Clinical trials: sponsored by Case Comprehensive Cancer Center
High Grade Glioma, Glioblastoma
Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression
The purpose of this study is to test the safety and feasibility of recording brain activity within and around high-grade glioma tumors at the time of surgery. A small biopsy will be taken at the sites of the recordings.
- Trial name
- NCT05565118
- Testing
- Standard Surgical Treatment, Intraoperative Electrocorticography
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Case Comprehensive Cancer Center
High Grade Glioma
Expedited Laser Interstitial Thermal Therapy + Chemoradiation For Newly Diagnosed High Grade Gliomas
The investigators of this study want to see if shortening the total treatment time for brain tumors is safe.The treatment for participant's brain tumors is laser surgery (Laser Interstitial Thermal Therapy (LITT)) followed by…
- Trial name
- NCT02970448
- Testing
- LITT, Radiation therapy, Temozolomide
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Adenocarcinoma, Prostate Cancer
Single-Port Transvesical Partial Prostatectomy Versus High Intensity Focused Ultrasound
This study aims to compare the novel single-port robotic partial prostatectomy to High-intensity focused ultrasound (HIFU) in patients with low to intermediate risk localized prostate cancer.
- Trial name
- NCT05610852
- Testing
- Transvesical Single Port Robotic Partial Prostatectomy, High-intensity focused ultrasound (HIFU)
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- Case Comprehensive Cancer Center
Surgery, Stomach Cancer
TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE)
Participants may take part in this study if they are scheduled to undergo a surgery that meets the following: (1) traditional open surgery via laparotomy, (2) length of surgery >3 hours, and (3) curative-intent surgical resection…
- Conditions
- Surgery, Stomach Cancer, Pancreas Cancer, Bile Duct Cancer
- Trial name
- NCT07653594
- Testing
- Music-assisted relaxation and imagery (MARI)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Case Comprehensive Cancer Center
Amyloid Light-chain Amyloidosis
Dose Schedule Study of BCMA Bispecific Antibody, Elranatamab, for Newly Diagnosed Immunoglobulin Light Chain (AL) Amyloidosis
This research study is for people who have newly diagnosed with AL (light chain) amyloidosis and have not yet received any treatment for this condition.
- Trial name
- NCT07524634
- Testing
- BCMA bispecific
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Case Comprehensive Cancer Center
Chemotherapy-induced Peripheral Neuropathy, CIPN - Chemotherapy-Induced Peripheral Neuropathy
Scrambler Therapy for Chemotherapy-Induced Peripheral Neuropathy
This research study is for people who have a condition called chemotherapy-induced peripheral neuropathy (CIPN). This condition develops as a result of receiving medication(s) to treat cancer, particularly chemotherapy.
- Trial name
- NCT07219472
- Testing
- Scrambler Therapy
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Case Comprehensive Cancer Center
Cancer
Feasibility and Acceptability of Wearable Sensors and ePROs in Early Phase Clinical Trials
Wearable sensors offer opportunities to improve the people's experiences with cancer treatment and to improve care delivery. This is a single-arm, prospective, unblinded pilot study designed to evaluate the feasibility and…
- Trial name
- NCT07541365
- Testing
- Wearable actigraphy, Electronic Patient-Reported Outcomes (ePROs)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Case Comprehensive Cancer Center
Non-hodgkin Lymphoma
Venetoclax in Combination With BEAM Conditioning Regimen for ASCT in Non-Hodgkin Lymphoma
The purpose of this study is to determine the correct dose and safety of adding a new cancer drug, Venetoclax, to a standard combination of chemotherapy drugs used prior to Autologous stem cell transplant (ASCT) in participants…
- Trial name
- NCT03713580
- Testing
- Venetoclax
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Case Comprehensive Cancer Center
Febrile Neutropenia
ECM and Monitoring w/ Alio Smart Patch in Cancer Pts Receiving Chemotherapy
Undergoing cancer treatment comes with various risks and side effects. This clinical trial aims to reduce those risks and side effects through continuous monitoring of vital signs and blood levels.
- Trial name
- NCT06657183
- Testing
- Alio Smart Patch™
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Case Comprehensive Cancer Center
Refractory Cancer, Relapsed Cancer
Individualized Treatments in Adults With Relapsed/Refractory Cancers
A personalized cancer medicine approach would address therapy resistance, cancer metastasis, and limited options after standard of care is exhausted in advanced cancer participants.
