Clinical trials: sponsored by British Columbia Cancer Agency
Rectal Bleeding
Trial of Argon Plasma Coagulation Versus APC and APC and Hemospray in the Treatment of Radiation Proctitis
Randomized trial of Argon Plasma Coagulation compared with Argon Plasma Coagulation and Hemospray in the therapy of bleeding from Radiation Proctitis
- Trial name
- NCT02233933
- Testing
- Hemospray
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- British Columbia Cancer Agency
Musculoskeletal Symptoms
Randomized Anastrozole Exercise Trial
This is a randomized, phase III trial of a 12 week exercise program, followed by a 36 week voluntary, self-directed exercise program (total 48 weeks) compared to standard supportive care.
- Trial name
- RAE (NCT00519883)
- Testing
- Exercise, Supportive Care
- Where
- 2 sites in Canada
- Volunteers
- 72 people
- Sponsor
- British Columbia Cancer Agency
Cervical Cancer, Precancerous Condition
Digital Colposcopy in Finding Cervical Intraepithelial Neoplasia in Patients With An Abnormal Pap Smear
RATIONALE: Diagnostic procedures, such as digital colposcopy, may help doctors find and diagnose cervical intraepithelial neoplasia.
- Trial name
- NCT00610662
- Where
- Canada
- Sponsor
- British Columbia Cancer Agency
Post-menopausal ER+ Stage I-IIIA Primary Operable Breast Cancer
Anti-Proliferative Effects and Genomic Alterations of Abiraterone Acetate Compared to an Aromatase Inhibitor in Post-menopausal HR+ Operable Breast Cancer
This study is being offered to patients who are post-menopausal, have breast cancer with a positive estrogen and/or progesterone hormone receptor test and are currently awaiting surgery for breast cancer.
- Trial name
- NCT01814865
- Testing
- Abiraterone Acetate, Prednisone, Aromatase Inhibitor
- Where
- 4 sites in Canada
- Sponsor
- British Columbia Cancer Agency
Prostate Cancer
Efficacy and Safety Study of Vandetanib (ZD 6474) in Combination With Bicalutamide Versus Bicalutamide Alone in Patients With Chemotherapy Naive Hormone Refractory Prostate Cancer.
Purpose To define the efficacy, tolerability and safety of Vandetanib in combination with bicalutamide in patients with chemotherapy naive hormone refractory prostate cancer Hypothesis There will be a PSA response when Vandetanib…
- Trial name
- NCT00757692
- Testing
- Vandetanib, Bicalutamide
- Where
- 4 sites in Canada
- Volunteers
- 74 people
- Sponsor
- British Columbia Cancer Agency
Prostate Cancer
Ability of a New Design of Iodine 125 Seed to Maintain Intended Position When Implanted in the Prostate
This study compares the ability of a new design of brachytherapy seed for prostate seed implants for treatment of prostate cancer to maintain their intended position in the prostate after being deposited.
- Trial name
- FAST (NCT01174017)
- Testing
- Iodine 125 standard loose brachytherapy seeds, AnchorSeed Iodine 125 brachytherapy prostate implant
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- British Columbia Cancer Agency
Head and Neck Carcinoma
Feasibility of VMAT and CBCT for Head and Neck Carcinomas
This will be a prospective longitudinal study describing clinical throughput metrics and patient reported quality of life outcome measures for patients undergoing Volumetric modulated arc therapy (VMAT) with and without Cone-beam…
- Trial name
- NCT01384890
- Testing
- VMAT with CBCT, VMAT with kV-ray
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- British Columbia Cancer Agency
Mesothelioma, Lung Cancer
Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos
This is a pilot study that aims to develop a lung cancer screening program for workers in British Columbia, Canada exposed to asbestos who are at risk of developing lung cancer/pleural mesothelioma.
- Trial name
- NCT01719068
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Breast Cancer
Long Term Outcomes of Breast Intensity-Modulated Radiation Therapy
The purpose of this study is to evaluate the frequency of chronic breast pain about 8 years after the delivery of the radiation treatment, and to compare the frequency between subjects that received breast Intensity-Modulated…
- Trial name
- BIMRT (NCT01537406)
- Testing
- BREAST IRRADIATION USING INTENSITY-MODULATED RADIATION THERAPY
- Where
- 2 sites in Canada
- Volunteers
- 314 people
- Sponsor
- British Columbia Cancer Agency
Lung Cancer, Tobacco Use Disorder
Screening Methods in Finding Lung Cancer Early in Current or Former Smokers
RATIONALE: Screening may help doctors find lung cancer sooner, when it may be easier to treat. PURPOSE: This clinical trial is studying screening methods to see how well they find lung cancer early in current or former smokers.
