers
- 42 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Dengzhanxixin Injection for Acute Ischemic Stroke Receiving Reperfusion Therapy
To assess the Efficacy and Safety of Dengzhanxixin Injection in Patients With Acute Ischemic Stroke Receiving Reperfusion Therapy.
- Trial name
- NCT05700097
- Testing
- Dengzhanxixin Injection
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing Tiantan Hospital
Respiratory Infection Virus, Respiratory Failure
Sivelestat for Acute Respiratory Distress Syndrome Due to COVID-19
A randomized, double-Blind, placebo-controlled trial aimed to investigate the safety and efficacy of sivelestat on treating adult patients with COVID-19-related acute respiratory distress syndrome (ARDS)
- Trial name
- NCT05697016
- Testing
- Sivelestat Sodium for Injection
- Volunteers
- 238 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-Ⅱ
A Phase Ⅲ, Multicenter, Prospective, Randomized, Open Label, Blinded-endpoint (PROBE) Controlled Trial of Recombinant Human TNK Tissue-type Plasminogen Activator (rhTNK-tPA) for Injection Versus Alteplase for Acute Ischemic…
- Trial name
- TRACEⅡ (NCT04797013)
- Testing
- rt-PA, rhTNK-tPA
- Where
- 61 sites in China
- Volunteers
- 1,430 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Indobufen
INdobufen Versus aSpirin in acUte Ischemic stRokE,INSURE
China has the largest burden of cerebrovascular disease in the world. About 60% to 80% of which are ischemic stroke. In recent years, stroke has replaced heart disease and tumor diseases as the first cause of death and disability…
- Conditions
- Ischemic Stroke, Indobufen, Aspirin
- Trial name
- NCT03871517
- Testing
- Indobufen, Aspirin
- Where
- China
- Volunteers
- 5,438 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Revascularization
Cerebral Autoregulation Guiding Blood Pressure Management After Revascularization
This clinical trial aims to learn whether blood pressure (BP) guided by individualized cerebral autoregulation (CA) is safe and provides a better prognosis than a fixed target in patients with ischemic stroke after endovascular…
- Conditions
- Ischemic Stroke, Revascularization, Blood Pressure, Cerebrovascular Insufficiency
- Trial name
- RESCUE-CA (NCT05670028)
- Testing
- Hypotensive Drugs and/or Vasoactive Drugs
- Volunteers
- 100 people
- Sponsor
- Beijing Tiantan Hospital
Medulloblastoma, Central Nervous System Tumor, Pediatric
Genetic and Molecular Risk Profiles of Pediatric Malignant Brain Tumors in China
Primary malignant central nervous system (CNS) tumors are the second most common childhood malignancies. Amongst, medulloblastomas are the most common malignant brain tumor of childhood and occur primarily in the cerebellum.
- Conditions
- Medulloblastoma, Central Nervous System Tumor, Pediatric, Ependymoma, Germ Cell Tumor
- Trial name
- GRIPP (NCT05672043)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Tiantan Hospital
Recurrent Glioblastoma
LITT Combined With Early Use of Temozolomide for Recurrent Glioblastomas
This study aims to investigate the safety and efficacy of Laser Interstitial Thermal Therapy (LITT) combined with postoperative early use of temozolomide in treating recurrent glioblastomas.
- Trial name
- NCT05663125
- Testing
- Laser interstitial thermal therapy, Temozolomide
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
A Retrospective, Multicenter, Controlled Clinical Trail: to Evaluate the Efficiency and Safety of Intracranial Aneurysm Assistive Software in the Preoperative Assessment
the goal of this clinical trail is to evaluate the efficiency and safety of intracranial aneurysm assistive software in the preoperative assessment. The trail is designed as retrospective, multicenter, controlled clinical trail.
- Trial name
- NCT05651425
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
Establishment of Online Registration Platform for Unruptured Intracranial Aneurysms Based on 100 Regional Medical Centers in China and Population Follow-up Study
In this study, 20 regional neurosurgery centers across the country will be included, and the study cohort will be constructed on the basis of the IARP-CP cohort.The artificial intelligence platform was used to analyze the…
- Trial name
- NCT04872842
- Testing
- Obervation
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Tiantan Hospital
Cervical Disc Degeneration
Real World Data Collection and Analysis on the Anterior Cervical Spine Surgery
This observational study aims to evaluate the efficacy and safety of anterior cervical spine surgery in patients with cervical degenerative disc disease
- Trial name
- ACCSS (NCT05602714)
- Testing
- Collection Data
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Small Vessel Diseases
Efficacy of Pentoxifylline on Cerebrovascular Function in Patients With Cerebral Small Vessel Disease(PERFORM)
This is a randomized, double-blinded, placebo-controlled, multi-center trial. Cerebral small vessel disease (CSVD) patients will be diagnosed according to STRIVE standards and randomized into the Pentoxifylline sustained-release…
- Trial name
- PERFORM (NCT05583266)
- Testing
- Pentoxifylline sustained-release tablets
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Small Vessel Diseases
CerebrAlcare Pills on CereBral Small VesseL DiseasE（CABLE）
This is a randomized, double-blinded, placebo-controlled, multicenter trial. Cerebral small vessel disease (CSVD) patients will be diagnosed by Magnetic Resonance Imaging (MRI) and randomized into treatment or control groups.
- Trial name
- NCT05578521
- Testing
- Cerebralcare pills
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Beijing Tiantan Hospital
Sugammadex, Motor Evoked Potentials
Effect of Muscle Relaxation Reversal on the Success Rate of Motor Evoked Potential Recording
Transcranial motor evoked potential (TcMEP) monitoring is conventionally performed during surgery without or with minimal neuromuscular blockade (NMB) because of its potential interference with signal interpretation.The…
- Trial name
- NCT04608682
- Testing
- Sugammadex, Saline
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Beijing Tiantan Hospital
Tranexamic Acid, Intraoperative Blood Loss
Intravenous Tranexamic Acid Reducing Intraoperative Blood Loss in Huge Meningiomas Resection
Intra-operative blood loss of huge meningioma resection patients on average was over 1000ml. Intra-operative massive hemorrhage was associated with longer hospital of stay, higher expense, and higher mortality.
- Conditions
- Tranexamic Acid, Intraoperative Blood Loss, Meningioma
- Trial name
- NCT05230381
- Testing
- Continous infusion, Single infusion
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Beijing Tiantan Hospital