Clinical trials: sponsored by Changhai Hospital
Pancreatic Cancer
Application of Newly Developed Endoscopic Ultrasound With Zone Sonography Technology for Diagnosis of Pancreatic Caner
The purpose of this study is to measure and compare the difference of sound speed between pancreatic cancer and non-pancreatic cancer, and determine the critical value of sound speed for benign and malignant pancreatic cancer.
- Trial name
- NCT03933111
- Testing
- local sound velocity measurement
- Where
- China
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Advanced Esophageal Squamous Carcinoma, Gastric Adenocarcinoma
Clinical Study of Personalized mRNA Vaccine Encoding Neoantigen in Patients With Advanced Digestive System Neoplasms
A single arm, open-label pilot study is designed to determine the safety, tolerability and effectiveness of personalized mRNA tumor vaccine encoding neoantigen in Patients with advanced esophageal squamous carcinoma, gastric…
- Conditions
- Advanced Esophageal Squamous Carcinoma, Gastric Adenocarcinoma, Pancreatic Adenocarcinoma, Colorectal Adenocarcinoma
- Trial name
- NCT03468244
- Testing
- Personalized mRNA Tumor Vaccine
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Changhai Hospital
Colorectal Cancer
Survival Outcome After Minilaparotomy for the Treatment of Colorectal Cancer
The primary aim of this study is to determine the difference of survival outcome (3-year overall survival, 3y OS) between after minilaparotomy and after laparoscopy..
- Trial name
- SoMiniCRC (NCT03843398)
- Testing
- Colorectal cancer resection via minilaparotomy, Laparoscopic colorectal cancer resection
- Volunteers
- 992 people
- Sponsor
- Changhai Hospital
Renal Calculus
A Multicenter Prospective Research on the Treatment of Low Pole Renal Calculus by Flexible Ureteroscope
This study centers on the treatment of low pole renal stones by flexible ureteroscope and intends to find the key anatomical parameters using a prospective, randomized multi-center trial design and to make a more appropriate…
- Trial name
- NCT03105206
- Testing
- Flexible Ureteroscopy
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Changhai Hospital
Acute Lung Injury, Acute Respiratory Distress Syndrome
The Role of Circulating CircRNAs and MicroRNAs in Acute Lung Injury
Efforts to identify circulating factors that predict severity of acute lung injury/acute respiratory distress syndrome（ALI/ARDS）patients is unrevealing.
- Trial name
- TRCCMALI (NCT03766204)
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Conscious Sedation During Endoscopic Retrograde Choledochopancreatography
Efficacy of Oxycodone-propofol Combination Compared With a Fentanyl-propofol Combination on Conscious Sedation Effect and Early Cognitive Function During Therapeutic Endoscopic Retrograde Cholangio-pancreatography
To evaluate and compare the sedative effect and effects on early period cognitive function of a fentanyl-propofol Combination (FP) regimen with a oxycodone-propofol(OP) combination during the endoscopic retrograde…
- Trial name
- NCT03755609
- Testing
- Oxycodone, fentanyl
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changhai Hospital
Lower Urinary Tract Symptoms
Prostatic Obstruction Investigation Team Multicenter Study
The present is a multicenter, observational study organized by the Prostatic Obstruction Investigation Team (POInT), with a main purpose of looking into the current status and symptom progression of male lower urinary tract…
- Trial name
- POInT (NCT03394651)
- Testing
- Oral medications to treat lower urinary tract symptoms, Minimal invasive transurethral prostate procedures
- Where
- China
- Volunteers
- 11,500 people
- Sponsor
- Changhai Hospital
Colonoscopy Insertion, Patient Position
Supine Position for Colonoscopy Insertion
The purpose of this study is to determine whether the supine position is better than the left lateral horizontal body position to decrease cecal intubation time, patients' pain and the difficulty of colonoscopy insertion.
- Trial name
- NCT03289442
- Testing
- supine position
- Where
- China
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colonoscopy Insertion
Left Lateral Tilt-down Position During Colonoscopy Insertion
The purpose of this study is to determine whether the left lateral tilt-down position, which includes procedures that involve placing patients on their left lateral side at an angle to make their heads lower than their feet, is…
- Trial name
- NCT02842489
- Testing
- left lateral tilt-down position, left lateral horizontal position
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Changhai Hospital
Early Gastric Cancer
Application of Linked Color Imaging（LCI） in Diagnosis of Early Gastric Cancer(EGC)
the purpose of this study is to evaluate application value of LCI in the diagnosis of early gastric cancer.
