Clinical trials: sponsored by Boston University
Aging
Neuroimaging Study of Exercise and Memory Function
The investigators are examining the effects of exercise and cardiovascular fitness on cognitive processes, brain function, and the amount of several proteins in the blood.
- Trial name
- EMF (NCT02057354)
- Testing
- Aerobic Exercise, Non-Aerobic Exercise
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Boston University
Panic Disorder
Exposure, D-Cycloserine Enhancement, and Genetic Modulators in Panic Disorder
This is a 5-year double blind, randomized, controlled, trial conducted at three treatment sites, aimed at showing the acute and longer-term effects of DCS augmentation of exposure-based CBT for panic disorder relative to placebo…
- Trial name
- DCSPanic (NCT00790868)
- Testing
- d-cycloserine
- Where
- 4 sites in United States
- Volunteers
- 180 people
- Sponsor
- Boston University Charles River Campus
Diabetes Mellitus
Effects of Resveratrol on Endothelial Function in Type 2 Diabetes Mellitus
The present study is designed to test the hypothesis that resveratrol supplementation will improve the function of the endothelium in patients with type 2 diabetes mellitus.
- Trial name
- NCT01881347
- Testing
- Resveratrol
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Boston University
Post-Traumatic Stress Disorder
Examining Written Disclosure as a Treatment for Post-Traumatic Stress Disorder
This study will test the effectiveness of writing about a traumatic incident to treat post-traumatic stress disorder in people who have been in car accidents.
- Trial name
- NCT00862498
- Testing
- Written Disclosure
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Boston University
Type 2 Diabetes Mellitus
Dose-Dependent Effects of Erythritol on Endothelial Function in Type 2 Diabetes Mellitus
This study is an open-label pilot designed to examine the dose-dependent effects of erythritol, a zero calorie sweetener, on endothelial function. Twenty-four subjects with type 2 diabetes mellitus will make three study visits.
- Trial name
- NCT01908348
- Testing
- Erythritol
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Boston University
HIV Infections, Acquired Immunodeficiency Syndrome
Medications for Chronic HIV: Education and Collaboration
This study will examine whether a computerized, self-administered assessment of patient medication adherence and health behaviors, plus support for adherence, improves the ability of clinicians to identify adherence problems and…
- Conditions
- HIV Infections, Acquired Immunodeficiency Syndrome, Medication Adherence
- Trial name
- MedCHEC (NCT01038076)
- Testing
- MedCHEC Tablet Computer & Adherence Care
- Where
- 3 sites in United States
- Volunteers
- 371 people
- Sponsor
- Boston University
Dental Caries in Children
Tooth Smart Healthy Start: Oral Health Advocates in Public Housing
Dental caries is the most common chronic disease of childhood and is increasing in prevalence in children 2-5 years old. Racial and ethnic minority groups as well as economically disadvantaged individuals are affected the most by…
- Trial name
- NCT01205971
- Testing
- Motivational Interviewing, Dental Preventive Services
- Where
- United States
- Volunteers
- 2,842 people, healthy volunteers welcome
- Sponsor
- Boston University
Obesity, Overweight
Effect of Concord Grape Juice on Endothelial Function
The study will compare Concord grape juice to a beverage that contains no grape flavonoids, but has a similar appearance and taste (placebo juice). A total of 60 overweight and obese participants over age 50 will be enrolled.
- Trial name
- NCT01775748
- Testing
- Active Concord Grape Juice 12 oz per day
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Boston University
Affect (Mental Function), Compassion
A Pilot Study of Positive Affect Training
The primary objective of this study is a proof-of-concept study to test whether a novel mindfulness based intervention, Positive Affect Training (PAT), can enhance positive affect and compassion, and decrease negative affect and…
- Trial name
- NCT01853098
- Testing
- Positive Affect Training (PAT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston University Charles River Campus
Phobic Disorders, Social Phobia
Treatment of Social Phobia
Social phobia is a very common and debilitating disorder, with public speaking anxiety being the most common fear. Psychologists have found that treating patients for their fear of public speaking, through cognitive-behavioral…
- Conditions
- Phobic Disorders, Social Phobia, Public Speaking Anxiety
- Trial name
- NCT00000370
- Testing
- Cognitive behavior therapy, Performance-based exposure therapy, Psychosocial intervention
- Where
- United States
- Sponsor
- Boston University Charles River Campus
HIV
A Pilot Voucher Incentive for Improving Retention in Postpartum HIV Care in South Africa
Given there is substantial loss to follow-up soon after delivery among HIV-positive pregnant women in South Africa, we will conduct a pilot study of an innovative approach to improve retention in care targeted to this specific…
- Trial name
- NCT02351362
- Testing
- Incentive Group
- Where
- South Africa
- Volunteers
- 100 people
- Sponsor
- Boston University
Mental Health Disorder
Asian Women's Action in Resilience and Empowerment
Our objective for this R34 is to develop gender/culture specific and trauma informed group psychotherapy intervention designed to treat Chinese-, Korean-, and Vietnamese-American young women with histories of interpersonal…
- Trial name
- AWARE (NCT03370549)
- Testing
- AWARE intervention
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Diabetes Mellitus
Integration of Continuous Glucose Monitoring Into a BiHormonal Closed-Loop Artificial Pancreas
The investigators hypothesize that our closed-loop glucose-control system can provide BG control in subjects with type 1 diabetes using the estimated BG signal from a CGM as the input signal to the controller.
