Clinical trials: sponsored by Boston University
Schizophrenia, Schizoaffective Disorder
Motivation and Skills Support (MASS)
Social impairment contributes to more severe symptoms, higher rates of hospitalization, and increased disability in persons with schizophrenia.
- Trial name
- NCT03404219
- Testing
- Motivation and Skills Support (MASS)
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Boston University Charles River Campus
Tobacco Smoking
Cognitive and Emotional Skills to Aid Smoking Prevention
The purpose of the current proposal is to investigate the extent to which interventions designed to improve cognitive (working memory) and emotional (distress tolerance) regulatory processes enhance the effectiveness of standard…
- Trial name
- DOAN (NCT03058991)
- Testing
- Distress Tolerance Intervention, Working Memory Intervention, Control Informational Intervention
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Alcoholism
Alcoholism: Emotion and Thinking
The purpose of this study is to determine whether long-term chronic alcoholism is associated with changes in emotional functioning and brain structure and function.
- Trial name
- NCT00300638
- Testing
- Magnetic Resonance Imaging (MRI), Interviews, cognitive tests, and emotional measurements
- Where
- United States
- Volunteers
- 599 people, healthy volunteers welcome
- Sponsor
- Boston University
Heavy Drinking, Alcohol Dependence
Alcohol Disorder hOsPital Treatment Trial
The specific aims of this pragmatic randomized controlled trial are to compare initiating injectable extended release naltrexone (XR-NTX) or oral naltrexone (PO-NTX) at the time of discharge from a medical hospitalization for…
- Conditions
- Heavy Drinking, Alcohol Dependence, Alcohol Use Disorder
- Trial name
- ADOPT (NCT02478489)
- Testing
- Oral naltrexone (PO-NTX), Extended-release injectable naltrexone (XR-NTX)
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Boston University
Dental Fear, Anesthesia, Local
Effectiveness of Synapse Transcutaneous Electronic Nerve Stimulation (TENS) During Dental Procedures Among Children
Dental Fear and Anxiety (DFA) are at higher levels among children and often leads to avoidance of dental treatment. Negative experiences in the early years such as experience of pain during injections, fillings, or extractions…
- Conditions
- Dental Fear, Anesthesia, Local, Pediatric Dentistry
- Trial name
- NCT03779659
- Testing
- Synapse TENS device, Topical anesthetic gel
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston University
Smoking, Cessation
Usability Study of a Smoking Cessation Intervention During a Dental Cleaning
The goal of this usability study is to pilot test the recruitment procedures, data acquisition methods, and text message program integration required to support the planning of a future clinical trial.
- Trial name
- NCT04247061
- Testing
- Educational video, Text-message program
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boston University
Alcohol; Harmful Use, Sex, Unsafe
MI With Text Messaging to Reduce Sexual Risk and Hazardous Drinking Among MSM
This is a small pilot study to provide effect size estimates for a brief intervention designed to reduce hazardous drinking and sexual risk behavior among men who have sex with men.
- Trial name
- MI&TXT4MSM (NCT03755661)
- Testing
- MI&TXT4MSM
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Aphasia
Predicting Rehabilitation Outcomes in Bilingual Aphasia Using Computational Modeling
The purpose of this investigation is to implement a computational model that can predict and optimize training and cross-language generalization patterns for bilingual persons with aphasia (BPA).
- Trial name
- PROCoM (NCT02916524)
- Testing
- Semantic Feature Analysis (SFA)
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Boston University Charles River Campus
Autism Spectrum Disorder, Autism
A Novel Intervention for Training Auditory Attention in Adolescents With Autism Spectrum Disorder
Background: Previous research has shown that individuals with ASD often have difficulties coping with auditory stimuli in the environment.
