Clinical trials: sponsored by Centre Hospitalier Universitaire de Nice
Hypopigmentation
Characterization of Bacterial and Mycosis Skin Flora in Seborrheic Macular Hypopigmentation - Microbiome
Hypopigmented skin changes are commonly encountered by dermatologists. A new dermatological entity was identified as scattered, hypopigmented oval-shaped macules and patches distributed mostly in seborrheic area of the face and…
- Trial name
- Microbiome_SHM (NCT06908889)
- Testing
- Skin's lesion patients, Skin's lesion vulunteers
- Where
- 3 sites in France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Orthodontic Wires
Prevalence of the Wire Syndrome
The Wire Syndrome problem referred to dental displacements that can be described as aberrant, inaccurate, unexplained, or excessive on teeth still contained by an intact orthodontic wire, without detachment or fracture, leading…
- Trial name
- NCT06434506
- Testing
- no intervention
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Odontologic Disorders
Patient Reported Experience Measures Following a First Remote Orthodontic Consultation : a Randomized Controlled Trial
The objective of this present randomized controlled trial was to investigate patient's and practitioner's Reported Outcomes Measures (PROMs) following a first standard face-to-face consultation versus a first orthodontic…
- Trial name
- NCT05646277
- Testing
- e-Consultation, Consultation
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Orthodontic Wires
Diagnosis of Wire Syndrome
The Wire Syndrome (WS) refers to aberrant, unexpected, unexplained, or excessive dental movements involving teeth held by an intact post-orthodontic retention wire. Its prevalence ranging from 1.1% to 43%.
- Trial name
- NCT07030023
- Testing
- Non intervention
- Where
- France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Orthodondic Appliances
A Survey on the Use of Removable Functional Appliances Among Patients Undergoing Treatment at the Orthodontic Unit of Nice University Hospital
The aim of the removable functional appliance is to restore functional balance (breathing, swallowing, chewing, etc.) and muscular balance (particularly of the facial muscles) in children.
- Trial name
- NCT07127341
- Testing
- Patient with removable functional appliance
- Where
- 2 sites in Belgium, France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Erosive Hand Osteoarthritis
Methotrexate Treatment in Hand Osteoarthritis Refractory to Usual Treatments
Randomized study comparing the structural efficacy of methotrexate versus placebo in digital osteoarthritis
- Trial name
- ADEM2 (NCT07501507)
- Testing
- Methotrexate Injectable Solution
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Demyelinating Diseases
Use of a Portable Pupillometer to Detect Optic Nerve Impairment in Patients With Suspected Multiple Sclerosis
In the diagnosis work-up of inflammatory disorders of the central nervous system (CNS), the assessment of optic nerve impairments, even in the absence of clinical symptoms, is now systematic, as it may shorten the time to…
- Trial name
- IRIS (NCT07837050)
- Testing
- Pupillometry measures
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Temporomandibular Disorders (TMD)
INNOVATIVE BENEFITS OF A 4D VIRTUAL SIMULATOR
Temporomandibular disorders (TMD) encompass all temporomandibular muscular and osteoarticular conditions. TMD affects 31% of the adult population, with chronic, debilitating pain in 10% of cases.
- Trial name
- DiagDTM (NCT07499869)
- Testing
- digital jaw impressions and Modjaw® records
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Orthodontic Appliances
Benefits of an Orthodontic Device Removable Functional Appliance in the Management of Malocclusions/Orofacial Dysfunctions
The removable functional appliance's goal is to restore functional balance (breathing, swallowing, chewing, etc.) and muscular balance (facial muscles, etc.) in the child.
- Trial name
- NCT07127328
- Testing
- Patient with removable funcitonal appliance
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Tobacco Use Cessation
Tabacco Cessation in Hospital Services
Tobacco poses a health risk, whatever the method of consumption. According to the baro cancer 2021 : Only 23% of smokers say they have discussed smoking with a healthcare professional in the last 12 months.
- Trial name
- NCT07031024
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Prematurity; Extreme
A Study of Factors Associated With Failure of the Golden Hour Protocol in the Initial Care of Extremely Preterm and Very Low Birth Weight Newborns
Preterm infants are a particularly vulnerable population, especially during the first hours of life as they adapt to life outside the womb.
- Trial name
- PREM-GH (NCT07829562)
- Testing
- Golden hour
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Gingiva, Phenotype
Prevalence of Lower and Upper Incisor Periodontal Phenotypes and Risk Indicators.
