Clinical trials: sponsored by Centre for Addiction and Mental Health
Schizophrenia, Schizo Affective Disorder
Examining a Digital Health Approach for Advancing Schizophrenia Illness Self-management and Provider Engagement
The effective treatment of schizophrenia is very challenging due to a number of factors. These include issues such as poor engagement with treatment plans and care providers, limited contacts with providers due to under-resourced…
- Conditions
- Schizophrenia, Schizo Affective Disorder, Psychotic Disorders
- Trial name
- NCT04602741
- Testing
- A4i Intervention
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- Centre for Addiction and Mental Health
Alcohol Withdrawal
Remote Treatment of Alcohol Withdrawal
This study will evaluate the feasibility of delivering symptom-triggered alcohol withdrawal management by telemedicine and determine whether this intervention is satisfactory to patients.
- Trial name
- NCT04858490
- Testing
- Diazepam
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre for Addiction and Mental Health
Treatment-resistant Depression
Does Psilocybin Require Psychedelic Effects to Treat Depression?
Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects.
- Trial name
- PSI-RIS (NCT05710237)
- Testing
- Psilocybin 25 mg, Risperidone 1 MG
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Centre for Addiction and Mental Health
Addiction, Substance Use Disorder (SUD)
HABITS Study (Helping Addiction by Individualized Therapeutic Stimulation): Pilot Trial of Deep Brain Stimulation Guided By Stereoelectroencephalography for Treatment-Refractory Substance Use Disorders
Substance use disorder (SUD) or addiction to drugs/alcohol is a devastating disease. Over 40,000 overdose deaths have happened in Canada since 2016, 1 in 5 Canadians will have a SUD, and 70% of those with SUD continue to relapse…
- Trial name
- HABITS (NCT06973512)
- Testing
- deep brain stimulation and stereoelectroencephalography
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Centre for Addiction and Mental Health
Anxiety, Depression
Culturally Adapting CBT for Chinese Youth in Ontario
This mixed methods study proposes a culturally adapted cognitive behavioural therapy (CA-CBT) model for a Chinese demographic in Canada.
- Trial name
- NCT03711344
- Testing
- Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Centre for Addiction and Mental Health
Depression, Anxiety
Development and Evaluation of Culturally Adapted CBT for South Asian Canadians
As CBT was developed for persons from North America and European background it needs to be adapted for persons from non-Western cultures.
- Trial name
- CaCBT (NCT04010890)
- Testing
- Culturally adapted CBT
- Where
- 3 sites in Canada
- Volunteers
- 146 people
- Sponsor
- Centre for Addiction and Mental Health
Opioid-Related Disorders, Relationship, Professional Patient
A4i-O: A Platform for Complex Behavioral Health to Address OUD
For the purposes of beta testing the first version of A4i-O, 15 individuals with OUD will use the platform for one month. From a design perspective this sample size is viewed as being sufficient to answer questions regarding app…
- Conditions
- Opioid-Related Disorders, Relationship, Professional Patient, Mental Health Wellness 1, Mobile Phone Use
- Trial name
- NCT06215963
- Testing
- App for Independence-O (A4i-O)
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Centre for Addiction and Mental Health
Mild Cognitive Impairment, Memory Impairment
Enhancing Frontal Lobes Plasticity in Mild Cognitive Impairment
More than 5 million people live with Alzheimer's dementia (AD) in North America. No effective treatment exists yet probably because by the time AD has developed it is too late to intervene.
- Trial name
- PAS-MCI (NCT04583215)
- Testing
- Paired Associative Stimulation (PAS)
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Homeless Persons
Examining the Effectiveness of a Critical Time Intervention to Stabilize Trajectories Out of Homelessness for Youth
Problem Statement: This proposal addresses the problem of youth not being adequately supported as they attempt to transition out of homelessness.
- Trial name
- NCT04755361
- Testing
- Housing Outreach Project Collaboration (HOP-C)
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- Centre for Addiction and Mental Health
Schizophrenia, Schizophrenia Relapse
Risk of Breakthrough Symptoms With Long-Acting Injectable Medications
This prospective longitudinal cohort study will follow patients with schizophrenia who are treated with second generation long-acting injectable antipsychotic medications (LAIs) for 48 weeks to determine the risk of psychotic…
- Trial name
- NCT05473741
- Testing
- Second Generation Long-Acting Injectable Antipsychotic Medications
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Centre for Addiction and Mental Health
Depression, Anxiety
CAMH PARTNERs Integrated Care Study
This research study will evaluate an integrated care model of telephone-based, computer-aided care management using a new role of Mental Health Technician and specialized software to support primary care providers in providing…
- Conditions
- Depression, Anxiety, Alcohol Drinking
- Trial name
- PARTNERs (NCT02345122)
- Testing
- Intervention: Mental Health Technician, Enhanced Usual Care
- Where
- Canada
- Volunteers
- 635 people
- Sponsor
- Centre for Addiction and Mental Health
Mild Cognitive Impairment (MCI)
TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)
This study is looking at a new non-invasive brain stimulation methods called transcranial alternating current stimulation (tACS) to see if it can improve working memory and thinking processes in people with Mild Cognitive…
- Trial name
- tACS-MCI (NCT06783283)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Aging, Mental Disorder
Improving Cognition of Older Adults in Community Housing
The I-COACH study will focus on seniors with mental health conditions who are living in senior community housing. This initiative proposes to assess the feasibility and acceptability of a 12-week integrated program of cognitive…
- Trial name
- I-COACH (NCT05932342)
- Testing
- Integrated program of cognitive remediation, physical exercise and socially stimulating activity
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Centre for Addiction and Mental Health
Mental Health Disorder, Substance Use
Stigma Intervention Among Primary Health Workers in Toronto
This project is measuring the effectiveness of an anti-stigma intervention among primary care providers. Both staff and clients will be asked to complete survey data in order to measure the effectiveness.
- Trial name
- NCT03043417
- Testing
- CHC's given the intervention
- Where
- Canada
- Volunteers
- 485 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Mood Disorders
The Roshni Project - Developing a Psychosocial Intervention
The mental health sector is being called upon to develop and implement interventions for youth that attend to gender, age and cultural diversity (Mental Health Commission of Canada, 2016).
- Trial name
- NCT04338464
- Testing
- Psychosocial therapy for South Asian women experiencing mood disorders
- Sponsor
- Centre for Addiction and Mental Health
Mild Cognitive Impairment, Major Depressive Disorder
Home-Based CR and tDCS to Enhance Cognition in Persons With Mild Cognitive Impairment and Late Life Depression
The overall goals of this project are to assess the feasibility and impact of designing and implementing an at-home intervention aimed at preventing long-term cognitive decline and improving cognition in individuals currently…
- Conditions
- Mild Cognitive Impairment, Major Depressive Disorder, Alzheimer's Dementia, Transcranial Direct Current Stimulation
- Trial name
- NCT02959502
- Testing
- Receive tDCS+CR, Facilitate tDCS + CR
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Addiction and Mental Health
Depression - Major Depressive Disorder, Depression Disorders
Racial Disparities in Antidepressant Treatment After a Psychiatric Consultation
Patients from black, indigenous, and people of color (BIPOC) communities are reported to have lower rates of antidepressant adherence and response. The investigators have a limited understanding of why this disparity exists.
- Trial name
- RITA-PC (NCT06799078)
- Testing
- Observation while participants receive treatment by their primary care provider
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Centre for Addiction and Mental Health
Alzheimer Disease, Dementia, Mixed
Targeting Brain Physiology to Treat Neuropsychiatric Symptoms of Dementia Using TMS-EEG and tDCS
Agitation and aggression impose a tremendous burden on the individuals living with dementia, their families, caregivers, and healthcare systems.
- Conditions
- Alzheimer Disease, Dementia, Mixed, Dementia, Behavior Problem
- Trial name
- tTED (NCT03846492)
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Alzheimer's Disease, Alzheimer Dementia (AD)
Standardizing Care for Neuropsychiatric Symptoms and Quality of Life in Dementia
The object of this study to evaluation an Integrated Care Pathway (ICP) to treat Aggression and Agitation in Alzheimer's disease (AD-AA).
- Conditions
- Alzheimer's Disease, Alzheimer Dementia (AD), Aggression
- Trial name
- StaN (NCT03672201)
- Testing
- Non-Pharmacological Intervention, Pharmacological Intervention
- Where
- 6 sites in Canada
- Volunteers
- 187 people
- Sponsor
- Centre for Addiction and Mental Health
Schizophrenia and Related Disorders, Drug Administration Schedule
"Extended" (Alternate Day) Antipsychotic Dosing
The study wishes to examine whether "extended" antipsychotic treatment, in this case, antipsychotic treatment every other day, is as effective as daily treatment.
- Conditions
- Schizophrenia and Related Disorders, Drug Administration Schedule, Drug Therapy, Antipsychotic Agents
- Trial name
- NCT04478838
- Testing
- Risperidone, Olanzapine, paliperidone
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Centre for Addiction and Mental Health