- Trial name
- CL2 (NCT01161862)
- Testing
- Bi-hormonal (insulin and glucagon) artificial pancreas
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Boston University Charles River Campus
Type 1 Diabetes
Closed-loop Glucose Control for Automated Management of Type 1 Diabetes
We hypothesize that our integrated closed-loop glucose-control system can provide effective, tight, and safe blood glucose (BG) control in type 1 diabetes, thereby establishing the feasibility of closed-loop BG control.
- Trial name
- NCT00811317
- Testing
- Closed-loop
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Anxiety Disorders, Mood Disorders
Efficacy Evaluation of a Unified Transdiagnostic Treatment for Anxiety Disorders
Anxiety disorders are common, chronic, costly, debilitating to quality of life, and are more prevalent than any other class of disorders in every country in the world where surveys have been taken.
- Trial name
- NCT01243606
- Testing
- Single Diagnosis Treatment Protocol, Unified Protocol (UP)
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Boston University Charles River Campus
Gingivitis
Dose-dependent Anti-inflammatory Effects of Vitamin D in a Human Gingivitis Model
The burden of chronic gingivitis and periodontitis in the US is disproportionately high among Non-Hispanic Blacks compared to Non-Hispanic Whites.
- Trial name
- NCT00779909
- Testing
- vitamin D3
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Boston University
Tuberculosis Multi Drug Resistant Active
Efficacy and Tolerability of Delamanid, Linezolid, Pyrazinamide and Levofloxacin
The proposed study will randomize adults (18 years of age or older) with pulmonary MDR-TB with sputum that contains M. tuberculosis that is isoniazid and rifampin resistant by MTBDRplus and fluoroquinolone susceptible by MTBDRsl…
- Trial name
- DAZZLE (NCT02975570)
- Testing
- Delamanid, Linezolid, Levofloxacin
- Sponsor
- Boston University
Pneumonia, Bacterial, Infections, Bacterial
Thermal Imaging of the Lung on a Smartphone to Differentiate Bacterial From Non Bacterial Causes of Pneumonia
This is a study of up to 275 participants from birth to 12 months who are having a chest x-ray while a patient at the Queen Elizabeth Central Hospital in Blantyre, Malawi.
- Trial name
- NCT02778672
- Testing
- Thermal imaging of infant's chest with a mobile phone
- Where
- Malawi
- Volunteers
- 273 people
- Sponsor
- Boston University
Amyloidosis
Safety and Effect of Doxycycline in Patients With Amyloidosis
The tetracycline antibiotic doxycycline disrupts A beta amyloid fibrils (AB) in Alzheimer's disease, transthyretin (ATTR) amyloid fibrils in familial amyloidotic polyneuropathy, and immunoglobulin light chain (AL) amyloid fibrils…
- Trial name
- NCT01677286
- Testing
- Doxycycline 100 mg po bid x 12 months
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Boston University
Neonatal Sepsis, Neonatal Mortality
Prevention of Nosocomial Bacteremia Among Zambian Neonates
The purpose of this study is to estimate the burden of disease, identify risk factors associated with nosocomial bacteremia among neonates and assess the efficacy of low-cost measures targeted to known and suspected nosocomial…
- Trial name
- NCT02386592
- Testing
- Chlorhexidine gluconate (CHG), Hand hygiene (HH), Infection control training
- Where
- Zambia
- Volunteers
- 9,410 people
- Sponsor
- Boston University