Clinical trials: sponsored by Case Comprehensive Cancer Center
Brain Metastases
Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)
Participants in this research study have cancer that has spread to their brain, called brain metastases. One treatment for this type of cancer is called whole brain radiotherapy that stays away from a specific neurocognitive…
- Trial name
- NCT07248228
- Testing
- MA-WBRT (Memory Avoidance Whole Brain Radiation Therapy (MA-WBRT)), HA-WBRT (Hippocampal Avoidance Whole Brain Radiation Therapy (HA-WBRT)), Memantine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Case Comprehensive Cancer Center
Chemotherapy-induced Peripheral Neuropathy, CIPN - Chemotherapy-Induced Peripheral Neuropathy
High-concentration Capsaicin Patch for the Prevention of Paclitaxel-induced Peripheral Neuropathy
This research study is for participants who are receiving paclitaxel infusion as part of their cancer treatment. The purpose of this study is to test the effectiveness of the Food and Drug Administration (FDA) approved…
- Trial name
- NCT07834281
- Testing
- High Concentration Capsaicin Patch (HCCP)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Case Comprehensive Cancer Center
Glioblastoma, Adult
Laser Interstitial Thermotherapy (LITT) Combined With Checkpoint Inhibitor for Recurrent GBM (RGBM)
The purpose of this study is to test the side effects and efficacy of using Laser Interstitial Thermotherapy (LITT) combined with Pembrolizumab.
- Trial name
- NCT03277638
- Testing
- Pembrolizumab at 7 days prior, Pembrolizumab at 14 days post, Pembrolizumab at 35 days post
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Case Comprehensive Cancer Center
Malignant Neoplasm of Prostate
Exercise Therapy and Radiation Therapy (EXERT) for Metastatic Prostate Cancer
This study is being done to determine if patients receiving personalized exercise therapy (versus those who do not receive personalized exercise therapy) have improved quality of life and physical functioning after completing…
- Trial name
- NCT04556045
- Testing
- Exercise therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Study to Investigate Efficacy of a Novel Probiotic on the Bacteriome and Mycobiome of Breast Cancer
The purpose of this study is to examine the effect of probiotics on the breast tumor microbiome and gut microbiome in breast cancer.
- Trial name
- NCT04362826
- Testing
- Novel probiotic
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Case Comprehensive Cancer Center
Unintended Weight Loss
Unintentional Weight Loss and Cancer: A Prospective Trial of Patient-centered Weight Tracking Combined With GRAIL Galleri Testing to Improve Early Detection
Unintentional weight loss (UWL) is commonly associated with a wide variety of diseases and there is still no valid diagnostic pathway for evaluating UWL.
- Trial name
- NCT05481697
- Testing
- GRAIL Galleri
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Case Comprehensive Cancer Center
Educational Intervention, Minorities
Patient Navigator PRE-ACT Educational Intervention to Promote Decision Making Among Minorities
This study focuses on psychosocial barriers at the patient level with the goal of promoting high quality decision making around clinical trials participation.
- Trial name
- NCT05701085
- Testing
- Educational Intervention
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Case Comprehensive Cancer Center
Cyst of Pancreas, Pancreatectomy
Is Intraperitoneal Drainage Necessary Following Distal Pancreatectomy?
The goal of this clinical trial is to analyze if intraperitoneal drainage is necessary following distal pancreatectomy. This study aims to determine whether the omission of routine intraperitoneal drainage in the setting of…
- Conditions
- Cyst of Pancreas, Pancreatectomy, Pancreas Neoplasm
- Trial name
- NCT05720338
- Testing
- 19 French Blake Drain
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Breast Margin Study: Routine Cavity Shave Margins Vs. Selective Margins Using Savi Scout®
This is a prospective study comparing partial mastectomy performed with routine cavity shave margins and Savi Scout® localization to partial mastectomy performed with selective margins and Savi Scout® localization.
- Trial name
- NCT05825482
- Testing
- Arm 1 Partial mastectomy with Savi Scout® localization and shave margins., Arm 2 Partial mastectomy with Savi Scout® localization and selective shave margins.
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Case Comprehensive Cancer Center
Glioblastoma, Venous Thromboembolism
Glioblastoma Remote Monitoring and Care - Research Protocol
The purpose of this research is to learn more about how what the Apple watch measures, in terms of walking data, heart rate, breathing rate, and sleep habits, relates to how participants feel.
- Conditions
- Glioblastoma, Venous Thromboembolism, Seizures
- Trial name
- NCT06129760
- Testing
- Apple Watch
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer, Malignant Neoplasm of Prostate
MDRT in Prostate Cancer Treated With Long-term Androgen Deprivation Therapy in the STAMPEDE Trial (METANOVA)
The purpose of this study is to find out if giving radiation therapy (RT) to areas of metastatic prostate cancer at the time a participant is diagnosed will help control disease better than the usual treatment.