- Trial name
- NCT03625999
- Testing
- video game training exercise
- Where
- United States
- Sponsor
- Boston University Charles River Campus
Diabetes Mellitus, Type 2, Insulin Response
Effects of TUDCA on Endothelial Function in Type 2 DM
The pilot study is designed to investigate the acute and chronic effects of the diet supplement tauroursodeoxycholic acid (TUDCA) on endothelial function in participants with type 2 diabetes mellitus.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Response, Endothelial Dysfunction
- Trial name
- NCT03462940
- Testing
- Tauroursodeoxycholic acid
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Boston University
Intravenous Drug Abuse
Pre-exposure Prophylaxis (PrEP) for People Who Inject Drugs (PWID)
People who inject drugs (PWID) experience high risk of HIV acquisition. Antiretroviral pre-exposure prophylaxis (PrEP) is an efficacious biomedical HIV prevention strategy for high risk HIV-uninfected individuals including PWID…
- Trial name
- NCT03869671
- Testing
- PrEP uptake/adherence intervention, Harm reduction standard of care
- Sponsor
- Boston University
Atopic Dermatitis
Scratch Behavior Under Standard of Care
Wrist-worn accelerometers and associated data analysis platforms will provide quantitative and qualitative knowledge regarding the action of scratching and sleep quantity in a symptomatic Atopic Dermatitis (AD) population.
- Trial name
- SOC (NCT03898427)
- Testing
- Wrist Actigraphy Devices, Polysomnography, Videography
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston University
Smoking Cessation
Multimodal Cue Exposure Therapy for Smoking Cessation
At two sites (Boston University and the University of Texas at Austin, under the MPI direction of Drs. Otto and Smits) the investigators propose to randomly assign 240 adult smokers who have achieved short-term abstinence…
- Trial name
- NCT04035603
- Testing
- D-Cycloserine, Open Phase CBT that preceeds the randomization phase, Open phase smoking cessation pharmacotherapy that proceeds the randomization phase
- Sponsor
- Boston University Charles River Campus
Heavy Drinking and Sexual Risk Behavior
Alcohol and Sex Risk Intervention for MSM Supplement
Open pilot trial to test the feasibility and efficacy of a brief intervention with text messaging to reduce sexual risk behavior and heavy drinking among MSM
- Trial name
- NCT03522948
- Testing
- Brief intervention with text messaging to reduce sexual risk and heavy drinking among MSM
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Parkinson Disease
Perception, Cognition, and Gait in Parkinson's Disease
The investigators are examining how aspects of daily function are perceived in persons with PD and in those who interact with them on a regular basis.
- Trial name
- NCT03241966
- Where
- United States
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Cardiovascular Diseases
eFHS Messaging Trial
In this research the investigators will develop and test an innovative scalable mobile health and digital cardiovascular monitoring system within a longitudinal deeply characterized cohort with three components: 1) smartphone…
- Trial name
- NCT03516019
- Testing
- personalized notices, standard notices, am notices
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- Boston University
Memory Disorders, Mild Cognitive Impairment
Effectiveness of Home-based Electronic Cognitive Therapy in Alzheimer's Disease
The current study will examine the use of a mobile electronic application used to deliver cognitive rehabilitation to patients with mild cognitive impairment due (MCI) due to Alzheimer's disease (AD), and patients with mild AD.
- Conditions
- Memory Disorders, Mild Cognitive Impairment, Alzheimer's Disease
- Trial name
- CTAD (NCT02521558)
- Testing
- Intervention Group, Control Group
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston University
Benign Prostatic Hyperplasia
Laser Enucleation of Prostate (LEP) Versus Transurethral Resection of Prostate (TURP)
Benign prostatic hyperplasia (BPH) refers to the proliferation of smooth muscle and epithelial cells of the prostate gland. The enlarged gland has the potential to result in lower urinary tract symptoms (LUTS) secondary to either…
- Trial name
- NCT03062111
- Testing
- ProTouch Laser Enucleation of Prostate (LEP), Transurethral Resection of Prostate (TURP)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Boston University
HIV/AIDS, Antiretroviral Therapy
Revised Simplified Algorithm for Treatment Eligibility for HIV (SLATEII)
In its 2017 revision of the global guidelines for HIV care and treatment, the World Health Organization called for rapid or same-day initiation of antiretroviral treatment (ART) for eligible patients testing positive for HIV.
- Trial name
- SLATEII (NCT03315013)
- Testing
- SLATE II
- Where
- South Africa
- Volunteers
- 600 people
- Sponsor
- Boston University
HIV
Simplified Algorithm for Treatment Eligibility
In its 2015 revision of the global guidelines for HIV care and treatment, the World Health Organization called for initiating lifelong antiretroviral treatment (ART) for all patients testing positive for HIV, regardless of CD4…
- Trial name
- SLATE (NCT02891135)
- Testing
- SLATE
- Where
- 2 sites in Kenya, South Africa
- Volunteers
- 1,077 people
- Sponsor
- Boston University