Clinical trials: sponsored by Boston Medical Center
HIV Infections, Opioid Use Disorder
Infectious Disease (ID) Testing OUtreach in Carceral Hubs
This pilot feasibility study represents part 3 of a larger R61 study, where the investigators will follow a cohort about their experiences with human immunodeficiency virus (HIV) testing.
- Trial name
- ID-TOUCH (NCT06679751)
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Boston Medical Center
Overdose
A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk
Adolescent (ages 10-19) overdose deaths are the third leading cause of pediatric death and continue to rise in the United States.
- Trial name
- NCT07022717
- Testing
- Brief youth overdose prevention education, Information about Naloxone, Usual standard of care
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Boston Medical Center
Post Traumatic Stress Disorder
Web-administered STAIR for Patients on Behavioral Health Waitlists
Posttraumatic stress disorder (PTSD) is a significant public health challenge with population prevalence rates in the US between 6.1 to 9.2%.
- Trial name
- webSTAIR (NCT06431022)
- Testing
- webSTAIR, CHW coaching
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Boston Medical Center
Calciphylaxis
Anti-Interleukin-6 (IL6) in Calciphylaxis
Calciphylaxis is a rare but incredibly dangerous condition that causes small blood vessels in the skin to become blocked by calcium buildup and blood clots. This leads to painful skin sores (necrosis) that do not heal easily.
- Trial name
- NCT07708038
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston Medical Center
Post Traumatic Stress Disorder
Stepped Care for Posttraumatic Stress Disorder Study
Less than 20% of people with PTSD receive any treatment. This study extends a program of research by the investigator focused on developing adaptive (stepped) interventions for PTSD.
- Trial name
- STEPPS (NCT06947538)
- Testing
- webSTAIR, WebSTAIR plus coaching, Clinician administered Brief STAIR
- Where
- United States
- Volunteers
- 428 people
- Sponsor
- Boston Medical Center
Vaccine Hesitancy, Vaccine Refusal
Vaccine Confidence Study Among Historically Marginalized Racial and Ethnic Groups
Achieving optimal vaccination rates is vital for protecting the health and well-being of all individuals. This specific study focuses on the MMR and RSV vaccines in pregnancy and early childhood, which have been shown to reduce…
- Trial name
- NCT06639386
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Autism Spectrum Disorder
Behavior Analytic Support of Needle-related Hospital Visits for Autistic Patients
The purpose of this study is to evaluate the effectiveness of the behavior analytic intervention in reducing the number of challenging behaviors exhibited by patients with Autism Spectrum Disorder (ASD) while increasing…
- Trial name
- NCT06712784
- Testing
- Treatment Package (for both simulation and procedure sessions
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston Medical Center
Prostate Cancer
Hypofractionated Stereotactic Body Radiation Therapy as a Boost to the Prostate
In this study, participants will have standard Androgen Deprivation Therapy and undergo standard external beam radiation therapy to the prostate and at-risk lymph nodes by Intensity Modulated Radiation Therapy.
- Trial name
- NCT01508390
- Testing
- CyberKnife Boost
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Boston Medical Center
Opioid Use Disorder, Bloodstream Infection
Retention and Re-Engagement in Treatment for Addiction Following Serious Injection Related Infections (RETAIN)
This project is a pilot study of an adapted intervention of an existing Opioid Use Disorder (OUD) treatment retention intervention called Recovery Management Checkups (RMC).
- Conditions
- Opioid Use Disorder, Bloodstream Infection, Osteomyelitis, Endocarditis
- Trial name
- RETAIN (NCT06489535)
- Testing
- RETAIN, Unrelated videos
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Medical Center
Human Papilloma Virus
Immunogenicity of the 9vHPV Vaccination 2-dose Regimen Among Children 4 to 8 Years Old
This study is an open-label nonrandomized exploratory proof of concept and descriptive 4-year immunogenicity study to assess immunogenicity after administration of a 2-dose regimen of 9-valent human papillomavirus vaccine (9vHPV)…
- Trial name
- NCT05329961
- Testing
- Gardasil9
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
HIV, Heavy Drinking
Gabapentin to Reduce Alcohol and Improve Viral Load Suppression
GRAIL is a Randomized Controlled Trial (RCT) among 300 HIV-positive persons with heavy alcohol consumption (by NIAAA definition) who have had detectable HIV viral load (HVL) at least 6 months after their HIV diagnosis.
- Trial name
- GRAIL (NCT05443555)
- Testing
- Gabapentin
- Where
- Uganda
- Volunteers
- 220 people
- Sponsor
- Boston Medical Center
Lower Back Pain
Improving Access to Chiropractic Care in Community Health Centers
The goal of this study is to evaluate the feasibility of new implementation strategies designed to increase the number of Primary Care Providers (PCPs) referrals to chiropractic care for lower back pain (LBP) in underserved…
- Trial name
- NCT06104605
- Testing
- Institutional interventions, PCPs interventions, Patient interventions
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Boston Medical Center
Chronic Low-back Pain
Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment
This study will identify unique signatures that people have which can cause pain by evaluating biological, psychological, and social markers using artificial intelligence.
- Trial name
- IMPACT (NCT06106191)
- Testing
- Mindfulness meditation, Perspectives on pain, Discussion
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Boston Medical Center
Emergencies, Cardiopulmonary Arrest
Simulation Trial of Telemedical Support for Paramedics
In the United States, the current standard of prehospital (i.e. outside of hospitals) emergency care for children with life-threatening illnesses in the community includes remote physician support for paramedics providing…
- Conditions
- Emergencies, Cardiopulmonary Arrest, Acute Respiratory Failure, Status Epilepticus
- Trial name
- R01 (NCT06441760)
- Testing
- Video teleconsultation, Audio support
- Where
- 9 sites in United States
- Volunteers
- 420 people
- Sponsor
- Boston Medical Center
Abortion, Second Trimester, Procedural Pain
Cervical Preparation for Same-Day Dilation & Evacuation
This is a noninferiority randomized control trial of two cervical preparation methods prior to same-day Dilation \& Evacuation (D\&E). Cervical preparation is a process that softens and dilates the cervix prior to a procedure.
- Conditions
- Abortion, Second Trimester, Procedural Pain, Procedural Complication
- Trial name
- NCT06799052
- Testing
- Transcervical single-balloon catheter, Synthetic osmotic dilators
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Prevention, Substance Use
Substance Use Prevention for Recently Displaced Adults - SUPRA (R33) RCT
This study is a randomized controlled trial among 144 internally displaced people to determine the feasibility, acceptability, and preliminary effectiveness of a single-session Acceptance of Commitment Therapy (ACT) group therapy…
- Conditions
- Prevention, Substance Use, Refugee Health
- Trial name
- SUPRA RCT R33 (NCT07672457)
- Testing
- Acceptance and Commitment Therapy, Attention Control
- Where
- Ukraine
- Volunteers
- 144 people
- Sponsor
- Boston Medical Center
Trauma Injury, Depression
Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries
Animal assisted therapy (AAT) with dogs has been shown to be beneficial for a wide range of patients with both acute and chronic illnesses, including spinal cord injuries, heart failure, myocardial infarctions, strokes, cancer…
- Conditions
- Trauma Injury, Depression, Anxiety, Anger
- Trial name
- NCT06812247
- Testing
- Therapy dog visits, Dog handler visits
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Boston Medical Center
Anxiety, Post Traumatic Stress Disorder
Improving Mental Health in Forcibly Displaced Populations
This project aims to improve mental health support for Venezuelan migrants living in Lima, Peru, who often face challenges like anxiety, depression, and post-traumatic stress disorder (PTSD).
- Conditions
- Anxiety, Post Traumatic Stress Disorder, Depression
- Trial name
- NCT06635486
- Testing
- Adapted cognitive-behavioral (CBT) intervention
- Where
- Peru
- Volunteers
- 90 people
- Sponsor
- Boston Medical Center
HPV Infection
An Exploratory Open-Label Clinical Trial Evaluating the Immunogenicity of the 9-valent 2-dose HPV Vaccination Regimen
The goal of this study is to explore and evaluate whether a 2-dose schedule of Gardasil 9 among young and mid-adult women 16-45 years of age is generally safe and immunogenic, with an antibody response that is not inferior to…
- Trial name
- NCT04206813
- Testing
- Gardasil 9 2 dose regimen, Gardasil 9 3 dose regimen, Gardasil 9 rescue dose
- Where
- United States
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Chronic Pain, Back Pain
Group-based Mindfulness for Chronic Pain in the Primary Care Setting
The purpose of this pragmatic clinical trial (PCT) research is to determine whether a group-visit approach modeled on Mindfulness-Based Stress Reduction can improve function for persons with chronic low back pain.
- Trial name
- OPTIMUM (NCT04129450)
- Testing
- Group medical visits with mindfulness-based stress reduction, Usual PCP care
- Where
- United States
- Volunteers
- 451 people
- Sponsor
- Boston Medical Center