Clinical trials: open to volunteers, sponsored by Boston University
Opioid Use Disorder
Behavioral Optimization for Overcoming Suboptimal Treatment Retention (BUP-BOOSTeR)
Buprenorphine, a medication for opioid use disorder (MOUD), is associated with decreased opioid overdose and all-cause mortality.
- Trial name
- BUP-BOOSTeR (NCT07607743)
- Testing
- Behavioral Activation (BA), Attendance Reinforcement (AR), Peer-Delivered Motivational Interviewing (PDMI)
- Volunteers
- 240 people
- Sponsor
- Boston University
Social Media Literacy
The Interactive Media and Gender-related Stressors and Strengths Study
The investigators have been developing an interactive psychoeducational website as a brief preventive intervention to enhance social media literacy. This study will determine if the website is feasible and acceptable to adults.
- Trial name
- NCT07836907
- Testing
- interactive website
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Boston University
Rotation of Tooth
A Novel Attachment Design for Tooth Rotation With Clear Aligner Therapy
Clear aligners are thin, transparent plastic trays that straighten teeth gradually and are a popular, more discreet alternative to traditional braces.
- Trial name
- NCT07881146
- Testing
- novel attachment configuration
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Boston University
Tooth Loss
Ti-Mesh Frame Comparison for Alveolar Bone Augmentation
This research compares a chairside Titanium Mesh frame fabrication used during bone grafting procedures with the use of a computer-aided design/computer-assisted manufacture (CAD-CAM) Titanium Mesh frame.
- Trial name
- NCT06077513
- Testing
- CAD-CAM designed and preprinted Ti-Mesh frame, Conventional chairside fabrication of Ti-Mesh frame
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston University
Domestic Violence, Post Traumatic Stress Disorder
Evaluation of a Trauma-Informed Partner Violence Intervention Program
The goal of this study is to conduct a randomized controlled trial (RCT) comparing outcomes between two programs to reduce intimate partner violence (IPV)- the Strength at Home (SAH) program and a standard, state-approved IPV…
- Trial name
- NCT06803043
- Testing
- SAH, TAU
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Boston University
Intimate Partner Violence (IPV)
RISE Versus Advocacy-based Enhanced Care as Usual for Patients Experiencing IPV
This study aims to improve treatment for Veterans Health Administration (VHA) patients who experience intimate partner violence (IPV).
- Trial name
- RISE (NCT06906302)
- Testing
- RISE, Advocacy-based ECAU
- Where
- 3 sites in United States
- Volunteers
- 172 people
- Sponsor
- Boston University
HIV
HIV Testing in Community Health Center Dental Clinics
This is a cluster randomized trial among dental clinics (n=4) to evaluate whether rapid HIV testing (RHT) during dental visits improves HIV testing rates compared to referral for laboratory HIV testing.
- Trial name
- TEETH (NCT07089849)
- Testing
- Rapid HIV testing, Referral for HIV testing
- Where
- 4 sites in United States
- Volunteers
- 6,715 people, healthy volunteers welcome
- Sponsor
- Boston University
Post Traumatic Stress Disorder
Cognitive Processing Therapy for Posttraumatic Stress Disorder and Co-occurring Lived Experience Stress
Populations facing health disparities include groups with significantly higher rates of posttraumatic stress disorder than the general population who frequently experience lived experience stress, which may complicate…
- Trial name
- NCT07714083
- Testing
- Standard CPT, CPT-LEAP
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Boston University
HIV
Integrating U=U Into HIV Counseling in South Africa (INTUIT-2.0)
Undetectable = Untransmittable (U=U) is the scientific consensus that people with human immunodeficiency virus (HIV) who achieve viral suppression through antiretroviral treatment (ART) cannot transmit the virus sexually.
- Trial name
- NCT07199634
- Testing
- "Undetectable & You" HIV treatment literacy app
- Volunteers
- 880 people
- Sponsor
- Boston University
Glucose Response
Glycemic Effects of Meals - Repeatability Trial With Continuous Glucose Monitoring
Almost half of adults in the United States have either diabetes mellitus (DM) or prediabetes (preDM), but many are undiagnosed and unaware of their condition.
- Trial name
- GEM-RT CGM (NCT07293143)
- Testing
- Six meal challenges
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Boston University
Intellectual Disability, Variable
A Pilot Project to Facilitate Dental Care and Reduce Barriers For Youth With Disabilities
This randomized clinical trial is an innovative pilot project to determine the acceptance and impact of telehealth visits on youth with intellectual and developmental disabilities (IDD), their caregivers, and dentists.
