Clinical trials: sponsored by Boston University
CVID
Respiratory Microbiota and Immune Response in CVID
Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency. Respiratory ailments are the most frequent complications of CVID, with chronic pulmonary disease developing in 30-60% and even…
- Trial name
- NCT06173128
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Boston University
HIV/AIDS, Violence
Effectiveness of Transdiagnostic Cognitive Behavioral Therapy for Improving HIV Treatment Outcomes in South Africa
This study will evaluate the impact of the Common Elements Treatment Approach (CETA), an evidence-based intervention comprised of cognitive-behavioral therapy elements, at improving HIV treatment outcomes among women with HIV who…
- Trial name
- CETA (NCT04242992)
- Testing
- CETA, Short Message Service (SMS) text reminders
- Where
- South Africa
- Volunteers
- 399 people, healthy volunteers welcome
- Sponsor
- Boston University
Autism Spectrum Disorder, Family Relations
Development of a Family-Based Transition Planning Program for Culturally-Diverse Youth on the Autism Spectrum
The goal of this clinical study is to develop a community-based program to support family members of transition-aged youth on the autism spectrum to help them plan for the future. The main aims of the study are: 1.
- Trial name
- NCT05965648
- Testing
- Families FORWARD (Focusing on Relationships, Well-being, and Responsibility aheaD)
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Diabetes Mellitus, Type 2, Endothelial Dysfunction
Assessment of Dapagliflozin on Vascular Health in Patients With Type 2 Diabetes
Patients with Type 2 Diabetes Mellitus (T2DM) have changes in blood vessel health that can lead to a higher chance of developing heart attacks or strokes.
- Trial name
- SFRNDM2 (NCT05139914)
- Testing
- Dapagliflozin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston University
HIV Infections, Sexually Transmitted Infection
PrEPwise Pilot Among Black Women in Eastern Virginia
HIV is a virus that affects many people, but Black women in the U.S. are a population at a much higher risk of getting it compared to white women-about 18 times higher.
- Trial name
- PrEPwise (NCT07398482)
- Testing
- PrEPwise, Usual care
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Boston University
HIV
DSD Models at Malawi Sentinel Sites (SENTINEL 2-Malawi)
To achieve global goals for the treatment of HIV, many countries are piloting and scaling up differentiated service delivery models (DSD).
- Trial name
- SENTINEL2MW (NCT05901727)
- Testing
- No intervention
- Where
- Malawi
- Volunteers
- 15,520 people
- Sponsor
- Boston University
Genetics Syndrome, Ehlers-Danlos Syndrome
Genetics of Ehlers-Danlos Syndrome
We are planning to collected blood and saliva for DNA extraction to use for genetic testing of children and adults with EDS and their relatives. Medical records from other institutions and clinical notes for visits in Dr.
- Trial name
- NCT03093493
- Testing
- Genotyping
- Where
- United States
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Boston University
Inferior Alveolar Nerve Block
The Optimal Injection Site for a 3D Guided Inferior Alveolar Nerve Block Device (IANBD)
Given the thicker cortical bone in the mandible compared to the maxilla, mandibular teeth cannot be effectively anesthetized via local infiltration anesthesia.
- Trial name
- IANBD (NCT06676098)
- Testing
- IANBD 3D guided approach
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston University
Systemic Scleroderma
Longitudinal Spatial Frequency Domain Imaging Study
Scleroderma (SSc) is an autoimmune disease characterized by fibrosis (or collagen deposition) of the skin and internal organs. The extent of skin fibrosis is an important predictor of internal organ complications and increased…
- Trial name
- SFDI (NCT05672992)
- Testing
- Spatial-frequency domain imaging (SFDI)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Boston University
HIV
DSD Models at South Africa Sentinel Sites
Many countries in sub-Saharan Africa are rapidly scaling up "differentiated service delivery" (DSD) models for HIV treatment to improve the quality of care, increase access, reduce costs, and support the continued expansion and…
- Trial name
- SENTINEL 2 (NCT05886530)
- Testing
- No intervention
- Where
- South Africa
- Volunteers
- 15,520 people
- Sponsor
- Boston University
HIV
Preferences for Services in a Patient's First Six Months on Antiretroviral Therapy for HIV in Zambia
With the advent of universal eligibility for HIV treatment ("treat all") and same-day and community-based antiretroviral therapy (ART) initiation, retention in care after a patient has started ART remains the main challenge to…
- Trial name
- PREFER-Zambia (NCT05454852)
- Testing
- Survey, Focus group
- Where
- 2 sites in South Africa, Zambia
- Volunteers
- 771 people
- Sponsor
- Boston University
HIV
DSD Models at Zambia Sentinel Sites (SENTINEL 2)
To achieve global goals for the treatment of HIV, many countries are piloting and scaling up differentiated service delivery models (DSD).