- Trial name
- Pan Can (NCT00751660)
- Testing
- laboratory biomarker analysis, screening questionnaire administration, bronchoscopic and lung imaging studies
- Where
- 6 sites in Canada
- Volunteers
- 2,504 people
- Sponsor
- British Columbia Cancer Agency
Lung Cancer, Precancerous Condition
Studying Genes in Blood and Lung Fluid Samples From Patients With Chronic Obstructive Pulmonary Disease With or Without a Previous Diagnosis of Lung Cancer or With Asthma Treated With Budesonide and Formoterol
RATIONALE: Studying the genes expressed in samples of blood and lung fluid in the laboratory from patients receiving budesonide and formoterol may help doctors learn more about the effect of budesonide and formoterol on gene…
- Trial name
- NCT00569712
- Testing
- budesonide/formoterol fumarate dihydrate inhalation aerosol, DNA methylation analysis, comparative genomic hybridization
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- British Columbia Cancer Agency
Breast Cancer
Evaluation of the Informational Content of Setup Verification Images for Patients Receiving Breast Radiation Therapy (Anterior EPI)
The purpose of this study is to determine if an alternative imaging protocol done at the time of radiotherapy treatments for patients with breast cancer can improve accuracy in patient set-up.
- Trial name
- Anterior EPI (NCT00800189)
- Testing
- Anterior electronic portal images (EPI)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- British Columbia Cancer Agency
Lung Cancer, Precancerous Condition
Green Tea Extract in Treating Current or Former Smokers With Bronchial Dysplasia
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of Polyphenon E, a substance found in green tea, may keep cancer from forming in current or former smokers with bronchial dysplasia.
- Conditions
- Lung Cancer, Precancerous Condition, Tobacco Use Disorder
- Trial name
- NCT00611650
- Testing
- defined green tea catechin extract
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- British Columbia Cancer Agency
Lung Cancer, Precancerous Condition
ACAPHA in Preventing Lung Cancer in Former Smokers With Bronchial Intraepithelial Neoplasia
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of ACAPHA, a combination of six herbs, may prevent lung cancer from forming in former smokers with bronchial intraepithelial neoplasia.
- Trial name
- NCT00522197
- Testing
- multi-herbal agent ACAPHA, Sugar Pill
- Volunteers
- 90 people
- Sponsor
- British Columbia Cancer Agency
Lung Cancer, Tobacco Use Disorder
Green Tea Extract in Preventing Cancer in Former and Current Heavy Smokers With Abnormal Sputum
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. Green tea extract may keep cancer from forming.
- Trial name
- NCT00573885
- Testing
- defined green tea catechin extract
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- British Columbia Cancer Agency
Cervical Cancer, Precancerous Condition
Identifying Biomarkers for Early Detection of Cancer in Patients With Cervical Dysplasia or Carcinoma in Situ of the Cervix
RATIONALE: Studying the genes expressed in samples of tissue from patients with abnormal cells may help doctors identify biomarkers related to cancer.
- Trial name
- NCT00601601
- Volunteers
- 80 people
- Sponsor
- British Columbia Cancer Agency
Radiation Therapy for Primary Breast Cancer
Can 3D Ultrasound Be Used Reproducibly by Radiation Therapists in Partial Breast Image-Guided Radiation Therapy
To determine if the Clarity 3DUS (3D Ultrasound) system can be used by multiple individuals to acquire 3DUS images and produce consistent TB (Tumor Bed) shifts for breast IGRT (Image-Guided Radiation Therapy).
- Trial name
- IGRT (NCT00911456)
- Testing
- Image-Guided Radiation Therapy using 3D Ultrasound Guided-Therapy, Ultrasound Guided Imaging, 3 DUS
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- British Columbia Cancer Agency
Cervix Cancer
Study of Tumour Response to Tirapazamine During Treatment of Cervical Cancer
The purpose of this study is as follows: to determine whether tirapazamine damages cervical tumour DNA immediately after its administration to determine the blood flow and oxygen level of cervical tumour before and after…
- Trial name
- NCT00493376
- Testing
- Cervical tissue biopsy analysis: Comet assay, Biopsy: Measurement of histone gamma H2AX phosphorylation, Biopsy: Immunohistochemistry: Ca9, Glut1, HIF-1 alpha
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- British Columbia Cancer Agency
Breast Cancer
Pilot Study of Partial Breast Irradiation Utilizing Permanent Breast Seed Implant to Treat Breast Cancer
Background: Recent single arm studies have suggested that partial breast irradiation (PBI), delivered in a relatively short overall treatment time of a few days, may be an effective alternative to adjuvant whole breast…
- Trial name
- NCT01191164
- Testing
- Partial Breast Irradiation Utilizing Permanent Breast Seed Implant
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- British Columbia Cancer Agency
Ovarian Cancer
Bone Health in Gynecologic Cancers-does FOSAVANCE Help?
Women who undergo bilateral oophorectomy and receive chemotherapy are at risk of increased bone loss. At present, despite having a risk factor profile that fits the indications for assessment and treatment there are no routine…
- Trial name
- FOSAVANCE (NCT00593580)
- Testing
- alendronate/cholecalciferol
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency