Clinical trials: sponsored by Case Comprehensive Cancer Center
Leukemia
Thiotepa Plus Fludarabine+ Melphalan as the Preparative Regime for Alternative Donor Transplantation
In the United States, thiotepa has been utilized in reduced intensity conditioning regimens for alternative donor courses (double umbilical cord blood transplant (dUCBT) and haplo-identical transplants).
- Trial name
- NCT03342196
- Testing
- Melphalan, Thiotepa, Fludarabine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Case Comprehensive Cancer Center
Head and Neck Cancer
Implementation of a Standardized Tracheostomy Education Discharge Protocol
The purpose of this study is to identify and establish a safe and effective tracheostomy teaching protocol for caregivers. Results of this study will help in the development of a discharge protocol that allows for caregiver…
- Trial name
- NCT04741256
- Testing
- Education booklet & standardized discharge training
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Cancer Pain, Oncology Pain
Reiki Therapy to Improve Key Symptoms in Integrative Oncology Clinic (REIKI)
The purpose of this research is to investigate the delivery of Reiki to integrative oncology patients and assess its potential for improving cancer-related symptoms in this population.
- Trial name
- NCT06354049
- Testing
- Reiki
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer, Prostate Cancer
NAVAH Impact on Radiation Therapy Completion in Black Breast & Prostate Cancer Patients
African-Americans have disparately limited access to optimal cancer care. They have the highest overall cancer death rate and shortest survival time of any racial or ethnic group in the United States.
- Trial name
- NCT05978232
- Testing
- NAVAH
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Case Comprehensive Cancer Center
Basal Cell Carcinoma of the Head and Neck
Neoadjuvant-Adjuvant Pembrolizumab in Resectable Advanced Basal Cell Carcinoma of H&N
The purpose of this study is to evaluate anti-PD-1 Neoadjuvant therapy in Basal cell carcinoma to provide a better outcome when administered prior to surgery and provide a therapeutic strategy to avoid surgery altogether.
- Trial name
- NCT04323202
- Testing
- Pembrolizumab, Tissue collection
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Case Comprehensive Cancer Center
Actinic Keratosis
Short Contact Protocols to Reduce Pain During 10% ALA Gel Red-light Photodynamic Therapy of Actinic Keratoses
The goal of this clinical trial is to see if shorter Photodynamic Therapy (PDT) treatment times will still be effective at treating actinic keratoses (AK) while reducing or eliminating the pain that patients sometimes experience…
- Trial name
- NCT06027619
- Testing
- Topical aminolevulinate (10% ALA gel), Red light illumination
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Evaluating the Effectiveness of an Individualized Nutrition and Physical Activity Counseling Program
More than 65% of breast cancer survivors are overweight and less than one-third participate in recommended levels of physical exercise.
- Trial name
- NCT04365569
- Testing
- Nutrition and physical activity counseling program
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Case Comprehensive Cancer Center
Cancer
Promoting Access, Resources and Treatment Through Novel and Equitable Solutions for Cancer Care
The purpose of this research is to evaluate a novel, integrated approach to providing navigation services to improve cancer outcomes and quality of life.
- Trial name
- PARTNERS (NCT06481774)
- Testing
- CONNECT platform
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- Case Comprehensive Cancer Center
Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Cancer
Ivosidenib + mFOLFIRINOX in Patients With Resectable Pancreatic Adenocarcinoma
This study is a single-arm, phase I trial, up to 16 participants with resectable PDA. The study will examine the efficacy of the mutant IDH1 inhibitor ivosidenib, in conjunction with standard-of-care mFOLFIRINOX in the…
- Trial name
- NCT05209074
- Testing
- Ivosidenib, mFOLFIRINOX
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Case Comprehensive Cancer Center
Thrombocytopenia
Collection of Peripheral Blood From Patients With Hematologic Malignancies With Thrombocytopenia
The purpose of the research project is to collect one blood sample from participants who are affected by very low platelets as a result of their condition or their treatment.
- Trial name
- NCT06824727
- Testing
- Baseline cell blood counts
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Case Comprehensive Cancer Center
Discordant Cancers
Genomic Analysis of Families With a History of Discordant Cancers
The purpose of this study is to identify novel gene mutations which have contributed to significant personal and family history of cancer. Adults with and without cancer will be accrued to the study.