- Trial name
- NCT06710483
- Testing
- Pre-Dental Telehealth (PDT)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston University
Pain, Postoperative
Management of Postoperative Discomfort in Young Children Following Dental Rehabilitation Under General Anesthesia
The purpose of this study is to investigate the effectiveness of various oral analgesic regimens in minimizing post-operative pain and discomfort in young children following dental rehabilitation under general anesthesia (DRGA).
- Trial name
- NCT06757075
- Testing
- Ibuprofen, Acetominophen
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Boston University
Alcohol Use, Unspecified, Relationship, Social
Whole Selves User Testing and Feasibility Study
Whole Selves is a novel print and online intervention using motivational interviewing principles and personalized feedback to address young adults' alcohol use and romantic relationship functioning.
- Conditions
- Alcohol Use, Unspecified, Relationship, Social, Depression, Anxiety
- Trial name
- NCT06392542
- Testing
- Whole Selves
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Boston University
Procedural Anxiety, Procedural Pain
Oral Surgery Virtual Reality Glasses Study
The goal of this randomized trial is to investigate if using virtual reality (VR) glasses for patients who require non-emergent oral surgery procedures under intravenous (IV) sedation improves their overall experience compared to…
- Trial name
- NCT06723158
- Testing
- Virtual reality (VR) glasses with relaxation module
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Boston University
Systemic Scleroderma, Diffuse Cutaneous Scleroderma
Diffuse Cutaneous Scleroderma (DSSc) SFDI Study
Scleroderma (SSc) is an autoimmune disease characterized by fibrosis (or collagen deposition) of the skin and internal organs. The extent of skin fibrosis is an important predictor of internal organ complications and increased…
- Trial name
- SFDI (NCT07090226)
- Testing
- Spatial-frequency domain imaging (SFDI)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Boston University
Substance Use Disorders, Alcohol Use Disorder
Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic
"Gold-standard" medications for opioid use disorder (MOUD) treatment combines FDA-approved medications, primarily methadone and buprenorphine, with behavioral therapies to provide "whole-patient" treatment.
- Conditions
- Substance Use Disorders, Alcohol Use Disorder, Opioid Use Disorder
- Trial name
- IMPACT (NCT07232641)
- Where
- United States
- Volunteers
- 185,810 people
- Sponsor
- Boston University
HIV Infections
Texting to Reduce Human Immunodeficiency Virus (HIV) Risk
This is a 3-year study to test the efficacy of a text message-based intervention program. Dental patients at 4 community health centers (n= 266) will be randomized to receive either text messages (TMs) regarding HIV prevention or…
- Trial name
- NCT06088277
- Testing
- TM HIV, TM HL
- Where
- 2 sites in United States
- Volunteers
- 266 people
- Sponsor
- Boston University
Hiv, Substance Use Disorders
Mitigating the Impact of Stigma and Shame Among People Living With HIV and Substance Use Disorders
People living with HIV and substance use disorders (SUDs) are less likely to be virally suppressed, which can lead to HIV transmission and negative health outcomes.
- Trial name
- MATTER (NCT05934305)
- Testing
- Matter Intervention, Control Condition
- Where
- 2 sites in United States
- Volunteers
- 256 people
- Sponsor
- Boston University
Intimate Partner Violence
Evaluating Interventions for Intimate Partner Violence Use in Washington State
Intimate partner violence (IPV), specifically physical and psychological aggression toward an intimate partner, represents a public health crisis that affects millions of Americans each year.
- Trial name
- NCT06526247
- Testing
- Strength at Home (SAH), Treatment as usual for IPV
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Boston University
Chronic Traumatic Encephalopathy (CTE), Alzheimer Disease
The DIAGNOSE CTE Research Project-II
Each year, millions of people are exposed to repetitive head impacts (RHI) through contact sports. RHI can result in concussions and asymptomatic non-concussions to confer risk for Alzheimer's disease (AD) and related dementias…
- Conditions
- Chronic Traumatic Encephalopathy (CTE), Alzheimer Disease, Alzheimer Disease and Related Dementias (ADRD), Brain Injuries, Traumatic
- Trial name
- NCT06860828
- Where
- 5 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Boston University