- Trial name
- NCT06024603
- Testing
- Drug Sensitivity Test (DST)
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Case Comprehensive Cancer Center
Glioblastoma, Brain Tumor
Magnetic Resonance Fingerprinting Guided Extended Resection in Glioblastomas
Magnetic resonance imaging, MRI, is a procedure that uses radio waves, a powerful magnet, and a computer to make a series of detailed pictures of areas inside the body.
- Trial name
- NCT06455189
- Testing
- Control Group - Standard of care neurosurgical resection, MRF/MRI infiltration guidance for extended resection
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Head and Neck Cancer, Head and Neck Neoplasms
Decitabine and Nivolumab in Participants With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck
This research study is for people who have recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) that has been confirmed by tissue or cell analysis and is considered incurable with local treatments.
- Conditions
- Head and Neck Cancer, Head and Neck Neoplasms, Head and Neck Squamous Cell Carcinoma
- Trial name
- NCT07216833
- Testing
- Decitabine, Nivolumab
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Refractory Acute Myeloid Leukemia, Relapsed Acute Myelomonocytic Leukemia
CPX-351 as a Novel Approach for the Treatment of Older Patients With AML and MDS
The purpose of this study is to evaluate how effective lower doses of CPX-351 are in older participants with relapsed/refractory acute myeloid leukemia (AML) who are not eligible to receive intensive chemotherapy and in…
- Conditions
- Refractory Acute Myeloid Leukemia, Relapsed Acute Myelomonocytic Leukemia, Myelodysplastic Syndromes
- Trial name
- NCT04668885
- Testing
- CPX-351
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Case Comprehensive Cancer Center
Glioblastoma
Improving Understanding of Brain Tumors Through Preservation of Biologically Active Brain Tissue
Recent experiments are giving researchers insight into the changes (mutations) that occur in an individual brain tumor cell compared to a normal cell.
- Trial name
- NCT04545177
- Testing
- NICO Myriad and Tissue Preservation System (TPS)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Case Comprehensive Cancer Center
Glioma, Glioblastoma
Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma
The purpose of this study is to test how well the drug works, safety and tolerability of an investigational drug called Ruxolitinib in gliomas and glioblastomas, when combined with standard treatment for brain cancer…
- Trial name
- NCT03514069
- Testing
- ruxolitinib, radiation, temozolomide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Case Comprehensive Cancer Center
Basal Cell Carcinoma
Alteration of the Immune Microenvironment in Basal Cell Carcinoma Following Photodynamic Therapy
The purpose of this study is to better understand the immune response to basal cell carcinoma (BCC) treated with Photodynamic Therapy (PDT) in order to develop new methods of treating BCC.
- Trial name
- NCT05020912
- Testing
- ALA, PDT
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Case Comprehensive Cancer Center
Small-cell Lung Cancer, Large Cell Neuroendocrine Carcinoma of the Lung
Targeted Therapy With CDK4/6 Inhibitors in Chemo-Refractory, Rb Wild-Type Extensive SCLC
The purpose of this study is to: Test how well the study medicine Abemaciclib, a CDK4/6 inhibitor, works to shrink lung cancer tumors in the body.
- Conditions
- Small-cell Lung Cancer, Large Cell Neuroendocrine Carcinoma of the Lung, Extrapulmonary Small Cell Carcinoma
- Trial name
- NCT04010357
- Testing
- Abemaciclib,
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Case Comprehensive Cancer Center
Cutaneous Malignant Melanoma, Renal Cell Cancer
Low-Dose-Rate Brachytherapy Combined With Immune Checkpoint Inhibition in Cancer
This is a pilot study of combination low dose rate brachytherapy (LDR) added to standard of care (SOC) immunotherapy in stage III and IV melanoma, stage IV renal call cancer, and stage IV urothelial cancer.
- Conditions
- Cutaneous Malignant Melanoma, Renal Cell Cancer, Urothelial Cancer of Renal Pelvis
- Trial name
- NCT04620603
- Testing
- Low Dose Rate Brachytherapy (LDR), Standard-of-Care Immunotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Interventional Program Educates, Identifies + Overcomes Barriers to Complete Screening Mammography
The purpose of this study is to identify interventions that are designed to better serve women who are homeless, with a specific focus on increasing screening rates and decreasing late stage breast cancer diagnosis among this…
- Trial name
- NCT04348123
- Testing
- Survey, Education Session
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer
Improving Patient Understanding of Their Prostate Cancer Diagnosis Using AI
The purpose of this study is to determine if ChatGPT (an artificial intelligence driven chatbot) can help patients better understand their own pathology results and prostate cancer diagnosis.
- Trial name
- NCT07040501
- Testing
- Chat GPT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Case Comprehensive Cancer Center