- Trial name
- SENTINEL2ZA (NCT05902572)
- Testing
- No intervention
- Where
- Zambia
- Volunteers
- 8,280 people
- Sponsor
- Boston University
HIV
Preferences for Services in a Patient's First Six Months on Antiretroviral Therapy for HIV in South Africa
With the advent of universal eligibility for HIV treatment ("treat all") and same-day and community-based antiretroviral therapy (ART) initiation, retention in care after a patient has started ART remains the main challenge to…
- Trial name
- PREFER-SA (NCT05454839)
- Testing
- Survey, Focus group
- Where
- 2 sites in South Africa, Zambia
- Volunteers
- 1,098 people
- Sponsor
- Boston University
Opioid-Related Disorders
Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings
Treating Opioid Patients' Pain and Sadness (TOPPS) focuses on the relationship of pain, depression, opioid and other substance misuse, and functioning.
- Trial name
- TOPPS (NCT03698669)
- Testing
- Treating Opioid Patients' Pain and Sadness (TOPPS), Health Education (HE)
- Where
- 2 sites in United States
- Volunteers
- 163 people
- Sponsor
- Boston University
Public Speaking, Speech Anxiety
Multisite Virtual Reality Intervention for Speech Anxiety
Exposure-based cognitive behavior therapy is an efficacious treatment for speech anxiety and has been delivered effectively in a virtual reality (VR) environment.
- Trial name
- ETC2 (NCT06593847)
- Testing
- Single-session VR exposure intervention
- Where
- 13 sites in United States, Australia and 3 more
- Volunteers
- 1,542 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Alzheimer Disease, Dementia, Mild
Event-Related Potential (ERP) Components in Clinical Diagnosis
In this study, the investigators will use a novel electroencephalogram (EEG) system that participants will wear during a single in-person research session to investigate whether ERPs are now ready for validation as a tool…
- Conditions
- Alzheimer Disease, Dementia, Mild, Mild Cognitive Impairment
- Trial name
- NCT05673759
- Testing
- Electroencephalogram (EEG) system, Standard Neuropsychological Testing, Additional neuropsychological tests
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Boston University
Posture
Postural Perturbations Tracing to the Stomatognathic System
A connection of the stomatognathic system [an anatomical system comprising the teeth, jaws, and associated soft tissues] to postural control has been suggested in the literature.
- Trial name
- NCT06974591
- Testing
- Dental splints, Dentures
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston University
Exercise Motivation
Motivation for Exercise: A Mood-Based Focus
The goal of this study is to assess the effects of an exercise-related video on exercise motivation and adherence. Specifically, the researchers are studying whether an exercise-for-mood video increase levels of exercise…
- Trial name
- NCT06706180
- Testing
- Exercise for Mood video, Exercise for Fitness video
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Hot Flashes
Wrist Cooling for Hot Flashes Clinical Trial
This pilot study aims to determine the impact of an experimental active cooling wrist device compared to a placebo device [the devices look identical] on symptom control of hot flashes in adult men and adult women experiencing…
- Trial name
- NCT05595213
- Testing
- Active cooling device with cooling plate, Hot Flash Diary
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Boston University
Influenza, COVID-19
Influenza & COVID-19 Obstetric and Perinatal Epidemiology Study in India
This study will be conducted as a prospective cohort study, enrolling all eligible women in their first trimester of pregnancy during a baseline visit during week 6-13 of pregnancy at Government Medical College Hospital, Nagpur.
- Conditions
- Influenza, COVID-19, SARS-COV-2 Infection, Other Respiratory Viruses
- Trial name
- ICOPE (NCT06168019)
- Testing
- Exposures
- Where
- 2 sites in United States, India
- Volunteers
- 10,000 people
- Sponsor
- Boston University