Clinical trials: sponsored by Beijing Tiantan Hospital
Irritable Bowel Syndrome (IBS)
Efficacy of Pregabalin for Patients With Irritable Bowel Syndrome
To explore the efficacy of pregabalin for patients with irritable bowel syndrome (IBS).
- Trial name
- NCT07635394
- Testing
- The pregabalin group, Routine Treatment
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Beijing Tiantan Hospital
Recurrent High-Grade Gliomas, Recurrent Glioblastoma IDH Wildtype
[177Lu]Lu-DOTA-EB-RGD2 Therapy in Patients With Recurrent High-grade Glioma
This is an investigator-initiated, Phase I clinical trial. It aims to evaluate the safety, tolerability, dosimetry, and preliminary anti-tumor activity of a novel radiopharmaceutical, [177Lu]Lu-DOTA-EB-RGD2, in patients with…
- Trial name
- NCT07655869
- Testing
- [177Lu]Lu-DOTA-EB-RGD2
- Where
- 2 sites in China
- Volunteers
- 24 people
- Sponsor
- Beijing Tiantan Hospital
Laparoscopic Surgery, Laparoscopic Cholecystectomy
Pre-incisional Infiltration With Ropivacaine Plus Triamcinolone for Relieving Postoperative Pain After Laparoscopic Surgery
Incisional infiltration is the simplest, safest, and most effective anesthesia method for preventing incision pain after laparoscopic surgery, but even using long-acting local anesthetics, the effectiveness of postoperative…
- Conditions
- Laparoscopic Surgery, Laparoscopic Cholecystectomy, Appendectomy, Laparoscopic, Hernia Repair
- Trial name
- NCT07591233
- Testing
- Pre-incisional infiltration with ropivacaine plus triamcinolone, Pre-incisional infiltration with ropivacaine alone
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Tiantan Hospital
Laparoscopic Surgery, Laparoscopic Appendectomy
Pre-incisional Infiltration With Ropivacaine Plus Diprospan for Relieving Postoperative Pain After Laparoscopic Surgery
Incisional infiltration is the simplest, safest, and most effective anesthesia method for preventing incision pain after laparoscopic surgery, but even using long-acting local anesthetics, the effectiveness of postoperative…
- Conditions
- Laparoscopic Surgery, Laparoscopic Appendectomy, Laparoscopic Cholecystectomy, Laparoscopic Hernia Repair Surgery
- Trial name
- NCT07626463
- Testing
- Pre-incisional infiltration with ropivacaine and diprospan, Pre-incisional infiltration with ropivacaine alone
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Tiantan Hospital
Video-assisted Thoracoscopic Surgery (VATS), Wedge Resection
Pre-incisional Infiltration With Ropivacaine Plus Diprospan for Relieving Postoperative Pain After Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy, but it is still reported that the incidence of acute pain following VATS exceeds 80%.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Wedge Resection, Segmentectomy, Lobectomy
- Trial name
- NCT07626489
- Testing
- Pre-incisional infiltration with ropivacaine plus diprospan
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Tiantan Hospital
Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block
Stellate Ganglion Block and Prognosis of Neurological Function After Subarachnoid Hemorrhage
The incidence of cerebral vasospasm after aneurysm subarachnoid hemorrhage (aSAH) is as high as 70%; cerebral vasospasm（CVS） is closely related to delayed cerebral ischemia （DCI）, which is one of the important reasons for poor…
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block, Neurological Prognosis
- Trial name
- NCT07652749
- Testing
- Intervention group
- Where
- China
- Volunteers
- 560 people
- Sponsor
- Beijing Tiantan Hospital
Recurrent Glioblastoma (WHO-Grade IV Glioma), Recurrent Glioblastoma
Dosimetry, Safety, and Efficacy Study of [177Lu]Lu-XT771 in Patients With Recurrent Glioblastoma
The primary objective of this study is to evaluate the dosimetry, safety, and tolerability of the investigational radiopharmaceutical [177Lu]Lu-XT771 in patients with recurrent glioblastoma, an aggressive form of brain cancer.
- Conditions
- Recurrent Glioblastoma (WHO-Grade IV Glioma), Recurrent Glioblastoma, Glioblastoma (GBM), Recurrent Glioblastoma IDH Wildtype
- Trial name
- NCT07648823
- Testing
- [177Lu]Lu-XT771
- Where
- 2 sites in China
- Volunteers
- 5 people
- Sponsor
- Beijing Tiantan Hospital
Loxoprofen Sodium Patch, Local Incision
The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Laparoscopic Surgery
Studies have shown that up to 80% of patients experience postoperative pain following laparoscopic surgery due to inflammation caused by surgical incisions and surrounding tissues, necessitating pharmacological relief.
- Conditions
- Loxoprofen Sodium Patch, Local Incision, Laparoscopic Cholecystectomy, Appendectomy, Laparoscopic
- Trial name
- NCT07591207
- Testing
- Loxoprofen Sodium Patch on the contralateral side, Loxoprofen Sodium Patch on the incision site
- Where
- 2 sites in China
- Volunteers
- 134 people
- Sponsor
- Beijing Tiantan Hospital
Gastrointestinal Dysfunction
Oliceridine for Gastrointestinal Dysfunction
Gastrointestinal dysfunction is common in patients after major surgery, especially for neurosurgery. It was reported 80% of neurosurgery patients could be combined with gastrointestinal dysfunction, and it may relate to old age…
- Trial name
- NCT07650812
- Testing
- Experimental: Oliceridine group, Active Comparator: Classical opioid group
- Volunteers
- 176 people
- Sponsor
- Beijing Tiantan Hospital
NMO Spectrum Disorder, MRI
Clinical and Imaging Cohort of Neuroinflammation Diseases in China (CLUE)
CLUE is a prospective study to assess structural and functional changes of the brain, spinal cord, and optic nerve, as well as the inflammatory environment in patients with neuroinflammatory and demyelinating diseases.
- Conditions
- NMO Spectrum Disorder, MRI, Multiple Sclerosis, MOGAD
- Trial name
- NCT04106830
- Testing
- Intravenous steroid
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Surgery, Pain Management
Comparison of Cumulative Opioid Consumption Between Variable-Rate Feedback Infusion and Fixed-Rate Basal Infusion Modes of Intravenous PCA Following Mixed Surgery
Perioperative pain management affects patient recovery. However, the rate of moderate to severe postoperative pain is as high as 73.8%, which hinders recovery and increases the risk of complications.
- Conditions
- Surgery, Pain Management, Opioid Consumption, Patient-controlled Analgesia
- Trial name
- NCT07361822
- Testing
- Fixed-rate basal infusion mode, Variable-rate feedback infusion mode
- Where
- China
- Volunteers
- 1,170 people
- Sponsor
- Beijing Tiantan Hospital
Hemorrhagic Transformation Stroke
Robot-Assisted Hematoma Evacuation With Intrahematoma Tenecteplase for Post-Reperfusion PH2 Hemorrhagic Transformation
The purpose of this phase I trial is to evaluate the safety and feasibility of robot-assisted stereotactic minimally invasive hematoma aspiration, followed when eligible by intrahematoma tenecteplase administration, in patients…
- Trial name
- REPORT (NCT07641998)
- Testing
- Robot-assisted stereotactic hematoma aspiration plus intrahematoma tenecteplase
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Tiantan Hospital
Alzheimer s Disease
A Study of the Metabolic Reconstruction Oral Biologics (Gut-X-001) Medication in People With Alzheimer's Disease (ESCAPE-AD)
This is an exploratory clinical trial aimed at preliminarily evaluating the efficacy, safety, and feasibility of orally administered Gut-X-001 in patients with Alzheimer's disease (AD).
- Trial name
- ESCAPE-AD (NCT07591727)
- Testing
- Gut-X-001
- Volunteers
- 120 people
- Sponsor
- Beijing Tiantan Hospital
Video-assisted Thoracoscopic Surgery (VATS), Loxoprofen Sodium Patch
The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy, but it is still reported that the incidence of acute pain following VATS exceeds 80%.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Loxoprofen Sodium Patch, Local Incision, Postoperative Pain
- Trial name
- NCT07591220
- Testing
- Loxoprofen Sodium Patch on the incision site, Loxoprofen Sodium Patch on the contralateral side
- Volunteers
- 156 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke From Large Vessel Occlusion
HBO After Thrombectomy for AIS With LVO
The purpose of this RCT trial is to evaluate whether the sequential hyperbaric oxygen therapy can improve the 90-day functional outcome in patients with acute large vessel occlusion ischemic stroke after endovascular treatment.
- Trial name
- NCT07626450
- Testing
- Hyperbaric oxygen therapy plus standard medical treatment, Standard medical treatment
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Beijing Tiantan Hospital
Craniotomy, Neurosurgical Patients
an Analgesia-first Strategy Without Hypnotic Sedatives in Adult Patients Admitted to the Intensive Care Unit After Neurosurgical Craniotomy
Analgesia and sedation are core components of intensive care unit (ICU) care. They are used to relieve pain and anxiety, prevent harmful physiological stress responses, improve tolerance of invasive devices and mechanical…
- Trial name
- NCT06727435
- Testing
- analgesia-first strategy without hypnotic sedatives
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Beijing Tiantan Hospital
Postoperative Seizures After Brain Tumor Surgery
Levetiracetam for Seizure Prevention After Brain Tumor Surgery
This study aims to evaluate the efficacy and safety of levetiracetam for the prevention of postoperative seizures in adult patients undergoing supratentorial brain tumor surgery.
- Trial name
- PREVENT (NCT07239115)
- Testing
- Levetiracetam
- Where
- China
- Volunteers
- 558 people
- Sponsor
- Beijing Tiantan Hospital
Spontaneous Intracranial Hypotension
Autologous Platelet-rich Plasma Versus Whole Blood for Epidural Patch in Spontaneous Intracranial Hypotension
Spontaneous intracranial hypotension (SIH) is a condition characterized by refractory orthostatic headache, mostly due to leaks of cerebrospinal fluid (CSF).
- Trial name
- NCT07602556
- Testing
- PRP Patch group, Whole Blood Patch Group
- Volunteers
- 218 people
- Sponsor
- Beijing Tiantan Hospital
Alzheimers Disease
Deep Cervical Lymphatic Venous Anastomosis in the Treatment of Alzheimer's Disease (CLEAN-AD)
This multicenter, prospective, open-label, blinded-endpoint, randomized controlled trial is to evaluate the efficacy and safety of deep cervical lymphatic venous anastomosis (DC-LVA) plus usual care versus usual care in reduing…
- Trial name
- NCT07073066
- Testing
- DC-LVA treatment plus usual care, Usual care
- Where
- 9 sites in China
- Volunteers
- 376 people
- Sponsor
- Beijing Tiantan Hospital
Spontaneous Intracranial Hypotension
Blind Versus Targeted Epidural Patch With Autologous Platelet-rich Plasma for Spontaneous Intracranial Hypotension
Spontaneous intracranial hypotension (SIH) is a condition characterized by refractory orthostatic headache, mostly due to loss of cerebrospinal fluid (CSF).
- Trial name
- NCT07283536
- Testing
- Targeted epidural PRP patch, Blind epidural PRP patch
- Sponsor
- Beijing Tiantan Hospital