- Trial name
- NCT03661671
- Testing
- LCI+white light
- Where
- China
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Bladder Cancer, Urine Marking
Genomic Imprinting Testing for Diagnosis of Bladder Cancer
Urine analysis provide a promising non-invasive liquid biopsy for diagnosis of bladder cancer. Molecular biomarkers in urine may serve as important diagnostic and prognostic indicators for bladder cancer.
- Conditions
- Bladder Cancer, Urine Marking, Diagnoses Disease
- Trial name
- NCT03563443
- Testing
- Genomic Imprinting Testing
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Pancreatitis
ESWL Versus ESWL and Endoscopic Treatment
The study wants to compare ESWL alone with ESWL and endoscopic drainage of the MPD for treatment of pain in chronic pancreatitis.
- Trial name
- NCT02971475
- Testing
- extracorporeal shock wave lithotripsy, endoscopic drainage of the main pancreatic duct, Analgesics
- Where
- 2 sites in China
- Volunteers
- 62 people
- Sponsor
- Changhai Hospital
Chronic Constipation
Efficacy of Vibrating Capsule in Patients With Chronic Constipation
Constipated patients in the participating center from February 2017 to June 2018 (anticipated) were prospectively enrolled. Number of defecation per week，Bristol score，and Colon transmission experiment were compared with the…
- Trial name
- NCT03508076
- Testing
- Vibrating Capsule
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Changhai Hospital
Prostatic Neoplasms, Digital Rectal Examination
Learning Curve of Digital Rectal Examination for Prostate Cancer Among Internship
The investigators conduct this prospective study to investigate the learning curve of digital rectal examination (DRE) for prostate cancer among internship.
- Conditions
- Prostatic Neoplasms, Digital Rectal Examination, Benign Prostatic Hyperplasia
- Trial name
- NCT03479359
- Testing
- Routine review of DRE results by attending doctors
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Changhai Hospital
Advanced Gastric Adenocarcinoma, Pancreatic Adenocarcinoma
Clinical Study of CAR-CLD18 T Cells in Patients With Advanced Gastric Adenocarcinoma and Pancreatic Adenocarcinoma
A single arm, open-label pilot study is designed to determine the safety, tolerability and engraftment of CAR-CLD18 T cells in patients with advanced gastric adenocarcinoma and pancreatic adenocarcinoma.
- Trial name
- NCT03159819
- Testing
- CAR-CLD18 T Cells
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Changhai Hospital
Lower Urinary Tract Symptoms
Irreversible Electroporation Versus Standard Medication for Benign Prostatic Obstruction
Irreversible electroporation (IRE) is a novel ablation modality using electric pulses to create nanoscale defects in the cell membrane. It has been verified to be safe on the treatment of prostate, lung, liver and kidney masses.
- Trial name
- NCT03448510
- Testing
- Irreversible electroporation, Standard Medication
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changhai Hospital
Barrett's Esophagus
Application of hybridAPC in the Treatment of Barrett
The purpose of this study is to evaluate the efficacy and safety of the new technique of HybridAPC in the treatment of Barrett.
- Trial name
- NCT03418584
- Testing
- HybridAPC
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Geriatric
Safety and Efficacy of ESWL for Geriatric Patients With Chronic Pancreatitis
Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is recommended as the first-line treatment for pancreatic stones. However, how well P-ESWL performs in geriatric patients remains unclear.
- Conditions
- Chronic Pancreatitis, Geriatric, Extracorporeal Shock Wave Lithotripsy
- Trial name
- ESWL (NCT03373682)
- Where
- China
- Volunteers
- 1,404 people
- Sponsor
- Changhai Hospital
Helicobacter Pylori Infection
Study the Effect of Probiotics Combined With Bismuth Quadruple Rescue Therapy on H Pylori Infective Patients
Retrospectivly follow-up the outpatients for H pylori eradication failures more than 2 times in the digestive department of Changhai hospital from 2015-2017,analyse the eradication rates and adverse effects of the therapy with…
- Trial name
- NCT03297242
- Volunteers
- 30 people
- Sponsor
- Changhai Hospital
Bowel Preparation Scale, Adenoma Detection Rate
Comparison Between 3-L and 4-L Polyethylene Glycol in Bowel Preparation
High quality bowel preparation is essential for successful colonoscopy. This study aimed to assess the impact of the dose of Polyethylene Glycol(PEG) on the quality of bowel preparation.
- Trial name
- NCT03356015
- Testing
- 4L Polyethylene Glycol, 3L Polyethylene Glycol
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital