Clinical trials: sponsored by Boston Medical Center
Osteoarthritis, Hip, Osteoarthritis, Knee
Total Joint Arthroplasty (TJA) Weight Loss Study
This is a randomized clinical trial (RCT) to assess the efficacy of bariatric surgery vs medical weight loss vs. the "usual standard of care" to optimize a morbidly obese patient with end-stage osteoarthritis of the hip or knee…
- Conditions
- Osteoarthritis, Hip, Osteoarthritis, Knee, Obesity, Morbid
- Trial name
- NCT05156762
- Testing
- Bariatric surgery, Medical weight loss, Patient research surveys
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Boston Medical Center
Breast Cancer
Monitoring Neoadjuvant Chemotherapy Response in Breast Cancer Patients Using Diffuse Optical Spectroscopic Imaging
This study seeks to enroll women with breast cancer undergoing neoadjuvant chemotherapy to evaluate if Diffuse Optical Spectroscopy Imaging (DOSI) can predict a patient response to chemotherapy treatment.
- Trial name
- DOSI (NCT02510456)
- Testing
- Diffuse Optical Spectroscopy Imaging (DOSI) - Neoadjuvant Chemo (NAC) Cohort, Diffuse Optical Spectroscopy Imaging (DOSI) - Non-NAC Cohort
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Boston Medical Center
Hypertension, Diabetes Mellitus
MA-CEAL Community Health Ambassador Program
This research is being conducted to investigate how to increase primary care health care visits and screenings and treatment for hypertension and diabetes in residents of housing developments in Boston.
- Conditions
- Hypertension, Diabetes Mellitus, Health Care Utilization
- Trial name
- CHANGE (NCT07136402)
- Testing
- Educating participants about healthcare resources, Healthcare appointments, Workshops
- Sponsor
- Boston Medical Center
Epilepsy
A Novel Social Emotional Learning Curriculum for Youth With Epilepsy
Youth with epilepsy (YWE) are significantly more likely than their peers without epilepsy to experience isolation, interpersonal victimization, and low relationship satisfaction. This is a serious health concern.
- Trial name
- NCT06427967
- Testing
- Project Dream Team
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Boston Medical Center
Breast Cancer Female
Comparing Breast Magnetic Resonance Imaging (MRI) and Contrast-enhanced Mammography (CEM)
The investigators will study the financial, time, and psychologic benefit of Contrast Enhanced Mammography (CEM) compared with Magnetic Resonance Imaging (MRI) for breast cancer evaluation and ultimately encourage practices and…
- Trial name
- NCT06008301
- Testing
- State-Trait Anxiety Inventory (STAI)
- Sponsor
- Boston Medical Center
Tuberculosis, Illicit Drug Use
Transmission of Tuberculosis Among Illicit Drug Use Linkages
Tuberculosis (TB) is the leading infectious disease killer globally and leading cause of death in persons with HIV. The most effective way to reduce TB incidence and mortality is to interrupt transmission.
- Trial name
- TOTAL (NCT04151602)
- Testing
- Smoked illicit drug use
- Where
- South Africa
- Volunteers
- 802 people
- Sponsor
- Boston Medical Center
Child Anxiety, Anxiety Disorders
Kids FACE FEARS Comparative Effectiveness Research
The Kids FACE FEARS (Kids Formats of Anxiety Care Effectiveness study For Extending the Acceptability and Reach of Services) is a large-scale, streamlined, pragmatic Randomized Controlled Trial (RCT) evaluating Therapist-Led CBT…
- Conditions
- Child Anxiety, Anxiety Disorders, Anxiety, Anxiety Symptoms
- Trial name
- NCT03707158
- Testing
- Therapist-Led CBT (telehealth, office-based, or hybrid), Guided Online CBT
- Where
- 8 sites in United States
- Volunteers
- 305 people
- Sponsor
- Boston Medical Center
Inflammatory Bowel Diseases
Shingrix Vaccine in Patients With Moderate to Severe Ulcerative Colitis on Tofacitinib
Patients with ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD), have been shown to be at increased risk of developing certain infections, such as shingles from the Herpes Zoster (HZ) virus, as a result of their…
- Trial name
- NCT03591770
- Testing
- SHINGRIX
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Boston Medical Center
Posttraumatic Stress Disorder
Implementing a Skills Training Evidence-Based Treatment for Posttraumatic Stress Disorder in Primary Care
A majority of residents in low income communities have been exposed to a potentially traumatic event, and up to half (30-50%) of trauma-exposed residents in safety net clinical settings meet criteria for posttraumatic stress…
- Trial name
- I-STEP (NCT04937504)
- Testing
- STAIR-PC Group, WebSTAIR Group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston Medical Center
HIV Infections
Improving Treatment and Retention Adherence in Nontraditional Settings
This is a hybrid implementation-effectiveness study using both qualitative and quantitative methods. The research aims to examine whether providing a new, but approved, HIV once a month injection treatment…
- Trial name
- I-TRAINS (NCT04973254)
- Testing
- CAB-RPV LA, Standard treatment within an HIV clinic
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Boston Medical Center
Smoking Cessation, HIV Infections
Quit For Life (QFL): Smoking Cessation Among Chinese Smokers Living With HIV
The purpose of this two arm randomized clinical trial (RCT) is to test if a smoking cessation program called Quit for Life (QFL) which was developed by the investigators is effective for patients in China with HIV who smoke.