The determination of the periodontal phenotype is an essential part of the periodontal diagnostic process, which must guide not only treatment but also prognosis (Kim et al. 2020).
- Trial name
- NCT06981871
- Testing
- Evaluation of the gingival phenotype of the incisors in the upper and lower jaws
- Where
- France
- Volunteers
- 245 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Colorectal Adenocarcinoma
Exploratory Evaluation of the BiP Inhibitor BPR001-615 in Primary Cells and the Diagnostic Value of Circulating BiP in Colorectal Adenocarcinomas
Colorectal cancer is one of the most common cancers worldwide. Although surgery and drug treatments have improved, some colorectal cancers may continue to grow or become resistant to treatment.
- Trial name
- COLBiP (NCT07813884)
- Testing
- BPR001-615
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Dental Anxiety
Behavioural Acceptability of PARO in Paediatric Dentistry : a Descriptive Observational Study
Socially assistive robots are increasingly being studied as tools to support children during healthcare procedures. This observational study aimed to assess the behavioural acceptability of the PARO therapeutic zoomorphic robot…
- Trial name
- NCT07824063
- Testing
- PARO socially assistive therapeutic robot
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Meningococcal ACWY Vaccines, HPV Coverage
Impact of an e-Bug Educational Intervention on HPV and Meningococcal ACWY Vaccine Uptake in Middle School Students
"This study is a non-interventional observational pilot analysis assessing the possible impact of an educational programme (e-Bug) on parental consent and HPV and meningococcal ACWY vaccination uptake during the 2025-2026…
- Conditions
- Meningococcal ACWY Vaccines, HPV Coverage, Meningitidis Infections, Vaccination Coverage
- Trial name
- NCT07824076
- Testing
- e-Bug School-Based Educational Intervention, Standard School-Based Vaccination Campaign
- Where
- France
- Volunteers
- 53,608 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Emergencies, Quality of Life
Quality of Life and Persistent Pain 3 Months After Emergency Surgery Before and After a National Urgency Classification
The aim of this study is to evaluate the impact of implementing a national surgical emergency classification system in the emergency operating room in Nice on patients' quality of life and persistent pain 3 months after surgery.
- Conditions
- Emergencies, Quality of Life, Postoperative Pain
- Trial name
- NCT07819903
- Testing
- Usual-practice emergency-surgery triage, National surgical-emergency classification-based triage
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Substance-related Disorders, Behavior, Addictive
A Study of the Correlation Between the Severity of Substance Use Disorder and the Intensity of Dependence on Generative Artificial Intelligence
This bicentric, cross-sectional observational study conducted in France evaluates the relationship between substance use disorder (SUD) severity and generative artificial intelligence dependency among outpatients treated in…
- Conditions
- Substance-related Disorders, Behavior, Addictive, Artificial Intelligence (AI)
- Trial name
- ADDICT-IA (NCT07819851)
- Testing
- Questionnaire assessment
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Geriatric Oncology
Preparation for Medical and Surgical Procedures in Oncogeriatry.
Surgical management is one of the most frequently used interventions in the treatment of many cancers, but it can be associated with a high risk of postoperative complications.
- Trial name
- PRIMECHO (NCT06443138)
- Testing
- Personalized pre-habilitation program
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Membranous Nephropathy, Membranous Nephropathy - PLA2R Induced
Single-cell RNA Sequencing (scRNA-seq) to Investigate the Mechanisms Underlying the Induction of Regulatory T Cells in Patients With Extramembranous Glomerulonephritis Treated With Rituximab
Membranous nephropathy is a rare autoimmune kidney disease in which autoantibodies, most commonly anti-PLA2R1 antibodies, target podocyte antigens and may cause nephrotic syndrome.
- Conditions
- Membranous Nephropathy, Membranous Nephropathy - PLA2R Induced, Nephrotic Syndrome
- Trial name
- TRANSCRIPT (NCT07811557)
- Testing
- Peripheral blood immune-cell profiling by single-cell RNA sequencing and in vitro pathway modulation assays
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Kidney Diseases
Effect of Empagliflozin in Patients With eGFR Between 10 and 20 ml/Min/1.73m2
The proximal tubule remains the main site for sodium reabsorption in patients with advanced renal failure. The investigators therefore hypothesize that SGLT2i should still exert a significant natriuretic effect in patients with…
- Trial name
- EMPA[10-20] (NCT07074418)
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Centre Hospitalier Universitaire de Nice