- Conditions
- Prostate Cancer, Malignant Neoplasm of Prostate, Secondary Malignant Neoplasm of Prostate
- Trial name
- NCT06150417
- Testing
- Androgen deprivation therapy (ADT), Androgen receptor signaling inhibitor (ARSI), Local Therapy: Radical Prostatectomy (RP) or Radiotherapy (RT)
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Case Comprehensive Cancer Center
Gastrointestinal Cancer, Colon Cancer
EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.
This research study is being conducted to improve the quality of care of participants who have a diagnosis of gastrointestinal cancer (anal, colon, rectal, esophageal, stomach, small bowel, appendix, pancreas, gall bladder…
- Conditions
- Gastrointestinal Cancer, Colon Cancer, Rectal Cancer, Anal Cancer
- Trial name
- NCT06263088
- Testing
- EQUITY GI
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer, Breast Cancer Female
Abbreviated MBCT for Depression in Older Black or African American Breast Cancer Survivors
The purpose of this research study is to develop and test an intervention designed to improve mood and reduce symptoms of depression.
- Conditions
- Breast Cancer, Breast Cancer Female, Breast Cancer Stage I, Breast Cancer Stage II
- Trial name
- NCT06336538
- Testing
- MBCT
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Case Comprehensive Cancer Center
Ovarian Cancer, Epithelial Ovarian Cancer
Prehabilitation for EOC, Fallopian Tube, Primary Peritoneal Carcinoma and Pancreatic Cancer w/ NACT
The purpose of this study is to see whether participants who are assigned to a multimodal prehabilitation intervention during chemotherapy are able to adhere with exercise and nutrition program to prepare for their cancer surgery.
- Conditions
- Ovarian Cancer, Epithelial Ovarian Cancer, Pancreatic Adenocarcinoma
- Trial name
- NCT06412510
- Testing
- Prehabilitation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer
Developing Inclusive Support and Intervention for Spanish-speaking Latiné Prostate Cancer Survivors
Prostate cancer is a significant concern for Latiné men, with over 17,000 new cases annually. Decision-making for treatment is complex, especially due to barriers like low health literacy and cultural factors.
- Trial name
- NCT06435871
- Testing
- Expanded Prostate Cancer Index Composite and Decision Regret Scale
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Case Comprehensive Cancer Center
Barrett Esophagus, Gastroesophageal Reflux
Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms
The goal of this clinical trial is to develop a method to detect Barrett's esophagus in individuals with a new office based diagnostic test.
- Conditions
- Barrett Esophagus, Gastroesophageal Reflux, Esophageal Adenocarcinoma
- Trial name
- NCT06687603
- Testing
- EsoCheck, EsoGuard
- Where
- 5 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
aGVHD, Acute Myelogenous Leukemia
Co-Transplant of an Unmodified Haplo-Identical Graft With Cord Blood
The purpose of this study is to see if see if adding the specific combination of donors can result in acceptable levels of survival without evidence of disease.
- Conditions
- aGVHD, Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia, Myelodysplastic Syndromes
- Trial name
- NCT06904482
- Testing
- Haplo-Identical / Cord Blood Transplant
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Case Comprehensive Cancer Center
Colorectal Cancer, Liver Metastases
Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis
The goal of this clinical trial is to learn if histotripsy plus chemotherapy works to treat unresectable, bilobar liver- confined colorectal cancer liver metastasis (CRLM).
- Conditions
- Colorectal Cancer, Liver Metastases, Liver Cancer
- Trial name
- NCT07044362
- Testing
- HistoSonics Edison® System, Chemotherapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer, Prostatic Neoplasm
Investigation of Impact of AI on Prostate Cancer Workflow
This study will enroll participants who are undergoing an MRI before a prostate biopsy due to suspected prostate cancer. The purpose of this study is to see if the use of Artificial Intelligence (AI) helps detect lesions on an…
- Conditions
- Prostate Cancer, Prostatic Neoplasm, Cancer of the Prostate, Neoplasms, Prostate
- Trial name
- NCT07084779
- Testing
- AI
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Case Comprehensive Cancer Center
Cancer
Artificial Intelligence-Powered Support For Quality Of Life Improvement In Participants With Cancer
This research study is for people who are diagnosed with cancer and are receiving treatment for cancer who may benefit from psychotherapy.
- Trial name
- NCT07167056
- Testing
- Standard of Care Psychotherapy, WYSA App
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Case Comprehensive Cancer Center