Clinical trials: sponsored by Beijing Tiantan Hospital
Glioblastoma Multiforme of Brain
Safety & Efficacy of DC Vaccine and TMZ for the Treatment of Newly-diagnosed Glioblastoma After Surgery
This is a single-center, single-arm phase I study to determine the safety and preliminary efficacy of autologous dendritic cells (DCs) loaded with multiple tumor neoantigen peptides administered as a cancer-treatment vaccine to…
- Trial name
- NCT04968366
- Testing
- Autologous dendritic cells pulsed with multiple neoantigen peptides., Temozolomide adjuvant chemotherapy
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Medium Vessel Occlusion
Intra-arterial Tenecteplase for Acute Medium Vessel Occlusion Stroke
The ANGEL-MeVO-TNK is a multicentered, prospective, randomized, open label, blinded endpoint (PROBE) phase III trial. A total of 488 AIS patients (age ≥18 years) with acute MeVO-AIS (occlusion of the M2/M3, the A1/A2/A3, the…
- Conditions
- Ischemic Stroke, Medium Vessel Occlusion, Tenecteplase, Endovascular Treatment
- Trial name
- ANGEL-MeVO-TNK (NCT07357987)
- Testing
- Intra-arterial Tenecteplase, standard medical management
- Where
- China
- Volunteers
- 488 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Intracranial Haemorrhage
Prospective, Randomized, Parallel-Controlled Study of Brain Computer Interface Integrated Robotic Mirror Therapy for Post-Stroke Upper Limb Motor Function Disorder
This study aims to utilize non-invasive brain-computer interface technology in conjunction with mirror therapy to design a new paradigm for rehabilitation robots to induce compensatory movements on the healthy side in stroke…
- Conditions
- Ischemic Stroke, Intracranial Haemorrhage, Brain-Computer Interfaces, Rehabilitation Exercise
- Trial name
- BCI-RMT (NCT07553416)
- Testing
- Brain computer interface-robotic mirror therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
Efficacy and Safety of Minocycline in Acute Spontaneous Intracerebral Hemorrhage
This is a prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial. It aims to evaluate the efficacy and safety of oral minocycline in patients with acute spontaneous intracerebral hemorrhage within…
- Trial name
- MISTICH (NCT07338175)
- Testing
- Minocycline hydrochloride capsules
- Where
- 41 sites in China
- Volunteers
- 1,192 people
- Sponsor
- Beijing Tiantan Hospital
Endovascular Therapy, Acute Ischaemic Stroke
Stratified Blood Pressure Management After Endovascular Treatment for Acute Ischemic Stroke
The RESCUE-BP is a multi-centered, prospective, randomized, open label, blinded endpoint (PROBE) phase III trial. In patients with acute ischemic stroke who have undergone endovascular treatment and achieved successful…
- Conditions
- Endovascular Therapy, Acute Ischaemic Stroke, Collateral Circulation, Blood Pressure Management
- Trial name
- RESCUE-BP (NCT07527013)
- Testing
- Stratified Blood Pressure Management
- Where
- China
- Volunteers
- 544 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
Non-invasive Ultrasound and Hematoma Clearance After Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is one of the stroke subtypes with the highest global rates of disability and mortality, accounting for 15%-20% of all strokes.
- Trial name
- NOTICE (NCT07246473)
- Testing
- non-invasive ultrasonic scalpel
- Where
- 3 sites in China
- Volunteers
- 86 people
- Sponsor
- Beijing Tiantan Hospital
Brain Arteriovenous Malformations
Language Function Reorganization in Patients With Arteriovenous Malformations
Brain arteriovenous malformation (AVM) is generally considered as a congenital lesion. Its unique clinical manifestation is that when the unruptured AVM involves and destroys the language function area of the left hemisphere, the…
- Trial name
- NCT07537504
- Testing
- MRI
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Ischemic Cerebral Infarction
Ongericimab Injection Reducing Recurrence of Ischemic Stroke
The Oris trial aims to evaluate whether the use of Ongericimab injection in patients with atherosclerotic ischemic cerebrovascular disease within 3 months of onset can reduce the risk of recurrent major cardiovascular events by…
- Trial name
- ORIS (NCT07242599)
- Testing
- High target group, Low target group
- Where
- 199 sites in China
- Volunteers
- 4,810 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Acute, Stroke, Ischemic
Low-Frequency REpetitive TRanscranial Magnetic Stimulation in ACute Ischemic StrokE Within 48 Hours
This is a multicenter, open-label, evaluator-blinded, investigator-initiated, randomized clinical trial, to evaluate the clinical efficacy and safety of LF-rTMS in reducing infarct size, reducing disability rate and improving…
- Trial name
- RETRACE-I (NCT06064734)
- Testing
- LF-rTMS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Artery Stenosis, Carotid Artery Stenting
CAS for Stenosis With High-risk Features for CEA
The purpose of this prospective, multicenter, single-group target-value study is to evaluate the safety and efficacy of the carotid artery stent system in patients with high-risk features for carotid endarterectomy.
- Trial name
- HeartCare CAS (NCT07370246)
- Testing
- Carotid artery stent system
- Where
- 16 sites in China
- Volunteers
- 212 people
- Sponsor
- Beijing Tiantan Hospital
Brain Tumor, Stroke
Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor
Previous studies have shown that the incidence of postoperative stroke, particularly covert stroke, is high following brain tumor resection and is closely associated with inflammatory responses and disruption of the blood-brain…
- Conditions
- Brain Tumor, Stroke, Ulinastatin, Perioperative Anti-inflammatory Therapy
- Trial name
- NCT07520370
- Testing
- Ulinastatin, 0.9% Saline
- Volunteers
- 1,370 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Acute Ischemic
Lesion Network MApping Navigated Continuous Theta-burst STimulation for Motor REcovery in Acute Ischemic Stroke
This is a multicenter, sham-controlled, double-blind, randomized clinical trial to evaluate the efficacy and safety of lesion network mapping navigated cTBS in improving motor function in patients with acute ischemic stroke…
- Trial name
- MASTRE (NCT06400407)
- Testing
- Continuous Theta-burst Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease
Family-Based Moyamoya Susceptibility and Early Detection
This single-center, prospective, family-based observational cohort study aims to investigate susceptibility to moyamoya disease (MMD) and to develop strategies for early screening in individuals at increased familial risk.
- Trial name
- FAMES (NCT07517354)
- Testing
- 5T High-Resolution MRI
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Stroke, Acute Ischemic
Low-Frequency REpetitive TRanscranial Magnetic Stimulation Combined With Endovascular Treatment in ACute Ischemic StrokE
This is a multicenter, randomized, double-blind, sham-controlled, investigator-initiated clinical study, to evaluate the clinical efficacy and safety of LF-rTMS in rescuing the ischemic penumbra, reducing disability rate and…
- Trial name
- RETRACE-II (NCT06064747)
- Testing
- LF-rTMS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Surgery, Pain Management
Comparison of the Efficacy and Safety of Fixed-rate Basal Infusion Mode and Time-programmed Decremental Background Infusion Mode of Intravenous PCA Following Mixed Surgery
Perioperative pain management affects patient recovery. However, the rate of moderate to severe postoperative pain is as high as 73.8%, which hinders recovery and increases the risk of complications.
- Conditions
- Surgery, Pain Management, Opioid Consumption, Patient Controlled Analgesia
- Trial name
- NCT07375121
- Testing
- Fixed-rate basal infusion mode, Time-programmed decremental background infusion mode
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Beijing Tiantan Hospital
Unruptured Intracranial Aneurysm
Treatment Strategies for Unruptured Intracranial Aneurysms in the Chinese Population China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA)
The goal of this prospective observational cohort study is to learn about treatment strategies for unruptured intracranial aneurysms in the Chinese population.
- Trial name
- ChTUIA (NCT05844163)
- Testing
- observation
- Where
- China
- Volunteers
- 31,595 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-BEYOND
The benefit-risk profile of thrombolysis for acute ischemic strokes beyond 24 hours has never been investigated. We initiated a multicenter, prospective, randomized, open label, blinded-endpoint (PROBE) controlled trial to assess…
- Trial name
- TRACE-BEYOND (NCT06954155)
- Testing
- Tenecteplase (0.25mg/kg), Standard medical treatment
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Ischemic, Medium Vessel Occlusions
Advancing Reperfusion Therapy for Ischemic Stroke (ARTS): Tenecteplase in Medium Vessel Occlusion (MeVO) for Acute Ischemic Stroke
Results from recent several trials provided data showing limits to the effectiveness of thrombectomy for ischemic stroke due to medium vessel occlusions.The benefit-risk profile of thrombolysis for these patients has never been…
- Trial name
- ARTS-MeVO (NCT07047014)
- Testing
- Tenecteplase (0.25mg/kg), Standard medical treatment
- Where
- 7 sites in China
- Volunteers
- 596 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage Lobar
Neuronavigation-assisted Stereotactic Minimally Invasive Puncture With Tenecteplase for Acute Lobar Intracerebral Hemorrhage
Introduction: Minimally invasive puncture surgery with thrombolysis is effective for hypertensive intracerebral hemorrhage, but its effect on neurological recovery remains uncertain.
- Trial name
- NALICE-TNK (NCT07471256)
- Testing
- Neuronavigation-assisted Stereotactic Minimally Invasive Puncture Combined with Tenecteplase, Standard medical treatment
- Where
- China
- Volunteers
- 636 people
- Sponsor
- Beijing Tiantan Hospital
Herpes Zoster, Mirogabalin
The Analgesic Efficacy and Safety of Mirogabalin in Patients With Herpes Zoster
Herpes zoster (HZ) is characterized by a painful dermatomal rash and significantly affects quality of life, with acute pain increasing the risk of postherpetic neuralgia.
- Conditions
- Herpes Zoster, Mirogabalin, Pain
- Trial name
- NCT07307170
- Testing
- Mirogabalin combined conventional therapy, Conventional therapy
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Beijing Tiantan Hospital