- Trial name
- QFL (NCT05020899)
- Testing
- Sessions with a trained counselor, Cell phone messages, Offered nicotine replacement therapy
- Where
- 2 sites in United States, China
- Volunteers
- 109 people
- Sponsor
- Boston Medical Center
Opioid-use Disorder, Neonatal Abstinence Syndrome
MOM NEST Study: Maternal Opioid Medication: Naltrexone Efficacy Study
This is a multi-center prospective comparative cohort study examining the safety, efficacy, pharmacokinetics, and pharmacogenomics of naltrexone for pregnant women with opioid use disorder.
- Conditions
- Opioid-use Disorder, Neonatal Abstinence Syndrome, Pregnancy, High Risk, Alcohol Use Disorder
- Trial name
- NCT03718104
- Testing
- Pharmacokinetic analysis, Safety and Efficacy, Genetic and epigenetic analysis
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Boston Medical Center
Hospital Discharge
Tools to Improve Discharge Equity (TIDE) Pilot RCT
The investigators will test the impact of a package of linguistically appropriate discharge teaching tools against current standard of care for patients with Limited English proficiency (LEP) in an unblinded randomized controlled…
- Trial name
- TIDE (NCT05988229)
- Testing
- Toolkit to improve discharge equity
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Boston Medical Center
Post Partum Depression
Improving Outcomes for Low-Income Mothers With Depression
This is a randomized comparative effectiveness trial to improve outcomes among pregnant and post-partum women with symptoms of depression.
- Trial name
- NCT03221556
- Testing
- Engagement-Focused Care Coordination (EFCC), Problem Solving Education (PSE)
- Where
- United States
- Volunteers
- 231 people
- Sponsor
- Boston Medical Center
Tuberculosis, Alcohol Consumption
The Impact of Alcohol Consumption on Tuberculosis Treatment Outcomes
After HIV/AIDS, tuberculosis (TB) remains the second leading cause of death due to an infectious disease globally. Retrospective studies from many countries, including the United States and South Africa, have consistently…
- Conditions
- Tuberculosis, Alcohol Consumption, Treatment Adverse Effect
- Trial name
- NCT02840877
- Testing
- DOT Adherence Monitoring
- Where
- South Africa
- Volunteers
- 303 people
- Sponsor
- Boston Medical Center
Drug Use, Pre-exposure Prophylaxis (PrEP)
Pre-exposure Prophylaxis (PrEP) Rapid Access
The goal of phase 1 is to determine the feasibility and acceptability of an intervention ('Rapid PrEP Access') providing people who use drugs (PWUD) one-time access to HIV self-testing at the Victory Program.
- Conditions
- Drug Use, Pre-exposure Prophylaxis (PrEP), Opioid Use Disorder
- Trial name
- NCT05528562
- Testing
- PrEP Rapid Access, HIV self-testing, Dried blood spot testing
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Medical Center
Rheumatoid Arthritis
Proactive Therapeutic Drug Monitoring Based Adalimumab Therapy Optimization in Patients With Rheumatoid Arthritis
Current standard of care of rheumatoid arthritis (RA) management includes a routine clinical assessment of disease activity to adjust therapy.
- Trial name
- TDM-RA (NCT05460390)
- Testing
- Therapeutic drug monitoring (TDM)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Boston Medical Center
Cancer, Breast
Translating Research Into Practice: Patient Navigation for Breast Cancer
The TRIP Project aims to overcome barriers to widespread implementation and dissemination of evidence-based practices that will improve the delivery of guideline-concordant care to vulnerable women with breast cancer.
- Trial name
- TRIP (NCT03514433)
- Testing
- TRIP Patient Navigation Intervention
- Where
- 5 sites in United States
- Volunteers
- 1,725 people
- Sponsor
- Boston Medical Center
Stroke, Cardiovascular
CT (Computerized Tomography) for Late EndovasculAr Reperfusion
The objective of this multicenter, retrospective, cross-sectional, chart review study is to compare outcomes (disability, complications and mortality) of patients with large vessel occlusion stroke presenting at late time window…
- Trial name
- CLEAR (NCT04096248)
- Where
- 19 sites in United States, Belgium and 8 more
- Volunteers
- 2,790 people
- Sponsor
- Boston Medical Center
Stroke, Acute Ischemic
Posterior cerebraL ArTery Occlusion Study
For this retrospective study, the investigators will collect and analyze data of patients who presented with posterior artery occlusion and underwent mechanical thrombectomy (the type of endovascular stroke treatment) and…
- Trial name
- PLATO (NCT05291637)
- Where
- 22 sites in United States, Finland and 5 more
- Volunteers
- 1,282 people
- Sponsor
- Boston Medical Center