- Trial name
- NCT04860453
- Testing
- WES via Illumina NextSeq 550 sequencing system, Blood Draw, Skin biopsy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Case Comprehensive Cancer Center
Rectal Cancer
Transanal Total Mesorectal Excision for Rectal Cancer on Anal Physiology + Fecal Incontinence
Low Anterior Resection (LAR) surgery can be done using various techniques. The traditional technique for performing the surgery is through one or multiple incision(s) in the muscular wall of the abdomen.
- Trial name
- NCT03283540
- Testing
- TaTME, TME
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Case Comprehensive Cancer Center
Multiple Myeloma
Effects of Early Palliative Care Integration on Patients With Newly Diagnosed Multiple Myeloma
Multiple Myeloma (MM) is a common type of cancer involving the cells in the blood (commonly affecting bones, kidneys and blood).
- Trial name
- NCT04248244
- Testing
- Palliative Care, FACT-MM questionnaire, HADS questionnaire
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Case Comprehensive Cancer Center
Stem Cell Transplant Complications, Myeloma
Transplant Wellness Clinic for Elderly or High Risk Patients Undergoing BMT
As the average age of individuals undergoing stem cell transplant continues to increase, challenges associated with balancing the side effects of cancer treatments while also managing other medical conditions develop.
- Conditions
- Stem Cell Transplant Complications, Myeloma, Lymphoma, Allogeneic and Autologous Stem Cell Transplant
- Trial name
- NCT04194840
- Testing
- physical therapy consult, Cognitive Assessment, Cancer Aging Research Group (CARG) assessment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Case Comprehensive Cancer Center
Tumors Metastatic to Brain, Unspecified Adult Solid Tumor
Stereotactic Radiosurgery in Treating Patients With Large Brain Metastases
This phase I/II trial studies the side effects and the best dose of stereotactic radiosurgery and to see how well it works in treating patients with large brain metastases.
- Trial name
- NCT01843413
- Testing
- stereotactic radiosurgery, quality-of-life assessment, cognitive assessment
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Case Comprehensive Cancer Center
Percutaneous Tumor Ablation
Intra-procedural 360-degree Display for Performing Percutaneous Liver Tumor Ablation
Medical images used to guide treatment of tumor(s) are presently displayed on flat-panel monitors (like screens used with computers).
- Trial name
- NCT03500757
- Testing
- HoloLens
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Case Comprehensive Cancer Center
Positive FIT or Stool DNA Testing Follow up
Incomplete Follow Up After Positive FIT or Stool DNA Testing: A Multimethod Approach
This study seeks to determine whether a patient navigator can help improve follow up care after a stool test shows the presence of blood or other abnormal markers.
- Trial name
- NCT03817905
- Testing
- Patient navigator
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Case Comprehensive Cancer Center
Mycosis Fungoides of Skin (Diagnosis), Cutaneous T-cell Lymphoma
Triamcinolone Acetonide Injections in Primary Cutaneous Lymphoma Plaques With a Novel Needle-free Drug-delivery System.
A study to compare pain differences between using MedJet needle-free drug-delivery system with standard of care treatment for cutaneous T-cell lymphomas and cutaneous B-cell lymphomas in participants.
- Conditions
- Mycosis Fungoides of Skin (Diagnosis), Cutaneous T-cell Lymphoma, Non Hodgkin Lymphoma, Lymphomatoid Papulosis
- Trial name
- NCT05106192
- Testing
- Med-Jet Injector, Triamcinolone Acetonide, Bexarotene 1% Top Gel
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Recurrent Glioblastoma
Regorafenib in Bevacizumab Refractory Recurrent Glioblastoma
The purpose of this study is to determine the safety and tolerability of Regorafenib in patients with recurrent or progressive glioblastoma (GBM) who have progressed on bevacizumab.
- Trial name
- NCT04051606
- Testing
- Regorafenib
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Case Comprehensive Cancer Center
Keratinocyte Carcinoma
Teach-back Method on Patient Satisfaction and Adherence to Wound Care Regimen
The purpose of this study is to examine a different way to educate patients about taking care of their wound and see how this method affects patient satisfaction, compliance to the wound care regimen, and patient experience.
- Trial name
- NCT04377971
- Testing
- SOC education, Ask-tell-ask education, Participant satisfaction survey
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Case Comprehensive Cancer Center